Specific molecular targets to control tropical diseases

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Chagas' disease or American trypanosomiasis is considered by the Word Health Organization to be one of the important tropical parasitic diseases worldwide together with malaria and schistosomiasis. The etiologic agent of this illness is the kinetoplastid protozoon Trypanosoma cruzi. The present...

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Autor principal: Rodriguez, J.B
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 2001
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MALARIA
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Biblioteca Central Dr. Luis F. Leloir (FCEN) de Universidad de Buenos Aires
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100 1 |a Rodriguez, J.B. 
245 1 0 |a Specific molecular targets to control tropical diseases 
260 |c 2001 
270 1 0 |m Rodriguez, J.B.; Dept. de Química Organica, Facultad Ciencias Exactas Naturales, Universidad de Buenos Aires, Pabellón 2, RA-1428 Buenos Aires, Argentina; email: JBR@qo.fcen.uba.ar 
506 |2 openaire  |e Política editorial 
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520 3 |a Chagas' disease or American trypanosomiasis is considered by the Word Health Organization to be one of the important tropical parasitic diseases worldwide together with malaria and schistosomiasis. The etiologic agent of this illness is the kinetoplastid protozoon Trypanosoma cruzi. The present chemotherapy for the treatment of Chagas' disease remains unsolved. The drugs currently in use are old, ineffective and toxic. Bearing in mind the metabolic differences between the parasite and the mammalian host, some attractive interesting molecular targets for drug design are presented.  |l eng 
593 |a Dept. de Química Organica, Facultad Ciencias Exactas Naturales, Universidad de Buenos Aires, Pabellón 2, RA-1428 Buenos Aires, Argentina 
690 1 0 |a 4 PHENOXYPHENOXYETHYL ALLYL ETHER 
690 1 0 |a 4 PHENOXYPHENOXYETHYL TETRAHYDRO 2H PYRAN 2 YL ETHER 
690 1 0 |a 4 PHENOXYPHENOXYETHYL THIOCYANATE 
690 1 0 |a ANTIINFECTIVE AGENT 
690 1 0 |a ARYLOXYETHYL THIOCYANATE 
690 1 0 |a BENZNIDAZOLE 
690 1 0 |a BENZOIC ACID DERIVATIVE 
690 1 0 |a CRYSTAL VIOLET 
690 1 0 |a DIHYDROFOLATE REDUCTASE INHIBITOR 
690 1 0 |a ENZYME INHIBITOR 
690 1 0 |a ETHER DERIVATIVE 
690 1 0 |a FENOXYCARB 
690 1 0 |a GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE INHIBITOR 
690 1 0 |a M CHLOROPERBENZOIC ACID 
690 1 0 |a METHOTREXATE 
690 1 0 |a N ACETYL 2,3 DIDEHYDRO 2 DEOXYNEURAMINIC ACID 
690 1 0 |a N ACETYLNEURAMINIC ACID DERIVATIVE 
690 1 0 |a NIFURTIMOX 
690 1 0 |a SIALIDASE 
690 1 0 |a THIOCYANIC ACID DERIVATIVE 
690 1 0 |a UNCLASSIFIED DRUG 
690 1 0 |a ANIMAL EXPERIMENT 
690 1 0 |a ANIMAL MODEL 
690 1 0 |a ANOREXIA 
690 1 0 |a ARTICLE 
690 1 0 |a CHAGAS DISEASE 
690 1 0 |a CONTROLLED STUDY 
690 1 0 |a DRUG DESIGN 
690 1 0 |a DRUG STRUCTURE 
690 1 0 |a DRUG TARGETING 
690 1 0 |a HOST 
690 1 0 |a HUMAN 
690 1 0 |a KINETOPLAST 
690 1 0 |a MAMMAL 
690 1 0 |a MOLECULAR BIOLOGY 
690 1 0 |a MOUSE 
690 1 0 |a NONHUMAN 
690 1 0 |a PERIPHERAL NEUROPATHY 
690 1 0 |a PRIORITY JOURNAL 
690 1 0 |a PROTOZOON 
690 1 0 |a SCHISTOSOMIASIS 
690 1 0 |a SKIN ALLERGY 
690 1 0 |a TROPICAL DISEASE 
690 1 0 |a TRYPANOSOMA CRUZI 
690 1 0 |a VOMITING 
690 1 0 |a WORLD HEALTH ORGANIZATION 
690 1 0 |a ANIMALS 
690 1 0 |a ANTIPROTOZOAL AGENTS 
690 1 0 |a CHAGAS DISEASE 
690 1 0 |a DRUG DESIGN 
690 1 0 |a HUMANS 
690 1 0 |a TRYPANOSOMA CRUZI 
650 1 7 |2 spines  |a MALARIA 
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