Basis of progesterone protection in spinal cord neurodegeneration

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Progesterone neuroprotection has been reported in experimental brain, peripheral nerve and spinal cord injury. To investigate for a similar role in neurodegeneration, we studied progesterone effects in the Wobbler mouse, a mutant presenting severe motoneuron degeneration and astrogliosis of the spin...

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Autor principal: Gonzalez Deniselle, M.C
Otros Autores: Lopez Costa, J.J, Gonzalez, S.L, Labombarda, F., Garay, L., Guennoun, R., Schumacher, M., De Nicola, A.F
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: Elsevier Ltd 2002
Acceso en línea:Registro en Scopus
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Biblioteca Central Dr. Luis F. Leloir (FCEN) de Universidad de Buenos Aires
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024 7 |2 scopus  |a 2-s2.0-0037981358 
024 7 |2 cas  |a adenosine triphosphatase (potassium sodium); progesterone, 57-83-0; adenosine triphosphatase, 37289-25-1, 9000-83-3; Adenosine Triphosphatases, EC 3.6.1.-; Cation Transport Proteins; Chromatin; GAP-43 Protein; Glial Fibrillary Acidic Protein; potassium transporting ATPase, EC 3.6.1.-; Progesterone, 57-83-0; RNA, Messenger 
040 |a Scopus  |b spa  |c AR-BaUEN  |d AR-BaUEN 
030 |a JSBBE 
100 1 |a Gonzalez Deniselle, M.C. 
245 1 0 |a Basis of progesterone protection in spinal cord neurodegeneration 
260 |b Elsevier Ltd  |c 2002 
270 1 0 |m De Nicola, A.F.; Department of Human Biochemistry, Inst. de Biol. y Med. Experimental, University of Buenos Aires, Obligado 2490, 1428 Buenos Aires, Argentina; email: denicola@dna.uba.ar 
506 |2 openaire  |e Política editorial 
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520 3 |a Progesterone neuroprotection has been reported in experimental brain, peripheral nerve and spinal cord injury. To investigate for a similar role in neurodegeneration, we studied progesterone effects in the Wobbler mouse, a mutant presenting severe motoneuron degeneration and astrogliosis of the spinal cord. Implant of a single progesterone pellet (20mg) during 15 days produced substantial changes in Wobbler mice spinal cord. Morphologically, motoneurons of untreated Wobbler mice showed severe vacuolation of intracellular organelles including mitochondria. In contrast, neuropathology was less pronounced in Wobbler mice receiving progesterone, together with a reduction of vacuolated cells and preservation of mitochondrial ultrastructure. Determination of mRNAs for the α3 and β1 subunits of neuronal Na, K-ATPase, showed that mRNA levels in untreated mice were significantly reduced, whereas progesterone therapy re-established the expression of both subunits. Additionally, progesterone treatment of Wobbler mice attenuated the aberrant expression of the growth-associated protein (GAP-43) mRNA which otherwise occurred in motoneurons of untreated animals. The hormone, however, was without effect on astrocytosis of Wobbler mice, determined by glial fibrillary acidic protein (GFAP)-immunostaining. Lastly, progesterone treatment of Wobbler mice enhanced grip strength and prolonged survival at the end of the 15-day observation period. Recovery of morphology and molecular motoneuron parameters of Wobbler mice receiving progesterone, suggest a new and important role for this hormone in the prevention of spinal cord neurodegenerative disorders. © 2003 Elsevier Science Ltd. All rights reserved.  |l eng 
536 |a Detalles de la financiación: Universidad de Buenos Aires, M048 
536 |a Detalles de la financiación: National Council for Scientific Research, PIP No. 02007 
536 |a Detalles de la financiación: Fondo para la Investigación Científica y Tecnológica, BID 802 OC AR PICT 2000 05-08663, ECOS/SECYT # A98SO1 
536 |a Detalles de la financiación: This work was supported by grants from the University of Buenos Aires (M048), National Research Council of Argentina (PIP No. 02007), Beca Carrillo Oñativia from the Minister of Health, FONCYT (BID 802 OC AR PICT 2000 05-08663) and a Cooperative Program between the Governments of France and Argentina (ECOS/SECYT # A98SO1). The laboratory assistance of Paulina Roig, Analia Lima and Esther I. Nievas and EM assistance of Emerita Jorge Vilela and Mariana López Ravasio is gratefully acknowledged. 
593 |a Department of Human Biochemistry, Inst. de Biol. y Med. Experimental, University of Buenos Aires, Obligado 2490, 1428 Buenos Aires, Argentina 
593 |a Faculty of Medicine, Inst. Biol. Cel. Neurociencias P., University of Buenos Aires, Buenos Aires, Argentina 
593 |a INSERM U488, Kremlin-Bicêtre, France 
690 1 0 |a NEURODEGENERATION 
690 1 0 |a PROGESTERONE 
690 1 0 |a SPINAL CORD 
690 1 0 |a WOBBLER MOUSE 
690 1 0 |a ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM) 
690 1 0 |a GLIAL FIBRILLARY ACIDIC PROTEIN 
690 1 0 |a MESSENGER RNA 
690 1 0 |a NEUROMODULIN 
690 1 0 |a PROGESTERONE 
690 1 0 |a ADENOSINE TRIPHOSPHATASE 
690 1 0 |a CATION TRANSPORT PROTEIN 
690 1 0 |a GLIAL FIBRILLARY ACIDIC PROTEIN 
690 1 0 |a MESSENGER RNA 
690 1 0 |a NEUROMODULIN 
690 1 0 |a POTASSIUM TRANSPORTING ATPASE 
690 1 0 |a PROGESTERONE 
690 1 0 |a ALPHA CHAIN 
690 1 0 |a ASTROCYTOSIS 
690 1 0 |a BETA CHAIN 
690 1 0 |a BRAIN MITOCHONDRION 
690 1 0 |a CELL ORGANELLE 
690 1 0 |a CELL ULTRASTRUCTURE 
690 1 0 |a CELL VACUOLE 
690 1 0 |a CONFERENCE PAPER 
690 1 0 |a DRUG IMPLANT 
690 1 0 |a DRUG PELLET 
690 1 0 |a GRIP STRENGTH 
690 1 0 |a HORMONAL REGULATION 
690 1 0 |a HORMONAL THERAPY 
690 1 0 |a HORMONE ACTION 
690 1 0 |a IMMUNOHISTOCHEMISTRY 
690 1 0 |a MORPHOLOGICAL TRAIT 
690 1 0 |a MOUSE STRAIN 
690 1 0 |a NERVE DEGENERATION 
690 1 0 |a NEUROPATHOLOGY 
690 1 0 |a NEUROPROTECTION 
690 1 0 |a NONHUMAN 
690 1 0 |a OBSERVATION 
690 1 0 |a PROGESTERONE SYNTHESIS 
690 1 0 |a PROTEIN BLOOD LEVEL 
690 1 0 |a PROTEIN DETERMINATION 
690 1 0 |a PROTEIN EXPRESSION 
690 1 0 |a SPECIES COMPARISON 
690 1 0 |a SPINAL CORD MOTONEURON 
690 1 0 |a SURVIVAL TIME 
690 1 0 |a ANIMAL 
690 1 0 |a APOPTOSIS 
690 1 0 |a ARTICLE 
690 1 0 |a ASTROCYTE 
690 1 0 |a CELL NUCLEUS 
690 1 0 |a CHROMATIN 
690 1 0 |a DEGENERATIVE DISEASE 
690 1 0 |a ELECTRON MICROSCOPY 
690 1 0 |a IN SITU HYBRIDIZATION 
690 1 0 |a METABOLISM 
690 1 0 |a MOUSE 
690 1 0 |a NERVE CELL 
690 1 0 |a PATHOLOGY 
690 1 0 |a SPINAL CORD 
690 1 0 |a ULTRASTRUCTURE 
690 1 0 |a ANIMALIA 
690 1 0 |a ADENOSINE TRIPHOSPHATASES 
690 1 0 |a ANIMALS 
690 1 0 |a APOPTOSIS 
690 1 0 |a ASTROCYTES 
690 1 0 |a CATION TRANSPORT PROTEINS 
690 1 0 |a CELL NUCLEUS 
690 1 0 |a CHROMATIN 
690 1 0 |a GAP-43 PROTEIN 
690 1 0 |a GLIAL FIBRILLARY ACIDIC PROTEIN 
690 1 0 |a IN SITU HYBRIDIZATION 
690 1 0 |a MICE 
690 1 0 |a MICROSCOPY, ELECTRON 
690 1 0 |a NEURODEGENERATIVE DISEASES 
690 1 0 |a NEURONS 
690 1 0 |a PROGESTERONE 
690 1 0 |a RNA, MESSENGER 
690 1 0 |a SPINAL CORD 
700 1 |a Lopez Costa, J.J. 
700 1 |a Gonzalez, S.L. 
700 1 |a Labombarda, F. 
700 1 |a Garay, L. 
700 1 |a Guennoun, R. 
700 1 |a Schumacher, M. 
700 1 |a De Nicola, A.F. 
773 0 |d Elsevier Ltd, 2002  |g v. 83  |h pp. 199-209  |k n. 1-5  |p J. Steroid Biochem. Mol. Biol.  |x 09600760  |w (AR-BaUEN)CENRE-5799  |t Journal of Steroid Biochemistry and Molecular Biology 
856 4 1 |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-0037981358&doi=10.1016%2fS0960-0760%2802%2900262-5&partnerID=40&md5=289759df0ba7799a42deac88f49b42bf  |y Registro en Scopus 
856 4 0 |u https://doi.org/10.1016/S0960-0760(02)00262-5  |y DOI 
856 4 0 |u https://hdl.handle.net/20.500.12110/paper_09600760_v83_n1-5_p199_GonzalezDeniselle  |y Handle 
856 4 0 |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09600760_v83_n1-5_p199_GonzalezDeniselle  |y Registro en la Biblioteca Digital 
961 |a paper_09600760_v83_n1-5_p199_GonzalezDeniselle  |b paper  |c PE 
962 |a info:eu-repo/semantics/article  |a info:ar-repo/semantics/artículo  |b info:eu-repo/semantics/publishedVersion 
999 |c 81443 

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