Facilitated glutamatergic transmission in the striatum of D2 dopamine receptor-deficient mice
Dopamine (DA) receptors play an important role in the modulation of excitability and the responsiveness of neurons to activation of excitatory amino acid receptors in the striatum. In the present study, we utilized mice with genetic deletion of D2 or D4 DA receptors and their wild-type (WT) controls...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
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2001
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| Acceso en línea: | Registro en Scopus Handle Registro en la Biblioteca Digital |
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| LEADER | 22431caa a22018017a 4500 | ||
|---|---|---|---|
| 001 | PAPER-20674 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205205.0 | ||
| 008 | 190411s2001 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0035124718 | |
| 024 | 7 | |2 cas |a 4-Aminopyridine, 504-24-5; Dopamine, 51-61-6; Glutamic Acid, 56-86-0; Receptors, Dopamine D2 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a JONEA | ||
| 100 | 1 | |a Cepeda, C. | |
| 245 | 1 | 0 | |a Facilitated glutamatergic transmission in the striatum of D2 dopamine receptor-deficient mice |
| 260 | |c 2001 | ||
| 270 | 1 | 0 | |m Levine, M.S.; Mental Retardation Research Center, University of California, Los Angeles, CA 90095, United States; email: mlevine@mednet.ucla.edu |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a Dopamine (DA) receptors play an important role in the modulation of excitability and the responsiveness of neurons to activation of excitatory amino acid receptors in the striatum. In the present study, we utilized mice with genetic deletion of D2 or D4 DA receptors and their wild-type (WT) controls to examine if the absence of either receptor subtype affects striatal excitatory synaptic activity. Immunocytochemical analysis verified the absence of D2 or D4 protein expression in the striatum of receptor-deficient mutant animals. Sharp electrode current- and whole cell patch voltage-clamp recordings were obtained from slices of receptor-deficient and WT mice. Basic membrane properties were similar in D2 and D4 receptor-deficient mutants and their respective WT controls. In current-clamp recordings in WT animals, very little low-amplitude spontaneous synaptic activity was observed. The frequency of these spontaneous events was increased slightly in D2 receptor-deficient mice. In addition, large-amplitude depolarizations were observed in a subset of neurons from only the D2 receptor-deficient mutants. Bath application of the K+ channel blocker 4-aminopyridine (100 μM) and bicuculline methiodide (10 μM, to block synaptic activity due to activation of GABAA receptors) markedly increased spontaneous synaptic activity in receptor-deficient mutants and WTs. Under these conditions, D2 receptor-deficient mice displayed significantly more excitatory synaptic activity than their WT controls, while there was no difference between D4 receptor-deficient mice and their controls. In voltage-clamp recordings, there was an increase in frequency of spontaneous glutamate receptor-mediated inward currents without a change in mean amplitude in D2 receptor-deficient mutants. In WT mice, activation of D2 family receptors with quinpirole decreased spontaneous excitatory events and conversely sulpiride, a D2 receptor antagonist, increased activity. In D2 receptor-deficient mice, sulpiride had very little net effect. Morphologically, a subpopulation of medium-sized spiny neurons from D2 receptor-deficient mice displayed decreased dendritic spines compared with cells from WT mice. These results provide evidence that D2 receptors play an important role in the regulation of glutamate receptor-mediated activity in the corticostriatal or thalamostriatal pathway. These receptors may function as gatekeepers of glutamate release or of its subsequent effects and thus may protect striatal neurons from excessive excitation. |l eng | |
| 593 | |a Mental Retardation Research Center, University of California, Los Angeles, CA 90095, United States | ||
| 593 | |a Department of Cell and Developmental Biology, Oregon Health Sciences University, Portland, OR 97201, United States | ||
| 593 | |a Vollum Institute, Oregon Health Sciences University, Portland, OR 97201, United States | ||
| 593 | |a Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina | ||
| 593 | |a Department of Neuroscience, Chicago Medical School, North Chicago, IL 60064, United States | ||
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| 690 | 1 | 0 | |a BICUCULLINE METHIODIDE |
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| 700 | 1 | |a Hurst, R.S. | |
| 700 | 1 | |a Altemus, K.L. | |
| 700 | 1 | |a Flores-Hernández, J. | |
| 700 | 1 | |a Calvert, C.R. | |
| 700 | 1 | |a Jokel, E.S. | |
| 700 | 1 | |a Grandy, D.K. | |
| 700 | 1 | |a Low, M.J. | |
| 700 | 1 | |a Rubinstein, M. | |
| 700 | 1 | |a Ariano, M.A. | |
| 700 | 1 | |a Levine, M.S. | |
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