Transgenic mice engineered to target Cre/LoxP-mediated DNA recombination into catecholaminergic neurons
To introduce restricted DNA recombination events into catecholaminergic neurons using the Cre/loxP technology, we generated transgenic mice carrying the Cre recombinase gene driven by a 9 kb rat tyrosine hydroxylase (TH) promoter. Immunohistochemistry performed on transgenic mouse brain sections rev...
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| Otros Autores: | , , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
2003
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 08337caa a22014177a 4500 | ||
|---|---|---|---|
| 001 | PAPER-21481 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205256.0 | ||
| 008 | 190411s2003 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0042386703 | |
| 024 | 7 | |2 cas |a dopamine, 51-61-6, 62-31-7; tyrosine 3 monooxygenase, 9036-22-0; Alkaline Phosphatase, EC 3.1.3.1; Catecholamines; Cre recombinase, EC 2.7.7.-; Integrases, EC 2.7.7.-; Tyrosine 3-Monooxygenase, EC 1.14.16.2; Viral Proteins | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a GNESF | ||
| 100 | 1 | |a Gelman, D.M. | |
| 245 | 1 | 0 | |a Transgenic mice engineered to target Cre/LoxP-mediated DNA recombination into catecholaminergic neurons |
| 260 | |c 2003 | ||
| 270 | 1 | 0 | |m Rubinstein, M.; INGEBI-CONICET, Vuelta de Obligado 2490, 1428-Buenos Aires, Argentina; email: mrubins@dna.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Asmus, S.E., Newman, S.W., Tyrosine hydroxylase mRNA-containing neurons in the medial amygdaloid nucleus and the reticular nucleus of the thalamus in the Syrian hamster (1993) Brain Res Mol Brain Res, 20, pp. 267-273 | ||
| 504 | |a Asmus, S.E., Kincaid, A.E., Newman, S.W., A species-specific population of tyrosine hydroxylase-immunoreactive neurons in the medial amygdaloid nucleus of the Syrian hamster (1992) Brain Res, 575, pp. 199-207 | ||
| 504 | |a Guillin, O., Diaz, J., Carroll, P., Griffon, N., Schwartz, J.C., Sokoloff, P., BDNF controls dopamine D3 receptor expression and triggers behavioural sensitization (2001) Nature, 411, pp. 86-89 | ||
| 504 | |a Gwinn-Hardy, K., Genetics of parkinsonism (2002) Mov Disord, 17, pp. 645-656 | ||
| 504 | |a Hillarp, N.A., Fuxe, K., Dahlstrom, A., Demonstration and mapping of central neurons containing dopamine, noradrenaline, and 5-hydroxytryptamine and their reactions to psychopharmaca (1966) Pharmacol Rev, 18, pp. 727-741 | ||
| 504 | |a Jonakait, G.M., Markey, K.A., Goldstein, M., Black, I.B., Transient expression of selected catecholaminergic traits in cranial sensory and dorsal root ganglia of the embryonic rat (1984) Dev Biol, 101, pp. 51-60 | ||
| 504 | |a Lobe, C.G., Koop, K.E., Kreppner, W., Lomeli, H., Gertsenstein, M., Nagy, A., Z/AP, a double reporter for cre-mediated recombination (1999) Dev Biol, 208, pp. 281-292 | ||
| 504 | |a Mezey, E., Phenylethanolamine N-methyltransferase-containing neurons in the limbic system of the young rat (1989) Proc Natl Acad Sci USA, 86, pp. 347-351 | ||
| 504 | |a Min, N., Joh, T.H., Kim, K.S., Peng, C., Son, J.H., 5′ upstream DNA sequence of the rat tyrosine hydroxylase gene directs high-level and tissue-specific expression to catecholaminergic neurons in the central nervous system of transgenic mice (1994) Brain Res Mol Brain Res, 27, pp. 281-289 | ||
| 504 | |a Mouradian, M.M., Recent advances in the genetics and pathogenesis of Parkinson disease (2002) Neurology, 5, pp. 179-185 | ||
| 504 | |a Nagy, A., Cre recombinase: The universal reagent for genome tailoring (2000) Genesis, 26, pp. 99-109 | ||
| 504 | |a Price, J., Mudge, A.W., A subpopulation of rat dorsal root ganglion neurons is catecholaminergic (1983) Nature, 301, pp. 241-243 | ||
| 504 | |a Rossant, J., McMahon, A., "Cre"-ating mouse mutants-a meeting review on conditional mouse genetics (1999) Genes Dev, 13, pp. 142-145 | ||
| 504 | |a Schimmel, J.J., Crews, L., Roffler-Tarlov, S., Chikaraishi, D.M., 4.5 kb of the rat tyrosine hydroxylase 5′ flanking sequence directs tissue specific expression during development and contains consensus sites for multiple transcription factors (1999) Brain Res Mol Brain Res, 74, pp. 1-14 | ||
| 504 | |a Zetterstrom, R.H., Solomin, L., Jansson, L., Hoffer, B.J., Olson, L., Perlmann, T., Dopamine neuron agenesis in Nurr1-deficient mice (1997) Science, 276, pp. 248-250 | ||
| 520 | 3 | |a To introduce restricted DNA recombination events into catecholaminergic neurons using the Cre/loxP technology, we generated transgenic mice carrying the Cre recombinase gene driven by a 9 kb rat tyrosine hydroxylase (TH) promoter. Immunohistochemistry performed on transgenic mouse brain sections revealed a high number of cells expressing Cre in areas where TH is normally expressed, including the olfactory bulb, hypothalamic and midbrain dopaminergic neurons, and the locus coeruleus. Double immunohistochemistry and immunofluorescence indicated that colocalization of TH and Cre is greater than 80%. Cre expression was also found in TH-positive amacrine neurons of the retina, chromaffin cells of the adrenal medulla, and sympathetic ganglia. We intercrossed TH-Cre mice with the floxed reporter strain Z/AP and observed efficient Cre-mediated recombination in all areas expressing TH, indicating that transgenic Cre is functional. Therefore, we have generated a valuable transgenic mouse strain to induce specific mutations of "floxed" genes in catecholaminergic neurons. © 2003 Wiley-Liss, Inc. |l eng | |
| 593 | |a Vollum Institute, Dept. of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, United States | ||
| 593 | |a Centro de Estudios Cientificos, Valdivia, Chile | ||
| 593 | |a INGEBI-CONICET, Vuelta de Obligado 2490, 1428-Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a CATECHOLAMINE |
| 690 | 1 | 0 | |a CRE RECOMBINASE |
| 690 | 1 | 0 | |a DOPAMINE |
| 690 | 1 | 0 | |a LOXP |
| 690 | 1 | 0 | |a NOREPINEPHRINE |
| 690 | 1 | 0 | |a TRANSGENIC MOUSE |
| 690 | 1 | 0 | |a TYROSINE HYDROXYLASE |
| 690 | 1 | 0 | |a CATECHOLAMINE |
| 690 | 1 | 0 | |a CRE RECOMBINASE |
| 690 | 1 | 0 | |a DOPAMINE |
| 690 | 1 | 0 | |a GENE PRODUCT |
| 690 | 1 | 0 | |a PROTEIN CRE LOXP |
| 690 | 1 | 0 | |a RECOMBINANT DNA |
| 690 | 1 | 0 | |a TYROSINE 3 MONOOXYGENASE |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
| 690 | 1 | 0 | |a ADRENAL MEDULLA |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a BRAIN REGION |
| 690 | 1 | 0 | |a CATECHOLAMINE NERVE CELL |
| 690 | 1 | 0 | |a CHROMAFFIN CELL |
| 690 | 1 | 0 | |a DNA RECOMBINATION |
| 690 | 1 | 0 | |a DOPAMINERGIC NERVE CELL |
| 690 | 1 | 0 | |a DOUBLE IMMUNOHISTOCHEMISTRY |
| 690 | 1 | 0 | |a FLOXED GENE |
| 690 | 1 | 0 | |a GENE FUNCTION |
| 690 | 1 | 0 | |a GENE MUTATION |
| 690 | 1 | 0 | |a GENE TARGETING |
| 690 | 1 | 0 | |a GENE TECHNOLOGY |
| 690 | 1 | 0 | |a GENETIC ENGINEERING |
| 690 | 1 | 0 | |a HYPOTHALAMUS |
| 690 | 1 | 0 | |a IMMUNOFLUORESCENCE |
| 690 | 1 | 0 | |a IMMUNOHISTOCHEMISTRY |
| 690 | 1 | 0 | |a LOCUS CERULEUS |
| 690 | 1 | 0 | |a MESENCEPHALON |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a OLFACTORY BULB |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROMOTER REGION |
| 690 | 1 | 0 | |a PROTEIN EXPRESSION |
| 690 | 1 | 0 | |a PROTEIN LOCALIZATION |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a RETINA AMACRINE CELL |
| 690 | 1 | 0 | |a STRAIN IDENTIFICATION |
| 690 | 1 | 0 | |a SYMPATHETIC GANGLION |
| 690 | 1 | 0 | |a TRANSGENIC MOUSE |
| 690 | 1 | 0 | |a ALKALINE PHOSPHATASE |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a BRAIN CHEMISTRY |
| 690 | 1 | 0 | |a CATECHOLAMINES |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a GENE EXPRESSION REGULATION, ENZYMOLOGIC |
| 690 | 1 | 0 | |a GENE TARGETING |
| 690 | 1 | 0 | |a GENES, REPORTER |
| 690 | 1 | 0 | |a GENETIC ENGINEERING |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a IMMUNOHISTOCHEMISTRY |
| 690 | 1 | 0 | |a INTEGRASES |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a MICE, TRANSGENIC |
| 690 | 1 | 0 | |a NEURONS |
| 690 | 1 | 0 | |a PREGNANCY |
| 690 | 1 | 0 | |a PROMOTER REGIONS (GENETICS) |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RECOMBINATION, GENETIC |
| 690 | 1 | 0 | |a TISSUE DISTRIBUTION |
| 690 | 1 | 0 | |a TRANSGENES |
| 690 | 1 | 0 | |a TYROSINE 3-MONOOXYGENASE |
| 690 | 1 | 0 | |a VIRAL PROTEINS |
| 690 | 1 | 0 | |a MUS MUSCULUS |
| 700 | 1 | |a Noaín, D. | |
| 700 | 1 | |a Avale, M.E. | |
| 700 | 1 | |a Otero, V. | |
| 700 | 1 | |a Low, M.J. | |
| 700 | 1 | |a Rubinstein, M. | |
| 773 | 0 | |d 2003 |g v. 36 |h pp. 196-202 |k n. 4 |p Genesis |x 1526954X |t Genesis | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-0042386703&doi=10.1002%2fgene.10217&partnerID=40&md5=f6c0d22af75fc207d935238e9135967c |y Registro en Scopus |
| 856 | 4 | 0 | |u https://doi.org/10.1002/gene.10217 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_1526954X_v36_n4_p196_Gelman |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1526954X_v36_n4_p196_Gelman |y Registro en la Biblioteca Digital |
| 961 | |a paper_1526954X_v36_n4_p196_Gelman |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 82434 | ||