Photooxidation of pterin in aqueous solutions: Biological and biomedical implications

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Studies of the photochemical reactivity of pterin (-2-aminopteridin-4(3H)- one; PT) in acidic (pH 5.0 -6.0) and alkaline (pH 10.2 - 10.8) aqueous solutions have been performed. The photochemical reactions were followed by UV/VIS spectrophotometry, thin layer chromatography (TLC), high-performance li...

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Autor principal: Cabrerizo, F.M
Otros Autores: Dantola, M.L, Thomas, A.H, Lorente, C., Braun, A.M, Oliveros, E., Capparelli, A.L
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 2004
Acceso en línea:Registro en Scopus
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Biblioteca Central Dr. Luis F. Leloir (FCEN) de Universidad de Buenos Aires
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024 7 |2 cas  |a pterin derivative, 948-60-7; water, 7732-18-5; Pterins; Solutions; Water, 7732-18-5 
040 |a Scopus  |b spa  |c AR-BaUEN  |d AR-BaUEN 
030 |a CBHIA 
100 1 |a Cabrerizo, F.M. 
245 1 0 |a Photooxidation of pterin in aqueous solutions: Biological and biomedical implications 
260 |c 2004 
270 1 0 |m Instituto de Investigaciones Fisicoquímicas Teoricas y Aplicadas (INIFTA), Departamento de Química, Universidad Nacional de la Plata, CIC Casilla de Correo 16, Sucursal 4, 1900-La Plata, Argentina 
506 |2 openaire  |e Política editorial 
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520 3 |a Studies of the photochemical reactivity of pterin (-2-aminopteridin-4(3H)- one; PT) in acidic (pH 5.0 -6.0) and alkaline (pH 10.2 - 10.8) aqueous solutions have been performed. The photochemical reactions were followed by UV/VIS spectrophotometry, thin layer chromatography (TLC), high-performance liquid chromatography (HPLC), and an enzymatic method for H2O2 determination. PT is not light-sensitive in the absence of molecular oxygen, but it undergoes photooxidation in the presence of O2 , yielding several nonpteridinic products. The quantum yields for PT disappearance were found to be 8.2 (-0.6)-10-4 and 1.2 (-0.2)-10-3 in acidic and alkaline media, respectively. H2O2 was detected and quantified in irradiated solutions of PT; and its importance from a biomedical point of view is discussed. The rate constant of the chemical reaction between singlet oxygen (1O2) and PT was determined to be 2.5 (-0.2)-105 l mol-1 s-1 in alkaline medium, and the role of 1O2 in the photooxidation of pterin was evaluated. © 2004 Verlag Helvetica Chimica Acta AG, Zürich.  |l eng 
593 |a Instituto de Investigaciones Fisicoquímicas Teoricas y Aplicadas (INIFTA), Departamento de Química, Universidad Nacional de la Plata, CIC Casilla de Correo 16, Sucursal 4, 1900-La Plata, Argentina 
593 |a CHIDECAR - CONICET, Departamento de Química Organica, Universidad de Buenos Aires X, Pabellon 2, 3p, Ciudad Universitaria, 1428-Buenos Aires, Argentina 
593 |a Lehrstuhl fur Umweltmesstechnik, Engler-Bunte Institut, Universitat Karlsruhe, D-76128 Karlsruhe, Germany 
690 1 0 |a PTERIN DERIVATIVE 
690 1 0 |a WATER 
690 1 0 |a ARTICLE 
690 1 0 |a METABOLISM 
690 1 0 |a OXIDATION REDUCTION REACTION 
690 1 0 |a PHOTOCHEMISTRY 
690 1 0 |a RADIATION EXPOSURE 
690 1 0 |a SOLUTION AND SOLUBILITY 
690 1 0 |a ULTRAVIOLET RADIATION 
690 1 0 |a OXIDATION-REDUCTION 
690 1 0 |a PHOTOCHEMISTRY 
690 1 0 |a PTERINS 
690 1 0 |a SOLUTIONS 
690 1 0 |a ULTRAVIOLET RAYS 
690 1 0 |a WATER 
700 1 |a Dantola, M.L. 
700 1 |a Thomas, A.H. 
700 1 |a Lorente, C. 
700 1 |a Braun, A.M. 
700 1 |a Oliveros, E. 
700 1 |a Capparelli, A.L. 
773 0 |d 2004  |g v. 1  |h pp. 1800-1811  |k n. 11  |p Chem. Biodiversity  |x 16121872  |t Chemistry and Biodiversity 
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856 4 0 |u https://doi.org/10.1002/cbdv.200490135  |y DOI 
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