Apoptosis and expression of Bcl-2 and Bax in eutopic endometrium from women with endometriosis
Objective: To evaluate and compare spontaneous apoptosis and Bcl-2 and Bax expression in eutopic endometrium from women with and without endometriosis. Design: Apoptosis and Bcl-2 and Bax expression were examined in eutopic endometrium from women with and without endometriosis. Setting: Instituto de...
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| Otros Autores: | , , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
2000
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 10735caa a22011177a 4500 | ||
|---|---|---|---|
| 001 | PAPER-20872 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205218.0 | ||
| 008 | 190411s2000 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0033799961 | |
| 024 | 7 | |2 cas |a Bax protein; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a FESTA | ||
| 100 | 1 | |a Meresman, G.F. | |
| 245 | 1 | 0 | |a Apoptosis and expression of Bcl-2 and Bax in eutopic endometrium from women with endometriosis |
| 260 | |c 2000 | ||
| 270 | 1 | 0 | |m Meresman, G.F.; Inst. de Biol. y Med. Experimental, Vuelta de Obligado 2490, Buenos Aires (1428), Argentina; email: meresman@dna.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Sampson, J.A., Benign and malignant endometrial implants in peritoneal cavity, and their relation to certain ovarian tumors (1924) Surg Gynecol Obstet, 38, pp. 287-311 | ||
| 504 | |a Wigfield, M., MacPherson, A., Healy, D., Rogers, P., Cell proliferation is increased in the endometrium of women with endometriosis (1995) Fertil Steril, 64, pp. 340-346 | ||
| 504 | |a Schwartzman, R.A., Cidlowski, J.A., Apoptosis: The biochemistry and molecular biology of programmed cell death (1993) Endocr Rev, 14, pp. 133-151 | ||
| 504 | |a Thompson, C.B., Apoptosis in the pathogenesis and treatment of disease (1995) Science, 267, pp. 1456-1462 | ||
| 504 | |a Hopwood, D., Levinson, D.A., Atrophy and apoptosis in the cyclical human endometrium (1995) J Pathol, 119, pp. 159-166 | ||
| 504 | |a Tabibzadeh, S., Kong, Q.F., Satyaswaroop, P.G., Distinct regional and menstrual cycle dependent distribution of apoptosis in human endometrium: Potential regulatory role of T-cells and TNF-α (1994) Endocrinol J, 2, pp. 87-95 | ||
| 504 | |a Nawaz, S., Lynch, M.P., Galand, P., Gerschenson, L.E., Hormonal regulation of cell death in rabbit uterine epithelium (1987) Am J Pathol, 127, pp. 51-59 | ||
| 504 | |a Rotello, R.J., Hocker, M.B., Gerschenson, L.E., Biochemical evidence for programmed cell death in rabbit uterine epithelium (1989) Am J Pathol, 134, pp. 491-495 | ||
| 504 | |a Tabibzadeh, S., Zupi, E., Babaknia, A., Site and menstrual cycle dependent expression of proteins of the TNF receptor family and Bcl-2 oncoprotein and phase specific production of TNFα in human endometrium (1995) Hum Reprod, 10, pp. 277-286 | ||
| 504 | |a Harada, M., Suganuma, N., Furuhashi, M., Nagasaka, T., Nakashima, N., Kikkawa, F., Detection of apoptosis in human endometriotic tissues (1996) Mol Hum Reprod, 2, pp. 307-315 | ||
| 504 | |a Korsmeyer, S.J., Bcl-2 initiates a new category of oncogenes: Regulators of cell death (1992) Blood, 80, pp. 879-886 | ||
| 504 | |a Oltvai, Z.N., Milliman, C.L., Korsmeyer, S.T., Bcl-2 heterodimerizes in vivo with a conserved homologue Bax that accelerates programmed cell death (1993) Cell, 74, pp. 609-619 | ||
| 504 | |a Chao, D.T., Korsmeyer, S.J., Bcl-2 family: Regulators of cell death (1998) Annu Rev Immunol, 16, pp. 395-419 | ||
| 504 | |a Gompel, A., Sabourin, J.C., Martin, A., Bcl-2 expression in normal endometrium during the menstrual cycle (1994) Am J Pathol, 144, pp. 1195-1202 | ||
| 504 | |a Otsuki, Y., Misaki, O., Sugimoto, O., Ito, Y., Cyclic Bcl-2 gene expression during the menstrual cycle (1994) Lancet, 344, pp. 28-29 | ||
| 504 | |a Koh, E.A.T., Illingworth, P.J., Duncan, W.C., Critchley, H.O.D., Immunolocalization of Bcl-2 protein in human endometrium in the menstrual cycle and stimulated early pregnancy (1995) Hum Reprod, 10, pp. 1557-1562 | ||
| 504 | |a McLaren, J., Prentice, A., Charnock-Jones, A.M., Immunolocalization of the apoptosis regulating proteins Bcl-2 and Bax in human endometrium and isolated peritoneal fluid macrophages in endometriosis (1997) Hum Reprod, 12, pp. 146-152 | ||
| 504 | |a Critchley, H.O.D., Tong, S., Cameron, S.T., Drudy, T.A., Kelly, R.W., Baird, D.T., Regulation of Bcl-2 gene family members in human endometrium by antiprogestin administration in vivo (1999) J Reprod Fertil, 115, pp. 389-395 | ||
| 504 | |a Gebel, H.M., Braun, D.P., Tambur, A., Frame, D., Rana, N., Dmowski, P., Spontaneous apoptosis of endometrial tissue is impaired in women with endometriosis (1998) Fertil Steril, 69, pp. 1042-1047 | ||
| 504 | |a Jones, R.K., Searle, R.F., Bulmer, J.N., Apoptosis and bcl-2 expression in normal human endometrium, endometriosis and adenomyosis (1998) Hum Reprod, 13, pp. 3496-3502 | ||
| 504 | |a Revised American Fertility Society classification of endometriosis: 1985 (1985) Fertil Steril, 43, pp. 351-352 | ||
| 504 | |a Meresman, G.F., Barañao, R.I., Tenenbaum, A., Singla, J.J., Neuspiller, N.R., Rumi, L.S., Effect of peritoneal fluid from patients with minimal and severe endometriosis on endometrial stromal cell proliferation (1997) Arch Gynecol Obstet, 259, pp. 109-115 | ||
| 504 | |a Andreu, C., Parborell, F., Vanzulli, S., Chemes, H., Tesone, M., Regulation of follicular luteinization by a gonadotropin-releasing hormone agonist: Relationship between steroidogenesis and apoptosis (1998) Mol Reprod Dev, 51, pp. 287-294 | ||
| 504 | |a Watanabe, H., Kanzaki, H., Narukawa, S., Inoue, T., Katsuragawa, H., Kaneko, Y., Bcl-2 and Fas expression in eutopic and ectopic endometrium during the menstrual cycle in relation to endometrial cell apoptosis (1997) Am J Obstet Gynecol, 176, pp. 360-368 | ||
| 504 | |a Dmowski, W.P., Gebel, H., Braun, D.P., Decreased apoptosis and sensitivity to macrophage mediated cytolysis of endometrial cells in endometriosis (1998) Hum Reprod Update, 4, pp. 696-701 | ||
| 504 | |a Tabibzadeh, S., The signals and molecular pathways involved in human menstruation, a unique process of tissue destruction and remodeling (1996) Mol Hum Reprod, 2, pp. 77-92 | ||
| 504 | |a Kokawa, K., Shikone, T., Nakano, R., Apoptosis in the human uterine endometrium during the menstrual cycle (1996) J Clin Endocrinol Metab, 81, pp. 4144-4147 | ||
| 504 | |a Tao, X.J., Tilly, K.I., Maravei, D.V., Shifren, J.L., Krajewski, S., Reed, J.C., Differential expression of members of the Bcl-2 gene family in proliferative and secretory human endometrium: Glandular epithelial cell apoptosis is associated with increased expression of bax (1997) J Clin Endocrinol Metab, 82, pp. 2738-2746 | ||
| 504 | |a Yamashita, H., Otsuki, Y., Ito, Y., Matsumoto, K., Ueki, K., Ueki, M., Fas ligand, Fas antigen and Bcl-2 expression in human endometrium during the menstrual cycle (1999) Mol Hum Reprod, 5, pp. 358-364 | ||
| 504 | |a Oltvai, Z.N., Korsmeyer, S.J., Checkpoints of dueling dimers foil death wishes (1994) Cell, 79, pp. 189-192 | ||
| 504 | |a Vinatier, D., Dufour, P., Subtil, D., Apoptosis: A programmed cell death involved in ovarian and uterine physiology (1996) Eur J Obstet Gynaecol Reprod Biol, 67, pp. 85-102 | ||
| 520 | 3 | |a Objective: To evaluate and compare spontaneous apoptosis and Bcl-2 and Bax expression in eutopic endometrium from women with and without endometriosis. Design: Apoptosis and Bcl-2 and Bax expression were examined in eutopic endometrium from women with and without endometriosis. Setting: Instituto de Biologia y Medicina Experimental-CONICET, Department of Gynecology and Department of Gynecological Pathology, Clinicas University Hospital, Buenos Aires, Argentina. Patient(s): Women with untreated endometriosis (n = 14) and controls (n = 16). Intervention(s): Collection of endometrial samples during diagnostic or therapeutic laparoscopy. Main Outcome Measure(s): Apoptotic cells were detected with use of the dUTP nick- end labeling (TUNEL) assay; Bcl-2 and Bax expressions were assessed with use of immunohistochemical techniques. Result(s): Spontaneous apoptosis was significantly lower in eutopic endometrium from patients with endometriosis, compared with healthy controls (2.26 ± 0.53 and 9.37 ± 1.69 apoptotic cells/field, respectively) and was independent of cycle phase. An increased expression of Bcl-2 protein was found in proliferative eutopic endometrium from patients with endometriosis. Bax expression was absent in proliferative endometrium, whereas there was an increase in its expression in secretory endometrium from both patients and controls. Conclusion(s): Women with endometriosis show decreased number of apoptotic cells in eutopic endometrium. The abnormal survival of endometrial cells may result in their continuing growth into ectopic locations. (C) 2000 by American Society for Reproductive Medicine. |l eng | |
| 593 | |a Institute de Biología y Medicina Experimental (IBYME), Buenos Aires, Argentina | ||
| 593 | |a Department of Gynecological Pathology, Hospital de Clínicas José de San Martín, Buenos Aires, Argentina | ||
| 593 | |a Department of Gynecology, Hospital de Clínicas José de San Martin, Buenos Aires, Argentina | ||
| 593 | |a Instituto de Biología y Medicina Experimental, Vuelta de Obligado 2490, Buenos Aires, 1428, Argentina | ||
| 690 | 1 | 0 | |a APOPTOSIS |
| 690 | 1 | 0 | |a BAX |
| 690 | 1 | 0 | |a BCL-2 |
| 690 | 1 | 0 | |a ENDOMETRIOSIS |
| 690 | 1 | 0 | |a EUTOPIC ENDOMETRIUM |
| 690 | 1 | 0 | |a PROTEIN BAX |
| 690 | 1 | 0 | |a PROTEIN BCL 2 |
| 690 | 1 | 0 | |a APOPTOSIS |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CLINICAL ARTICLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a ENDOMETRIOSIS |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a HUMAN TISSUE |
| 690 | 1 | 0 | |a IMMUNOHISTOCHEMISTRY |
| 690 | 1 | 0 | |a LAPAROSCOPY |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROTEIN EXPRESSION |
| 690 | 1 | 0 | |a APOPTOSIS |
| 690 | 1 | 0 | |a ENDOMETRIOSIS |
| 690 | 1 | 0 | |a ENDOMETRIUM |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a IN SITU HYBRIDIZATION |
| 690 | 1 | 0 | |a MENSTRUAL CYCLE |
| 690 | 1 | 0 | |a PROTO-ONCOGENE PROTEINS |
| 690 | 1 | 0 | |a PROTO-ONCOGENE PROTEINS C-BCL-2 |
| 690 | 1 | 0 | |a SUPPORT, NON-U.S. GOV'T |
| 700 | 1 | |a Vighi, S. | |
| 700 | 1 | |a Buquet, R.A. | |
| 700 | 1 | |a Contreras-Ortiz, O. | |
| 700 | 1 | |a Tesone, M. | |
| 700 | 1 | |a Rumi, L.S. | |
| 773 | 0 | |d 2000 |g v. 74 |h pp. 760-766 |k n. 4 |p Fertil. Steril. |x 00150282 |w (AR-BaUEN)CENRE-4731 |t Fertility and Sterility | |
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| 856 | 4 | 0 | |u https://doi.org/10.1016/S0015-0282(00)01522-3 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00150282_v74_n4_p760_Meresman |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00150282_v74_n4_p760_Meresman |y Registro en la Biblioteca Digital |
| 961 | |a paper_00150282_v74_n4_p760_Meresman |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 81825 | ||