Glucocorticoid effects on Fos immunoreactivity and NADPH-diaphorase histochemical staining following spinal cord injury
Glucocorticoids (GC) provide neuroprotection and early recovery after spinal cord injury (SCI). While several mechanisms were proposed to account for these effects, limited information exists regarding GC actions in sensory areas of the spinal cord. Presently, we studied the time course of Fos expre...
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2001
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| 001 | PAPER-20587 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205159.0 | ||
| 008 | 190411s2001 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0035823376 | |
| 024 | 7 | |2 cas |a Dexamethasone, 50-02-2; Glucocorticoids; NADPH Dehydrogenase, EC 1.6.99.1; Nitric Oxide, 10102-43-9; Proto-Oncogene Proteins c-fos | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a BRREA | ||
| 100 | 1 | |a González, S. | |
| 245 | 1 | 0 | |a Glucocorticoid effects on Fos immunoreactivity and NADPH-diaphorase histochemical staining following spinal cord injury |
| 260 | |c 2001 | ||
| 270 | 1 | 0 | |m De Nicola, A.F.; Lab. of Neuroendocrine Biochemistry, Instituto de Biología, Obligado 2490, 1428 Buenos Aires, Argentina; email: denicola@proteus.dna.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a Glucocorticoids (GC) provide neuroprotection and early recovery after spinal cord injury (SCI). While several mechanisms were proposed to account for these effects, limited information exists regarding GC actions in sensory areas of the spinal cord. Presently, we studied the time course of Fos expression, and reduced nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemical staining to monitor neuronal responses to SCI with or without GC treatment. Rats with sham-operation or transection at the thoracic level (T7-T8) received vehicle or 5 mg/kg of the GC dexamethasone (DEX) at 5 min post-lesion and were sacrificed 2 or 4 h after surgery. Another group of SCI rats received vehicle or intensive DEX treatment (5 min, 6 h, 18 h and 46 h post-lesion) and were sacrificed 48 h after surgery. The number of NADPH-d positive neurons or Fos immunoreactive nuclei was studied by computer-assisted image analysis in superficial dorsal horn (Laminae I-III) and central canal area (Lamina X) below the lesion. While constitutive Fos immunoreactive nuclei were sparse in controls, SCI increased Fos expression at 2 and 4 h after injury. DEX treatment significantly enhanced the number of Fos positive nuclei in Laminae I-III by 4 h after transection, although the response was not maintained by intensive steroid treatment when tested at 48 h after SCI. NADPH-d positive neurons in Laminae I-III increased at 2 and 4 h after SCI while a delayed increased was found in central canal area (Lamina X). DEX treatment decreased NADPH-d positive neurons to sham-operated levels at all time points examined. Thus, while GC stimulation of Fos suggests activation of neurons involved in sympathetic outflow and/or pain, down-regulation of NADPH-d indicates attenuation of nociceptive outflow, considering the role of enzyme-derived nitric oxide in pain-related mechanisms. Differential hormonal effects on these molecules agree with their localization in different cell populations. © 2001 Elsevier Science B.V. All rights reserved. |l eng | |
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires, MT13 | ||
| 536 | |a Detalles de la financiación: Fondo para la Investigación Científica y Tecnológica, BID 802 OC AR PICT 97 05-00438 | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas, PEI 03228/98, PIP 4103 | ||
| 536 | |a Detalles de la financiación: This work was supported by grants from CONICET (PIP 4103 and PEI 03228/98), University of Buenos Aires (MT13), FONCYT (BID 802 OC AR PICT 97 05-00438), Fundación Barceló (Buenos Aires) and Beca Ramón Carrillo-Arturo Oñativia from the Minister of Health of Argentina. | ||
| 593 | |a Laboratory of Neuroendocrine Biochemistry, Instituto de Biología y Medicina Experimental, Obligado 2490, 1428 Buenos Aires, Argentina | ||
| 593 | |a Department of Human Biochemistry, Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Instituto Universitario de Ciencias de la Salud, Fundación Barceló, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a DEXAMETHASONE |
| 690 | 1 | 0 | |a FOS |
| 690 | 1 | 0 | |a GLOCOCORTICOID |
| 690 | 1 | 0 | |a NADPH-DIAPHORASE |
| 690 | 1 | 0 | |a NEUROPROTECTION |
| 690 | 1 | 0 | |a SPINAL CORD INJURY |
| 690 | 1 | 0 | |a DEXAMETHASONE |
| 690 | 1 | 0 | |a GLUCOCORTICOID |
| 690 | 1 | 0 | |a NITRIC OXIDE |
| 690 | 1 | 0 | |a PROTEIN FOS |
| 690 | 1 | 0 | |a REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE |
| 690 | 1 | 0 | |a ADRENERGIC SYSTEM |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CELL ACTIVATION |
| 690 | 1 | 0 | |a CELL COUNT |
| 690 | 1 | 0 | |a CELL POPULATION |
| 690 | 1 | 0 | |a COMPUTER ANALYSIS |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DOSE TIME EFFECT RELATION |
| 690 | 1 | 0 | |a DOWN REGULATION |
| 690 | 1 | 0 | |a IMAGE ANALYSIS |
| 690 | 1 | 0 | |a IMMUNOCOMPETENT CELL |
| 690 | 1 | 0 | |a IMMUNOHISTOCHEMISTRY |
| 690 | 1 | 0 | |a IMMUNOREACTIVITY |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a NERVE POTENTIAL |
| 690 | 1 | 0 | |a NOCICEPTION |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PAIN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROTEIN EXPRESSION |
| 690 | 1 | 0 | |a PROTEIN INDUCTION |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a SPINAL CORD DORSAL HORN |
| 690 | 1 | 0 | |a SPINAL CORD INJURY |
| 690 | 1 | 0 | |a SPINAL CORD TRANSSECTION |
| 690 | 1 | 0 | |a THORACIC SPINAL CORD |
| 690 | 1 | 0 | |a TIME |
| 690 | 1 | 0 | |a VERTEBRAL CANAL |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a CELL COUNT |
| 690 | 1 | 0 | |a DEXAMETHASONE |
| 690 | 1 | 0 | |a DOSE-RESPONSE RELATIONSHIP, DRUG |
| 690 | 1 | 0 | |a DOWN-REGULATION |
| 690 | 1 | 0 | |a DRUG ADMINISTRATION SCHEDULE |
| 690 | 1 | 0 | |a GLUCOCORTICOIDS |
| 690 | 1 | 0 | |a IMMUNOHISTOCHEMISTRY |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a NADPH DEHYDROGENASE |
| 690 | 1 | 0 | |a NITRIC OXIDE |
| 690 | 1 | 0 | |a PAIN |
| 690 | 1 | 0 | |a PROTO-ONCOGENE PROTEINS C-FOS |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RATS, SPRAGUE-DAWLEY |
| 690 | 1 | 0 | |a SPINAL CORD INJURIES |
| 690 | 1 | 0 | |a SUBSTANTIA GELATINOSA |
| 690 | 1 | 0 | |a TIME FACTORS |
| 690 | 1 | 0 | |a UP-REGULATION |
| 700 | 1 | |a Labombarda, F. | |
| 700 | 1 | |a Gonzalez Deniselle, M.C. | |
| 700 | 1 | |a Saravia, F.E. | |
| 700 | 1 | |a Roig, P. | |
| 700 | 1 | |a De Nicola, A.F. | |
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