Testis structure and function in a nongenetic hyperadipose rat model at prepubertal and adult ages
There are few data for hormonal levels and testis structure and function during postnatal development in rats neonatally treated with monosodium L-glutamate (MSG). In our study, newborn male pups were ip injected with MSG (4 mg/g body weight) every 2 d up to 10 d of age and investigated at prepubert...
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2006
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| LEADER | 20104caa a22019817a 4500 | ||
|---|---|---|---|
| 001 | PAPER-21863 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205321.0 | ||
| 008 | 190411s2006 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-32644441730 | |
| 024 | 7 | |2 cas |a corticosterone, 50-22-6; follitropin, 9002-68-0; glutamate sodium, 142-47-2, 16177-21-2, 16690-92-9; luteinizing hormone, 39341-83-8, 9002-67-9; testosterone, 58-22-0; Corticosterone, 50-22-6; Follicle Stimulating Hormone, 9002-68-0; Leptin; Prolactin, 9002-62-4; Testosterone, 58-22-0; Thyroxine, 7488-70-2 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a ENDOA | ||
| 100 | 1 | |a França, L.R. | |
| 245 | 1 | 0 | |a Testis structure and function in a nongenetic hyperadipose rat model at prepubertal and adult ages |
| 260 | |c 2006 | ||
| 270 | 1 | 0 | |m França, L.R.; Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte-MG, Brazil; email: lrfranca@icb.ufmg.br |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Barash, I.A., Cheung, C.C., Weigle, D.S., Ren, H., Kabigting, E.B., Kuijper, J.L., Clifton, D.K., Steiner, R.A., Leptin is a metabolic signal to the reproductive system (1996) Endocrinology, 137, pp. 3144-3147 | ||
| 504 | |a Magni, P., Motta, M., Martini, L., Leptin: A possible link between food intake, energy expenditure, and reproductive function (2000) Regul Pept, 92, pp. 51-56 | ||
| 504 | |a Caprio, M., Fabbrini, E., Isidori, A.M., Aversa, A., Fabbri, A., Leptin in reproduction (2001) Trends Endocrinol Metab, 12, pp. 65-72 | ||
| 504 | |a Smith, G.D., Jackson, L.M., Foster, D.L., Leptin regulation of reproductive function and fertility (2002) Theriogenology, 57, pp. 73-86 | ||
| 504 | |a McGregor, G.P., Desaga, J.F., Ehlenz, K., Fischer, A., Heese, F., Hegele, A., Lammer, C., Lang, R.E., Radioimmunological measurement of leptin in plasma of obese and diabetic human subjects (1996) Endocrinology, 137, pp. 1501-1504 | ||
| 504 | |a Garcia-Mayor, R.V., Andrade, M.A., Rios, M., Lage, M., Dieguez, C., Casanueva, F.F., Serum leptin levels in normal children: Relationship to age, gender, body mass index, pituitary-gonadal hormones, and pubertal stage (1997) J Clin Endocrinol Metab, 82, pp. 2849-2855 | ||
| 504 | |a Tartaglia, L.A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G.J., Deeds, J., Identification and expression cloning of a leptin receptor, OB-R (1995) Cell, 83, pp. 1263-1271 | ||
| 504 | |a Sone, M., Nagata, H., Takekoshi, S., Osamura, R.Y., Expression and localization of leptin receptor in the normal rat pituitary gland (2001) Cell Tissue Res, 305, pp. 351-356 | ||
| 504 | |a Caprio, M., Isidori, A.M., Carta, A.R., Moretti, C., Dufau, M.L., Fabbri, A., Expression of functional leptin receptors in rodent Leydig cells (1999) Endocrinology, 140, pp. 4939-4947 | ||
| 504 | |a El-Hefnawy, T., Ioffe, S., Dym, M., Expression of the leptin receptor during germ cell development in the mouse testis (2000) Endocrinology, 141, pp. 2624-2630 | ||
| 504 | |a Banks, W.A., McLay, R.N., Kastin, A.J., Sarmiento, U., Scully, S., Passage of leptin across the blood-testis barrier (1999) Am J Physiol, 276, pp. E1099-1104 | ||
| 504 | |a Tena-Sempere, M., Pinilla, L., Zhang, F.P., Gonzalez, L.C., Huhtaniemi, I., Casanueva, F.F., Dieguez, C., Aguilar, E., Developmental and hormonal regulation of leptin receptor (Ob-R) messenger ribonucleic acid expression in rat testis (2001) Biol Reprod, 64, pp. 634-643 | ||
| 504 | |a Lahlou, N., Clement, K., Carel, J.C., Vaisse, C., Lotton, C., Le Bihan, Y., Basdevant, A., Guy-Grand, B., Soluble leptin receptor in serum of subjects with complete resistance to leptin: Relation to fat mass (2000) Diabetes, 49, pp. 1347-1352 | ||
| 504 | |a Bjorbaek, C., Kahn, B.B., Leptin signaling in the central nervous system and the periphery (2004) Recent Prog Horm Res, 59, pp. 305-331 | ||
| 504 | |a Mounzih, K., Lu, R., Chehab, F.F., Leptin treatment rescues the sterility of genetically obese ob/ob males (1997) Endocrinology, 138, pp. 1190-1193 | ||
| 504 | |a Redding, T.W., Schally, A.V., Arimura, A., Wakabayashi, I., Effect of monosodium glutamate on some endocrine functions (1971) Neuroendocrinology, 8, pp. 245-255 | ||
| 504 | |a Spinedi, E., Johnston, C., Negro-Vilar, A., Increased responsiveness of the hypothalamic-pituitary axis after neurotoxin-induced hypothalamic denervation (1984) Endocrinology, 115, pp. 267-272 | ||
| 504 | |a Rush, M.E., Follicle-stimulating hormone secretion in monosodium glutamate-lesioned rats: Response to unilateral gonadectomy or porcine follicular fluid (inhibin) (1986) Life Sci, 38, pp. 1941-1949 | ||
| 504 | |a Giovambattista, A., Suescun, M.O., Nessralla, C.C., Franca, L.R., Spinedi, E., Calandra, R.S., Modulatory effects of leptin on Leydig cell function of normal and hyperleptinemic rats (2003) Neuroendocrinology, 78, pp. 270-279 | ||
| 504 | |a Russell, L.D., Ettlin, R.A., Sinha Hikim, A.P., Clegg, E.D., (1990) Histological and Histopathological Evaluation of the Testis. 1st Ed., , Clearwater, FL: Cache River Press | ||
| 504 | |a Giovambattista, A., Chisari, A.N., Gaillard, R.C., Spinedi, E., Food intake-induced leptin secretion modulates hypothalamo-pituitary- adrenal axis response and hypothalamic Ob-Rb expression to insulin administration (2000) Neuroendocrinology, 72, pp. 341-349 | ||
| 504 | |a Suescun, M.O., Calandra, R.S., Lustig, L., Alterations of testicular function after induced autoimmune orchitis in rats (1994) J Androl, 15, pp. 442-448 | ||
| 504 | |a Suescun, M.O., Gonzalez, S.I., Chiauzzi, V.A., Calandra, R.S., Effects of induced hypoprolactinemia on testicular function during gonadal maturation in the rat (1985) J Androl, 6, pp. 77-82 | ||
| 504 | |a Russell, L.D., Corbin, T.J., Borg, K.E., França, L.R., Grasso, P., Bartke, A., Recombinant human follicle-stimulating hormone is capable of exerting a biological effect in the adult hypophysectomized rat by reducing the numbers of degenerating germ cells (1993) Endocrinology, 133, pp. 2062-2070 | ||
| 504 | |a França, L.R., Godinho, C.L., Testis morphometry, seminiferous epithelium cycle length, and daily sperm production in domestic cats (Felis catus) (2003) Biol Reprod, 68, pp. 1554-1561 | ||
| 504 | |a Abercrombie, M., Estimation of nuclear populations from microtome sections (1946) Anat Rec, 94, pp. 238-248 | ||
| 504 | |a Amann, R.P., Reproductive capacity of dairy bulls: III. the effect of ejaculation frequency, unilateral vasectomy, and age on spermatogenesis (1962) Am J Anat, 110, pp. 49-67 | ||
| 504 | |a Hochereau-de Reviers, M.T., Lincoln, G.A., Seasonal variation in the histology of the testis of the red deer, Cervus elaphus (1978) J Reprod Fertil, 54, pp. 209-213 | ||
| 504 | |a França, L.R., Daily sperm production in Piau boars estimated from Sertoli cell population and Sertoli cell index (1992) Proc 12th International Congress on Animal Reproduction (ICAR), pp. 1716-1718. , The Hague, The Netherlands | ||
| 504 | |a Zar, J., (1974) Biostatistical Analysis, , Englewood Cliffs, NJ: Prentice-Hall | ||
| 504 | |a Perello, M., Gaillard, R.C., Chisari, A., Spinedi, E., Adrenal enucleation in MSG-damaged hyperleptinemic male rats transiently restores adrenal sensitivity to leptin (2003) Neuroendocrinology, 78, pp. 176-184 | ||
| 504 | |a Heiman, M.L., Ben-Jonathan, N., Increase in pituitary dopaminergic receptors after monosodium glutamate treatment (1983) Am J Physiol, 245, pp. E261-E265 | ||
| 504 | |a Bodnar, I., Gooz, P., Okamura, H., Toth, B.E., Vecsernye, M., Halasz, B., Nagy, G.M., Effect of neonatal treatment with monosodium glutamate on dopaminergic and L-DOPA-ergic neurons of the medial basal hypothalamus and on prolactin and MSH secretion of rats (2001) Brain Res Bull, 55, pp. 767-774 | ||
| 504 | |a Perez-Villamil, B., Bordiu, E., Puente-Cueva, M., Involvement of physiological prolactin levels in growth and prolactin receptor content of prostate glands and testes in developing male rats (1992) J Endocrinol, 132, pp. 449-459 | ||
| 504 | |a Bakke, J.L., Lawrence, N., Bennett, J., Robinson, S., Bowers, C.Y., Late endocrine effects of administering monosodium glutamate to neonatal rats (1978) Neuroendocrinology, 26, pp. 220-228 | ||
| 504 | |a Orth, J.M., Cell biology of testicular development in fetus and neonate (1993) Cell and Molecular Biology of the Testis, pp. 3-42. , Desjardins C, Ewing LL, eds. New York: Oxford University Press | ||
| 504 | |a França, L.R., Silva Jr., V.A., Chiarini-Garcia, H., Garcia, S.K., Debeljuk, L., Cell proliferation and hormonal changes during postnatal development of the testis in the pig (2000) Biol Reprod, 63, pp. 1629-1636 | ||
| 504 | |a Mendis-Handagama, S.M., Ariyaratne, H.B., Differentiation of the adult Leydig cell population in the postnatal testis (2001) Biol Reprod, 65, pp. 660-671 | ||
| 504 | |a Sharpe, R.M., McKinnell, C., Kivlin, C., Fisher, J.S., Proliferation and functional maturation of Sertoli cells, and their relevance to disorders of testis function in adulthood (2003) Reproduction, 125, pp. 769-784 | ||
| 504 | |a Cooke, P., Holsberger, D.R., França, L.R., Thyroid hormone regulation of Sertoli cell development (2005) The Sertoli Cell Biology, pp. 217-226. , Skinner MK, Griswold MD, eds. San Diego: Elsevier Science | ||
| 504 | |a Sharpe, R.M., Regulation of spermatogenesis (1994) The Physiology of Reproduction. 2nd Ed., pp. 1363-1434. , Knobil E, Neill JD, eds. New York: Raven Press | ||
| 504 | |a Griswold, M.D., The central role of Sertoli cells in spermatogenesis (1998) Semin Cell Dev Biol, 9, pp. 411-416 | ||
| 504 | |a Benahmed, M., Tabone, E., Grenot, C., Sanchez, P., Chauvin, M.A., Morera, A.M., Paracrine control of Leydig cell activity by FSH dependent proteins from Sertoli cells: An in vitro study (1986) J Steroid Biochem, 24, pp. 311-315 | ||
| 504 | |a Schlatt, S., Meinhardt, A., Nieschlag, E., Paracrine regulation of cellular interactions in the testis: Factors in search of a function (1997) Eur J Endocrinol, 137, pp. 107-117 | ||
| 504 | |a Vermeulen, A., Kaufman, J.M., Goemaere, S., Van Pottelberg, I., Estradiol in elderly men (2002) Aging Male, 5, pp. 98-102 | ||
| 504 | |a Jannini, E.A., Ulisse, S., D'Armiento, M., Thyroid hormone and male gonadal function (1995) Endocr Rev, 16, pp. 443-459 | ||
| 504 | |a Buzzard, J.J., Morrison, J.R., O'Bryan, M.K., Song, Q., Wreford, N.G., Developmental expression of thyroid hormone receptors in the rat testis (2000) Biol Reprod, 62, pp. 664-669 | ||
| 504 | |a Miranda, J.R., (2002) Effects of Neonatal Treatment with 6-n-propil-2-tiouracil (PTU) and FSH on Sertoli Cell Proliferation and Testis Function in Wistar Rats [In Portuguese], p. 47. , Belo Horizonte, Brazil: Federal University of Minas Gerais | ||
| 504 | |a Caprio, M., Fabbrini, E., Ricci, G., Basciani, S., Gnessi, L., Arizzi, M., Carta, A.R., Fabbri, A., Ontogenesis of leptin receptor in rat Leydig cells (2003) Biol Reprod, 68, pp. 1199-1207 | ||
| 504 | |a Robaire, B., Viger, R.S., Regulation of epididymal epithelial cell functions (1995) Biol Reprod, 52, pp. 226-236 | ||
| 504 | |a Ezer, N., Robaire, B., Androgenic regulation of the structure and functions of the epididymis (2002) The Epididymis: From Molecules to Clinical Practice, pp. 297-316. , Robaire B, Hinton BT, eds. New York: Kluwer Academic/Plenum | ||
| 504 | |a Dolnikoff, M.S., Kater, C.E., Egami, M., De Andrade, I.S., Marmo, M.R., Neonatal treatment with monosodium glutamate increases plasma corticosterone in the rat (1988) Neuroendocrinology, 48, pp. 645-649 | ||
| 504 | |a Clemens, J.A., Roush, M.E., Fuller, R.W., Shaar, C.J., Changes in luteinizing hormone and prolactin control mechanisms produced by glutamate lesions of the arcuate nucleus (1978) Endocrinology, 103, pp. 1304-1312 | ||
| 504 | |a Miskowiak, B., Partyka, M., Effects of neonatal treatment with MSG (monosodium glutamate) on hypothalamo-pituitary-thyroid axis in adult male rats (1993) Histol Histopathol, 8, pp. 731-734 | ||
| 504 | |a Russell, L.D., Franca, L.R., Building a testis (1995) Tissue Cell, 27, pp. 129-147 | ||
| 504 | |a Mori, H., Christensen, A.K., Morphometric analysis of Leydig cells in the rat testis (1980) J Cell Biol, 84, pp. 340-354 | ||
| 504 | |a Zirkin, B.R., Ewing, L.L., Leydig cell differentiation during maturation of the rat testis: A stereological study of cell number and ultrastructure (1987) Anat Rec, 219, pp. 157-163 | ||
| 504 | |a Berndtson, W.E., Igboeli, G., Pickett, B.W., Relationship of absolute numbers of Sertoli cells to testicular size and spermatogenesis in young beef bulls (1987) J Anim Sci, 64, pp. 241-246 | ||
| 504 | |a Orth, J.M., Gunsalus, G.L., Lamperti, A.A., Evidence from Sertoli cell-depleted rats indicates that spermatid number in adults depends on numbers of Sertoli cells produced during perinatal development (1988) Endocrinology, 122, pp. 787-794 | ||
| 504 | |a Johnson, L., Carter, G.K., Varner, D.D., Taylor, T.S., Blanchard, T.L., Rembert, M.S., The relationship of daily sperm production with number of Sertoli cells and testicular size in adult horses: Role of primitive spermatogonia (1994) J Reprod Fertil, 100, pp. 315-321 | ||
| 504 | |a França, L.R., Russell, L.D., The testis of domestic animals (1998) Male Reproduction: A Multidisciplinary Overview, pp. 197-219. , Martínez-Garcia F, Regadera J, eds. Madrid: Churchill Communications Europe España; | ||
| 504 | |a Hess, R.A., Cooke, P.S., Bunick, D., Kirby, J.D., Adult testicular enlargement induced by neonatal hypothyroidism is accompanied by increased Sertoli and germ cell numbers (1993) Endocrinology, 132, pp. 2607-2613 | ||
| 504 | |a Dohle, G.R., Smit, M., Weber, R.F., Androgens and male fertility (2003) World J Urol, 21, pp. 341-345 | ||
| 504 | |a Perello, M., Moreno, G., Gaillard, R.C., Spinedi, E., Glucocorticoid-dependency of increased adiposity in a model of hypothalamic obesity (2004) Neuro Endocrinol Lett, 25, pp. 119-126 | ||
| 504 | |a Pizzi, W.J., Barnhart, J.E., Fanslow, D.J., Monosodium glutamate administration to the newborn reduces reproductive ability in female and male mice (1977) Science, 196, pp. 452-454 | ||
| 504 | |a Lalau, J.D., Aubert, M.L., Carmignac, D.F., Gregoire, I., Dupouy, J.P., Reduction in testicular function in rats. II. Reduction by dexamethasone in fetal and neonatal rats (1990) Neuroendocrinology, 51, pp. 289-293 | ||
| 504 | |a Biagini, G., Pich, E.M., Corticosterone administration to rat pups, but not maternal separation, affects sexual maturation and glucocorticoid receptor immunoreactivity in the testis (2002) Pharmacol Biochem Behav, 73, pp. 95-103 | ||
| 520 | 3 | |a There are few data for hormonal levels and testis structure and function during postnatal development in rats neonatally treated with monosodium L-glutamate (MSG). In our study, newborn male pups were ip injected with MSG (4 mg/g body weight) every 2 d up to 10 d of age and investigated at prepubertal and adult ages. Plasma levels of leptin, LH, FSH, prolactin, testosterone (T), corticosterone, and free T4 (FT4) were measured. MSG rats displayed elevated circulating levels of corticosterone and hyperadiposity/ hyperleptinemia, regardless of the age examined; conversely, circulating prolactin levels were not affected. Moreover, prepubertal MSG rats revealed a significant (P < 0.05) reduction in testis weight and the number of Sertoli (SC) and Leydig cells per testis. Leptin plasma levels were severalfold higher (2.41 vs. 8.07; P < 0.05) in prepubertal MSG rats, and these animals displayed plasma LH, FSH, T, and FT4 levels significantly decreased (P < 0.05). Taken together, these data indicate that testis development, as well as SC and Leydig cell proliferation, were disturbed in prepubertal MSG rats. Adult MSG rats also displayed significantly higher leptin plasma levels (7.26 vs. 27.04; P < 0.05) and lower (P < 0.05) LH and FSH plasma levels. However, T and FT4 plasma levels were normal, and no apparent alterations were observed in testis structure of MSG rats. Only the number of SCs per testis was significantly (P < 0.05) reduced in the adult MSG rats. In conclusion, although early installed hyperadipose/hyperleptinemia phenotype was probably responsible for the reproductive axis damages in MSG animals, it remains to be investigated whether this condition is the main factor for hypothalamus-pituitary-gonadal axis dysfunction in MSG rats. Copyright © 2006 by The Endocrine Society. |l eng | |
| 593 | |a Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte-MG 31270-901, Brazil | ||
| 593 | |a Laboratory of Reproductive Endocrinology, Instituto Multidiscipliario de Biologia Celular, Universidad Nacional de la Plata, La Plata 1900, Argentina | ||
| 593 | |a Neuroendocrine Unit, Instituto Multidiscipliario de Biologia Celular, Universidad Nacional de la Plata, La Plata 1900, Argentina | ||
| 593 | |a School of Exact Sciences, Universidad Nacional de la Plata, La Plata 1900, Argentina | ||
| 593 | |a Instituto de Biologia Y Medicina Experimental, Buenos Aires 1428, Argentina | ||
| 593 | |a Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte-MG, Brazil | ||
| 690 | 1 | 0 | |a CORTICOSTERONE |
| 690 | 1 | 0 | |a FOLLITROPIN |
| 690 | 1 | 0 | |a GLUTAMATE SODIUM |
| 690 | 1 | 0 | |a LEPTIN |
| 690 | 1 | 0 | |a LUTEINIZING HORMONE |
| 690 | 1 | 0 | |a TESTOSTERONE |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a BODY WEIGHT |
| 690 | 1 | 0 | |a CELL PROLIFERATION |
| 690 | 1 | 0 | |a CORTICOSTERONE BLOOD LEVEL |
| 690 | 1 | 0 | |a DATA ANALYSIS |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a FOLLITROPIN BLOOD LEVEL |
| 690 | 1 | 0 | |a FREE THYROXINE INDEX |
| 690 | 1 | 0 | |a GENETICS |
| 690 | 1 | 0 | |a HORMONE BLOOD LEVEL |
| 690 | 1 | 0 | |a HYPERLEPTINEMIA |
| 690 | 1 | 0 | |a HYPOTHALAMUS HYPOPHYSIS SYSTEM |
| 690 | 1 | 0 | |a LEYDIG CELL |
| 690 | 1 | 0 | |a LUTEINIZING HORMONE BLOOD LEVEL |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MEASUREMENT |
| 690 | 1 | 0 | |a NEWBORN |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a OBESITY |
| 690 | 1 | 0 | |a PHENOTYPE |
| 690 | 1 | 0 | |a PREPUBERTY |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROLACTIN BLOOD LEVEL |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a REPRODUCTION |
| 690 | 1 | 0 | |a SERTOLI CELL |
| 690 | 1 | 0 | |a TESTIS |
| 690 | 1 | 0 | |a TESTIS FUNCTION |
| 690 | 1 | 0 | |a TESTIS WEIGHT |
| 690 | 1 | 0 | |a TESTOSTERONE BLOOD LEVEL |
| 690 | 1 | 0 | |a ADIPOSE TISSUE |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a ANIMALS, NEWBORN |
| 690 | 1 | 0 | |a CELL NUCLEUS |
| 690 | 1 | 0 | |a CELL PROLIFERATION |
| 690 | 1 | 0 | |a CORTICOSTERONE |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a FOLLICLE STIMULATING HORMONE |
| 690 | 1 | 0 | |a LEPTIN |
| 690 | 1 | 0 | |a LEYDIG CELLS |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a PHENOTYPE |
| 690 | 1 | 0 | |a PROLACTIN |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RATS, SPRAGUE-DAWLEY |
| 690 | 1 | 0 | |a SEMINIFEROUS TUBULES |
| 690 | 1 | 0 | |a SERTOLI CELLS |
| 690 | 1 | 0 | |a TESTIS |
| 690 | 1 | 0 | |a TESTOSTERONE |
| 690 | 1 | 0 | |a THYROXINE |
| 690 | 1 | 0 | |a TIME FACTORS |
| 700 | 1 | |a Suescun, M.O. | |
| 700 | 1 | |a Miranda, J.R. | |
| 700 | 1 | |a Giovambattista, A. | |
| 700 | 1 | |a Perello, M. | |
| 700 | 1 | |a Spinedi, E. | |
| 700 | 1 | |a Calandra, R.S. | |
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