Effects of polyamines on the release of gonadotropin-releasing hormone and gonadotropins in developing female rats
Polyamines, putrescine (PUT), spermidine (SPD), spermine (SPM), and agmatine (AGM), are polycationic amines related to multiple cell functions found in high concentrations during the development of hypothalamus and pituitary. In previous works, we demonstrated that α-difluoromethylornithine (DFMO),...
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2002
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| LEADER | 10910caa a22011657a 4500 | ||
|---|---|---|---|
| 001 | PAPER-20394 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205147.0 | ||
| 008 | 190411s2002 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0036553899 | |
| 024 | 7 | |2 cas |a Eflornithine, 70052-12-9; Gonadotropin-Releasing Hormone, 33515-09-2; Gonadotropins; Polyamines | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a EBMMB | ||
| 100 | 1 | |a Thyssen, S.M. | |
| 245 | 1 | 0 | |a Effects of polyamines on the release of gonadotropin-releasing hormone and gonadotropins in developing female rats |
| 260 | |c 2002 | ||
| 270 | 1 | 0 | |m Libertun, C.; Lab. de Neuroendocrinología, Inst. de Biologia y Medicina Exp., V. Obligado 2490, (1428) Buenos Aires, Argentina; email: libertun@dna.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Scalabrino, G., Lorenzini, E.C., Polyamines and mammalian hormones: Part lI: Paracrine signals and intracellular regulators (1991) Mol Cell Endocrinol, 77, pp. 37-56 | ||
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| 504 | |a Gilad, G.M., Dornay, M., Gilad, V.H., Polyamines induce precocious development in rats: Possible interaction with growth factors (1989) Int J Devl Neurosci, 7, pp. 641-653 | ||
| 504 | |a Persson, L., Nilsson, M., Rosengren, E., Ornithine decarboxylase activity and polyamines in the anterior pituitary gland during the rat oestrous cycle (1985) J Endocrinol, 107, pp. 83-87 | ||
| 504 | |a White, W.F., Cohen, A.I., Rippel, R.H., Story, J.C., Schally, A.V., Some hypothalamic polyamines that deplete pituitary follicle stimulating hormone (1968) Endocrinology, 82, pp. 742-752 | ||
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| 504 | |a Nicholson, S.A., Wynne-Jones, G.A., Differential effect of α-difluoromethylornithine on the increases in plasma concentrations of reproductive hormones on the afternoon of pro-oestrus in the rat (1989) J Endocrinol, 121, pp. 495-499 | ||
| 504 | |a Kordon, C., Drouva, S.V., Martinez de la Escalera, G., Weiner, R.I., Role of classic and peptide neuromediators in the neuroendocrine regulation of luteinizing hormone and prolactin (1994) The Physiology of Reproduction, pp. 1621-1681. , Knobil E, Neill JD, Eds. New York: Raven Press | ||
| 504 | |a Thyssen, S.M., Becu-Villalobos, D., Lacau-Mengido, I.M., Libertun, C., α-Difuoromethylornithine modifies gonadotropin-releasing hormone release and follicle-stimulating hormone secretion in the immature female rat (1997) Proc Soc Exp Biol Med, 215, pp. 192-197 | ||
| 504 | |a Thyssen, S.M., Libertun, C., α-Difluoromethylornithine modifies FSH secretion and puberty onset in the female rat (1996) Proc Soc Exp Biol Med, 211, pp. 76-80 | ||
| 504 | |a Becu-Villalobos, D., Libertun, C., Ontogenesis of 3(H) serotonin binding sites in the hypothalamus of the female rat: Relation to serotonin induced LH release in moxestrol pretreated rats (1986) Dev Brain Res, 25, pp. 111-116 | ||
| 504 | |a Lux-Lantos, V., Becu-Villalobos, D., Bianchi, M., Rey-Roldán, E.B., Chamson-Reig, A., Pignataro, O., Libertun, C., GABAB receptors in anterior pituitary cells (2001) Neuroendocrinology, 73, pp. 334-343 | ||
| 504 | |a Yu, W.H., Karanth, S., Walczewska, A., Sower, S.A., McCann, S.M., A hypothalamic follicle-stimulating hormone-releasing decapeptide in the rat (2000) Proc Natl Acad Sci U S A, 94, pp. 9499-9503 | ||
| 504 | |a Lux-Lantos, V.A.R., Rey, E.B., Libertun, C., Activation of GABA B receptors in the anterior pituitary inhibits prolactin and luteinizing hormone secretion (1992) Neuroendocrinology, 56, pp. 687-693 | ||
| 504 | |a Sokal, R.R., Rohlf, F.J., (1995) Biometry, , New York: W.H. Freeman and Co | ||
| 504 | |a Pegg, A.E., McCann, P.P., Polyamine metabolism and function (1982) Am J Physiol, 243, pp. C212-C221 | ||
| 504 | |a Kalra, S.P., Pearson, E., Sahu, A., Kalra, P.S., Agmatine, a novel hypothalamic amine, stimulates pituitary luteinizing hormone release in vivo and hypothalamic luteinizing hormone-releasing hormone release in vitro (1995) Neurosci Lett, 194, pp. 165-168 | ||
| 504 | |a Yamasaki, E.N., Barbosa, V.D., De Mello, F.G., Hokoc, J.N., GABAergic system in the developing mammalian retina: Dual sources of GABA at early stages of postnatal development (1999) Int J Dev Neurosci, 17, pp. 201-213 | ||
| 504 | |a Abraham, J.H., Hansen, G.H., Seiler, N., Schoubsoe, A., Depletion of polyamines prevents the neurotrophic activity of the GABA-agonist THIP in cultured rat cerebellar granule cells (2001) Neurochem Res, 18, pp. 153-158 | ||
| 504 | |a Bilger, M., Heger, S., Brann, D.W., Paredes, A., Ojeda, S.R., A conditional tetracycline-regulated increase in γ-amino butyric acid production near luteinizing hormone-releasing hormone nerve terminals disrupts estrous cyclicity in the rat (2001) Endocrinology, 142, pp. 2102-2104 | ||
| 504 | |a Leonhardt, S., Böning, B., Luft, H., Wuttke, W., Jarry, H., Activation of gene expression of the γ-aminobutyric acid rather than the glutamatergic system in the preoptic area during the preovulatory gonadotropin surge of the rat (2000) Neuroendocrinology, 71, pp. 8-15 | ||
| 504 | |a Perrot-Sinal, T.S., Davis, A.M., Gregerson, K., Kao, J., McCarthy, M.M., Estradiol enhances excitatory gammabutyric acid mediated calcium signalling in neonatal hypothalamic neurons (2001) Endocrinology, 142, pp. 2238-2243 | ||
| 520 | 3 | |a Polyamines, putrescine (PUT), spermidine (SPD), spermine (SPM), and agmatine (AGM), are polycationic amines related to multiple cell functions found in high concentrations during the development of hypothalamus and pituitary. In previous works, we demonstrated that α-difluoromethylornithine (DFMO), an inhibitor of polyamines biosynthesis, induced a delay in puberty of female rats, accompanied by high, sustained follicle-stimulating hormone (FSH) levels during the infantile period. Also, DFMO treatment induced changes in polyamine concentration both in hypothalamus and pituitary of rats, mainly a decrease of PUT and SPD, an increase in SPM, and no change in AGM. In the present work, we investigated the direct effects of polyamines on the secretion of hypothalamic GnRH and pituitary gonadotropins in 6- and 15-day-old female rats. In 6-day-old animals, in vitro incubations with PUT, SPD, and AGM of hypothalami or anterior pituitaries were able to inhibit GnRH, FSH, and leutinizing hormone (LH) secretion, respectively. SPM showed a nonspecific transient inhibitory effect on FSH. When challenged with either high K+ (hypothami) or GnRH (pituitaries), the tissues incubated in the presence of polyamines showed no differences when compared with their controls. No effects of polyamines in 15-day-old rats in either tissue were observed. Pituitary cell cultures of 6-day-old animals incubated with DFMO for 4 days showed a significant increase in FSH, but not in LH. We conclude that high PUT, SPD, and AGM levels during the first 10 days of life are important for the development of the hypothalamic-hypophyseal unit, probably related to an inhibitory effect on GnRH and gonadotropins. Therefore, polyamine participation, especially PUT and SPD, is of importance in the regulation of GnRH and gonadotropin secretion in the neonatal and infantile periods, critical stages in the establishment of sexual differentiation. |l eng | |
| 593 | |a Laboratorio de Neuroendocrinología, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, V. Obligado 2490, 1428 Buenos Aires, Argentina | ||
| 593 | |a Departmento Physiology, University of Buenos Aires, Medical School, Argentina | ||
| 593 | |a Laboratorio de Neuroendocrinología, Instituto de Biología y Medicina Experimental, V. Obligado 2490, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a ADENOHYPOPHYSIS |
| 690 | 1 | 0 | |a GNRH |
| 690 | 1 | 0 | |a GONADOTROPINS |
| 690 | 1 | 0 | |a HYPOTHALAMUS |
| 690 | 1 | 0 | |a POLYAMINES |
| 690 | 1 | 0 | |a AGMATINE |
| 690 | 1 | 0 | |a EFLORNITHINE |
| 690 | 1 | 0 | |a FOLLITROPIN |
| 690 | 1 | 0 | |a GONADORELIN |
| 690 | 1 | 0 | |a GONADOTROPIN |
| 690 | 1 | 0 | |a LUTEINIZING HORMONE |
| 690 | 1 | 0 | |a POLYAMINE |
| 690 | 1 | 0 | |a PUTRESCINE |
| 690 | 1 | 0 | |a SPERMIDINE |
| 690 | 1 | 0 | |a SPERMINE |
| 690 | 1 | 0 | |a ADENOHYPOPHYSIS |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CELL CULTURE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DEVELOPMENT |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HORMONE RELEASE |
| 690 | 1 | 0 | |a HYPOTHALAMUS |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a RADIOIMMUNOASSAY |
| 690 | 1 | 0 | |a SEX DIFFERENTIATION |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a CELLS, CULTURED |
| 690 | 1 | 0 | |a EFLORNITHINE |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a GONADOTROPIN-RELEASING HORMONE |
| 690 | 1 | 0 | |a GONADOTROPINS |
| 690 | 1 | 0 | |a PITUITARY GLAND |
| 690 | 1 | 0 | |a POLYAMINES |
| 690 | 1 | 0 | |a PREGNANCY |
| 690 | 1 | 0 | |a RADIOIMMUNOASSAY |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RATS, SPRAGUE-DAWLEY |
| 690 | 1 | 0 | |a ANIMALIA |
| 700 | 1 | |a Hockl, P.F. | |
| 700 | 1 | |a Chamson, A. | |
| 700 | 1 | |a Lux-Lantos, V.A.R. | |
| 700 | 1 | |a Libertun, C. | |
| 773 | 0 | |d 2002 |g v. 227 |h pp. 276-281 |k n. 4 |p Exp. Biol. Med. |x 00379727 |w (AR-BaUEN)CENRE-2685 |t Experimental Biology and Medicine | |
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| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00379727_v227_n4_p276_Thyssen |y Handle |
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| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||