Free and immobilised Citrobacter amalonaticus CECT 863 as a biocatalyst for nucleoside synthesis
The synthesis of modified nucleosides has received a great deal of attention due to their applications as antiviral and antitumoral agents. Among the different synthetic strategies, microbial transglycosylation has already shown to provide successful results. In the present work, we analyse the use...
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2004
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 09104caa a22010817a 4500 | ||
|---|---|---|---|
| 001 | PAPER-21141 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205234.0 | ||
| 008 | 190411s2004 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-8644245910 | |
| 024 | 7 | |2 cas |a polyacrylamide, 9003-05-8 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a IJBNB | ||
| 100 | 1 | |a Trelles, J.A. | |
| 245 | 1 | 0 | |a Free and immobilised Citrobacter amalonaticus CECT 863 as a biocatalyst for nucleoside synthesis |
| 260 | |c 2004 | ||
| 270 | 1 | 0 | |m Lewkowicz, E.S.; Universidad Nacional de Quilmes, R.S. Peña 180, (1876) Bernal, Buenos Aires, Argentina; email: elewko@unq.edu.ar |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Ewing, D.F., Holy, A., Votruba, I., Humble, R.W., Mackenzie, G., Hewedi, F., Shaw, G., Synthesis of 4- and 5-amino-1-(2-deoxy-D-erythro-pentofuranosyl)imidazole nucleosides by chemical and biotransformation methods (1991) Carbohydr. Res., 216, pp. 109-118 | ||
| 504 | |a Ferrero, M., Gotor, V., Chemoenzymatic transformations in nucleoside chemistry (2000) Monatshefte für Chemie, 131, pp. 585-616 | ||
| 504 | |a Freeman, A., Aharonowitz, Y., Immobilization of microbial cells in crosslinked, prepolymerized, linear polyacrylamide gels: Antibiotic production by immobilized Streptomyces daruligerus cells (1981) Biotechnol. Bioeng., 23, pp. 2747-2750 | ||
| 504 | |a Gaevaia, L.V., Zhukov, V.N., The use of immobilized enzymes for the synthesis of nucleosides and nucleotides including the ones labeled with radioactive isotopes (1987) Prikl. Biokhim. Mikrobiol., 23, pp. 309-316 | ||
| 504 | |a Garg, R., Gupta, S., Gao, H., Babu, M., Debnath, A., Hansch, C., Comparative quantitative structure-activity relationship studies on anti-HIV drugs (1999) Chemical Reviews, 99, pp. 3523-3601 | ||
| 504 | |a Hanrahan, J.R., Hutchinson, D.W., The enzymatic synthesis of antiviral agents (1992) Journal of Biotechnology, 23, pp. 193-210 | ||
| 504 | |a Hemachander, C., Bose, N., Puvanakrishnan, R., Whole cell immobilization of Ralstonia pickettii for lipase production (2001) Process Biochem., 36, pp. 629-633 | ||
| 504 | |a Herdewijn, P., De Clercq, E., (1990) Design of Anti-AIDS Drugs, 14, pp. 141-158. , Ed. Elsevier | ||
| 504 | |a Hoffman, A.S., Hydrogels for biomedical applications (2002) Adv. Drug Delivery Rev., 43, pp. 3-12 | ||
| 504 | |a Holy, A., Antiviral agents in 2000 - And then what next (2001) Cas Lek Cesk, 140, pp. 583-591 | ||
| 504 | |a Holy, A., Votruba, I., Facile preparation of purine and pyrimidine 2-deoxy-beta-D- ribonucleosides by biotransformation on encapsulated cells (1987) Nucleic Acids Symp. Ser., 18, pp. 69-72 | ||
| 504 | |a Hori, N., Watanabe, M., Sunagawa, K., Uehara, K., Mikami, Y., Production of 5-methyluridine by immobilized thermostable purine nucleoside phosphorylase and pyrimidine nucleoside phosphorylase from Bacillus stearothermophilus JS 859 (1991) J. Biotechnol., 17, pp. 121-131 | ||
| 504 | |a Iaskovich, G.A., Iakovleva, E.P., Microbiological synthesis of virazole by immobilized cells (1999) Prikl. Biokhim. Mikrobiol., 35, pp. 146-149 | ||
| 504 | |a Ichikawa, E., Kato, K., Sugar-modified nucleosides in past 10 years, a review (2001) Current Medicinal Chemistry, 8, pp. 385-423 | ||
| 504 | |a Krenitzky, T., Koszalka, G., Purine nucleoside synthesis, an efficient method employing nucleoside phosphorylases (1981) Biochemistry, 20, pp. 3615-3621 | ||
| 504 | |a Lianes, N., Fernandes, P., Leon, R., Cabrai, J.M.S., Pinheiro, H.M., Conversion of β-sitosterol by Mycobacterium sp. NRRL B-3805 cells immobilized on Celite supports (2001) J. Mol. Catal. B: Enzym., 11, pp. 523-530 | ||
| 504 | |a Lloyd, J.R., Lovley, D.R., Microbial detoxification of metals and radionuclides (2001) Current Opinion in Biotech., 12, pp. 248-253 | ||
| 504 | |a Lozinsky, V.I., Plieva, P.M., Poly (vinyl alcohol) cryogels employed as matrices for cell immobilization. 3. Overview of recent research and developments (1998) Enzyme Microb. Technol., 23, pp. 227-242 | ||
| 504 | |a Pizarro, C., Fernandez-Torroba, M.A., Benito, C., Gonzalez-Saiz, J.M., Optimization by experimental design of polyacrylamide gel composition as support for enzyme immobilization by entrapment (1997) Biotechnol Bioeng., 53, pp. 497-510 | ||
| 504 | |a Prasad, A.K., Trikha, S., Parmar, V.S., Nucleoside synthesis mediated by glycosyl transferring enzymes (1999) Bioorganic Chem., 27, pp. 135-154 | ||
| 504 | |a Pugmire, M.J., Ealick, S.E., Structural analyses reveal two distinct families of nucleoside phosphorylases (2002) Biochem. J., 361, pp. 1-25 | ||
| 504 | |a Rastogi, S., Kumar, A., Mehra, N.K., Makhijani, S.D., Manoharan, A., Gangal, V., Kumar, R., Development and characterization of a novel immobilized microbial membrane for rapid determination of biochemical oxygen demand load in industrial waste-waters (2003) Biosensors and Bioelectronics, 18, pp. 23-29 | ||
| 504 | |a Rogert, M.C., Trelles, J.A., Porro, S., Lewkowicz, E.S., Iribarren, A.M., Microbial synthesis of antiviral nucleosides using E. coli BL 21 as biocatalyst (2002) Biocatalysis & Biotransformations, 20, pp. 347-351 | ||
| 504 | |a Trelles, J.A., Fernández, M., Lewkowicz, E.S., Iribarren, A.M., Sinisterra, J.V., Purine nucleoside synthesis from uridine using immobilised Enterobacter gergoviae CECT 875 whole cells (2003) Tetrahedron Lett., 44, pp. 2606-2609 | ||
| 504 | |a Utagawa, T., Enzymatic preparation of nucleoside antibiotics (1999) Journal of Molecular Catalysis B: Enzymatic, 6, pp. 215-222 | ||
| 504 | |a Utagawa, T., Morisawa, H., Yoshinaga, F., Yamazaki, A., Mitsugi, K., Hirose, Y., Microbiological synthesis of adenine arabinoside (1985) Agric. Biol. Chem., 49, pp. 1053-1058 | ||
| 504 | |a Yokozeki, K., Shirae, H., Kobayashi, K., Shiragami, H., Irie, Y., (1990) Method of Producing 2′,3′-Dideoxyinosine, US Patent No. 4,970,148 | ||
| 520 | 3 | |a The synthesis of modified nucleosides has received a great deal of attention due to their applications as antiviral and antitumoral agents. Among the different synthetic strategies, microbial transglycosylation has already shown to provide successful results. In the present work, we analyse the use of Citrobacter amalonaticus CECT 863 cells - free or immobilised - in the synthesis of some modified nucleosides. The main characteristics of the immobilised biocatalysts such as type and concentration of polymer, mechanical and storage stability and reuse were assessed. From these studies, polyacrylamide was selected as the best support based on its performance and potential industrial applications. In particular, it can be reused more than 50 times without significant loss of activity. |l eng | |
| 593 | |a Universidad Nacional de Quilmes, R.S. Peña 180, (1876) Bernal, Buenos Aires, Argentina | ||
| 593 | |a Depto. de Quim. Organ. y Farmaceut., Facultad de Farmacia, Universidad Complutense de Madrid, E-28040 Madrid, Spain | ||
| 593 | |a INGEBI, CONICET, Vuelta de Obligado 2490, (1428) Buenos Aires, Argentina | ||
| 593 | |a University of Quilmes, Argentina | ||
| 593 | |a University of Buenos Aires, Argentina | ||
| 593 | |a Universidad Complutense de Madrid, Spain | ||
| 593 | |a Pharmaceutical Chemistry, Universidad Complutense de Madrid, Spain | ||
| 690 | 1 | 0 | |a CELL IMMOBILISATION |
| 690 | 1 | 0 | |a CITROBACTER AMALONATICUS |
| 690 | 1 | 0 | |a MICROBIAL TRANSGLYCOSYLATION |
| 690 | 1 | 0 | |a MODIFIED NUCLEOSIDES |
| 690 | 1 | 0 | |a POLYACRYLAMIDE |
| 690 | 1 | 0 | |a CONCENTRATION (PROCESS) |
| 690 | 1 | 0 | |a PERFORMANCE |
| 690 | 1 | 0 | |a POLYMERS |
| 690 | 1 | 0 | |a SYNTHESIS (CHEMICAL) |
| 690 | 1 | 0 | |a ANTITUMORAL AGENTS |
| 690 | 1 | 0 | |a ANTIVIRAL AGENTS |
| 690 | 1 | 0 | |a CITROBACTER AMALONATICUS |
| 690 | 1 | 0 | |a POLYACRYLAMIDE |
| 690 | 1 | 0 | |a BIOCATALYSTS |
| 690 | 1 | 0 | |a NUCLEOSIDE |
| 690 | 1 | 0 | |a POLYACRYLAMIDE |
| 690 | 1 | 0 | |a CATALYSIS |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a BACTERIAL METABOLISM |
| 690 | 1 | 0 | |a CATALYSIS |
| 690 | 1 | 0 | |a CITROBACTER |
| 690 | 1 | 0 | |a CITROBACTER AMALONATICUS |
| 690 | 1 | 0 | |a GLYCOSYLATION |
| 690 | 1 | 0 | |a IMMOBILIZED CELL |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a NUCLEOTIDE METABOLISM |
| 690 | 1 | 0 | |a BACTERIA (MICROORGANISMS) |
| 690 | 1 | 0 | |a CITROBACTER |
| 690 | 1 | 0 | |a CITROBACTER AMALONATICUS |
| 700 | 1 | |a Lewkowicz, E.S. | |
| 700 | 1 | |a Sinisterra, J.V. | |
| 700 | 1 | |a Iribarren, A.M. | |
| 773 | 0 | |d 2004 |g v. 6 |h pp. 376-384 |k n. 4 |p Int. J. Biotechnol. |x 09636048 |t International Journal of Biotechnology | |
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| 856 | 4 | 0 | |u https://doi.org/10.1504/IJBT.2004.005520 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_09636048_v6_n4_p376_Trelles |y Handle |
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