Estrogens and neuroendocrine hypothalamic-pituitary-adrenal axis function
The function of the HPA axis is subject to regulation by many factors, which achieve relevance under normal and pathological conditions. In the case of aging, this period of life is associated with disturbances of the HPA axis and signs of hippocampal vulnerability. We examined 20-month-old male rat...
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2006
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 11434caa a22011777a 4500 | ||
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| 001 | PAPER-21788 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205316.0 | ||
| 008 | 190411s2006 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-33745803474 | |
| 024 | 7 | |2 cas |a Estrogens; Steroids | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 100 | 1 | |a De Nicola, A.F. | |
| 245 | 1 | 0 | |a Estrogens and neuroendocrine hypothalamic-pituitary-adrenal axis function |
| 260 | |c 2006 | ||
| 270 | 1 | 0 | |m De Nicola, A.F.; Instituto de Biología Y Medicina Experimental, Obligado 2490, 1428 Buenos Aires, Argentina; email: denicola@dna.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Engelmann, M., Landgraf, R., Wotjak, C.T., The hypothalamic-neurohypophysial system regulates the hypothalamic-pituitary-adrenal axis under stress: An old concept revisited (2004) Front Neuroendocrinol, 25, pp. 132-149 | ||
| 504 | |a Angulo, J.A., Ledoux, M., McEwen, B.S., Genomic effects of cold and isolation stress on magnocellular vasopressin mRNA-containing cells in the hypothalamus of the rat (1991) J Neurochem, 23, pp. 2033-2038 | ||
| 504 | |a (1998) Williams Textbook of Endocrinology, , Wilson JD, Foster DW, Kronenberg HM, Larsen PR (eds): Philadelphia, Saunders | ||
| 504 | |a De Kloet, E.R., Joels, M., Holsboer, F., Stress and the brain: From adaptation to disease (2005) Nat Rev Neurosci, 6, pp. 463-475 | ||
| 504 | |a Hurbin, A., Boissin-Agasse, L., Orcel, H., Rabié, A., Joux, N., Desarrménien, G., Richard, P., Moos, F.C., The V1a and V1b, but not the V2, vasopressin receptor genes are expressed in the supraoptic nucleus of the rat hypothalamus, and the transcripts are essentially colocalized in the vasopressinergic magnocellular neurons (1998) Endocrinology, 139, pp. 4701-4707 | ||
| 504 | |a Ratka, A., Sutanto, W., Bloemers, M., De Kloet, E.R., On the role of brain mineralocorticoid (type I) and glucocorticoid (type II) receptors in neuroendocrine regulation (1989) Neuroendocrinology, 50, pp. 117-123 | ||
| 504 | |a Magariños, A.M., Ferrini, M., De Nicola, A.F., Corticosteroid receptors and glucocorticoid content in microdissected brain regions: Correlative aspects (1989) Neuroendocrinology, 50, pp. 673-678 | ||
| 504 | |a Edwards, C.R., Stewart, P.M., Burt, D., McIntyre, M.A., De Kloet, E.R., Brett, L., Sutanto, W., Monder, C., Localisation of 11beta-hydroxysteroid dehydrogenase: Tissue-specific protector of the mineralocorticoid receptor (1988) Lancet, 2, pp. 986-999 | ||
| 504 | |a Funder, J.W., Aldosterone, mineralocorticoid receptors and vascular inflammation (2004) Mol Cell Endocrinol, 217, pp. 263-269 | ||
| 504 | |a Perrot-Applanat, M., Racadot, O., Milgrom, E., Specific localization of plasma corticosteroid-binding globulin in pituitary corticotrophs (1984) Endocrinology, 115, pp. 559-569 | ||
| 504 | |a Sapolsky, R., Krey, L.C., McEwen, B.S., The neuroendocrinology of stress and aging: The glucocorticoid cascade hypothesis (1986) Endocr Rev, 7, pp. 284-304 | ||
| 504 | |a Van Eekelen, J.A.M., Rots, N.Y., Sutanto, W., De Kloet, E.R., The effect of aging on stress responsiveness and central corticosteroid receptors in the Brown Norway rat (1991) Neurobiol Aging, 13, pp. 159-170 | ||
| 504 | |a Tornello, S., Orti, E., De Nicola, A.F., Rainbow, T.C., McEwen, B.S., Regulation of glucocorticoid receptors in brain by CORT treatment of adrenalectomized rats (1982) Neuroendocrinology, 35, pp. 411-417 | ||
| 504 | |a Watanabe, Y., Gould, E., McEwen, B.S., Stress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons (1992) Brain Res, 588, pp. 341-345 | ||
| 504 | |a Ferrini, M., Piroli, G., Frontera, M., Falbo, A., Lima, A., De Nicola, A.F., Estrogens normalize the hypothalamic-pituitary-adrenal axis response to stress and increase glucocorticoid receptor immunoreactivity in hippocampus of aging male rats (1999) Neuroendocrinology, 69, pp. 129-137 | ||
| 504 | |a Herman, J.P., Schafer, M.K., Young, E.A., Thompson, R., Doiuglass, J., Akil, H., Watson, S.J., Evidence for hippocampal regulation of neuroendocrine neurones of the hypothalamic-pituitary-adrenocortical axis (1989) J Neurosci, 9, pp. 3071-3082 | ||
| 504 | |a Magariños, A.M., Somoza, G., De Nicola, A.F., Glucocorticoid negative feedback and glucocorticoid receptors after hippocampectomy in rats (1987) Horm Metab Res, 19, pp. 105-109 | ||
| 504 | |a Revsin, Y., Saravia, F., Roig, P., Lima, A., De Kloet, E.R., Homo-Delarche, F., De Nicola, A.F., Neuronal and astroglial alterations in the hippocampus of a mouse model for type 1 diabetes (2005) Brain Res, 1038, pp. 22-31 | ||
| 504 | |a Shughrue, P.J., Lane, M.V., Merchentaler, I., Comparative distribution of estrogen receptor α and β mRNA in the rat central nervous system (1997) J Comp Neurol, 388, pp. 507-525 | ||
| 504 | |a Gould, E., Wooley, C.S., Frankfurt, M., McEwen, B.S., Gonadal steroids regulate dendritic spine density in hippocampal pyramidal cells in adulthood (1990) J Neurosci, 10, pp. 1286-1291 | ||
| 504 | |a Goodman, Y., Bruce, A.J., Cheng, B., Mattson, M.P., Estrogens attenuate and CORT exacerbates excitotoxicity, oxidative injury, and amyloid-peptide toxicity in hippocampal neurons (1996) J Neurochem, 66, pp. 1836-1844 | ||
| 504 | |a Cameron, H., McKay, R.D.G., Restoring production of hippocampal neurons in old age (1999) Nature Neurosci, 2, pp. 894-897 | ||
| 504 | |a Isgor, C., Watson, S.J., Estrogen receptor α and β mRNA expressions by proliferating and differentiating cells in the adult rat dentate gyrus and subventricular zone (2005) Neuroscience, 134, pp. 847-856 | ||
| 504 | |a Pfeiffer, A., Lapointe, B., Barden, N., Hormonal regulation of type II glucocorticoid receptor messenger ribonucleic acid in rat brain (1991) Endocrinology, 129, pp. 2166-2174 | ||
| 504 | |a Ferrini, M., De Nicola, A.F., Estrogens up-regulate type I and type II glucocorticoid receptors in brain regions from ovariectomized rats (1991) Life Sci, 48, pp. 2593-2601 | ||
| 504 | |a Ferrini, M., Lima, A., De Nicola, A.F., Estradiol abolishes down-regulation of glucocorticoid receptors in brain (1995) Life Sci, 57, pp. 2403-2412 | ||
| 504 | |a Lephart, E.D., Galindo, E., Bu, L.H., Stress (hypothalamic-pituitary-adrenal axis) and pain response in male rats exposed lifelong to high vs. low phytoestrogen diets (2003) Neurosci Lett, 342, pp. 65-68 | ||
| 504 | |a Isgor, C., Cecchi, M., Kabbai, M., Akil, H., Watson, S.J., Estrogen receptor beta in the paraventricular nucleus of hypothalamus regulates the neuroendocrine response to stress and is regulated by CORT (2003) Neuroscience, 121, pp. 837-845 | ||
| 504 | |a Nomura, M., McKenna, E., Korach, K.S., Pfaff, D.W., Ogawa, S., Estrogen receptor-beta regulates transcript levels for oxytocin and arginine vasopressin in the hypothalamic paraventricular nucleus of male mice (2002) Brain Res Mol Brain Res, 30, p. 109 | ||
| 504 | |a McEwen, B.S., Estrogen actions throughout the brain (2002) Rec Progr Horm Res, 57, pp. 357-384 | ||
| 504 | |a Ferrini, M., Bisagno, V., Piroli, G., Grillo, C., Gonzalez Deniselle, M.C., De Nicola, A.F., Effects of estrogens on choline-acetyltransferase immunoreactivity and GAP43 mRENA in the forebrain of young and aging male rats (2002) Cell Mol Neurobiol, 22, pp. 289-301 | ||
| 504 | |a Wong, E.Y.H., Herbert, J., Roles of mineralocorticoid and glucocorticoid receptors in the regulation of progenitor proliferation in the adult hippocampus (2005) Eur J Neurosci, 22, pp. 785-792 | ||
| 520 | 3 | |a The function of the HPA axis is subject to regulation by many factors, which achieve relevance under normal and pathological conditions. In the case of aging, this period of life is associated with disturbances of the HPA axis and signs of hippocampal vulnerability. We examined 20-month-old male rats, in which abnormalities of the HPA axis included altered response to stress, reduced effectiveness of the steroid negative feedback and low expression of hippocampal glucocorticoid receptors (GR). Estrogen treatment of aging rats normalized the response to stress, restored the dexamethasone inhibition of the stress response and increased GR density in defined hippocampal areas. Although estrogens could influence the hippocampus of aging animals directly, their effects could be also mediated by estrogen-sensitive forebrain cholinergic neurons projecting to the hippocampus. Additionally, estrogens normalized the deficient granule cell proliferation that aging mice present in the dentate gyrus, and attenuated several markers of hippocampal aging, such as astrocytosis, high lipofucsin content and neuronal loss in the hilus of the dentate gyrus. These effects may be important for the regulation of the HPA axis, in the context that hippocampal function as a whole was normalized by estrogen action. Therefore, estrogens are powerful neuroprotectants in cases of hippocampal dysfunction, and as part of this effect, they contribute to stabilize the function of the HPA axis. Copyright © 2006 S. Karger AG. |l eng | |
| 593 | |a Laboratory of Neuroendocrine Biochemisty, Instituto de Biología Y Medicina Experimental, Buenos Aires, Argentina | ||
| 593 | |a Department of Human Biochemistry, Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Research and Education Institute, Harbor-UCLA Medical Center, Urology, Torrance, CA, United States | ||
| 593 | |a Instituto de Biología Y Medicina Experimental, Obligado 2490, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a ESTROGEN |
| 690 | 1 | 0 | |a STEROID |
| 690 | 1 | 0 | |a ADRENAL GLAND |
| 690 | 1 | 0 | |a AGING |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a CHOLINERGIC NERVE |
| 690 | 1 | 0 | |a CONFERENCE PAPER |
| 690 | 1 | 0 | |a DRUG EFFECT |
| 690 | 1 | 0 | |a FEEDBACK SYSTEM |
| 690 | 1 | 0 | |a FOREBRAIN |
| 690 | 1 | 0 | |a HIPPOCAMPUS |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a HYPOPHYSIS ADRENAL SYSTEM |
| 690 | 1 | 0 | |a HYPOTHALAMUS HYPOPHYSIS SYSTEM |
| 690 | 1 | 0 | |a METABOLISM |
| 690 | 1 | 0 | |a NEUROSECRETION |
| 690 | 1 | 0 | |a PHYSIOLOGY |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a ADRENAL GLANDS |
| 690 | 1 | 0 | |a AGING |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a CHOLINERGIC FIBERS |
| 690 | 1 | 0 | |a ESTROGENS |
| 690 | 1 | 0 | |a FEEDBACK, BIOCHEMICAL |
| 690 | 1 | 0 | |a HIPPOCAMPUS |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a HYPOTHALAMO-HYPOPHYSEAL SYSTEM |
| 690 | 1 | 0 | |a NEUROSECRETORY SYSTEMS |
| 690 | 1 | 0 | |a PITUITARY-ADRENAL SYSTEM |
| 690 | 1 | 0 | |a PROSENCEPHALON |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a STEROIDS |
| 700 | 1 | |a Saravia, F.E. | |
| 700 | 1 | |a Beauquis, J. | |
| 700 | 1 | |a Pietranera, L. | |
| 700 | 1 | |a Ferrini, M.G. | |
| 700 | 1 | |a Arzt E. | |
| 700 | 1 | |a Guitelman M | |
| 700 | 1 | |a Bronstein M. | |
| 773 | 0 | |d 2006 |g v. 35 |h pp. 157-168 |p Front. Horm. Res. |x 03013073 |z 3805581556 |z 9783805581554 |t Frontiers of Hormone Research | |
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| 856 | 4 | 0 | |u https://doi.org/10.1159/000094324 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_03013073_v35_n_p157_DeNicola |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03013073_v35_n_p157_DeNicola |y Registro en la Biblioteca Digital |
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| 999 | |c 82741 | ||