The [Ru(Hedta)NO] 0,1- system: Structure, chemical reactivity and biological assays

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The [Ru II(Hedta)NO +] complex is a diamagnetic species crystallizing in a distorted octahedral geometry, with the Ru-N(O) length 1.756(4) Å and the RuNO angle 172.3(4)°. The complex contains one protonated carboxylate (pK a = 2.7 ± 0.1). The [Ru II(Hedta)NO +] complex undergoes a nitrosyl-centered...

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Detalles Bibliográficos
Autor principal: Zanichelli, P.G
Otros Autores: Miotto, A.M, Estrela, H.F.G, Soares, F.R, Grassi-Kassisse, D.M, Spadari-Bratfisch, R.C, Castellano, Eduardo Ernesto, Roncaroli, F., Parise, A.R, Olabe, J.A, De Brito, A.R.M.S, Franco, D.W
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 2004
Acceso en línea:Registro en Scopus
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Aporte de:Registro referencial: Solicitar el recurso aquí
Biblioteca Central Dr. Luis F. Leloir (FCEN) de Universidad de Buenos Aires
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024 7 |2 scopus  |a 2-s2.0-7644243550 
024 7 |2 cas  |a hydroxide, 14280-30-9; nitric oxide, 10102-43-9; nitroprusside sodium, 14402-89-2, 15078-28-1; Edetic Acid, 60-00-4; N-(hydroxyethyl)ethylenediaminetriacetic acid, 150-39-0; Nitric Oxide, 10102-43-9; Ruthenium, 7440-18-8 
030 |a JIBID 
040 |a Scopus  |b spa  |c AR-BaUEN  |d AR-BaUEN 
100 1 |a Zanichelli, P.G. 
245 1 4 |a The [Ru(Hedta)NO] 0,1- system: Structure, chemical reactivity and biological assays 
260 |c 2004 
270 1 0 |m Inst. de Quím. de S. Carlos, Univ. S. Paulo - Av. Trabalhador S., CEP: 13560-970 - S. Carlos - SP, B.Brazil; email: douglas@iqsc.usp.br 
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506 |2 openaire  |e Política editorial 
520 3 |a The [Ru II(Hedta)NO +] complex is a diamagnetic species crystallizing in a distorted octahedral geometry, with the Ru-N(O) length 1.756(4) Å and the RuNO angle 172.3(4)°. The complex contains one protonated carboxylate (pK a = 2.7 ± 0.1). The [Ru II(Hedta)NO +] complex undergoes a nitrosyl-centered one-electron reduction (chemical or electrochemical), with E NO+/NO = -0.31 V vs SCE (I = 0.2 M, pH 1), yielding [Ru II(Hedta)NO] -, which aquates slowly: k -NO = 2.1 ± 0.4 × 10 -3 s -1 (pH 1.0, I = 0.2 M, CF 3COOH/NaCF 3COO, 25°C). At pHs > 12, the predominant species, [Ru II(edta)NO] -, reacts according to [Ru II(edta) NO] - + 2OH - ⇒ [Ru II(edta)NO 2] 3-, with K eq = 1.0 ± 0.4 × 10 3 M -2 (I = 1.0 M, NaCl; T = 25.0 ± 0.1°C). The rate-law is first order in each of the reactants for most reaction conditions, with k OH - = 4.35 ± 0.02 M -1 s -1 (25.0°C), assignable mechanistically to the elementary step comprising the attack of one OH - on [Ru II(edta)NO] -, with subsequent fast deprotonation of the [Ru II(edta) NO 2H] 2- intermediate. The activation parameters were ΔH # = 60 ± 1 kJ/mol, ΔS # = -31 ± 3 J/K mol, consistent with a nucleophilic addition process between likely charged ions. In the toxicity up-and-down tests performed with Swiss mice, no death was observed in all the doses administered (3-9.08 × 10 -5 mol/kg). The biodistribution tests performed with Wistar male rats showed metal in the liver, kidney, urine and plasma. Eight hours after the injection no metal was detected in the samples. The vasodilator effect of [Ru II(edta)NO] - was studied in aortic rings without endothelium, and was compared with sodium nitroprusside (SNP). The times of maximal effects of [Ru II(edta)NO] - and SNP were 2 h and 12 min, respectively, suggesting that [Ru II(edta)NO] - releases NO slowly to the medium in comparison with SNP. © 2004 Elsevier Inc. All rights reserved.  |l eng 
593 |a Inst. de Quím. de S. Carlos, Univ. S. Paulo - Av. Trabalhador S., CEP: 13560-970 - S. Carlos - SP, B., Brazil 
593 |a Depto. de Fisiol. e Biofísica, Instituto de Biologia, Univ. Estadual Campinas - C., Brazil 
593 |a Inst. de Fís. de S. Carlos, Universidade de São Paulo, 135 - Av. Trabalhador S. C., Brazil 
593 |a Depto. de Quím. Inorg., Analitica Y Quim. Fis., INQUIMAE, Fac. Cie. Exact. Y N., Argentina 
690 1 0 |a NITROSYL REACTIVITY 
690 1 0 |a NO-DONORS 
690 1 0 |a NUCLEOPHILIC REACTIVITY 
690 1 0 |a RUTHENIUM NITROSYL 
690 1 0 |a VASODILATOR ACTIVITY 
690 1 0 |a CARBOXYLIC ACID 
690 1 0 |a HYDROXIDE 
690 1 0 |a METAL 
690 1 0 |a NITRIC OXIDE 
690 1 0 |a NITROPRUSSIDE SODIUM 
690 1 0 |a RUTHENIUM DERIVATIVE 
690 1 0 |a ADDITION REACTION 
690 1 0 |a ANIMAL EXPERIMENT 
690 1 0 |a ARTICLE 
690 1 0 |a BIOACCUMULATION 
690 1 0 |a BIOASSAY 
690 1 0 |a CHEMICAL REACTION 
690 1 0 |a CONTROLLED STUDY 
690 1 0 |a CRYSTALLIZATION 
690 1 0 |a DEATH 
690 1 0 |a DRUG EFFECT 
690 1 0 |a DRUG STRUCTURE 
690 1 0 |a ELECTRICITY 
690 1 0 |a ELECTROCHEMISTRY 
690 1 0 |a ELECTRON 
690 1 0 |a ENDOTHELIUM 
690 1 0 |a GEOMETRY 
690 1 0 |a INJECTION 
690 1 0 |a KIDNEY 
690 1 0 |a LIVER 
690 1 0 |a MALE 
690 1 0 |a NONHUMAN 
690 1 0 |a PARAMETER 
690 1 0 |a PLASMA 
690 1 0 |a PROTON TRANSPORT 
690 1 0 |a RAT 
690 1 0 |a REACTION ANALYSIS 
690 1 0 |a REDUCTION 
690 1 0 |a SAMPLE 
690 1 0 |a STRUCTURE ANALYSIS 
690 1 0 |a TIME 
690 1 0 |a TOXICITY 
690 1 0 |a URINE 
690 1 0 |a VASCULAR RING 
690 1 0 |a VASODILATATION 
690 1 0 |a ANIMALS 
690 1 0 |a CRYSTALLOGRAPHY, X-RAY 
690 1 0 |a EDETIC ACID 
690 1 0 |a ELECTROCHEMISTRY 
690 1 0 |a MALE 
690 1 0 |a MICE 
690 1 0 |a MODELS, MOLECULAR 
690 1 0 |a MOLECULAR CONFORMATION 
690 1 0 |a NITRIC OXIDE 
690 1 0 |a RUTHENIUM 
690 1 0 |a TISSUE DISTRIBUTION 
690 1 0 |a XENOX 
700 1 |a Miotto, A.M. 
700 1 |a Estrela, H.F.G. 
700 1 |a Soares, F.R. 
700 1 |a Grassi-Kassisse, D.M. 
700 1 |a Spadari-Bratfisch, R.C. 
700 1 |a Castellano, Eduardo Ernesto 
700 1 |a Roncaroli, F. 
700 1 |a Parise, A.R. 
700 1 |a Olabe, J.A. 
700 1 |a De Brito, A.R.M.S. 
700 1 |a Franco, D.W. 
773 0 |d 2004  |g v. 98  |h pp. 1921-1932  |k n. 11  |p J. Inorg. Biochem.  |x 01620134  |w (AR-BaUEN)CENRE-818  |t Journal of Inorganic Biochemistry 
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856 4 0 |u https://doi.org/10.1016/j.jinorgbio.2004.08.020  |x doi  |y DOI 
856 4 0 |u https://hdl.handle.net/20.500.12110/paper_01620134_v98_n11_p1921_Zanichelli  |x handle  |y Handle 
856 4 0 |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01620134_v98_n11_p1921_Zanichelli  |x registro  |y Registro en la Biblioteca Digital 
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