Bisphosphonates derived from fatty acids are potent growth inhibitors of Trypanosoma cruzi
We have investigated the effect of a series of bisphosphonates derived from fatty acids against Trypanosoma cruzi proliferation in in vitro assays. Some of these drugs proved to be potent inhibitors against the intracellular form of the parasite exhibiting IC50 values at the low micromolar level. As...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
2001
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 08404caa a22012257a 4500 | ||
|---|---|---|---|
| 001 | PAPER-2067 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203124.0 | ||
| 008 | 190411s2001 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0035953026 | |
| 024 | 7 | |2 cas |a Diphosphonates; Fatty Acids; Trypanocidal Agents | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a BMCLE | ||
| 100 | 1 | |a Szajnman, S.H. | |
| 245 | 1 | 0 | |a Bisphosphonates derived from fatty acids are potent growth inhibitors of Trypanosoma cruzi |
| 260 | |c 2001 | ||
| 270 | 1 | 0 | |m Rodriguez, J.B.; Departamento de Quimica Organica, Facultad Ciencias Exact. y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, 1428 Buenos Aires, Argentina; email: jbr@qo.fcen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Rogers, M.J., Xiong, X., Ji, X., Mönkkönen, J., Russell, G.G., Williamson, M.P., Ebetino, F.H., Watts, D.J., (1997) Pharm. Res., 14, p. 625 | ||
| 520 | 3 | |a We have investigated the effect of a series of bisphosphonates derived from fatty acids against Trypanosoma cruzi proliferation in in vitro assays. Some of these drugs proved to be potent inhibitors against the intracellular form of the parasite exhibiting IC50 values at the low micromolar level. As bisphosphonates are FDA clinically approved for treatment of bone resorption, their potential innocuousness makes them good candidates to control tropical diseases. © 2001 Elsevier Science Ltd. |l eng | |
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires, TX-073 | ||
| 536 | |a Detalles de la financiación: National Institutes of Health, AI-23259 | ||
| 536 | |a Detalles de la financiación: Agencia Nacional de Promoción Científica y Tecnológica, PICT 00579 | ||
| 536 | |a Detalles de la financiación: American Heart Association | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: This work was supported by grants from the CONICET, the ANPCyT (PICT 00579), and the Universidad de Buenos Aires (TX-073) to J.B.R., and the United Nations Development Programme/World Bank/World Health Organization Special Programme for Research and Training in Tropical Diseases and the National Institutes of Health (AI-23259) to R.D. B.N.B. was supported by a predoctoral fellowship of the American Heart Association, Midwest Affiliate. | ||
| 593 | |a Departamento de Química Orgánica, Fac. de Cie. Exact. y Nat., Univ. de Buenos Aires, Pabellon 2, Cd. Univ., 1428 Buenos Aires, Argentina | ||
| 593 | |a Laboratory of Molecular Parasitology, Dept. of Pathobiology, Univ. of Illinois at Urbana-Champaign, 2001 S. Lincoln Ave., Urbana, IL 61802, United States | ||
| 690 | 1 | 0 | |a BISPHOSPHONIC ACID DERIVATIVE |
| 690 | 1 | 0 | |a FATTY ACID DERIVATIVE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CHAGAS DISEASE |
| 690 | 1 | 0 | |a CONCENTRATION RESPONSE |
| 690 | 1 | 0 | |a DRUG APPROVAL |
| 690 | 1 | 0 | |a DRUG EFFECT |
| 690 | 1 | 0 | |a DRUG POTENCY |
| 690 | 1 | 0 | |a DRUG STRUCTURE |
| 690 | 1 | 0 | |a DRUG SYNTHESIS |
| 690 | 1 | 0 | |a FOOD AND DRUG ADMINISTRATION |
| 690 | 1 | 0 | |a IC 50 |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a OSTEOLYSIS |
| 690 | 1 | 0 | |a PARASITE DEVELOPMENT |
| 690 | 1 | 0 | |a REACTION ANALYSIS |
| 690 | 1 | 0 | |a STRUCTURE ANALYSIS |
| 690 | 1 | 0 | |a TROPICAL DISEASE |
| 690 | 1 | 0 | |a TRYPANOSOMA CRUZI |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a BONE RESORPTION |
| 690 | 1 | 0 | |a DIPHOSPHONATES |
| 690 | 1 | 0 | |a FATTY ACIDS |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a INHIBITORY CONCENTRATION 50 |
| 690 | 1 | 0 | |a PARASITIC SENSITIVITY TESTS |
| 690 | 1 | 0 | |a TRYPANOCIDAL AGENTS |
| 690 | 1 | 0 | |a TRYPANOSOMA CRUZI |
| 690 | 1 | 0 | |a UNITED STATES |
| 690 | 1 | 0 | |a UNITED STATES FOOD AND DRUG ADMINISTRATION |
| 690 | 1 | 0 | |a TRYPANOSOMA |
| 690 | 1 | 0 | |a TRYPANOSOMA CRUZI |
| 700 | 1 | |a Bailey, B.N. | |
| 700 | 1 | |a Docampo, R. | |
| 700 | 1 | |a Rodriguez, J.B. | |
| 773 | 0 | |d 2001 |g v. 11 |h pp. 789-792 |k n. 6 |p Bioorg. Med. Chem. Lett. |x 0960894X |w (AR-BaUEN)CENRE-3990 |t Bioorganic and Medicinal Chemistry Letters | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-0035953026&doi=10.1016%2fS0960-894X%2801%2900057-9&partnerID=40&md5=409da2805f894a48f69b2270fbca4a6b |y Registro en Scopus |
| 856 | 4 | 0 | |u https://doi.org/10.1016/S0960-894X(01)00057-9 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_0960894X_v11_n6_p789_Szajnman |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0960894X_v11_n6_p789_Szajnman |y Registro en la Biblioteca Digital |
| 961 | |a paper_0960894X_v11_n6_p789_Szajnman |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 63020 | ||