Embryolethality induced by metronidazole (MTZ) in Rattus norvegicus
Parasitic illnesses is increasing all over the world, especially in developing countries, and metronidazole (MTZ) is the therapeutic agent usually administered to children as well as adults at the reproductive age. In this work, we propose an evaluation of MTZ in order to analyze the potential repro...
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| Formato: | Capítulo de libro |
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| Publicado: |
2001
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 11564caa a22012857a 4500 | ||
|---|---|---|---|
| 001 | PAPER-20645 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205204.0 | ||
| 008 | 190411s2001 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0035029506 | |
| 024 | 7 | |2 cas |a Antitrichomonal Agents; Metronidazole, 443-48-1 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a TCMUD | ||
| 100 | 1 | |a Mudry, M.D. | |
| 245 | 1 | 0 | |a Embryolethality induced by metronidazole (MTZ) in Rattus norvegicus |
| 260 | |c 2001 | ||
| 270 | 1 | 0 | |m Mudry, M.D.; GIBE-Grupo Inv. Biologia Evolutiva, Depto. de Cs. Biológicas, FCEyN, UBA, Ciudad Universitaria, (1428) Buenos Aires, Argentina; email: mmudry@bg.fcen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Russell, L.B., Russell, W.L., Frequency and nature of specific-locus mutation induced in female mice by radiation and chemicals: A review (1992) Mutation Res, 296, pp. 107-127 | ||
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| 504 | |a Martínez-Flores, I., Saez, C., Egozcue, J., Garcia, M., Effects of ionizing radiation on oocytes prepubertally irradiated rats (2000) Int J Radiat Biol | ||
| 504 | |a Martínez-Flores, I., Saez, C., Egozcue, J., Garcia, M., Effects of female fertility and germinal cells in prepubertal and adult rats (Rattus norvegicus) after X-ray irradiation (1998) Reprod Toxicol, pp. 215-219 | ||
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| 504 | |a Lau, A.H., Lam, N.P., Piscitelli, S.C., Wilkes, L., Danziger, L.H., Clinical pharmacokinetics of metronidazole and other nitroimidazole anti-infective (1992) Clin Pharmacokinet, 23, pp. 328-364 | ||
| 520 | 3 | |a Parasitic illnesses is increasing all over the world, especially in developing countries, and metronidazole (MTZ) is the therapeutic agent usually administered to children as well as adults at the reproductive age. In this work, we propose an evaluation of MTZ in order to analyze the potential reproductive damage in females by using Rattus norvegicus (Sprague-Dawley) as an animal model. Adult female rats were mated after MTZ treatments, and they were sacrificed at 21 days of gestation. Different types of damage were evaluated by using mortality, phenotypic abnormalities and reproductive capacity as parameters, and were studied and scored in 70 adult specimens (450 g/bw). They were divided into five groups: a) untreated females as a control group; females treated with b) DMSO as a solvent control group or c) 500 mg/kg/bw of MTZ per day for 7 days as therapeutic dose (TD); d) a half therapeutic dose (HD); and e) a double therapeutic dose (DD). Pre-implantation death in MTZ-treated groups was not significantly different from controls. However, drug treatments significantly increased the frequency of post-implantation deaths and the dominant lethals were ranged between 12.0 % and 17.8 %. © 2001 Wiley-Liss, Inc. |l eng | |
| 593 | |a GIBE (Grupo de Investigacion en Biologia Evolutiva), Departamento de Biologia, Universidad de Buenos Aires (UBA), Argentina | ||
| 593 | |a CIGETOX (Centro de Investigaciones en Genetica Toxicologica), Departamento de Bioquimica Clinica, Universidad de Buenos Aires (UBA), Argentina | ||
| 593 | |a Departament de Biologia Cellular de Fisiologia i Dimmunologia, Unitat de Biologia (Medicina), Universitat Autonoma de Barcelona (UAB), Spain | ||
| 593 | |a CITEFA, Buenos Aires, Argentina | ||
| 593 | |a GIBE-Grupo de Inv. en Biologia Evolutiva, Depto. de Cs. Biologicas, Ciudad Universitaria, Pabellon II, (1428) Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a DOMINANT LETHALITY |
| 690 | 1 | 0 | |a MATERNAL EXPOSURE |
| 690 | 1 | 0 | |a NITROIMIDAZOLE |
| 690 | 1 | 0 | |a POST-IMPLANTATION DEATH |
| 690 | 1 | 0 | |a METRONIDAZOLE |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a EMBRYOTOXICITY |
| 690 | 1 | 0 | |a ENVIRONMENTAL EXPOSURE |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a GESTATIONAL AGE |
| 690 | 1 | 0 | |a MORTALITY |
| 690 | 1 | 0 | |a NIDATION |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PHENOTYPE |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a REPRODUCTION |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a ANTITRICHOMONAL AGENTS |
| 690 | 1 | 0 | |a EMBRYO |
| 690 | 1 | 0 | |a EMBRYO IMPLANTATION |
| 690 | 1 | 0 | |a EMBRYO LOSS |
| 690 | 1 | 0 | |a EMBRYONIC DEVELOPMENT |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a FERTILITY |
| 690 | 1 | 0 | |a FETAL DEATH |
| 690 | 1 | 0 | |a FETUS |
| 690 | 1 | 0 | |a MATERNAL EXPOSURE |
| 690 | 1 | 0 | |a METRONIDAZOLE |
| 690 | 1 | 0 | |a PREGNANCY |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RATS, SPRAGUE-DAWLEY |
| 690 | 1 | 0 | |a REPRODUCTION |
| 690 | 1 | 0 | |a ANIMALIA |
| 690 | 1 | 0 | |a RATTUS NORVEGICUS |
| 700 | 1 | |a Martinez-Flores, I. | |
| 700 | 1 | |a Palermo, A.M. | |
| 700 | 1 | |a Carballo, M.A. | |
| 700 | 1 | |a Egozcue, J. | |
| 700 | 1 | |a Garcia Caldes, M. | |
| 773 | 0 | |d 2001 |g v. 21 |h pp. 197-205 |k n. 3 |p Teratog. Carcinog. Mutag. |x 02703211 |t Teratogenesis Carcinogenesis and Mutagenesis | |
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