Neuronal and astroglial alterations in the hippocampus of a mouse model for type 1 diabetes
The influence of diabetes mellitus on brain pathology is increasingly recognized. Previous contributions of our laboratory demonstrated in models of type 1 diabetes (nonobese diabetic and streptozotocin (STZ)-treated mice), a marked astrogliosis and neurogenesis deficit in hippocampus and increased...
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Elsevier
2005
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| LEADER | 21042caa a22018617a 4500 | ||
|---|---|---|---|
| 001 | PAPER-22152 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205341.0 | ||
| 008 | 190411s2005 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-14844322311 | |
| 024 | 7 | |2 cas |a reduced nicotinamide adenine dinucleotide phosphate dehydrogenase, 9001-68-7; streptozocin, 18883-66-4 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a BRREA | ||
| 100 | 1 | |a Revsin, Y. | |
| 245 | 1 | 0 | |a Neuronal and astroglial alterations in the hippocampus of a mouse model for type 1 diabetes |
| 260 | |b Elsevier |c 2005 | ||
| 270 | 1 | 0 | |m De Nicola, A.F.; Lab. of Neuroendocrine Biochemistry, Inst. de Biol. Y Med. Experimental, Obligado 2490, 1428, Buenos Aires, Argentina; email: denicola@dna.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a The influence of diabetes mellitus on brain pathology is increasingly recognized. Previous contributions of our laboratory demonstrated in models of type 1 diabetes (nonobese diabetic and streptozotocin (STZ)-treated mice), a marked astrogliosis and neurogenesis deficit in hippocampus and increased expression of hypothalamic neuropeptides. In the present investigation, we further analyzed alterations of astroglia and neurons in the hippocampus of mice 1 month after STZ-induced diabetes. Results showed that these STZ-diabetic mice presented: (a) increased number of astrocytes positive for apolipoprotein-E (Apo-E), a marker of ongoing neuronal dysfunction; (b) abnormal expression of early gene products associated with neuronal activation, including a high number of Jun + neurons in CA1 and CA3 layers and dentate gyrus, and of Fos-expressing neurons in CA3 layer; (c) augmented activity of NADPH-diaphorase, linked to oxidative stress, in CA3 region. These data support the concept that uncontrolled diabetes leads to hippocampal pathology, which adjoin to changes in other brain structures such as hypothalamus and cerebral cortex. © 2005 Elsevier B.V. All rights reserved. |l eng | |
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires, M011, TM048, M094 | ||
| 536 | |a Detalles de la financiación: Ministerio de Salud de la Nación, MSAL | ||
| 536 | |a Detalles de la financiación: WB 88-252 | ||
| 536 | |a Detalles de la financiación: Fundación Antorchas | ||
| 536 | |a Detalles de la financiación: This study was supported by an International agreement between CONICET-INSERM, NWO-WOTRO Grant (WB 88-252), University of Buenos Aires (TM048, M011 and M094), Antorchas Foundation and Beca Carrillo-Oñativia, Ministerio de Salud, Argentina. Appendix A | ||
| 593 | |a Lab. of Neuroendocrine Biochemistry, Inst. of Biol. and Exp. Medicine, Obligado 2490, (1428) Buenos Aires, Argentina | ||
| 593 | |a Department of Human Biochemistry, Faculty of Medicine, University of Buenos Aires, Argentina | ||
| 593 | |a Department of Medical Pharmacology, Leiden University, Netherlands | ||
| 593 | |a CNRS UMR 7059, University Paris 7/D. Diderot, Paris, France | ||
| 593 | |a Lab. of Neuroendocrine Biochemistry, Inst. de Biol. Y Med. Experimental, Obligado 2490, 1428, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a APOLIPOPROTEIN-E, FOS, JUN, NADPH-DIAPHORASE |
| 690 | 1 | 0 | |a ASTROCYTES |
| 690 | 1 | 0 | |a DIABETES MELLITUS |
| 690 | 1 | 0 | |a HIPPOCAMPUS |
| 690 | 1 | 0 | |a NEURODEGENERATION |
| 690 | 1 | 0 | |a NEURONS |
| 690 | 1 | 0 | |a STREPTOZOTOCIN |
| 690 | 1 | 0 | |a APOLIPOPROTEIN E |
| 690 | 1 | 0 | |a GENE PRODUCT |
| 690 | 1 | 0 | |a MOLECULAR MARKER |
| 690 | 1 | 0 | |a PROTEIN C FOS |
| 690 | 1 | 0 | |a PROTEIN C JUN |
| 690 | 1 | 0 | |a REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE |
| 690 | 1 | 0 | |a STREPTOZOCIN |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a BRAIN CORTEX |
| 690 | 1 | 0 | |a BRAIN REGION |
| 690 | 1 | 0 | |a CELL ACTIVATION |
| 690 | 1 | 0 | |a CELL COUNT |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DENTATE GYRUS |
| 690 | 1 | 0 | |a ENZYME ACTIVITY |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a GENE EXPRESSION |
| 690 | 1 | 0 | |a GENE MUTATION |
| 690 | 1 | 0 | |a GENETIC ANALYSIS |
| 690 | 1 | 0 | |a GENETIC LINKAGE |
| 690 | 1 | 0 | |a HIPPOCAMPUS |
| 690 | 1 | 0 | |a INSULIN DEPENDENT DIABETES MELLITUS |
| 690 | 1 | 0 | |a MACROGLIA |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a NERVE CELL LESION |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a OXIDATIVE STRESS |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a STREPTOZOCIN DIABETES |
| 700 | 1 | |a Saravia, F. | |
| 700 | 1 | |a Roig, P. | |
| 700 | 1 | |a Lima, A. | |
| 700 | 1 | |a De Kloet, E.R. | |
| 700 | 1 | |a Homo-Delarche, F. | |
| 700 | 1 | |a De Nicola, A.F. | |
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