Unsuspected hyperhomocysteinemia in chronically anticoagulated patients

Hyperhomocysteinemia is a risk factor for arterial and venous thrombosis. The aim of this study was to evaluate plasmatic homocysteine levels in patients under chronic anticoagulant treatment with dietary restriction of green vegetables. This kind of food is a very important source not only of vitam...

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Autor principal: Murúa, A.
Otros Autores: Quintana, I., Galarza, C., Alfie, J., Kordich, L.
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 2001
Acceso en línea:Registro en Scopus
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Registro en la Biblioteca Digital
Aporte de:Registro referencial: Solicitar el recurso aquí
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024 7 |2 scopus  |a 2-s2.0-0035126127 
024 7 |2 cas  |a Anticoagulants; Folic Acid, 59-30-3; Homocysteine, 454-28-4; Vitamin K, 12001-79-5 
040 |a Scopus  |b spa  |c AR-BaUEN  |d AR-BaUEN 
030 |a BLFIE 
100 1 |a Murúa, A. 
245 1 0 |a Unsuspected hyperhomocysteinemia in chronically anticoagulated patients 
260 |c 2001 
270 1 0 |m Kordich, L.; Lab. de Hemostasia y Trombosis, Departamento de Quimica Biologica, Facultad de Cie. Exactas y Naturales, Ciudad Universitaria, 1428 Buenos Aires, Argentina; email: lht@qb.fcen.uba.ar 
506 |2 openaire  |e Política editorial 
504 |a Eikelboom, J.W., Loon, E., Genest J., Jr., Hankey, G., Yusuf, S., Homocyst(e)ine and cardiovascular disease: A critical review of the epidemiologic evidence (1999) Ann Intern Med, 131, pp. 363-375 
504 |a Ray, J.G., Meta-analysis of hyperhomocysteinemia as a risk factor for venous thromboembolic disease (1998) Arch Intern Med, 158, pp. 2101-2106 
504 |a Langman, L.J., Ray, J.G., Evrovski, J., Yeo, E., Cole, D.E., Hyperhomocyst(e)inemia and the increased risk of venous thromboembolism: More evidence from a case-control study (2000) Arch Intern Med, 160, pp. 961-964 
504 |a Peterson, J.C., Spence, J.D., Vitamins and progression of atherosclerosis in hyperhomocysteinemia (1998) Lancet, 351, p. 263 
504 |a Mallinow, M.R., Nieto, F.J., Kruger, W.D., Duell, P., Hess, D.L., Glukman, R.A., The effects of folic acid supplementation on plasma total homocysteine are modulate by multivitamin use and methylenetetrahydrofolate reductase genotypes (1997) Arterioscler Thromb Vasc Biol, 17, pp. 1157-1162 
504 |a Selhub, J., Jacques, P.F., Rosemberg, I.H., Rogers, G., Bowman, B.A., Gunter, E.W., Serum total homocysteine concentrations in the Third National Health and Nutrition Examination Survey (1991-1994): Population reference ranges and contribution of vitamin status to high serum concentration (1999) Ann Intern Med, 131, pp. 331-339 
504 |a Jacob, R.A., Wu, M.M., Henning, S.M., Swendseid, M.E., Homocysteine increases as folate decreases in plasma of healthy men during short-term dietary folate and methyl group restriction (1994) J. Nutr, 124, pp. 1072-1080 
504 |a Lubetsky, A., Vitamin K intake and sensitivity to warfarin patients consuming regular diets (1999) Thromb Haemostas, 81, pp. 396-399 
504 |a Boot, S.L., Charnley, J.M., Sadoski, J.A., Saltzman, E., Bowill, E.G., Cushman, M., Dietary vitamin K1 and stability of oral anticoagulation proposal of a diet with constant vitamin K1 content (1997) Thromb Haemostas, 77, pp. 504-509 
520 3 |a Hyperhomocysteinemia is a risk factor for arterial and venous thrombosis. The aim of this study was to evaluate plasmatic homocysteine levels in patients under chronic anticoagulant treatment with dietary restriction of green vegetables. This kind of food is a very important source not only of vitamin K but also of folates, which are involved in Hcy metabolism. It is known that the lower the folate levels, the higher the Hcy concentration, so we suspected that these patients could show hyperhomocysteinemia. A group of patients receiving oral anticoagulant treatment and a restricted diet (Group 1, n =20) was compared with a group of untreated subjects of a similar age that were not on a restricted diet (Group II, n = 35). Group I showed significantly higher levels of plasmatic Hcy and significantly lower levels of serum folate than Group II. Therefore, a diet restricted in vitamin K applied to oral anticoagulated patients could induce an unwanted increase of homocysteine levels. © 2001 Lippincott Williams & Wilkins.  |l eng 
593 |a Lab. de Hemostasia y Trombosis, Departamento de Quimica Biologica, Facultad de Cie. Exactas y Naturales, Ciudad Universitaria, 1428 Buenos Aires, Argentina 
690 1 0 |a ANTICOAGULANT TREATMENT 
690 1 0 |a DIET 
690 1 0 |a HYPERHOMOCYSTEINEMIA 
690 1 0 |a ANTICOAGULANT AGENT 
690 1 0 |a FOLIC ACID DERIVATIVE 
690 1 0 |a HOMOCYSTEINE 
690 1 0 |a VITAMIN K GROUP 
690 1 0 |a ADULT 
690 1 0 |a ANTICOAGULATION 
690 1 0 |a ARTERY THROMBOSIS 
690 1 0 |a ARTICLE 
690 1 0 |a CLINICAL ARTICLE 
690 1 0 |a CONTROLLED STUDY 
690 1 0 |a DIET RESTRICTION 
690 1 0 |a HUMAN 
690 1 0 |a HYPERHOMOCYSTEINEMIA 
690 1 0 |a METABOLISM 
690 1 0 |a PRIORITY JOURNAL 
690 1 0 |a RISK FACTOR 
690 1 0 |a VEGETABLE 
690 1 0 |a VEIN THROMBOSIS 
690 1 0 |a AGED 
690 1 0 |a ANTICOAGULANTS 
690 1 0 |a CASE-CONTROL STUDIES 
690 1 0 |a CHRONIC DISEASE 
690 1 0 |a DIET 
690 1 0 |a FOLIC ACID 
690 1 0 |a HOMOCYSTEINE 
690 1 0 |a HUMANS 
690 1 0 |a HYPERHOMOCYSTEINEMIA 
690 1 0 |a MIDDLE AGED 
690 1 0 |a VEGETABLES 
690 1 0 |a VITAMIN K 
700 1 |a Quintana, I. 
700 1 |a Galarza, C. 
700 1 |a Alfie, J. 
700 1 |a Kordich, L. 
773 0 |d 2001  |g v. 12  |h pp. 79-80  |k n. 1  |p Blood Coagul. Fibrinolysis  |x 09575235  |t Blood Coagulation and Fibrinolysis 
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