Bioactive constituents of Conyza albida
The bioactivity-guided fractionation of an active chloroform extract of Conyza albida led to the isolation of three alkenynes, deca-4,6-diyn-2-(Z)-enoic methyl ester (1), deca-4,6-diyn-2-(Z)-enoic ethyl ester (2) and deca-2,4-diene-4-hydroxy-6-yn-l,4-olide (3), and the terpenoid spathulenol (4), as...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
2000
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 08136caa a22010337a 4500 | ||
|---|---|---|---|
| 001 | PAPER-2214 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203136.0 | ||
| 008 | 140217s2000 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0034518963 | |
| 024 | 7 | |2 pubmed |a 11199128 | |
| 024 | 7 | |2 cas |a DNA, 9007-49-2; DNA topoisomerase, 80449-01-0; chloroform, 67-66-3; methyl green, 54327-10-5; spathulenol, 6750-60-3; Plant Extracts | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a PLMEA | ||
| 100 | 1 | |a Del Pacciaroni, A.V. | |
| 245 | 1 | 0 | |a Bioactive constituents of Conyza albida |
| 260 | |c 2000 | ||
| 270 | 1 | 0 | |m Silva, G.L.; Departamento de Química Org., Fac. de Ciencias Quím. U.N.C., IMBIV-CONICET, Ciudad Universitaria, 5000 Córdoba, Argentina; email: silvagl@dqo.fcq.unc.edu.ar |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Ariza Espinar, L., Conyza albida (Compositae) en Argentina (1982) Boletín de la Sociedad Argentina de Botánica, 21, pp. 269-271 | ||
| 504 | |a Marzocca, A., Conyza bonariensis (1997) Vademécum de Malezas Medicinales de la Argentina, Indígenas y Exóticas, p. 259. , Editorial Hemisferio Sur, Buenos Aires, Argentina: | ||
| 504 | |a González, A., Ferreira, F., Vázquez, A., Moyna, P., Alonso Paz, E., Biological screening of Uruguayan medicinal plants (1993) Journal of Ethnopharmacology, 39, pp. 217-220 | ||
| 504 | |a Gutierrez-Lugo, M.T., Barrientos-Benitez, T., Luna, B., Ramirez-Gamma, R.M., Bye, R., Linares, E., Mata, R., Antimicrobial and cytotoxic activities of some crude drug extracts from Mexican medicinal plants (1996) Phytomedicine, 2, pp. 341-347 | ||
| 504 | |a Al-Yahya, M.A., Mossa, J.S., Al-Meshal, I.A., Antoun, M.D., Mc Cloud, T.G., Cassady, J.M., Jacobsen, L.B., McLaughlin, J.L., Phytochemical and biological studies on Saudi medicinal plants part 9. Antitumor testing (1985) International Journal of Crude Drug Research, 23, pp. 45-66 | ||
| 504 | |a Anderberg, A.A., Taxonomy and phylogeny of the tribe Plucheeae (Asteraceae) (1991) Plant Systematic Evolution, 176, pp. 145-177 | ||
| 504 | |a Bohlmann, F., Jakupovic, J., 8-Oxo-α-selinen und neue Scopoletin-derivative aus Conyza-arten (1979) Phytochemistry, 18, pp. 1367-1370 | ||
| 504 | |a Sanz, J.F., Marco, J.A., Ein neues Butenolid aus Conyza bonariensis (1991) Liebigs Annalen Chemie, pp. 399-400 | ||
| 504 | |a Krebs, H.C., Rakotoarimanga, J.V., Habermehl, G.C., Isolation of spathulenol and (-)-caryophyllene oxide from Vernonia mollissima Don and 1H and 13C reassignment by two-dimensional NMR spectroscopy (1990) Magnetic Resonance in Chemistry, 28, pp. 124-128 | ||
| 504 | |a Mongelli, E., Romano, A., Desmarchelier, C., Coussio, J., Ciccia, G., Cytotoxic 4-nerolidylcatechol from Pothomorphe peltata inhibits topoisomerase 1 activity (1999) Planta Medica, 65, pp. 376-378 | ||
| 504 | |a McLaughlin, J., Methods in Plant Biochemistry. Crown gall tumors on potato discs and brine shrimp lethality: Two bioassays for higher plant screening and fractionation (1991), pp. 1-32. , Harborne JB, editor. Academic Press, New York:Sugiyama, H., Ehrenfeld, G.N., Shipley, J.B., Kilkuskie, R.E., Chang, L.H., Hecht, S.M., DNA strand scission by bleomycin group antibiotics (1985) Journal of Natural Products, 48, pp. 869-877 | ||
| 504 | |a Carpita, A., Neri, D., Rossi, R., Stereocontrolled synthesis of naturally-occurring poliacetylenes characterized by (E)-1-en-3-yne, (E)-1-en-3,5-diyne, (1E,5E)-1,5-dien-3-yne, and (1E,7E)-1,7-dien-3,5-diyne moieties (1987) Gazzetta Chimica Italiana, 117, pp. 481-497 | ||
| 504 | |a Miyazawa, M., Yamamoto, K., Kameoka, H., The essential oil of Erigeron canadensis (1992) Journal of Essential Oil Research, 4, pp. 227-230 | ||
| 504 | |a Köning, G., Wright, A., Sticher, O., Angerhofer, C., Pezzuto, J., Biological activities of selected marine natural products (1994) Planta Medica, 60, pp. 532-537 | ||
| 504 | |a Fullas, F., Hussain, R.A., Chai, H.B., Pezzuto, J.M., Soejarto, D.D., Kinghorn, A.D., Cytotoic constituents of Baccharis gaudichaudiana (1994) Journal of Natural Products, 57, pp. 801-807 | ||
| 504 | |a Bonjean, K., De Pauw-Gillet, M., Bassleer, R., Quentin-Leclercq, J., Angenot, L., Wright, A., Cytotoxic activities of Colombian plant extracts on Chinense hamster lung fibroblasts (1996) Phytotherapy Research, 10, pp. 159-160 | ||
| 504 | |a Suffness, M., Pezzuto, J., Methods in Plant Biochemistry. Assays related to cancer drug discovery (1991), pp. 71-133. , Harborne JB, editor. Academic Press, New York:Liu, L.F., DNA Topoisomerase poisons as antitumor drugs (1989) Annual Review of Biochemistry, 58, pp. 351-375 | ||
| 504 | |a Jung, J.H., Kim, Y., Lee, C.O., Kang, S.S., Park, J.H., Im, K.S., Cytotoxic constituents of Saussurea lappa (1998) Archives of Pharmaceutical Research, 21, pp. 153-156 | ||
| 504 | |a Takaishi, Y., Okuyama, T., Masuda, A., Nakano, K., Murakami, K., Tomimatsu, T., Acetylenes from Cirsium japonicum (1990) Phytochemistry, 29, pp. 3849-3852 | ||
| 520 | 3 | |a The bioactivity-guided fractionation of an active chloroform extract of Conyza albida led to the isolation of three alkenynes, deca-4,6-diyn-2-(Z)-enoic methyl ester (1), deca-4,6-diyn-2-(Z)-enoic ethyl ester (2) and deca-2,4-diene-4-hydroxy-6-yn-l,4-olide (3), and the terpenoid spathulenol (4), as the active toxic metabolites in the Artemia sp. lethality test. When tested in the KB cell cytotoxicity assay, compounds 1-4 demonstrated 1C 50 values of 52.2, 38.4, 117.9, and 83.8 μM, respectively. All compounds studied were inactive in the DNA methyl green and DNA strand scission assays, while compounds 3 and 4 showed moderate activity as inhibitors of human topoisomerase I. Compound 2 is reported here for the first time. |l eng | |
| 593 | |a Departamento de Química Orgánica, Facultad de Ciencias Quím. U.N.C., IMBIV-CONICET, Pabellón de Ciencias II, Ciudad Universitaria, 5000 Córdoba, Argentina | ||
| 593 | |a Cátedra de Microbiología Industrial y Biotecnología, IQUIMEFA-CONICET, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina | ||
| 593 | |a Cátedra de Farmacognosia, IQUIMEFA-CONICET, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a ALKENYNES |
| 690 | 1 | 0 | |a COMPOSITAE |
| 690 | 1 | 0 | |a CONYZA ALBIDA |
| 690 | 1 | 0 | |a CYTOTOXIC ACTIVITY |
| 690 | 1 | 0 | |a DNA INTERACTION |
| 690 | 1 | 0 | |a DNA STRAND SCISSION |
| 690 | 1 | 0 | |a TOPOISOMERASE 1 |
| 690 | 1 | 0 | |a CHLOROFORM |
| 690 | 1 | 0 | |a DECA 2,4 DIENE 4 HYDROXY 6 YN 1,4 OLIDE |
| 690 | 1 | 0 | |a DECA 4,6 DIYN 2 ENOIC ETHYL ESTER |
| 690 | 1 | 0 | |a DECA 4,6 DIYN 2 ENOIC METHYL ESTER |
| 690 | 1 | 0 | |a DNA |
| 690 | 1 | 0 | |a DNA TOPOISOMERASE |
| 690 | 1 | 0 | |a METHYL GREEN |
| 690 | 1 | 0 | |a PLANT EXTRACT |
| 690 | 1 | 0 | |a SPATHULENOL |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a CYTOTOXICITY |
| 690 | 1 | 0 | |a DRUG ACTIVITY |
| 690 | 1 | 0 | |a FRACTIONATION |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a HUMAN CELL |
| 690 | 1 | 0 | |a MEDICINAL PLANT |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PLANT LEAF |
| 690 | 1 | 0 | |a SHRIMP |
| 690 | 1 | 0 | |a ASTERACEAE |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a MOLECULAR STRUCTURE |
| 690 | 1 | 0 | |a PLANT EXTRACTS |
| 690 | 1 | 0 | |a SPECTRUM ANALYSIS |
| 700 | 1 | |a Mongelli, E. | |
| 700 | 1 | |a Espinar, L.A. | |
| 700 | 1 | |a Romano, A. | |
| 700 | 1 | |a Ciccia, G. | |
| 700 | 1 | |a Silva, G.L. | |
| 773 | 0 | |d 2000 |g v. 66 |h pp. 720-723 |k n. 8 |p Planta Med. |x 00320943 |t Planta Medica | |
| 856 | 4 | 1 | |u http://www.scopus.com/inward/record.url?eid=2-s2.0-0034518963&partnerID=40&md5=431466fff1b5c3a0942d2e8edb829709 |y Registro en Scopus |
| 856 | 4 | 0 | |u https://doi.org/10.1055/s-2000-9600 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00320943_v66_n8_p720_DelPacciaroni |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00320943_v66_n8_p720_DelPacciaroni |y Registro en la Biblioteca Digital |
| 961 | |a paper_00320943_v66_n8_p720_DelPacciaroni |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 63167 | ||