Influence of HLA-DR alleles on rheumatoid arthritis: Susceptibility and severity in Argentine patients
Objective. To determine the frequency of shared epitopes in our population of patients with rheumatoid arthritis (RA) and to investigate whether the presence of these alleles is associated with a more aggressive form of disease. Methods. Demographic and clinical data were obtained from 140 patients...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
2001
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| Acceso en línea: | Registro en Scopus Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 10835caa a22012257a 4500 | ||
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| 001 | PAPER-20600 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205200.0 | ||
| 008 | 190411s2001 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0034932012 | |
| 024 | 7 | |2 cas |a Epitopes; HLA-DR Antigens; HLA-DR11 antigen; HLA-DR3 Antigen | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a JRHUA | ||
| 100 | 1 | |a Citera, G. | |
| 245 | 1 | 0 | |a Influence of HLA-DR alleles on rheumatoid arthritis: Susceptibility and severity in Argentine patients |
| 260 | |c 2001 | ||
| 270 | 1 | 0 | |m Maldonado Cocco, J.A.; Department of Rheumatology, Inst. Rehab. Psicofis. Echever. 955, Buenos Aires 1428, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Pincus, T., Rheumatoid arthritis: A medical emergency? (1994) Scand J Rheumatol, 23 (SUPPL. 100), pp. 21-30 | ||
| 504 | |a Wolf, F., The natural history of rheumatoid arthritis (1996) J Rheumatol, 23 (SUPPL. 44), pp. 13-22 | ||
| 504 | |a Pincus, T., Callahan, L., How many types of patients meet classification criteria for rheumatoid arthritis? (1994) J Rheumatol, 21, pp. 1385-1389 | ||
| 504 | |a Van der Heijde, D.M.F.M., Van Riel, P.L.C.M., Van Rijswijk, M.H., Van de Putte, L.B.A., Influence of prognostic features on the final outcome in rheumatoid arthritis. A review of the literature (1988) Semin Arthritis Rheum, 17, pp. 284-292 | ||
| 504 | |a Stastny, P., Association of B cell alloantigen DRw4 with rheumatoid arthritis (1978) N Engl J Med, 298, pp. 869-871 | ||
| 504 | |a Nepom, G.T., Gersuk, V., Nepom, B., Prognostic implications of HLA genotyping in the early assessment of patients with rheumatoid arthritis (1996) J Rheumatol, 23 (SUPPL. 44), pp. 5-9 | ||
| 504 | |a Weyand, C.M., Hicok, K.C., Conn, D.L., Goronzy, J.Z., The influence of HLA-DRB1 genes on disease severity in rheumatoid arthritis (1992) Ann Intern Med, 117, pp. 801-806 | ||
| 504 | |a Suárez Almazor, M.E., Tao, S., Moustarah, F., Russell, A.S., Maksymowych, W., HLA DR1, DR4 and DRB1 disease related subtypes in rheumatoid arthritis: Association with susceptibility but not severity in a city wide community based study (1995) J Rheumatol, 22, pp. 2027-2033 | ||
| 504 | |a Teller, K., Budhai, L., Zhang, M., Haramati, N., Keiser, H.D., Davidson, A., HLA-DRB1 and DQB typing of Hispanic American patients with rheumatoid arthritis: The "shared epitope" hypothesis may not apply (1996) J Rheumatol, 23, pp. 1363-1368 | ||
| 504 | |a González, A., Nicovani, S., Massardo, L., Bull, P., Rodríguez, L., Jacobelli, S., Novel genetic markers of rheumatoid arthritis in Chilean patients, by DR serotyping and restriction fragment length polymorphism analysis (1992) Arthritis Rheum, 35, pp. 282-289 | ||
| 504 | |a Arnett, F.C., Edworthy, S.N., Bloch, D.A., The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis (1988) Arthritis Rheum, 31, pp. 315-324 | ||
| 504 | |a Bland, J.M., Altman, D.D., Statistical methods for assessing agreement between two methods of clinical measurement (1986) Lancet, 8476, pp. 307-310 | ||
| 504 | |a Larsen, A., Dale, K., Eck, M., Radiographic evaluation of rheumatoid arthritis and related conditions by standard reference films (1977) Acta Radiol, 18, pp. 481-491 | ||
| 504 | |a Svejgarard, A., Jersild, C., Nielsen, L.S., Bodner, W.F., HLA antigens and disease: Statistical and genetical considerations (1974) Tissue Antigens, 4, pp. 95-105 | ||
| 504 | |a Drosos, A.A., Lanchbury, J.S., Panayi, G.S., Moutsopoulos, H.M., Rheumatoid arthritis in Greek and British patients (1992) Arthritis Rheum, 35, pp. 745-748 | ||
| 504 | |a McDaniel, D.O., Alarcón, G.S., Pratt, P.W., Reveille, J.D., Most African-American patients with rheumatoid arthritis do not have the rheumatoid antigenic determinant (epitope) (1995) Ann Intern Med, 123, pp. 181-187 | ||
| 504 | |a Massardo, L., Jacobelli, S., Rodríguez, L., Rivero, S., González, A., Marchetti, R., Weak association between HLA-DR4 and rheumatoid arthritis in Chilean patients (1990) Ann Rheum Dis, 49, pp. 290-292 | ||
| 504 | |a González, A., Nicovani, S., Massardo, L., Influence of the HLA-DRB shared epitope on susceptibility to and clinical expression of rheumatoid arthritis in Chilean patients (1997) Ann Rheum Dis, 56, pp. 191-193 | ||
| 504 | |a Massardo, L., Aguirre, V., García, M.E., Clinical expression of rheumatoid arthritis in Chilean patients (1995) Semin Arthritis Rheum, 25, pp. 203-213 | ||
| 504 | |a Del Rincón, Y., Castro, M., Escalante, A., Sensitivity and specificity of HLA-DRB 1 alleles in the susceptibility to rheumatoid arthritis in Mexican-Americans (1997) Arthritis Rheum, 40 (SUPPL.), pp. S156 | ||
| 504 | |a Cerna, M., Falco, M., Friedman, H., Differences in HLA class II alleles of isolated South American Indian populations from Brazil and Argentina (1993) Human Immunol, 37, pp. 213-220 | ||
| 504 | |a Vullo, C.M., Pesoa, S.A., Onetti, C.M., Riera, C.M., Rheumatoid arthritis and its association with HLA-DR antigens. I. Cell mediated immune response against connective tissue antigens (1987) J Rheumatol, 14, pp. 221-225 | ||
| 504 | |a Salvarani, C., Macchioni, P.L., Mantovani, W., HLA-DRB1 alleles associated with rheumatoid arthritis in Northern Italy: Correlation with disease severity (1998) Br J Rheumatol, 37, pp. 165-169 | ||
| 504 | |a Ferraccioli, G.F., Sari, M., Association between DR antigens, rheumatoid arthritis with and without extra-articular features and systemic lupus erythematosus in Northern Italy (1988) J Rheumatol, 15, pp. 51-53 | ||
| 504 | |a Eberbardt, K., Fex, E., Johnson, U., Wollheim, F.A., Associations of HLA-DRB and DQB genes with two and five year outcome in rheumatoid arthritis (1996) Ann Rheum Dis, 55, pp. 34-39 | ||
| 504 | |a Higami, K., Hakoda, M., Matsuda, J., Ueda, H., Kashiwasaki, S., Lack of association of HLA-DRB1 genotype with radiologic progression in Japanese patients with early rheumatoid arthritis (1997) Arthritis Rheum, 40, pp. 2241-2247 | ||
| 504 | |a Van Jaarsveld, C.H.M., Otten, H.G., Jacobs, J.W.G., Kruize, A.A., Brus, H.L.M., Bijlsma, J.W.J., Association of HLA-DR with susceptibility to and clinical expression of rheumatoid arthritis: Re-evaluation by means of genomic tissue typing (1998) Br J Rheumatol, 37, pp. 411-416 | ||
| 504 | |a Combe, B., Eliaou, J.F., Daures, J.P., Meyer, O., Clot, J., Sany, J., Prognostic factors in rheumatoid arthritis, Comparative study of two subsets of patients according to severity of articular damage (1995) Br J Rheumatol, 34, pp. 529-534 | ||
| 504 | |a Saag, K.G., Low-dose corticosteroid therapy in rheumatoid arthritis: Balancing the evidence (1997) Am J Med, 103 (SUPPL. 6A), pp. 31S-39S | ||
| 504 | |a Van der Horst-Bruinsama, I.E., De Vries, R.R.P., Hazes, J.M.W., Reevaluating the role of HLA in rheumatoid arthritis: Some DRB1 alleles prevent disease onset (1997) Arthritis Rheum, 40 (SUPPL.), pp. S156 | ||
| 520 | 3 | |a Objective. To determine the frequency of shared epitopes in our population of patients with rheumatoid arthritis (RA) and to investigate whether the presence of these alleles is associated with a more aggressive form of disease. Methods. Demographic and clinical data were obtained from 140 patients with RA, 123 female, mean age 49.9 ± 11.7 years and mean disease duration 9.4 ± 6.3 years. Radiographs of both hands were taken and scored by Larsen's method. HLA-DR alleles were determined by PCR-SSP. The control group comprised 202 healthy ethnic-matched subjects. Results. DR4 was significantly more frequent in patients with RA than controls, and was observed in 70/140 patients (50%) versus 47/202 controls (23.27%) (odds ratio 3.25, CI 1.99-5.35, Pcorr 5 × 10-5). Within DR4 subtypes *0404 and *0401 were the most commonly found (37.7 and 29%, respectively). DR3 and DR11 exerted a protective effect with significantly higher frequency in controls than in patients with RA. When patients were divided into 2 groups according to disease severity (radiographic score) the frequency of alleles with QKRAA and QRRAA sequences was similar in both groups. Although with lower frequency, subtype *1001 alone was significantly more frequent in the severe-condition group [7 (13.5 %) vs 3 (3.4 %), p = 0.03]. Conclusion. These results are in accordance with findings observed in Caucasians and differ from other Latin American populations. However shared epitope alleles failed to correlate with more severe disease with the exception of subtype *1001 which, although infrequent, was significantly more frequent in patients with relevant radiological damage. |l eng | |
| 593 | |a Department of Rheumatology, Inst. Rehab. Psicofis. Echever. 955, Buenos Aires 1428, Argentina | ||
| 690 | 1 | 0 | |a DISEASE SEVERITY |
| 690 | 1 | 0 | |a HLA-DR ALLELES |
| 690 | 1 | 0 | |a RHEUMATOID ARTHRITIS |
| 690 | 1 | 0 | |a SHARED EPITOPE |
| 690 | 1 | 0 | |a EPITOPE |
| 690 | 1 | 0 | |a HLA DR ANTIGEN |
| 690 | 1 | 0 | |a HLA DR11 ANTIGEN |
| 690 | 1 | 0 | |a HLA DR3 ANTIGEN |
| 690 | 1 | 0 | |a HLA DR4 ANTIGEN |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
| 690 | 1 | 0 | |a ADULT |
| 690 | 1 | 0 | |a AGED |
| 690 | 1 | 0 | |a ALLELISM |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DISEASE DURATION |
| 690 | 1 | 0 | |a DISEASE PREDISPOSITION |
| 690 | 1 | 0 | |a DISEASE SEVERITY |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HAND RADIOGRAPHY |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a MAJOR CLINICAL STUDY |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a POLYMERASE CHAIN REACTION |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a RHEUMATOID ARTHRITIS |
| 690 | 1 | 0 | |a SCORING SYSTEM |
| 690 | 1 | 0 | |a ADULT |
| 690 | 1 | 0 | |a AGED |
| 690 | 1 | 0 | |a ALLELES |
| 690 | 1 | 0 | |a ARTHRITIS, RHEUMATOID |
| 690 | 1 | 0 | |a EPITOPES |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a GENETIC PREDISPOSITION TO DISEASE |
| 690 | 1 | 0 | |a GENOTYPE |
| 690 | 1 | 0 | |a HLA-DR ANTIGENS |
| 690 | 1 | 0 | |a HLA-DR3 ANTIGEN |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MIDDLE AGED |
| 690 | 1 | 0 | |a SEVERITY OF ILLNESS INDEX |
| 651 | 4 | |a ARGENTINA | |
| 651 | 4 | |a ARGENTINA | |
| 700 | 1 | |a Padulo, L.A. | |
| 700 | 1 | |a Fernandez, G. | |
| 700 | 1 | |a Lazaro, M.A. | |
| 700 | 1 | |a Rosemffet, M.G. | |
| 700 | 1 | |a Maldonado Cocco, J.A. | |
| 773 | 0 | |d 2001 |g v. 28 |h pp. 1486-1491 |k n. 7 |p J. Rheumatol. |x 0315162X |t Journal of Rheumatology | |
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| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_0315162X_v28_n7_p1486_Citera |y Handle |
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