Protective role of medroxyprogesterone acetate on N-methyl-N-nitrosourea-induced lymphomas in BALB/c female mice
In a previous paper we reported the occurrence of a high incidence of lymphomas in N-methyl-N-nitrosourea (MNU)-treated mice, in the course of an experiment of combined chemical-hormonal carcinogenesis in mammary gland, in which we used medroxyprogesterone acetate (MPA) and MNU in different treatmen...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
2001
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 06573caa a22008177a 4500 | ||
|---|---|---|---|
| 001 | PAPER-20675 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205205.0 | ||
| 008 | 190411s2001 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0035136813 | |
| 024 | 7 | |2 cas |a Medroxyprogesterone 17-Acetate, 71-58-9; Methylnitrosourea, 684-93-5 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a LERED | ||
| 100 | 1 | |a Pazos, P. | |
| 245 | 1 | 0 | |a Protective role of medroxyprogesterone acetate on N-methyl-N-nitrosourea-induced lymphomas in BALB/c female mice |
| 260 | |c 2001 | ||
| 270 | 1 | 0 | |m Molinolo, A.A.; Laboratory Hormonal Carcinogenesis, Inst. Biologia/Med. Experimental, CONICET, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina; email: monlinolo@proteus.dna.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Briggs, M.H., Briggs, M., Glucocorticoid properties of progestogens (1973) Steroids, 22, pp. 555-559 | ||
| 504 | |a Lelli, G., Angelelli, B., Giambiasi, M.E., Colalongo, F., Camaggi, C.M., Costanti, B., Strocchi, E., Pannuti, F., The anabolic effect of high dose medroxyprogesterone acetate in oncology (1983) Pharmacol. Res. Commun., 15, pp. 561-568 | ||
| 504 | |a Kurebayashi, J., Yamamoto, S., Otsuki, T., Sonoo, H., Medroxyprogesterone acetate inhibits interleukin 6 secretion from KPL-4 human breast cancer cells both in vitro and in vivo: a possible mechanism of the anticachectic effect (1999) Br. J. Cancer, 79, pp. 631-636 | ||
| 504 | |a Amadori, D., Frassineti, G.L., Flamini, E., Falcini, F., Maltoni, M., Nanni, O., Riccobon, A., Piccinini, C., Clinical and laboratory evaluation of the myeloprotective effect of medroxyprogesterone acetate in head and neck cancer (1992) Eur. J. Cancer, 28 A, pp. 1331-1334 | ||
| 504 | |a Molinolo, A.A., Lanari, C., Charreau, E.H., Sanjuan, N., Pasqualini, C.D., Mouse mammary tumors induced by medroxyprogesterone acetate: immunohistochemistry and hormonal receptors (1987) J. Natl. Cancer Inst., 79, pp. 1341-1350 | ||
| 504 | |a Seidel, H.J., Kreja, L., Leukemia induction by methylnitrosourea (MNU) in selected mouse strains. Effects of MNU on hemopoietic stem cells, the immune system and natural killer cells (1984) J. Cancer Res. Clin. Oncol., 108, pp. 214-220 | ||
| 504 | |a Pazos, P., Lanari, C., Elizalde, P., Montecchia, F., Charreau, E.H., Molinolo, A.A., Promoter effect of medroxyprogesterone acetate (MPA) in N-methyl-N-nitrosourea (MNU) induced mammary tumors in BALB/c mice (1998) Carcinogenesis, 19, pp. 529-531 | ||
| 504 | |a Guzman, R.C., Osborn, R.C., Swanson, S.M., Sakthivel, R., Hwang, S.I., Miyamoto, S., Nandi, S., Incidence of c-Ki-ras activation in N-methyl-N-nitrosourea-induced mammary carcinomas in pituitary-isografted mice (1992) Cancer Res., 52, pp. 5732-5737 | ||
| 520 | 3 | |a In a previous paper we reported the occurrence of a high incidence of lymphomas in N-methyl-N-nitrosourea (MNU)-treated mice, in the course of an experiment of combined chemical-hormonal carcinogenesis in mammary gland, in which we used medroxyprogesterone acetate (MPA) and MNU in different treatment protocols. In this report we have analyzed the action of MPA in the leukemogenic effects of MNU, by specifically selecting for the analysis experimental groups in which only few mammary carcinomas had developed. A high incidence of lymphomas (65%, median latency: 176 days) was registered in MNU-treated mice, and the administration of MPA was associated with a significant reduction in the incidence of lymphomas (P<0.001) in all protocols. Copyright © 2001 Elsevier Science Ltd. |l eng | |
| 536 | |a Detalles de la financiación: Inter-American Development Bank | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: We thank Laboratorios Gador, Buenos Aires for kindly providing medroxyprogesterone acetate and Dr CD Pasqualini, Academia Nacional de Medicina, Buenos Aires, for the BALB/c female mice. CL is a Member of the Research Career, CONICET. This study was supported by grants of CONICET: PMT.PICT 0446 Préstamo BID 802/OC-AR, Fundación Sales. We are grateful to Dr Mirta Giordano, Academia Nacional de Medicina, Buenos Aires, for providing the antibodies. P. Pazos provided the concept, design, drafted the paper and assembled the data. C. Lanari provided statistical expertise and analysis of the data as well as contributing to the study design. A.A. Molinolo contributed to the concept and study design, assisted in data interpretation and provided the critical revision of the paper. | ||
| 593 | |a Laboratory of Hormonal Carcinogenesis, Instituto De Biología Y Medicina Experimental (IBYME), Consejo Nacional De Investigaciones Científicas Y Técnicas (CONICET), Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a LYMPHOMA |
| 690 | 1 | 0 | |a MEDROXYPROGESTERONE ACETATE |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a N-METHYL-N-NITROSOUREA |
| 690 | 1 | 0 | |a PROGESTINS |
| 690 | 1 | 0 | |a MEDROXYPROGESTERONE ACETATE |
| 690 | 1 | 0 | |a METHYLNITROSOUREA |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DRUG EFFECT |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a IMMUNOCYTOCHEMISTRY |
| 690 | 1 | 0 | |a INCIDENCE |
| 690 | 1 | 0 | |a LYMPHOMA |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROTECTION |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a IMMUNOHISTOCHEMISTRY |
| 690 | 1 | 0 | |a INCIDENCE |
| 690 | 1 | 0 | |a LYMPHOMA |
| 690 | 1 | 0 | |a MEDROXYPROGESTERONE 17-ACETATE |
| 690 | 1 | 0 | |a METHYLNITROSOUREA |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a MICE, INBRED BALB C |
| 700 | 1 | |a Lanari, C. | |
| 700 | 1 | |a Molinolo, A.A. | |
| 773 | 0 | |d 2001 |g v. 25 |h pp. 165-167 |k n. 2 |p Leuk. Res. |x 01452126 |w (AR-BaUEN)CENRE-5948 |t Leukemia Research | |
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| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_01452126_v25_n2_p165_Pazos |y Handle |
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