The genome sequence of Trypanosoma cruzi, etiologic agent of chagas disease

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Whole-genome sequencing of the protozoan pathogen Trypanosoma cruzi revealed that the diploid genome contains a predicted 22,570 proteins encoded by genes, of which 12,570 represent allelic pairs. Over 50% of the genome consists of repeated sequences, such as retrotransposons and genes for large fam...

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Autor principal: El-Sayed, N.M
Otros Autores: Myler, P.J, Bartholomeu, D.C, Nilsson, D., Aggarwal, G., Tran, A.-N, Ghedin, E., Worthey, E.A, Delcher, A.L, Blandin, G., Westenberger, S.J, Caler, E., Cerqueira, G.C, Branche, C., Haas, B., Anupama, A., Arner, E., slund, L., Attipoe, P., Bontempi, E., Bringaud, F., Burton, P., Cadag, E., Campbell, D.A, Carrington, M., Crabtree, J., Darban, H., Da Silveira, J.F, De Jong, P., Edwards, K., Englund, P.T, Fazelina, G., Feldblyum, T., Ferella, M., Frasch, A.C, Gull, K., Horn, D., Hou, L., Huang, Y., Kindlund, E., Klingbeil, M., Kluge, S., Koo, H., Lacerda, D., Levin, M.J, Lorenzi, H., Louie, T., Machado, C.R, McCulloch, R., McKenna, A., Mizuno, Y., Mottram, J.C, Nelson, S., Ochaya, S., Osoegawa, K., Pai, G., Parsons, M., Pentony, M., Pettersson, U., Pop, M., Ramirez, J.L, Rinta, J., Robertson, L., Salzberg, S.L, Sanchez, D.O, Seyler, A., Sharma, R., Shetty, J., Simpson, A.J, Sisk, E., Tammi, M.T, Tarleton, R., Teixeira, S., Van Aken, S., Vogt, C., Ward, P.N, Wickstead, B., Wortman, J., White, O., Fraser, C.M, Stuart, K.D, Andersson, B.
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 2005
Materias:
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Acceso en línea:Registro en Scopus
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Biblioteca Central Dr. Luis F. Leloir (FCEN) de Universidad de Buenos Aires
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024 7 |2 cas  |a phosphatase, 9013-05-2; protein kinase, 9026-43-1; sialidase, 9001-67-6; DNA, Mitochondrial; DNA, Protozoan; Membrane Proteins; Protozoan Proteins; Retroelements; Trypanocidal Agents 
040 |a Scopus  |b spa  |c AR-BaUEN  |d AR-BaUEN 
030 |a SCIEA 
100 1 |a El-Sayed, N.M. 
245 1 4 |a The genome sequence of Trypanosoma cruzi, etiologic agent of chagas disease 
260 |c 2005 
270 1 0 |m El-Sayed, N.M.; Department of Parasite Genomics, Institute for Genomic Research, Rockville, MD 20850, United States; email: nelsayed@tigr.org 
506 |2 openaire  |e Política editorial 
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520 3 |a Whole-genome sequencing of the protozoan pathogen Trypanosoma cruzi revealed that the diploid genome contains a predicted 22,570 proteins encoded by genes, of which 12,570 represent allelic pairs. Over 50% of the genome consists of repeated sequences, such as retrotransposons and genes for large families of surface molecules, which include trans-sialidases, mucins, gp63s, and a large novel family (>1300 copies) of mucin-associated surface protein (MASP) genes. Analyses of the T. cruzi, T. brucei, and Leishmania major (Tritryp) genomes imply differences from other eukaryotes in DNA repair and initiation of replication and reflect their unusual mitochondrial DNA. Although the Tritryp lack several classes of signaling molecules, their kinomes contain a large and diverse set of protein kinases and phosphatases; their size and diversity imply previously unknown interactions and regulatory processes, which may be targets for intervention.  |l eng 
593 |a Department of Parasite Genomics, Institute for Genomic Research, Rockville, MD 20850, United States 
593 |a Department of Microbiology and Tropical Medicine, George Washington University, Washington, DC 20052, United States 
593 |a Seattle Biomedical Research Institute, Seattle, WA 98109, United States 
593 |a Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195, United States 
593 |a Department of Medical Education and Biomedical Informatics, University of Washington, Seattle, WA 98195, United States 
593 |a Center for Genomics and Bioinformatics, Karolinska Institutet, Berzelius väg 35, S-171 77 Stockholm, Sweden 
593 |a Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA 90095, United States 
593 |a Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, CEP 31270-901, Belo Horizonte, MG, Brazil 
593 |a Department of Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden 
593 |a Instítuto Nacional de Parasitología Dr. M. Fatala Chabén, Administración Nacional de Laboratories e Insitutos de Salud (ANLIS), 1063, Buenos Aires, Argentina 
593 |a Laboratoire de Génomique Fonctionnelle des Trypanosomatides, UMR-CNRS 5162, Université Victor Segalen Bordeaux II, 33076 Bordeaux Cedex, France 
593 |a Wellcome Centre for Molecular Parasitology, University of Glasgow, Glasgow G11 6NU, United Kingdom 
593 |a Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom 
593 |a Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de São Paulo, CEP 04023-062, São Paulo, SP, Brazil 
593 |a BACPAC Resources, Children's Hospital Oakland Research Institute, Oakland, CA 94609, United States 
593 |a Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States 
593 |a Instituto de Investigaciones Biotecnologicas-Instituto Tecnologico de Chascomus, National University of San Martin, National Research Council, 1650 Buenos Aires, Argentina 
593 |a Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, United Kingdom 
593 |a London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, United Kingdom 
593 |a Department of Microbiology, University of Massachusetts, Amherst, MA 01003, United States 
593 |a René Rachou Research Center, CPqRR, Oswaldo Cruz Foundation, Belo Horizonte, MG, Brazil 
593 |a Laboratory of Molecular Biology of Chagas Disease, Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Centro de Genomica Aplicada-CeGA-University of Buenos Aires, 1428 Buenos Aires, Argentina 
593 |a Instituto de Biología Experimental, Universidad Central de Venezuela and ADEA-MCT, 1041-A Caracas, Venezuela 
593 |a Department of Biological Sciences, National University of Singapore, Singapore, Singapore 
593 |a Center for Tropical and Emerging Global Diseases, Department of Cellular Biology, University of Georgia, Athens, GA 30602, United States 
690 1 0 |a DISEASES 
690 1 0 |a DNA 
690 1 0 |a PROTEINS 
690 1 0 |a CHAGAS DISEASES 
690 1 0 |a SURFACE MOLECULES 
690 1 0 |a TRYPANOSOMA CRUZI 
690 1 0 |a PROTOZOA 
690 1 0 |a GENE PRODUCT 
690 1 0 |a MEMBRANE PROTEIN 
690 1 0 |a MITOCHONDRIAL DNA 
690 1 0 |a MUCIN 
690 1 0 |a PHOSPHATASE 
690 1 0 |a PROTEIN KINASE 
690 1 0 |a PROTOZOAL PROTEIN 
690 1 0 |a SIALIDASE 
690 1 0 |a GENOME 
690 1 0 |a ALLELE 
690 1 0 |a ARTICLE 
690 1 0 |a CHAGAS DISEASE 
690 1 0 |a DIPLOIDY 
690 1 0 |a DNA REPAIR 
690 1 0 |a DNA REPLICATION 
690 1 0 |a EUKARYOTE 
690 1 0 |a GENE SEQUENCE 
690 1 0 |a GENOME ANALYSIS 
690 1 0 |a LEISHMANIA MAJOR 
690 1 0 |a MOLECULAR SIZE 
690 1 0 |a MULTIGENE FAMILY 
690 1 0 |a NONHUMAN 
690 1 0 |a PRIORITY JOURNAL 
690 1 0 |a RETROPOSON 
690 1 0 |a SIGNAL TRANSDUCTION 
690 1 0 |a TRYPANOSOMA BRUCEI 
690 1 0 |a TRYPANOSOMA CRUZI 
690 1 0 |a ANIMALS 
690 1 0 |a CHAGAS DISEASE 
690 1 0 |a DNA REPAIR 
690 1 0 |a DNA REPLICATION 
690 1 0 |a DNA, MITOCHONDRIAL 
690 1 0 |a DNA, PROTOZOAN 
690 1 0 |a GENES, PROTOZOAN 
690 1 0 |a GENOME, PROTOZOAN 
690 1 0 |a HUMANS 
690 1 0 |a MEIOSIS 
690 1 0 |a MEMBRANE PROTEINS 
690 1 0 |a MULTIGENE FAMILY 
690 1 0 |a PROTOZOAN PROTEINS 
690 1 0 |a RECOMBINATION, GENETIC 
690 1 0 |a REPETITIVE SEQUENCES, NUCLEIC ACID 
690 1 0 |a RETROELEMENTS 
690 1 0 |a SEQUENCE ANALYSIS, DNA 
690 1 0 |a SIGNAL TRANSDUCTION 
690 1 0 |a TELOMERE 
690 1 0 |a TRYPANOCIDAL AGENTS 
690 1 0 |a TRYPANOSOMA CRUZI 
690 1 0 |a EUKARYOTA 
690 1 0 |a LEISHMANIA MAJOR 
690 1 0 |a PROTOZOA 
690 1 0 |a TRYPANOSOMA CRUZI 
650 1 7 |2 spines  |a GENES 
700 1 |a Myler, P.J. 
700 1 |a Bartholomeu, D.C. 
700 1 |a Nilsson, D. 
700 1 |a Aggarwal, G. 
700 1 |a Tran, A.-N. 
700 1 |a Ghedin, E. 
700 1 |a Worthey, E.A. 
700 1 |a Delcher, A.L. 
700 1 |a Blandin, G. 
700 1 |a Westenberger, S.J. 
700 1 |a Caler, E. 
700 1 |a Cerqueira, G.C. 
700 1 |a Branche, C. 
700 1 |a Haas, B. 
700 1 |a Anupama, A. 
700 1 |a Arner, E. 
700 1 |a slund, L. 
700 1 |a Attipoe, P. 
700 1 |a Bontempi, E. 
700 1 |a Bringaud, F. 
700 1 |a Burton, P. 
700 1 |a Cadag, E. 
700 1 |a Campbell, D.A. 
700 1 |a Carrington, M. 
700 1 |a Crabtree, J. 
700 1 |a Darban, H. 
700 1 |a Da Silveira, J.F. 
700 1 |a De Jong, P. 
700 1 |a Edwards, K. 
700 1 |a Englund, P.T. 
700 1 |a Fazelina, G. 
700 1 |a Feldblyum, T. 
700 1 |a Ferella, M. 
700 1 |a Frasch, A.C. 
700 1 |a Gull, K. 
700 1 |a Horn, D. 
700 1 |a Hou, L. 
700 1 |a Huang, Y. 
700 1 |a Kindlund, E. 
700 1 |a Klingbeil, M. 
700 1 |a Kluge, S. 
700 1 |a Koo, H. 
700 1 |a Lacerda, D. 
700 1 |a Levin, M.J. 
700 1 |a Lorenzi, H. 
700 1 |a Louie, T. 
700 1 |a Machado, C.R. 
700 1 |a McCulloch, R. 
700 1 |a McKenna, A. 
700 1 |a Mizuno, Y. 
700 1 |a Mottram, J.C. 
700 1 |a Nelson, S. 
700 1 |a Ochaya, S. 
700 1 |a Osoegawa, K. 
700 1 |a Pai, G. 
700 1 |a Parsons, M. 
700 1 |a Pentony, M. 
700 1 |a Pettersson, U. 
700 1 |a Pop, M. 
700 1 |a Ramirez, J.L. 
700 1 |a Rinta, J. 
700 1 |a Robertson, L. 
700 1 |a Salzberg, S.L. 
700 1 |a Sanchez, D.O. 
700 1 |a Seyler, A. 
700 1 |a Sharma, R. 
700 1 |a Shetty, J. 
700 1 |a Simpson, A.J. 
700 1 |a Sisk, E. 
700 1 |a Tammi, M.T. 
700 1 |a Tarleton, R. 
700 1 |a Teixeira, S. 
700 1 |a Van Aken, S. 
700 1 |a Vogt, C. 
700 1 |a Ward, P.N. 
700 1 |a Wickstead, B. 
700 1 |a Wortman, J. 
700 1 |a White, O. 
700 1 |a Fraser, C.M. 
700 1 |a Stuart, K.D. 
700 1 |a Andersson, B. 
773 0 |d 2005  |g v. 309  |h pp. 409-415+435  |k n. 5733  |p Science  |x 00368075  |w (AR-BaUEN)CENRE-344  |t Science 
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856 4 0 |u https://doi.org/10.1126/science.1112631  |y DOI 
856 4 0 |u https://hdl.handle.net/20.500.12110/paper_00368075_v309_n5733_p409_ElSayed  |y Handle 
856 4 0 |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00368075_v309_n5733_p409_ElSayed  |y Registro en la Biblioteca Digital 
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999 |c 83019 

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