Calcium channels coupled to neurotransmitter release at dually innervated neuromuscular junctions in the newborn rat
We studied the effect of several calcium channel blockers (ω-Conotoxin-GVIA, 1 and 3 μM; ω-Agatoxin-IVA, 100 nM; Nitrendipine, 1 and 10 μM) on evoked transmitter release at singly and dually innervated endplates of the levator auris longus muscle from three- to six-day-old rats. In dually innervated...
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2001
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| LEADER | 16557caa a22015857a 4500 | ||
|---|---|---|---|
| 001 | PAPER-20679 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205206.0 | ||
| 008 | 190411s2001 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0035808838 | |
| 024 | 7 | |2 cas |a Calcium Channel Blockers; Calcium Channels; Neurotransmitter Agents; Nitrendipine, 39562-70-4; omega-Agatoxin IVA; omega-Conotoxin GVIA, 92078-76-7 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a NRSCD | ||
| 100 | 1 | |a Santafé, M.M | |
| 245 | 1 | 0 | |a Calcium channels coupled to neurotransmitter release at dually innervated neuromuscular junctions in the newborn rat |
| 260 | |c 2001 | ||
| 270 | 1 | 0 | |m Santafé, M.M.; Unitat d'Histologia i Neurobiologia, Facultat Medicina Ciencies Salut, Universitat Rovira i Virgili, carrer St. Llorenç num 21, 43201 Reus, Spain; email: msm@fmcs.urv.es |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a We studied the effect of several calcium channel blockers (ω-Conotoxin-GVIA, 1 and 3 μM; ω-Agatoxin-IVA, 100 nM; Nitrendipine, 1 and 10 μM) on evoked transmitter release at singly and dually innervated endplates of the levator auris longus muscle from three- to six-day-old rats. In dually innervated fibers, a second endplate potential may appear after the first one when we increase the stimulation intensity. The lowest and highest endplate potential amplitudes are designated "small endplate potential" and "large endplate potential", respectively. The percentage of doubly innervated junctions remains almost constant throughout the age range examined. Nevertheless, the percentage of junctions innervated by three or more terminal axons drops, whereas the singly innervated junctions increase. Therefore, between postnatal days 3 and 6, roughly half the neuromuscular junctions may experience the final process of axonal elimination. The synaptic efficacy of the large endplate potential in dual junctions, measured as the mean amplitude of the synaptic potential and mean quantal content, was the same as in the junctions that had become recently mono-innervated in the same postnatal period. In singly innervated fibers, the endplate potential size was strongly reduced by both the P/Q-type voltage-dependent calcium channel blocker ω-Agatoxin-IVA (79.17 ± 4.02%; P < 0.05) and the N-type voltage-dependent calcium channel blocker ω-Conotoxin-GVIA (56.31 ± 7.80%; P < 0.05), whereas endplate potential amplitude was not significantly changed by the L-type voltage-dependent calcium channel blocker Nitrendipine. In dually innervated fibers, the P/Q-type voltage-dependent calcium channel blocker ω-Agatoxin-IVA and L-type voltage-dependent calcium channel blocker Nitrendipine increased the size of the small endplate potential (161.29 ± 47.87% and 109.32 ± 11.03%, respectively; P < 0.05 in both cases) and reduced the large endplate potential (74.42 ± 15.32% and 70.91 ± 10.04%, respectively; P < 0.05 in both cases). The N-type voltage-dependent calcium channel blocker ω-Conotoxin-GVIA significantly increased the small endplate potential in the first few minutes after toxin application (at 10 min: 90.23 ± 17.38%; P < 0.05). This increase was not maintained, while the large endplate potential was strongly inhibited (69.25 ± 7.5%; P < 0.05). In conclusion, in the dually innervated endplates of the newborn rat, presynaptic calcium channel types can have different roles in transmitter release from each of the two inputs, which suggests that nerve terminal voltage-dependent calcium channels are involved in neonatal synaptic maturation. © 2001 IBRO. |l eng | |
| 536 | |a Detalles de la financiación: SAF97-0127 | ||
| 536 | |a Detalles de la financiación: We would like to thank Dr M. R. Fenoll, Dr M. T. Colomina and Lic M. Rosato-Siri for reading the manuscript and offering valuable suggestions. We thank C. Sanmartı́ for technical assistance. This work was supported by grants from the CYCYT (SAF97-0127) and FISS (2000-00/0953). | ||
| 593 | |a Unitat d'Histologia i Neurobiologia (UHN), Facultat de Medicina i Ciencies de la Salut, Universitat Rovira i Virgili, Carrer St. Llorenc Num 21, 43201 Reus, Spain | ||
| 593 | |a Laboratorio de Fisiología y Biología Molecular (LFBM), Fac. de Cie. Exact. y Nat., Univ. de Buenos Aires, Cd. Univ., 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a Ω-AGATOXIN-IVA |
| 690 | 1 | 0 | |a Ω-CONOTOXIN-GVIA |
| 690 | 1 | 0 | |a CALCIUM CHANNELS |
| 690 | 1 | 0 | |a NITRENDIPINE |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a SYNAPSE ELIMINATION |
| 690 | 1 | 0 | |a CALCIUM CHANNEL |
| 690 | 1 | 0 | |a CALCIUM CHANNEL BLOCKING AGENT |
| 690 | 1 | 0 | |a CHOLINERGIC RECEPTOR |
| 690 | 1 | 0 | |a NITRENDIPINE |
| 690 | 1 | 0 | |a OMEGA AGATOXIN IVA |
| 690 | 1 | 0 | |a OMEGA CONOTOXIN GVIA |
| 690 | 1 | 0 | |a RINGER SOLUTION |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DRUG EFFECT |
| 690 | 1 | 0 | |a ELECTROPHYSIOLOGY |
| 690 | 1 | 0 | |a ENDPLATE POTENTIAL |
| 690 | 1 | 0 | |a MUSCLE EXCITATION |
| 690 | 1 | 0 | |a MUSCLE INNERVATION |
| 690 | 1 | 0 | |a NERVE ENDING |
| 690 | 1 | 0 | |a NERVE FIBER |
| 690 | 1 | 0 | |a NEUROMUSCULAR SYNAPSE |
| 690 | 1 | 0 | |a NEUROTRANSMISSION |
| 690 | 1 | 0 | |a NEUROTRANSMITTER RELEASE |
| 690 | 1 | 0 | |a NEWBORN |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a AGING |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a ANIMALS, NEWBORN |
| 690 | 1 | 0 | |a CALCIUM CHANNEL BLOCKERS |
| 690 | 1 | 0 | |a CALCIUM CHANNELS |
| 690 | 1 | 0 | |a ELECTRIC STIMULATION |
| 690 | 1 | 0 | |a EVOKED POTENTIALS |
| 690 | 1 | 0 | |a MOTOR ENDPLATE |
| 690 | 1 | 0 | |a MUSCLE, SKELETAL |
| 690 | 1 | 0 | |a NEUROMUSCULAR JUNCTION |
| 690 | 1 | 0 | |a NEUROTRANSMITTER AGENTS |
| 690 | 1 | 0 | |a NITRENDIPINE |
| 690 | 1 | 0 | |a OMEGA-AGATOXIN IVA |
| 690 | 1 | 0 | |a OMEGA-CONOTOXIN GVIA |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RATS, SPRAGUE-DAWLEY |
| 690 | 1 | 0 | |a SYNAPSES |
| 700 | 1 | |a Garcia, N. | |
| 700 | 1 | |a Lanuza, M.A. | |
| 700 | 1 | |a Uchitel, O.D. | |
| 700 | 1 | |a Tomás, J. | |
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