Tumor necrosis factor-alfa production by monocytes from lung and colorectal cancer patients

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Tumour necrosis factor-alpha (TNF-α) is a monocyte (MO)-derived cytokine that plays an essential role in the immunological system. In the present study our aim was to evaluate the levels of TNF-α secreted by MO from cancer patients. Blood MO were obtained from 10 lung cancer patients (LCP), 10 color...

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Detalles Bibliográficos
Autor principal: Trejo, Y.G
Otros Autores: Bordenave, R.H, Beviacqua, M., Zanoni, L., Rumi, L.S
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 2001
Acceso en línea:Registro en Scopus
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Registro en la Biblioteca Digital
Aporte de:Registro referencial: Solicitar el recurso aquí
Biblioteca Central Dr. Luis F. Leloir (FCEN) de Universidad de Buenos Aires
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024 7 |2 scopus  |a 2-s2.0-0035013683 
024 7 |2 cas  |a Tumor Necrosis Factor-alpha 
040 |a Scopus  |b spa  |c AR-BaUEN  |d AR-BaUEN 
030 |a JECRD 
100 1 |a Trejo, Y.G. 
245 1 0 |a Tumor necrosis factor-alfa production by monocytes from lung and colorectal cancer patients 
260 |c 2001 
270 1 0 |m Rumi, L.S.; Inst. de Biologia y Medicina Exp., Vuelta de Obligado 2490, (1428) Buenos Aires, Argentina; email: rumilia@ibyme.edu.ar 
506 |2 openaire  |e Política editorial 
504 |a Seljelid, S.R., Busund, L.-T.R., The biology of macrophages: Inflammation and tumors (1994) Eur. J. Haematol., 52, pp. 1-12 
504 |a Balkwill, F.R., Tumor necrosis factor (1989) Br. Medical Bull., 45 (2), pp. 389-400 
504 |a DelPedro, A.D., Barjavel, M.J., Mamdouh, Z., Activation of human monocytes by LPS and DHEA (1998) J. Interferon Cytokine Res., 18 (2), pp. 125-135 
504 |a Smith, D.M., Lackides, G.A., Epstein, L.B., Coordinated induction of autocrine tumor necrosis factor and the interleukinin-1 in normal human monopcytes and the implications for monocyte-mediated cytotoxicity (1990) Cancer Res., 59, pp. 3146-3153 
504 |a Economou, J.S., Colquhoun, S.D., Anderson, T.M., Interleukin-1 and tumor necrosis factor production by tumor-asociated mononuclear leukocytes and peripheral mononuclear cells in cancer patients (1988) Int. J. Cancer, 42, pp. 712-714 
504 |a Heriot, A.G., Marriott, J.B., Cookson, S., Reduction in cytokine production in colorectal cancer patients: Association with stage and reversal by resection (2000) Br. J. Cancer, 82 (5), pp. 1009-10012 
504 |a Novellino, P.S., Trejo, Y.G., Beviacqua, M., Regulation of LA-DR in monocytes from colorectal cancer patients by in vitro treatment with human recombinant gamma-interferon (2000) J. Invest. Allergol. Clin. Immunol., 10 (2) 
504 |a Tartour, T., Fridman, W.H., Cytokines and cancer (1998) Int. Rev. Immunol., 16, pp. 683-704 
504 |a Barna, B.P., Rogers, L.R., Thomassen, M.J., Monocyte tumoricidal activity and tumor necrosis factor production in patients with malignant brain tumors (1991) Cancer Immunol. Immunother., 33, pp. 314-318 
504 |a Ikemoto, S., Sugimura, K., Yoshida, N., TNF alpha, IL-1 beta and IL-6 production by peripheral blood monocytes in patients with renal cell carcinoma (2000) Anticancer Res., 20 (1 A), pp. 317-321 
504 |a Wieckiewicz, J., Krzeszowiak, A., Ruggirro, I., Detection of cytokine gene expression inhuman monocytes and lymphocytes by fluorescent in situ hybridization in cell suspension and flow cytometry (1998) Int. J. Mol. Med., 1 (6), pp. 995-999 
504 |a Trulson, A., Nilson, S., Venge, P., Monocyte activation in patients with non-seminomatous germ cell tumor of the testis before and after tumour erradication (1996) J. Clin. Pathol., 49, pp. 381-385 
504 |a Novellino, P.S., Trejo, Y.G., Beviacqua, M., Effects of culture supernatants from two cancer cell lines on heathy donors' monocytes (1999) Allergol. et Immunopathol., 27 (4), pp. 195-199 
504 |a Aderka, D., Le, J., Vilcek, J., IL-6 inhibits lipopolysaccharide-induced tumor necrosis factor production in cultured human monocytes, U937 cells and in mice (1989) J. Immunol., 143 (11), pp. 3517-3523 
504 |a Ben-Efraim, S., Tak, C., Fieren, M.J.W.A., Activity of human peritoneal macrophages against a human tumor: Role of tumor necrosis factor-a, PGE2 and nitrite, in vitro studies (1993) Immunol. Letters, 37, pp. 27-33 
504 |a Anand, M., Chodda, S.K., Parikh, P.M., Dysregulated cytokine production by monocytes from chronic lymphocytic leukemia patients (1998) Cancer Biother. Radiopharm., 13 (1), pp. 43-48 
504 |a Nakashima, J., Tachibana, M., Ueno, M., Association between tumor necrosis factor in serum and cachexia in patients with prostate cancer (1998) Clin. Cancer Res., 4, pp. 1743-1748 
504 |a Michiel, D.F., Oppenheim, J.J., Cytokines as positive and negative regulators of tumor promotion and progression (1992) Semin. Cancer Biol., 3 (1), pp. 3-15 
504 |a Logan, T.F., Gooding, W.E., Whiteside, T.L., Biologic response modulation by tumor necrosis factor alfa in a phase 1b clinical trial in cancer patients (1997) J. Immunother. with emphasis in tumor Biol., 20 (5), pp. 387-398 
504 |a Koshiji, M., Adachi, Y., Sogo, S., Apoptosis of colorectal carcinoma (COLO 201) by tumor necrosis factor-alpha (TNF-α) and/or interferon-gamma (IFN-γ) resulting from down-modulation of Bcl-2 expression (1998) Clin. Experim. Immunol., 111 (1), pp. 211-218 
520 3 |a Tumour necrosis factor-alpha (TNF-α) is a monocyte (MO)-derived cytokine that plays an essential role in the immunological system. In the present study our aim was to evaluate the levels of TNF-α secreted by MO from cancer patients. Blood MO were obtained from 10 lung cancer patients (LCP), 10 colorectal cancer patients (CCP) and 10 healthy donors (HD). TNF-α levels in MO culture supernatants spontaneously (sp) secreted or after stimulation with LPS treatment were evaluated using a commercial ELISA kit (sensibility: 10-1000 pg/ml). Mean values, expressed as pg/ml were: LCP: sp= 452.6 ± 107.2, LPS= 589.5 ± 126.7); CCP: sp= 84.1 ± 25.0, LPS= 437.3 ± 93.2; HD: sp= 74.2 ± 21.5, LPS= 573.5 ± 87.1. We concluded that MO from LCP secrete high levels of TNF-α spontaneously (p< 0.003 versus HD) and it was also observed an absence of response to LPS treatment in the 33% of the cases in these patients.  |l eng 
593 |a Inst. de Biologia y Medicina Exp., Vuelta de Obligado 2490, (1428) Buenos Aires, Argentina 
690 1 0 |a COLON CANCER 
690 1 0 |a LUNG CANCER 
690 1 0 |a MONOCYTES 
690 1 0 |a TUMOR NECROSIS FACTOR ALFA 
690 1 0 |a LIPOPOLYSACCHARIDE 
690 1 0 |a TUMOR NECROSIS FACTOR ALPHA 
690 1 0 |a ARTICLE 
690 1 0 |a CLINICAL ARTICLE 
690 1 0 |a COLORECTAL CANCER 
690 1 0 |a CONTROLLED STUDY 
690 1 0 |a CYTOKINE PRODUCTION 
690 1 0 |a CYTOKINE RELEASE 
690 1 0 |a ENZYME LINKED IMMUNOSORBENT ASSAY 
690 1 0 |a HUMAN 
690 1 0 |a HUMAN CELL 
690 1 0 |a LUNG CANCER 
690 1 0 |a MONOCYTE 
690 1 0 |a MONONUCLEAR CELL 
690 1 0 |a PRIORITY JOURNAL 
690 1 0 |a TUMOR IMMUNOLOGY 
690 1 0 |a ADULT 
690 1 0 |a AGED 
690 1 0 |a AGED, 80 AND OVER 
690 1 0 |a CELLS, CULTURED 
690 1 0 |a COLORECTAL NEOPLASMS 
690 1 0 |a ENZYME-LINKED IMMUNOSORBENT ASSAY 
690 1 0 |a HUMANS 
690 1 0 |a LUNG NEOPLASMS 
690 1 0 |a MIDDLE AGED 
690 1 0 |a MONOCYTES 
690 1 0 |a REFERENCE VALUES 
690 1 0 |a TUMOR NECROSIS FACTOR-ALPHA 
700 1 |a Bordenave, R.H. 
700 1 |a Beviacqua, M. 
700 1 |a Zanoni, L. 
700 1 |a Rumi, L.S. 
773 0 |d 2001  |g v. 20  |h pp. 71-73  |k n. 1  |p J. Exp. Clin. Cancer Res.  |x 03929078  |t Journal of Experimental and Clinical Cancer Research 
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999 |c 81594 

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