Dopamine D2R DNA transfer in dopamine D2 receptor-deficient mice: Effects on ethanol drinking
Dopamine (DA) signals are transmitted via specific receptors including the D2 receptors (D2R). Previous studies have shown that D2R upregulation in the nucleus accumbens (NAc) attenuated alcohol consumption. We hypothesized that upregulation of D2R in the NAc would significantly influence alcohol dr...
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| Lenguaje: | Inglés |
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Elsevier Inc.
2005
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 14343caa a22012737a 4500 | ||
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| 001 | PAPER-22103 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205337.0 | ||
| 008 | 190411s2005 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-18044390103 | |
| 024 | 7 | |2 cas |a alcohol, 64-17-5; DNA, 9007-49-2 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a LIFSA | ||
| 100 | 1 | |a Thanos, P.K. | |
| 245 | 1 | 0 | |a Dopamine D2R DNA transfer in dopamine D2 receptor-deficient mice: Effects on ethanol drinking |
| 260 | |b Elsevier Inc. |c 2005 | ||
| 270 | 1 | 0 | |m Thanos, P.K.; Department of Medicine, Brookhaven National Laboratory, Upton, NY 11973-5000, United States; email: thanos@bnl.gov |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Blum, K., Cull, J.C., Braverman, E.R., Commings, D.E., Reward deficiency syndrome (1996) Am. Scient., 84, pp. 132-145 | ||
| 504 | |a Crystal, R.G., Gene therapy strategies for pulmonary disease (1992) Am. J. Med., 92 (6 A), pp. 44S-52S | ||
| 504 | |a Cunningham, C.L., Howard, M.A., Gill, S.J., Rubinstein, M., Low, M.J., Grandy, D.K., Ethanol-conditioned place preference is reduced in dopamine D2 receptor-deficient mice (2000) Pharmacol Biochem Behav, 67 (4), pp. 693-699 | ||
| 504 | |a Di Chiara, G., Acquas, E., Tanda, G., Ethanol as a neurochemical surrogate of conventional reinforcers: The dopamine opioid link (1996) Alcohol, 13, pp. 13-17 | ||
| 504 | |a Dyr, W., McBride, W.J., Lumeng, L., Li, T.K., Murphy, J.M., Effects of D1 and D2 dopamine receptor agents on ethanol consumption in the high-alcohol-drinking (HAD) line of rats (1993) Alcohol, 10 (3), pp. 207-212 | ||
| 504 | |a George, S.R., Fan, T., Ng, G.Y., Jung, S.Y., O'Dowd, B.F., Naranjo, C.A., Low endogenous dopamine function in brain predisposes to high alcohol preference and consumption: Reversal by increasing synaptic dopamine (1995) J Pharm and Experim Ther, 273 (1), pp. 373-379 | ||
| 504 | |a Guardia, J., Catafau, A.M., Batlle, F., Martin, J.C., Segura, L., Gonzalvo, B., Prat, G., Casas, M., Striatal dopaminergic D(2) receptor density measured by [(123)I]iodobenzamide SPECT in the prediction of treatment outcome of alcohol-dependent patients (2000) Am J Psychiatry, 157 (1), pp. 127-129 | ||
| 504 | |a Horvitz, J.C., Mesolimbocortical and nigrostriatal dopamine responses to salient non-reward events (2000) Neuroscience, 96 (4), pp. 651-656 | ||
| 504 | |a Ikari, H., Umegaki, H., Iguchi, A., Gene therapy to treat Parkinson's disease (1999) Nippon Ronen Igakkai Zasshi, 36 (2), pp. 103-109 | ||
| 504 | |a Ikari, H., Zhang, L., Chernak, J.M., Mastrangeli, A., Kato, S., Kuo, H., Crystal, R.G., Roth, G.S., Adenovirus-mediated gene transfer of dopamine D2 receptor cDNA into rat striatum (1995) Brain Res Mol Brain Res, 34 (2), pp. 315-320 | ||
| 504 | |a Ingram, D.K., Ikari, H., Umegaki, H., Chernak, J.M., Roth, G.S., Application of gene therapy to treat age-related loss of dopamine D2 receptor (1998) Exp Gerontol, 33 (7-8), pp. 793-804 | ||
| 504 | |a Israel, Y., Crews, F.T., Thurman, R.G., Tu, G.C., Garver, E., Ponnappa, B., Karahanian, E., Wheeler, M.D., Gene and antisense delivery in alcoholism research (2002) Alcohol Clin Exp Res, 26 (4), pp. 582-585 | ||
| 504 | |a Koob, G.F., Roberts, A.J., Schulteis, G., Parsons, L.H., Heyser, C.J., Hyytia, P., Merlo-Pich, E., Weiss, F., Neurocircuitry Targets in Ethanol Reward and Dependence (1998) Alcoholism Clinical and Experimental Research, 22 (1), pp. 3-9 | ||
| 504 | |a Koob, G.F., Vaccarino, F.G., Amalric, M., Bloom, F.E., Positive reinforcement properties of drugs: Search for neural substrates (1987) Brain Reward Systems and Abuse, pp. 70-83. , Raven Press New York | ||
| 504 | |a Levy, A.D., Murphy, J.M., McBride, W.J., Lumeng, L., Li, T.K., Microinjection of sulpiride into the nucleus accumbens increases ethanol drinking in alcohol-preferring (P) rats (1991) Alcohol Suppl, 1, pp. 417-420 | ||
| 504 | |a Li, T.K., Pharmacogenetics of responses to alcohol and genes that influence alcohol drinking (2000) J Stud Alcohol, 61 (1), pp. 5-12 | ||
| 504 | |a Lu, R.B., Lee, J.F., Ko, H.C., Lin, W.W., Dopamine D2 receptor gene (DRD2) is associated with alcoholism with conduct disorder (2001) Alcohol Clin Exp Res, 25 (2), pp. 177-184 | ||
| 504 | |a Matsumoto, I., Wilce, P.A., Buckley, T., Dodd, P., Puzke, J., Spanagel, R., Zieglgansberger, W., Schmidt, L.G., Ethanol and gene expression in brain (2001) Alcohol Clin Exp Res, 25 (5 SUPPL. ISBRA), pp. 82S-86S | ||
| 504 | |a McBride, W.J., Chernet, E., Dyr, W., Lumeng, L., Li, T.K., Densities of Dopamine D2 Receptors Are Reduced in CNS Regions of Alcohol-Preferring P Rats (1993) Alcohol, 10, pp. 387-390 | ||
| 504 | |a McBride, W.J., Li, T.K., Animal models of alcoholism: Neurobiology of high alcohol-drinking behavior in rodents (1998) Crit Rev Neurobiol, 12 (4), pp. 339-369 | ||
| 504 | |a McBride, W.J., Murphy, J.M., Gatto, G.J., Levy, A.D., Yoshimoto, K., Lumeng, L., Li, T.K., CNS Mechanisms of Alcohol Self-Administration (1993) Alcohol Alcohol, 2, pp. 461-467 | ||
| 504 | |a Nowak, K.L., Ingraham, C.M., McKinzie, D.L., McBride, W.J., Lumeng, L., Li, T.K., Murphy, J.M., An assessment of novelty-seeking behavior in alcohol-preferring and nonpreferring rats (2000) Pharmacol Biochem Behav, 66 (1), pp. 113-121 | ||
| 504 | |a Ogawa, O., Umegaki, H., Ishiwata, K., Asai, Y., Ikari, H., Oda, K., Toyama, H., Senda, M., In vivo imaging of adenovirus-mediated over-expression of dopamine D2 receptors in rat striatum by positron emission tomography (2000) Neuroreport, 11 (4), pp. 743-748 | ||
| 504 | |a Palmer, A.A., Low, M.J., Grandy, D.K., Phillips, T.J., Effects of a Drd2 deletion mutation on ethanol-induced locomotor stimulation and sensitization suggest a role for epistasis (2003) Behav Genet, 33 (3), pp. 311-324 | ||
| 504 | |a Paxinos, G., Franklin, K.B., (2001) The Mouse Brain in Stereotaxic Coordinates, , 2nd edition Academic Press San Diego | ||
| 504 | |a Phillips, T.J., Brown, K.J., Burkhart-Kasch, S., Wenger, C.D., Kelly, M.A., Rubinstein, M., Grandy, D.K., Low, M.J., Alcohol preference and sensitivity are markedly reduced in mice lacking dopamine D2 receptors (1998) Nat Neurosci, 1 (7), pp. 610-615 | ||
| 504 | |a Risinger, F.O., Freeman, P.A., Rubinstein, M., Low, M.J., Grandy, D.K., Lack of Operant Ethanol Self-administration in Dopamine D2 Receptor Knockout Mice (2000) Psychopharmacology, 152, pp. 343-350 | ||
| 504 | |a Samson, H.H., Harris, R.A., Neurobiology of Alcohol Abuse (1992) TiPS, 13, pp. 206-212 | ||
| 504 | |a Smith, J.W., Fetsko, L.A., Xu, R., Wang, Y., Dopamine D2L receptor knockout mice display deficits in positive and negative reinforcing properties of morphine and in avoidance learning (2002) Neuroscience, 113 (4), pp. 755-765 | ||
| 504 | |a Stefanini, E., Frau, M., Garau, M.G., Garau, B., Fadda, F., Gessa, G.L., Alcohol-Preferring rats have fewer dopamine D2 receptors in the limbic system (1992) Alcohol & Alcoholism, 27 (2), pp. 127-130 | ||
| 504 | |a Suhr, S.T., Gage, F.H., Gene therapy for neurologic disease (1993) Arch Neurol, 50 (11), pp. 1252-1268 | ||
| 504 | |a Tajuddin, N.F., Druse, M.J., Effects of chronic alcohol consumption and aging on dopamine D2 receptors in Fischer 344 rats (1996) Alcohol Clin Exp Res, 20 (1), pp. 144-151 | ||
| 504 | |a Thanos, P.K., Thanos, P.K., Taintor, N.B., Rivera, S.N., Umegaki, H., Ikari, H., Roth, G., Volkow, N.D., DRD2 Gene Transfer into the Nucleus Accumbens of the Alcohol Preferring (P) and Non Preferring (NP) Rats Attenuates Alcohol Drinking (2004) Alcohol Clin and Exper Res, 28 (5), pp. 720-728 | ||
| 504 | |a Thanos, P.K., Volkow, N.D., Freimuth, P., Umegaki, H., Ikari, H., Roth, G., Ingram, D.K., Hitzemann, R., Overexpression of dopamine D2 receptors reduces alcohol self- administration (2001) J Neurochem, 78 (5), pp. 1094-1103 | ||
| 504 | |a Tran, A.H., Tamura, R., Uwano, T., Kobayashi, T., Katsuki, M., Matsumoto, G., Ono, T., Altered accumbens neural response to prediction of reward associated with place in dopamine D2 receptor knockout mice (2002) Proc Natl Acad Sci U S a, 99 (13), pp. 8986-8991 | ||
| 504 | |a Umegaki, H., Chernak, J.M., Ikari, H., Roth, G.S., Ingram, D.K., Rotational behavior produced by adenovirus-mediated gene transfer of dopamine D2 receptor into rat striatum (1997) Neuroreport, 8 (16), pp. 3553-3558 | ||
| 504 | |a Volkow, N.D., Fowler, J.S., Gatley, S.J., Logan, J., Wang, G.J., Ding, Y.S., Dewey, S., PET evaluation of the dopamine system of the human brain (1996) J Nucl Med, 37 (7), pp. 1242-1256 | ||
| 504 | |a Volkow, N.D., Wang, G.J., Fowler, J.S., Logan, J., Gatley, S.J., MacGregor, R.R., Schlyer, D.J., Wolf, A.P., Decreases in dopamine receptors but not in dopamine transporters in alcoholics (1996) Alcohol Clin Exp Res, 20 (9), pp. 1594-1598 | ||
| 504 | |a Volkow, N.D., Fowler, J.S., Wang, G.J., Imaging studies on the role of dopamine in cocaine reinforcement and addiction in humans (1999) J Psychopharmacol, 13 (4), pp. 337-345 | ||
| 504 | |a Volkow, N.D., Wang, G.J., Fowler, J.S., Logon, J., Gatley, S.J., Gifford, A., Hitzemann, R., Pappas, N., Prediction of reinforcing responses to psychostimulants in humans by brain dopamine D2 receptor levels (1999) Am J Psychiatry, 156 (9), pp. 1440-1443 | ||
| 504 | |a Volkow, N.D., Volkow, N.D., Wang, G.J., Fowler, J.S., Thanos, P.P., Logan, J., Gatley, S.J., Thanos, P.K., Brain DA D2 receptors predict reinforcing effects of stimulants in humans: Replication study (2002) Synapse, 46 (2), pp. 79-82 | ||
| 520 | 3 | |a Dopamine (DA) signals are transmitted via specific receptors including the D2 receptors (D2R). Previous studies have shown that D2R upregulation in the nucleus accumbens (NAc) attenuated alcohol consumption. We hypothesized that upregulation of D2R in the NAc would significantly influence alcohol drinking. We tested this hypothesis by determining the effect that D2R upregulation has on alcohol intake in genetically altered mice lacking D2Rs. After a steady baseline of drinking behavior was established for all mice, a null vector or a genetically modified adenoviral vector containing the rat D2R cDNA was infused into the NAc of wild-type (Drd2+/+), heterozygous (Drd2+/-), and receptor-deficient mice (Drd2-/-). Ethanol intake and preference were then determined using the two-bottle choice paradigm. Our results indicated that Drd2+/+ mice treated with the D2R vector significantly attenuated (58 %) their ethanol intake as well as reduced preference. Drd2+/- and mutant mice showed a similar attenuation, although the change was not as marked (12 %) and did not last as long. In contrast, Drd2-/- mice treated with the D2R vector displayed a temporary but significant increase (46 %) in ethanol intake and preference (consumption). These results supported the notion that the D2R plays an important role in alcohol consumption in mice and suggest that a key threshold range of D2R levels is associated with elevated alcohol consumption. Significant deviations in D2R levels from this range could impact alcohol consumption, and could help to explain possible individual variations in alcohol response, metabolism, sensitivity and consumption. © 2005 Elsevier Inc. All rights reserved. |l eng | |
| 536 | |a Detalles de la financiación: U.S. Department of Energy, DE-AC02-98CH10886 | ||
| 536 | |a Detalles de la financiación: National Institute on Alcohol Abuse and Alcoholism, AA07611, AA 11034, AA07574 | ||
| 536 | |a Detalles de la financiación: National Institute of Mental Health, MH67497, MH66360 | ||
| 536 | |a Detalles de la financiación: National Institute of Development Administration, DA12062 | ||
| 536 | |a Detalles de la financiación: The authors thank, Katherine Suchland, Andrew Lee, Brittney Tejada, Maryann Kershaw and Dr. Bruce Scharf for assistance with this study and for veterinary care. We would also like to thank Brian Murfin, Kevin Manning and the SULI program at Brookhaven National Laboratory for supporting KW. This work was supported by the NIAAA (AA 11034 & AA07574, AA07611), NIMH (MH66360 & MH67497) and NIDA (DA12062) and by the U.S. Department of Energy under contract DE-AC02-98CH10886. | ||
| 593 | |a Department of Medicine, Brookhaven National Laboratory, Upton, NY 11973-5000, United States | ||
| 593 | |a Dept. of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97201, United States | ||
| 593 | |a INGEBI (CONICET), Dept. Fisiol., Biol. Molec. Y Cel., University of Buenos Aires, 1428 Buenos Aires, Argentina | ||
| 593 | |a Dept. of Geriatrics, Univ. of Nagoya, School of Medicine, Aichi 466-8550, Japan | ||
| 690 | 1 | 0 | |a ADDICTION |
| 690 | 1 | 0 | |a ALCOHOLISM |
| 690 | 1 | 0 | |a ASSOCIATIVE LEARNING |
| 690 | 1 | 0 | |a GENE THERAPY |
| 690 | 1 | 0 | |a ADENOVIRUS VECTOR |
| 690 | 1 | 0 | |a ALCOHOL |
| 690 | 1 | 0 | |a COMPLEMENTARY DNA |
| 690 | 1 | 0 | |a DNA |
| 690 | 1 | 0 | |a DOPAMINE 2 RECEPTOR |
| 690 | 1 | 0 | |a ALCOHOL CONSUMPTION |
| 690 | 1 | 0 | |a ALCOHOL METABOLISM |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DNA MODIFICATION |
| 690 | 1 | 0 | |a DNA TRANSFER |
| 690 | 1 | 0 | |a DRINKING BEHAVIOR |
| 690 | 1 | 0 | |a HETEROZYGOSITY |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a NUCLEUS ACCUMBENS |
| 690 | 1 | 0 | |a RECEPTOR UPREGULATION |
| 690 | 1 | 0 | |a WILD TYPE |
| 700 | 1 | |a Rivera, S.N. | |
| 700 | 1 | |a Weaver, K. | |
| 700 | 1 | |a Grandy, D.K. | |
| 700 | 1 | |a Rubinstein, M. | |
| 700 | 1 | |a Umegaki, H. | |
| 700 | 1 | |a Wang, G.J. | |
| 700 | 1 | |a Hitzemann, R. | |
| 700 | 1 | |a Volkow, N.D. | |
| 773 | 0 | |d Elsevier Inc., 2005 |g v. 77 |h pp. 130-139 |k n. 2 |p Life Sci. |x 00243205 |w (AR-BaUEN)CENRE-749 |t Life Sciences | |
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