Steroid Effects on Glial Cells: Detrimental or Protective for Spinal Cord Function?
Repair of damage and recovery of function are fundamental endeavors for recuperation of patients and experimental animals with spinal cord injury. Steroid hormones, such as progesterone (PROG), show regenerative and myelinating properties following injury of the peripheral and central nervous system...
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| Formato: | Capítulo de libro |
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New York Academy of Sciences
2003
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 09347caa a22012017a 4500 | ||
|---|---|---|---|
| 001 | PAPER-21663 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205309.0 | ||
| 008 | 190411s2003 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-1342287963 | |
| 024 | 7 | |2 cas |a nitric oxide synthase, 125978-95-2; progesterone, 57-83-0; reduced nicotinamide adenine dinucleotide phosphate dehydrogenase, 9001-68-7 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a ANYAA | ||
| 100 | 1 | |a De Nicola, A.F. | |
| 245 | 1 | 0 | |a Steroid Effects on Glial Cells: Detrimental or Protective for Spinal Cord Function? |
| 260 | |b New York Academy of Sciences |c 2003 | ||
| 270 | 1 | 0 | |m De Nicola, A.F.; Inst. de Biol. y Med. Experimental, Obligado 2490, 1428 Buenos Aires, Argentina; email: denicola@dna.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Beattie, M.S., Farooqui, A.A., Bresnahan, J.E., Review of current evidence for apoptosis after spinal cord injury (2000) J. Neurotrauma, 17, pp. 915-923 | ||
| 504 | |a Fournier, A.E., Striittmattrer, S.M., Repulsive factors and axon regeneration in the CNS (2001) Curr. Opin. Neurobiol., 11, pp. 89-94 | ||
| 504 | |a Priestley, J.V., Ramer, M.S., King, V.R., Stimulating regeneration in the damaged spinal cord (2002) J. Physiol., 96, pp. 123-133. , Paris | ||
| 504 | |a Hall, E.D., Pharmacological treatment of acute spinal cord injury: How do we build on past success? (2001) J. Spinal Cord Med., 24, pp. 142-146 | ||
| 504 | |a De Nicola, A.F., Steroid hormones and neuronal regeneration (1993) Adv. Neurol., 59, pp. 199-206 | ||
| 504 | |a Hall, E., Neuroprotective actions of glucocorticoid and non-glucocorticoid steroids in acute neuronal injury (1993) Cell. Mol. Neurobiol., 13, pp. 415-432 | ||
| 504 | |a Jones, K.J., Drengler, S.M., Oblinger, M., Gonadal steroid regulation of growth-associated protein mRNA expression in axotomized hamster facial motor neurons (1997) Neurochem. Res., 22, pp. 1367-1374 | ||
| 504 | |a Stein, D.G., Fulop, Z.L., Progesterone and recovery after traumatic brain injury: An overview (1998) Neuroscientist, 4, pp. 435-442 | ||
| 504 | |a Roof, R., Hall, E., Gender differences in acute CNS trauma and stroke: Neuroprotective effects and progesterone (2000) J. Neurotrauma, 17, pp. 367-388 | ||
| 504 | |a Labombarda, F., Gonzalez, S., Gonzalez Deniselle, M.C., Cellular basis for progesterone neuroprotection in the injured spinal cord (2002) J. Neurotrauma, 19, pp. 343-355 | ||
| 504 | |a Desarnaud, F., Do Thi, A.N., Brown, A.M., Progesterone stimulates the activity of the promoters of peripheral myelin protein-22 and protein zero genes in Schwann cells (1998) J. Neurochem., 71, pp. 1765-1768 | ||
| 504 | |a Melcangi, R.C., Magnaghi, V., Martini, L., Aging in peripheral nerves: Regulation of myelin protein genes by steroid hormones (2000) Prog. Neurobiol., 60, pp. 291-308 | ||
| 504 | |a Schumacher, M., Akwa, I., Guennoun, R., Steroid synthesis and metabolism in the nervous system: Trophic and protective effects (2000) J. Neurocytol., 29, pp. 307-326 | ||
| 504 | |a Garcia-Estrada, J., Del Rio, J.A., Luquin, S., Gonadal hormones down-regulate reactive gliosis and astrocyte proliferation after a penetrating brain injury (1993) Brain Res., 628, pp. 271-278 | ||
| 504 | |a Labombarda, F., Guennoun, R., Gonzalez, S., Immunocytochemical evidence for a progesterone receptor in neurons and glial cells of the rat spinal cord (2000) Neurosci. Lett., 288, pp. 29-32 | ||
| 504 | |a Krebs, C.J., Jarvis, E.D., Chan, J., A membrane-associated progesterone-binding protein, 25-Dx, is regulated by progesterone in brain regions involved in female reproductive behaviors (2000) Proc. Natl. Acad. Sci. USA, 97, pp. 12816-12821 | ||
| 504 | |a Labombarda, F., Gonzalez, S., Roig, P., Modulation of NADPH-diaphorase and glial fibrillary acidic protein by progesterone in astrocytes from normal and injured rat spinal cord (2000) J. Steroid Biochem. Mol. Biol., 73, pp. 159-169 | ||
| 504 | |a Stojkovic, T., Colin, C., Le Saux, F., Jacke, C., Specific pattern of nitric oxide synthase expression in glial cells after hippocampal injury (1998) Glia, 22, pp. 329-1327 | ||
| 504 | |a Liedtke, W., Edelman, W., Bieri, P.L., GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination (1996) Neuron, 17, pp. 607-615 | ||
| 504 | |a Melcangi, R.C., Riva, M.A., Fumagalli, F., Effect of progesterone, testosterone and their 5 alpha-reduced metabolites on GFAP gene expression in type 1 astrocytes (1996) Brain Res., 711, pp. 10-15 | ||
| 504 | |a Muller, H.W., Matthiese, H.P., Schmalenbach, C., Schroeder, W.O., Glial support of CNS neuronal survival, neurite growth and regeneration (1991) Rest. Neurol. Neurosci., 2, pp. 229-232 | ||
| 504 | |a McTigue, D.M., Wei, P., Stokes, B.T., Proliferation of NG2-positive cells and altered oligodendrocyte numbers in the contused spinal cord (2001) J. Neurosci., 21, pp. 3392-3400 | ||
| 504 | |a Gago, N., Akwa, Y., Sananes, N., Guennoun, R., Progesterone and the oligodendroglial lineage: Stage-dependent biosynthesis and metabolism (2001) Glia, 36, pp. 295-308 | ||
| 520 | 3 | |a Repair of damage and recovery of function are fundamental endeavors for recuperation of patients and experimental animals with spinal cord injury. Steroid hormones, such as progesterone (PROG), show regenerative and myelinating properties following injury of the peripheral and central nervous system. In this work, we studied PROG effects on glial cells of the normal and transected (TRX) spinal cord, to complement previous studies in motoneurons. Both neurons and glial cells expressed the classical PROG receptor (PR), suggesting that genomic mechanisms participated in PROG action. In TRX rats, PROG treatment stimulated the number of NADPH-diaphorase (nitric oxide synthase) active astrocytes, whereas the number of astrocytes expressing the glial fibrillary acidic protein (GFAP) was stimulated in control but not in TRX rats. PROG also stimulated the immunocytochemical staining for myelin-basic protein (MBP) and the number of oligodendrocyte precursor cells expressing the chondroitin sulfate proteoglycan NG2 in TRX rats. In terms of beneficial or detrimental consequences, these PROG effects may be supportive of neuronal recuperation, as shown for several neuronal functional parameters that were normalized by PROG treatment of spinal cord injured animals. Thus, PROG effects on glial cells go in parallel with morphological and biochemical evidence of survival of damaged motoneurons. |l eng | |
| 593 | |a Inst. de Biol. y Med. Experimental, Department of Biochemistry, University of Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a INSERM U488, Hôpital de Bicêtre, 94276 Bicêtre, France | ||
| 593 | |a Inst. de Biol. y Med. Experimental, Obligado 2490, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a ASTROCYTES |
| 690 | 1 | 0 | |a GLIAL FIBRILLARY ACIDIC PROTEIN |
| 690 | 1 | 0 | |a MYELIN BASIC PROTEIN |
| 690 | 1 | 0 | |a NEUROPROTECTION |
| 690 | 1 | 0 | |a NG2 CELLS |
| 690 | 1 | 0 | |a NITRIC OXIDE SYNTHASE |
| 690 | 1 | 0 | |a OLIGODENDROCYTES |
| 690 | 1 | 0 | |a PROGESTERONE |
| 690 | 1 | 0 | |a SPINAL CORD INJURY |
| 690 | 1 | 0 | |a GLIAL FIBRILLARY ACIDIC PROTEIN |
| 690 | 1 | 0 | |a MYELIN BASIC PROTEIN |
| 690 | 1 | 0 | |a NITRIC OXIDE SYNTHASE |
| 690 | 1 | 0 | |a PROGESTERONE |
| 690 | 1 | 0 | |a PROGESTERONE RECEPTOR |
| 690 | 1 | 0 | |a PROTEOCHONDROITIN SULFATE |
| 690 | 1 | 0 | |a REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE |
| 690 | 1 | 0 | |a STEROID |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ASTROCYTE |
| 690 | 1 | 0 | |a CELL ACTIVATION |
| 690 | 1 | 0 | |a CELL COUNT |
| 690 | 1 | 0 | |a CELL DAMAGE |
| 690 | 1 | 0 | |a CELL STRUCTURE |
| 690 | 1 | 0 | |a CELL SURVIVAL |
| 690 | 1 | 0 | |a CONFERENCE PAPER |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a ENZYME ACTIVATION |
| 690 | 1 | 0 | |a GENOMICS |
| 690 | 1 | 0 | |a GLIA CELL |
| 690 | 1 | 0 | |a HORMONE DETERMINATION |
| 690 | 1 | 0 | |a IMMUNOCYTOCHEMISTRY |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MOTONEURON |
| 690 | 1 | 0 | |a NEUROPROTECTION |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a OLIGODENDROGLIA |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a SPINAL CORD FUNCTION |
| 690 | 1 | 0 | |a SPINAL CORD INJURY |
| 690 | 1 | 0 | |a SPINAL CORD TRANSSECTION |
| 690 | 1 | 0 | |a ANIMALIA |
| 700 | 1 | |a Labombarda, F. | |
| 700 | 1 | |a Gonzalez, S.L. | |
| 700 | 1 | |a Gonzalez Deniselle, M.C. | |
| 700 | 1 | |a Guennoun, R. | |
| 700 | 1 | |a Schumacher, M. | |
| 773 | 0 | |d New York Academy of Sciences, 2003 |g v. 1007 |h pp. 317-328 |p Ann. New York Acad. Sci. |x 00778923 |w (AR-BaUEN)CENRE-1541 |t Annals of the New York Academy of Sciences | |
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| 856 | 4 | 0 | |u https://doi.org/10.1196/annals.1286.030 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00778923_v1007_n_p317_DeNicola |y Handle |
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