Synthesis and antiviral evaluation of some carbonucleoside analogues

1,2-O-Isopropylidene-α-L-threofuranosyl heterocyclic derivatives were synthesized from 1,2-O-isopropylidene-α-D-xilopentadialdo-1,4-furanose and tested for antiviral activity against herpes simplex virus type 1, dengue virus type 2 and Junín virus. For comparative propose, the antiviral activity of...

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Autor principal: Martins Alho, M.A
Otros Autores: Errea, M.I, Sguerra, V.L, D'Accorso, N.B, Talarico, L.B, García, C.C, Damonte, E.B
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 2005
Acceso en línea:Registro en Scopus
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Registro en la Biblioteca Digital
Aporte de:Registro referencial: Solicitar el recurso aquí
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100 1 |a Martins Alho, M.A. 
245 1 0 |a Synthesis and antiviral evaluation of some carbonucleoside analogues 
260 |c 2005 
270 1 0 |m CIHIDECAR (CONICET), Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales ArgentinaArgentina; email: norma@qo.fcen.uba.ar 
506 |2 openaire  |e Política editorial 
504 |a Zhang, H.Y., Yu, H.W., Ma, L.T., Min, J.M., Zhang, L.H., (1998) Tetrahedron Asymmetry, 9, p. 141 
504 |a Yu, H.W., Zhang, H.Y., Yang, Z.J., Min, J.M., Ma, L.T., Zhang, L.H., (1998) Pure Appl. Chem., 70, p. 435 
504 |a Yang, Z.J., Yu, H.W., Min, J.M., Ma, L.T., Zhang, L.H., (1997) Tetrahedron Asymmetry, 8, p. 2739 
504 |a Zhang, M., Zhang, H., Yang, Z., Ma, L., Min, J., Zhang, L., (1999) Carbohydr. Res., 318, p. 157 
504 |a Lehman, J., Steck, J., Weiser, W., (1998) Carbohydr. Res., 184, p. 113 
504 |a Lehman, J., Sandhoff, K., (1990) Justus Liebigs Ann. Chem., p. 1261 
504 |a Casiraghi, G., Cornia, M., Rassu, G., Sante, C.D., Spanu, P., (1992) Tetrahedron, 48, p. 5619 
504 |a Damonte, E.B., Junin virus (2002) Wiley Encyclopedia of Molecular Medicine, pp. 1844-1846. , Creighton, T. E., Eds.; John Wiley & Sons, New York 
504 |a Martins Alho, M.A., D'Accorso, N.B., (2000) J. Heterocyclic Chem., 37, p. 811 
504 |a Seldes, A.M., D'Accorso, N.B., Souto, M.F., Martins Alho, M., Arabehety, C., (2001) J. Mass Spectrom., 36, p. 1069 
504 |a Martins Alho, M.A., D'Accorso, N.B., (1999) J. Heterocyclic Chem., 36, p. 177 
504 |a McKee, K.T., Huggins, J.W., Trahan, C.J., Mahlandi, B.G., (1988) Antimicrob. Agents Chemother., 32, p. 1304 
504 |a Enria, D.A., Maiztegui, J.I., (1994) Antiviral Res., 23, p. 23 
504 |a Fascio, M.L., Montesano, V.J., D'Accorso, N.B., (1998) J. Heterocyclic Chem., 35, p. 103. , and references therein 
520 3 |a 1,2-O-Isopropylidene-α-L-threofuranosyl heterocyclic derivatives were synthesized from 1,2-O-isopropylidene-α-D-xilopentadialdo-1,4-furanose and tested for antiviral activity against herpes simplex virus type 1, dengue virus type 2 and Junín virus. For comparative propose, the antiviral activity of some of their pyranosyl analogues were also tested. The furanosyl derivatives showed to be moderate inhibitors of Junin virus and, in general, proved to be more effective than the pyranosyl analogues.  |l eng 
593 |a CIHIDECAR (CONICET), Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales Argentina, Argentina 
593 |a Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales Argentina, Argentina 
690 1 0 |a 1,2 O ISOPROPYLIDENE ALPHA DEXTRO XYLOPENTADIALDO 1,4 FURANOSE 
690 1 0 |a 1,2 O ISOPROPYLIDENE ALPHA LEVO FURANOSYL DERIVATIVE 
690 1 0 |a ANTIVIRUS AGENT 
690 1 0 |a CARBONUCLEOSIDE DERIVATIVE 
690 1 0 |a HETEROCYCLIC COMPOUND 
690 1 0 |a NUCLEOSIDE DERIVATIVE 
690 1 0 |a PYRANOSYL DERIVATIVE 
690 1 0 |a UNCLASSIFIED DRUG 
690 1 0 |a ANTIVIRAL ACTIVITY 
690 1 0 |a ARTICLE 
690 1 0 |a DENGUE VIRUS 
690 1 0 |a DRUG SYNTHESIS 
690 1 0 |a HERPES SIMPLEX VIRUS 1 
690 1 0 |a JUNIN VIRUS 
690 1 0 |a NONHUMAN 
700 1 |a Errea, M.I. 
700 1 |a Sguerra, V.L. 
700 1 |a D'Accorso, N.B. 
700 1 |a Talarico, L.B. 
700 1 |a García, C.C. 
700 1 |a Damonte, E.B. 
773 0 |d 2005  |g v. 42  |h pp. 979-983  |k n. 5  |p J. Heterocycl. Chem.  |x 0022152X  |w (AR-BaUEN)CENRE-780  |t Journal of Heterocyclic Chemistry 
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856 4 0 |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0022152X_v42_n5_p979_MartinsAlho  |y Registro en la Biblioteca Digital 
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