Postnatal haloperidol eliminates the deficit in circling behavior produced by prenatal exposure to the same drug
Up to 35% of pregnant women take psychotropic drugs at least once during gestation [Austin and Mitchell, 1998]. From concurrent animal and human evidence, it has been proposed that exposure to several psychoactive medications in utero or during lactation increases the risk for permanent brain disord...
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2004
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| 005 | 20230518205239.0 | ||
| 008 | 190411s2004 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-2942625682 | |
| 024 | 7 | |2 cas |a haloperidol, 52-86-8; Dopamine Antagonists; Haloperidol, 52-86-8; Spiperone, 749-02-0; Tritium, 10028-17-8 | |
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| 030 | |a NETEE | ||
| 100 | 1 | |a Wolansky, M.J. | |
| 245 | 1 | 0 | |a Postnatal haloperidol eliminates the deficit in circling behavior produced by prenatal exposure to the same drug |
| 260 | |c 2004 | ||
| 270 | 1 | 0 | |m Azcurra, J.M.C. F. Melo 4127 (C.P. 1602), Buenos Aires, Argentina; email: azcuipon@bg.fcen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a Up to 35% of pregnant women take psychotropic drugs at least once during gestation [Austin and Mitchell, 1998]. From concurrent animal and human evidence, it has been proposed that exposure to several psychoactive medications in utero or during lactation increases the risk for permanent brain disorders. Present preventive or therapy practices applied on humans for this type of long-lasting behavioral alterations are mainly based on empirical results. Here, we test an experimental approach designed to counteract a circling performance deficit that appears in Sprague-Dawley rats at puberty on exposure to the dopaminergic blocker haloperidol (HAL) during gestation [J.L. Brusés, J.M. Azcurra, The circling training: A behavioral paradigm for functional teratology testing, in: P.M. Conn (Ed.), Paradigms for the study of behavior, Acad. Press, New York, 1993, pp. 166-179. Method Neurosci. 14]. Gestational exposure to HAL (GD 5-18, 2.5 mg/kg/day ip) induced the expected circling activity decrease in the offspring at the fifth week of life. When prenatal exposure to HAL was continued through lactation (PD5-21, 1.5 mg/kg/day ip), rats otherwise showed a control-like circling performance. No difference was yet found between lactation-only, HAL-exposed pups and saline (SAL)-treated controls (n=8 each group). We further performed saturating (3H)-spiroperidol (SPI) binding assays on striatal P2 membrane fractions 2 months later. The dopamine-type D2-specific binding results suggested that above circling behavior findings could be partially explained by enduring HAL-induced neurochemical changes. The role of critical periods of sensitivity as transient windows for opportunistic therapies for behavioral teratology is discussed. © 2004 Elsevier Inc. All rights reserved. |l eng | |
| 536 | |a Detalles de la financiación: Umweltbundesamt | ||
| 536 | |a Detalles de la financiación: Universidad Nacional del Centro de la Provincia de Buenos Aires | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: This work was supported with grants from Universidad Nacional de Buenos Aires (UBA) and Consejo Nacional de Investigaciones Cientı́ficas y Técnicas (CONICET), Argentina. MJW gratefully acknowledges UBA for the granting of a fellowship. We are especially grateful to Gustavo Paratcha. We also thank the efforts of Beatriz Gonzalez and Javier Calcagno (Biometry, School of Sciences, UBA). The authors would like to express our appreciation to Mr. Stein, from Janssen Laboratories (Buenos Aires), for fulfilling our request for haloperidol, and Robert Macphail and Kevin Crofton for their kind help in revising the original version of the manuscript. | ||
| 593 | |a Interdisc. Proj. on Neuroteratology, Depto. de Biodiversidad Y Biol. Exp., Universidad de Buenos Aires, C1428EHA Buenos Aires, Argentina | ||
| 593 | |a C. F. Melo 4127 (C.P. 1602), Buenos Aires, Argentina | ||
| 593 | |a Neurotoxicology Division, Natl. Hlth. Environ. Effects Res. L., US EPA, Research Triangle Park, NC 27711, United States | ||
| 690 | 1 | 0 | |a BEHAVIORAL TERATOGEN |
| 690 | 1 | 0 | |a HALOPERIDOL |
| 690 | 1 | 0 | |a THERAPEUTIC AGENT |
| 690 | 1 | 0 | |a HALOPERIDOL |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a BEHAVIOR DISORDER |
| 690 | 1 | 0 | |a BEHAVIOR TERATOLOGY |
| 690 | 1 | 0 | |a CIRCLING BEHAVIOR |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a LACTATION |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PERINATAL DRUG EXPOSURE |
| 690 | 1 | 0 | |a PRENATAL DRUG EXPOSURE |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROGENY |
| 690 | 1 | 0 | |a ANALYSIS OF VARIANCE |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a ANIMALS, NEWBORN |
| 690 | 1 | 0 | |a BEHAVIOR, ANIMAL |
| 690 | 1 | 0 | |a BRAIN |
| 690 | 1 | 0 | |a DOPAMINE ANTAGONISTS |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HALOPERIDOL |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a PREGNANCY |
| 690 | 1 | 0 | |a PRENATAL EXPOSURE DELAYED EFFECTS |
| 690 | 1 | 0 | |a RADIOLIGAND ASSAY |
| 690 | 1 | 0 | |a RANDOM ALLOCATION |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RATS, SPRAGUE-DAWLEY |
| 690 | 1 | 0 | |a SPIPERONE |
| 690 | 1 | 0 | |a STEREOTYPED BEHAVIOR |
| 690 | 1 | 0 | |a STEREOTYPIC MOVEMENT DISORDER |
| 690 | 1 | 0 | |a TRITIUM |
| 690 | 1 | 0 | |a ANIMALIA |
| 700 | 1 | |a Soiza-Reilly, M. | |
| 700 | 1 | |a Fossati, M. | |
| 700 | 1 | |a Azcurra, J.M. | |
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