Gonadotropins and inhibins along the development of a luteinized rat ovarian tumor
Luteinized intrasplenic ovarian tumors develop in response to high circulating gonadotropins. The relationship between tumor development, gonadotropins and inhibins was studied. Tumor-bearing animals were sacrificed weekly along the first 6 weeks of development. Inhibins were measured by enzyme-link...
Guardado en:
| Autor principal: | |
|---|---|
| Otros Autores: | , , , , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier Ireland Ltd
2003
|
| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 16910caa a22014897a 4500 | ||
|---|---|---|---|
| 001 | PAPER-21524 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205300.0 | ||
| 008 | 190411s2003 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0037684969 | |
| 024 | 7 | |2 cas |a follitropin, 9002-68-0; gonadotropin, 63231-54-9; inhibin, 57285-09-3, 69494-61-7; inhibin B, 115088-91-0; luteinizing hormone, 39341-83-8, 9002-67-9; somatomedin C, 67763-96-6 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a MCEND | ||
| 100 | 1 | |a Hockl, P. | |
| 245 | 1 | 0 | |a Gonadotropins and inhibins along the development of a luteinized rat ovarian tumor |
| 260 | |b Elsevier Ireland Ltd |c 2003 | ||
| 270 | 1 | 0 | |m Libertun, C.; Lab. de Neuroendocrinologia, Inst. Biol. Med. E., V. de Obligado 2490, Buenos Aires 1428, Argentina; email: libertun@dna.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Abel, M.H., Wooton, A.N., Wilkins, V., Huhtaniemi, I., Knight, P.G., Charlton, H.M., The effect of a null mutations in the follicle-stimulating hormone receptor gene on mouse reproduction (2000) Endocrinology, 141, pp. 1795-1803 | ||
| 504 | |a Auersperg, N., Edelson, M.I., Mok, S.C., Johnson, S.W., Hamilton, T.C., The biology of ovarian cancer (1998) Semin. Oncol., 25, pp. 281-304 | ||
| 504 | |a Barontini, M., Garcia-Rudaz, M.C., Veldhuis, J.D., Mechanisms of hypothalamic-pituitary-gonadal disruption in polycystic ovarian syndrome (2001) Arch. Med. Res., 32, pp. 544-552 | ||
| 504 | |a Bicsak, T., Cajander, S., Vale, W., Hsueh, A.J.W., Inhibin: Studies of stored and secreted forms by biosynthetic labeling and immunodetection in cultured rat granulosa cells (1988) Endocrinology, 122, pp. 741-748 | ||
| 504 | |a Biskind, M., Biskind, G., Development of tumors in the rat ovary after transplantation into the spleen (1944) Proc. Soc. Exp. Biol. Med., 55, pp. 176-179 | ||
| 504 | |a Breier, B., Gallaher, B., Gluckman, P., Radioimmunoassay for insulin-like growth factor-1: Solutions to some potential problems and pitfalls (1991) J. Endocrinol., 128, pp. 347-357 | ||
| 504 | |a Burton, K., A study of conditions and mechanisms of the diphenyl amine reaction for the colorimetric estimation od deoxiribonucleic acid (1956) Biochem. J., 62, pp. 315-317 | ||
| 504 | |a Chamson-Reig, A., Lux-Lantos, V.A.R., Tesone, M., Libertun, C., GnRH receptors and GnRH endocrine effects on luteoma cells (1997) Endocrine, 6, pp. 165-171 | ||
| 504 | |a Chamson-Reig, A., Bianchi, M.S., Rey-Roldán, E.B., Sorianello, E., Libertun, C., Lux-Lantos, V.A., Development of an experimental ovarian tumor over a year in the rat (1999) Life Sci., 65, pp. 1275-1285 | ||
| 504 | |a Chamson-Reig, A., Pignataro, O.P., Libertun, C., Lux-Lantos, V., Alterations in intracellular messengers mobilized by gonadotropin-releasing hormone in an experimental ovarian tumor (1999) Endocrinology, 140, pp. 3573-3580 | ||
| 504 | |a Danilovich, N., Roy, I., Sairam, M.R., Ovarian pathology and high incidence of sex cord tumors in follitropin receptor knockout (FORKO) mice (2001) Endocrinology, 142, pp. 3673-3684 | ||
| 504 | |a Dierich, A., Sairam, M.R., Monaco, L., Fimia, G.M., Gansmuller, A., LeMeur, M., Sassone-Corsi, P., Impairing follicle-stimulating hormone (FSH) signalling in vivo: Targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance (1998) Proc. Natl. Acad. Sci. USA, 95, p. 13617 | ||
| 504 | |a Flemming, P., Grothe, W., Maschek, H., Petry, K.U., Wellmann, A., Georgii, A., The site of inhibin production in ovarian neoplasms (1996) Histopathology, 29, pp. 465-468 | ||
| 504 | |a Foreman, D.F., Wilder, M., Inhibin is present in the corpus luteum of pseudopregnant rats and can interact with progesterone to inhibit resumption of estrous cycles (1995) Endocr. Res., 21, pp. 595-614 | ||
| 504 | |a Fox, H., Sex cord-stromal tumors of the ovary (1985) J. Pathol., 145, pp. 127-148 | ||
| 504 | |a Groome, N.P., O'Brien, M., Immunoassays for inhibin and its subunits. Further applications of the synthetic peptide approach (1993) J. Immunol. Methods, 165, pp. 167-176 | ||
| 504 | |a Groome, N.P., Illingworth, P., O'Brien, M., Pai, R., Rodger, F., Mather, J., McNeilly, A.S., Measurement of dimeric inhibin B throughout the human menstrual cycle (1996) J. Clin. Endocrinol. Metab., 81, pp. 1401-1405 | ||
| 504 | |a Hsueh, A.J., Eisenhauer, K., Chun, S.-Y., Hsu, S.Y., Billig, H., Gonadal cell apoptosis (2002) Rec. Prog. Horm. Res., 51, pp. 433-455 | ||
| 504 | |a Huhtamiemi, I., Zhang, F.P., Kero, J., Hamalainen, T., Poutanen, M., Transgenic and knockout mouse models for the study of luteinizing hormone and luteinizing hormone receptor function (2002) Mol. Cell. Endocrinol., 187, pp. 49-56 | ||
| 504 | |a Kananen, K., Rilianawati, Paukku, T., Markkula, M., Rainio, E.-M., Huhtamiemi, I., Suppression of gonadotropins inhibits gonadal tumorigenesis in mice transgenic for the mouse inhibin α-subunit promoter/Simian virus 40 T-antigen fusion gene (1997) Endocrinology, 138, pp. 3521-3531 | ||
| 504 | |a Kommoss, F., Oliva, E., Bhan, A.K., Young, R.H., Scully, R.E., Inhibin expression in ovarian tumors and tumor-like lesions: An immunohistological study (1998) Mod. Pathol., 11, pp. 656-664 | ||
| 504 | |a Kumar, T., Wang, Y., Matzuk, M., Gonadotropins are essential modifier factors for gonadal tumor development in inhibin-deficient mice (1996) Endocrinology, 137, pp. 4210-4216 | ||
| 504 | |a Lanari, C., Kordon, E., Molinolo, A., Pasqualini, C., Charreau, E., Mammary adenocarcinomas induced by medroxyprogesterone acetate: Hormone dependence and EGF receptors of BALB/c in vivo sublines (1989) Int. J. Cancer, 43, pp. 845-850 | ||
| 504 | |a Lanuza, G., Groome, N., Barañao, L., Campo, S., Dimeric inhibin A and B production are differentially regulated by hormones and local factors in rat granulosa cells (1999) Endocrinology, 140, pp. 2549-2554 | ||
| 504 | |a Leeuwenberg, B., Hudson, N., Moore, L., Hurst, P., Mc Natty, K., Peripheral and ovarian IGF-1 concentration during the ovine oestrous cycle (1996) J. Endocrinol., 148, pp. 281-289 | ||
| 504 | |a Li, D., Kubo, T., Kim, H., Shimasaki, S., Erickson, G.F., Endogenous insulin-like growth factor-I is obligatory for stimulation of rat inhibin alpha subunit expression by follicle-stimulating hormone (1998) Biol. Reprod., 58, pp. 219-225 | ||
| 504 | |a Liu, J., Yakar, S., LeRoith, D., Conditional knockout of mouse insulin-like growth factor 1 gene using the Cre/LoxP system (2000) Proc. Soc. Exp. Biol. Med., 223, pp. 344-351 | ||
| 504 | |a Lux, V.A.R., Tesone, M., Larrea, G.A., Libertun, C., High correlation between prolactinemia, 125-I hLH binding and progesterone secretion by an experimental luteoma (1984) Life Sci., 35, pp. 2345-2352 | ||
| 504 | |a Lux-Lantos, V.A.R., Thyssen, S.M., Chamson-Reig, A., Libertun, C., Effect of a gonadotropin releasing hormone analog on an experimental ovarian tumor: Direct and indirect actions (1995) Life Sci., 57, pp. 291-300 | ||
| 504 | |a Matzuk, M., Finegold, M., Su, J., Hsueh, A.J.W., Bradley, A., Inhibin is a tumour-suppressor gene with gonadal specificity in mice (1992) Nature, 360, pp. 313-319 | ||
| 504 | |a McCracken, J.A., Custer, E.E., Lamsa, J.C., Luteolysis: A neuroendocrine-mediated event (1999) Physiol. Rev., 79, pp. 263-323 | ||
| 504 | |a Mc Lachlan, R., Cohen, N.L., Vale, W., Rivier, C., Burger, H.G., Bremner, W.J., Soules, M.R., The importance of the luteinizing hormone in the control of inhibin and progesterone secretion by the human corpus luteum (1989) J. Clin. Endocrinol. Metab., 68, pp. 1078-1085 | ||
| 504 | |a Ogawa, K., Kurohmaru, S., Shiota, K., Takahashi, M., Nishida, T., Hayashi, Y., Histochemical localization of inhibin and activin alpha, beta A and beta B subunits in rat gonads (1991) J. Vet. Med. Sci., 53, pp. 207-212 | ||
| 504 | |a Owens, G., Keri, R., Nilson, J.H., Ovulatory surges of human CG prevent hormone-induced granulosa cell tumor formation leading to the identification of tumor-associated changes in the transcriptome (2002) Mol. Endocrinol., 16, pp. 1230-1242 | ||
| 504 | |a Petraglia, F., Zanin, E., Faletti, A., Reis, F.M., Inhibins: Paracrine and endocrine effects in female reproductive function (1999) Curr. Opin. Obstet. Gynecol., 11, pp. 241-247 | ||
| 504 | |a Rahman, N., Kananen, K., Rilianawati, Paukku, T., Mikola, M., Markkula, M., Hämäläinen, T., Huhtaniemi, I., Transgenic mouse models for gonadal tumorigenesis (1998) Mol. Cell. Endocrinol., 145, pp. 167-174 | ||
| 504 | |a Rilianawati, Paukku, T., Kero, J., Zhang, F., Rahman, N., Kananen, K., Huhtaniemi, I., Direct luteinizing hormone action triggers adrenocortical tumorigenesis in castrated mice transgenic form the murine inhibin alpha-subunit promoter/simian virus 40 T-antigen fusion gene (1998) Mol. Endocrinol., 12, pp. 801-809 | ||
| 504 | |a Risbridger, G.P., Schmitt, J.F., Robertson, D.M., Activins and inhibins in endocrine and other tumors (2001) Endocr. Rev., 22, pp. 836-858 | ||
| 504 | |a Risma, K.A., Clay, C.M., Nett, T.M., Wagner, T., Yun, J., Nilson, J.H., Targeted overexpression of luteinizinghormone in transgenic mice leads to infertility, polycystic ovaries, and ovarian tumors (1995) Proc. Natl. Acad. Sci. USA, 92, pp. 1322-1326 | ||
| 504 | |a Roberts, V., Barth, S., El-Roeij, A., Yen, S.C.C., Expression of inhibin/activin subunits and follistatin messenger ribonucleic acids and proteins in ovarian follicles and the corpus-luteum during the human menstrual cycle (1993) J. Clin. Endocrinol. Metab., 77, pp. 1402-1410 | ||
| 504 | |a Rulli, S., Kuorelahti, A., Karaer, O., Pelliniemi, L., Poutanen, M., Huhtamiemi, I., Reproductive disturbances, pituitary lactotrope adenomas and mammary gland tumors in transgenic female mice producing high levels of human chorionic gonadotropin (2002) Endocrinology, 143, pp. 4084-4095 | ||
| 504 | |a Salazar, H., Godwin, A.K., Daly, M.B., Laub, P.B., Hogan, W.M., Rosenblum, N., Boente, M.P., Hamilton, T.C., Microscopic benign and invasive malignant neoplasms and a cancer-prone phenotype in prophylactic oophprectomies (1996) J. Natl. Cancer Inst., 88, pp. 1810-1820 | ||
| 504 | |a Sorianello, E., Fritz, S., Beyer, C., Hales, D., Mayerhofer, A., Libertun, C., Lux-Lantos, V., Development of an experimental ovarian tumor: Immunocytochemical analysis (2002) Eur. J. Endocrinol., 147, pp. 387-395 | ||
| 504 | |a Vanttinen, T., Liu, J., Hyden-Granskog, C., Parviainen, M., Penttila, I., Voutilainen, R., Regulation of immunoreactive inhibin A and B secretion in cultured human granulosa-luteal cells by gonadotropins, activin A and insulin-like growth factor type-1 receptor (2000) J. Endocrinol., 167, pp. 289-294 | ||
| 504 | |a Welt, C., Smith, Z.A., Pauler, D.K., Hall, J.E., Differential regulation of inhibin A and inhibin B by luteinizing hormone, follicle-stimulating hormone, and stage of follicle development (2001) J. Clin. Endocrinol. Metab., 86, pp. 2531-2537 | ||
| 504 | |a Wise, P.M., Neuroendocrine correlates of aging (2000) Neuroendocrinology in Phisiology and Medicine, pp. 371-387. , P.M. Conn, & M.E. Freeman. Totowa: Humana Press | ||
| 504 | |a Woodruff, T.K., D'Agostino, J.B., Schwartz, N., Mayo, K.E., Dynamic changes in inhibin messenger RNAs in rat ovarian follicles during the reproductive cycle (1988) Science, 239, pp. 1296-1299 | ||
| 504 | |a Woodruff, T.K., Besecke, L.M., Groome, N., Draper, L.B., Schwartz, N.B., Weiss, J., Inhibin A and inhibin B are inversely correlated to follicle-stimulating hormone, yet are discordant during the follicular phase of the rat estrous cycle, and inhibin A is expressed in a sexually dimorphic manner (1996) Endocrinology, 137, pp. 5463-5467 | ||
| 504 | |a Young, R.H., Scully, R.E., Sex cord-stromal and steroid-cell tumors (1993) Ovarian Cancer, pp. 153-172. , S.C. Rubin, & G.P. Sutton. New York: McGraw-Hill | ||
| 520 | 3 | |a Luteinized intrasplenic ovarian tumors develop in response to high circulating gonadotropins. The relationship between tumor development, gonadotropins and inhibins was studied. Tumor-bearing animals were sacrificed weekly along the first 6 weeks of development. Inhibins were measured by enzyme-linked immunosorbent assay (ELISA), serum gonadotropins, GH and IGF-1 by RIA. Inhibin subunit mRNAs were determined by Northern blot. Tumor histology was examined. Ovarian grafts grew significantly along development. LH increased ten-fold on week 1; a further significant increment was observed on week 3. FSH peaked on weeks 1 and 2 and fell significantly thereafter. Serum inhibins markedly increased on weeks 3-5. Tumor inhibin A content and mRNA levels for α and βA subunits also increased on week 3. Inverse correlations between inhibins and FSH and direct correlations between inhibins and LH were observed. Tumor inhibin A and IGF-1 contents correlated significantly. Increasing levels of luteinization were observed along tumor development. These luteinized tumors develop mainly in response to LH, since growth continues under FSH inhibition. The active inhibin secretion and the positive correlation between inhibins and LH suggests that LH may be the main driving force behind this production, while growth factors produced by the gonads may also participate in their regulation. © 2003 Elsevier Science Ireland Ltd. All rights reserved. |l eng | |
| 536 | |a Detalles de la financiación: Ministerio de Salud de la Nación | ||
| 536 | |a Detalles de la financiación: Agencia Nacional de Promoción Científica y Tecnológica, BID 1201 OC-AR PICT 2000 05-08664 | ||
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires | ||
| 536 | |a Detalles de la financiación: Umweltbundesamt | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: This work was supported by Consejo Nacional de Investigaciones Cientı́ficas y Técnicas (CONICET), University of Buenos Aires (UBA), Agencia Nacional de Promoción Cientı́fica y Tecnológica (BID 1201 OC-AR PICT 2000 05-08664) and Ministerio de Salud de la Nación. We wish to thank the NIDDK's National Hormone and Pituitary Program and Dr A.F. Parlow for the antibodies and RIA kits, Dr A. Hsueh for inhibin/activin probes and Dr A. Molinolo for his invaluable assistance in the histological analysis. | ||
| 593 | |a Lab. de Neuroendocrinologia, Inst. Biol. Med. E., V. de Obligado 2490, Buenos Aires 1428, Argentina | ||
| 593 | |a Department of Physiology, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a CEDIE, Htal. de Niños R. Gutierrez, Buenos Aires, Argentina | ||
| 593 | |a Oxford Brookes University, Htal. de Niños R. Gutierrez, Oxford, United Kingdom | ||
| 690 | 1 | 0 | |a GONADOTROPINS |
| 690 | 1 | 0 | |a HISTOLOGY |
| 690 | 1 | 0 | |a IGF-1 |
| 690 | 1 | 0 | |a INHIBINS |
| 690 | 1 | 0 | |a LUTEINIZED OVARIAN RAT TUMOR |
| 690 | 1 | 0 | |a FOLLITROPIN |
| 690 | 1 | 0 | |a GONADOTROPIN |
| 690 | 1 | 0 | |a INHIBIN |
| 690 | 1 | 0 | |a INHIBIN A |
| 690 | 1 | 0 | |a INHIBIN B |
| 690 | 1 | 0 | |a LUTEINIZING HORMONE |
| 690 | 1 | 0 | |a MESSENGER RNA |
| 690 | 1 | 0 | |a PROTEIN SUBUNIT |
| 690 | 1 | 0 | |a SOMATOMEDIN C |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a CORRELATION ANALYSIS |
| 690 | 1 | 0 | |a ENZYME LINKED IMMUNOSORBENT ASSAY |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HISTOPATHOLOGY |
| 690 | 1 | 0 | |a HORMONAL REGULATION |
| 690 | 1 | 0 | |a HORMONE DETERMINATION |
| 690 | 1 | 0 | |a LUTEINIZATION |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a NORTHERN BLOTTING |
| 690 | 1 | 0 | |a OVARY TUMOR |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROTEIN BLOOD LEVEL |
| 690 | 1 | 0 | |a PROTEIN SECRETION |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a REGULATORY MECHANISM |
| 700 | 1 | |a Sorianello, E. | |
| 700 | 1 | |a Chamson-Reig, A. | |
| 700 | 1 | |a Ballerini, G. | |
| 700 | 1 | |a Campo, S. | |
| 700 | 1 | |a Groome, N. | |
| 700 | 1 | |a Lux-Lantos, V. | |
| 700 | 1 | |a Libertun, C. | |
| 773 | 0 | |d Elsevier Ireland Ltd, 2003 |g v. 203 |h pp. 137-146 |k n. 1-2 |p Mol. Cell. Endocrinol. |x 03037207 |w (AR-BaUEN)CENRE-6138 |t Molecular and Cellular Endocrinology | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-0037684969&doi=10.1016%2fS0303-7207%2803%2900085-6&partnerID=40&md5=77c070328fbf6b916f349309a4a2727b |y Registro en Scopus |
| 856 | 4 | 0 | |u https://doi.org/10.1016/S0303-7207(03)00085-6 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_03037207_v203_n1-2_p137_Hockl |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03037207_v203_n1-2_p137_Hockl |y Registro en la Biblioteca Digital |
| 961 | |a paper_03037207_v203_n1-2_p137_Hockl |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 963 | |a VARI | ||