Oral contraceptives suppress cell proliferation and enhance apoptosis of eutopic endometrial tissue from patients with endometriosis
Objective: To evaluate the effects of administering combination oral contraceptives (COCs) to patients with endometriosis on the regulation of cell growth in the eutopic endometrium. Design: Prospective study. Setting: Research institute and clinical fertility center. Patient(s): Thirteen women with...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
2002
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 11025caa a22013697a 4500 | ||
|---|---|---|---|
| 001 | PAPER-20349 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205144.0 | ||
| 008 | 190411s2002 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0036282586 | |
| 024 | 7 | |2 cas |a BAX protein, human; bcl-2-Associated X Protein; Contraceptives, Oral; Ki-67 Antigen; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a FESTA | ||
| 100 | 1 | |a Meresman, G.F. | |
| 245 | 1 | 0 | |a Oral contraceptives suppress cell proliferation and enhance apoptosis of eutopic endometrial tissue from patients with endometriosis |
| 260 | |c 2002 | ||
| 270 | 1 | 0 | |m Meresman, G.F.; Inst. de Biologia/Med. Experimental, Vuelta de Obligado 2490, Buenos Aires (1428), Argentina; email: meresman@dna.uba.ai |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Dahmoun, M., Boman, K., Cajander, S., Westin, P., Bäckström, T., Apoptosis, proliferation and sex hormone receptors in superficial parts of human endometrium at the end of the secretory phase (1999) J Clin Endocrinol Metab, 84, pp. 1737-1743 | ||
| 504 | |a Hopwood, D., Levinson, D.A., Atrophy and apoptosis in the cyclical human endometrium (1975) J Pathol, 119, pp. 159-166 | ||
| 504 | |a Schwartzman, R.A., Cidlowski, J.A., Apoptosis: The biochemistry and molecular biology of programmed cell death (1993) Endocrinol Rev, 14, pp. 133-151 | ||
| 504 | |a Nawaz, S., Lynch, M.P., Galand, P., Gerschenson, L.E., Hormonal regulation of cell death in rabbit uterine epithelium (1987) Am J Pathol, 127, pp. 51-59 | ||
| 504 | |a Sandow, B.A., West, N.B., Norman, R.N., Brenner, R.B., Hormonal control of apoptosis in hamster uterine luminal epithelium (1979) Am J Anat, 156, pp. 15-36 | ||
| 504 | |a Slayden, O.D., Hirst, J.J., Brenner, R.M., Estrogen action in reproductive tract of rhesus monkeys during antiprogestin treatment (1993) Endocrinology, 132, pp. 1845-1856 | ||
| 504 | |a Spencer, S.J., Cataldo, N.A., Jaffe, R.B., Apoptosis in the human female reproductive tract (1996) Obstet Gynecol Surv, 51, pp. 314-323 | ||
| 504 | |a Meresman, G.F., Vighi, S., Buquet, R.A., Contreras-Ortiz, O., Tesone, M., Rumi, L.S., Apoptosis and expression of Bcl-2 and Bax in eutopic endometrium from women with endometriosis (2000) Fertil Steril, 74, pp. 760-766 | ||
| 504 | |a Nunez, G., Clarke, M.F., The Bcl-2 family of proteins: Regulators of cell death and survival (1994) Trends Cell Biol, 4, pp. 399-403 | ||
| 504 | |a Oltvai, Z.N., Milliman, C.L., Korsmeyer, S.T., Bcl-2 heterodimerises in vivo with a conserved homologue Bax that accelerates programmed cell death (1993) Cell, 74, pp. 609-619 | ||
| 504 | |a Garcia-Velasco, J.A., Arici, A., Is the endometrium or oocyte/embryo affected in endometriosis? (1999) Hum Reprod, 14 (SUPPL. 2), pp. 77-89 | ||
| 504 | |a Lessey, B.A., Medical management of endometriosis and infertility (2000) Fertil Steril, 73, pp. 1089-1096 | ||
| 504 | |a Vercellini, P., Ragni, G., Trespidi, L., Colombo, A., Vendola, N., Marchini, M., A gonadotropin releasing hormone agonist vs. a low dose oral contraceptive for pelvic pain associated with endometriosis (1993) Fertil Steril, 60, pp. 75-79 | ||
| 504 | |a Deligdisch, L., Hormonal pathology of the endometrium (2000) Mod Pathol, 13, pp. 285-294 | ||
| 504 | |a Meresman, G.F., Barañao, R.I., Tenenbaum, A., Singla, J.J., Neuspiller, N.R., Rumi, L.S., Effect of peritoneal fluid from patients with minimal and severe endometriosis on endometrial stromal cell proliferation (1997) Arch Gynecol Obstet, 259, pp. 109-115 | ||
| 504 | |a Koh, E.A.T., Illingworth, P.J., Duncan, W.C., Critchley, H.O.D., Immunolocalization of Bcl-2 protein in human endometrium in the menstrual cycle and stimulated early pregnancy (1995) Hum Reprod, 10, pp. 1557-1562 | ||
| 504 | |a Sampson, J.A., Peritoneal endometriosis due to menstrual dissemination of endometrial tissue into the peritoneal cavity (1927) Am J Obstet Gynecol, 14, p. 422 | ||
| 504 | |a Liu, D.T., Hitchcock, A., Endometriosis: Its association with retrograde menstruation, dysmenorrhoea and tubal pathology (1986) Br J Obstet Gynaecol, 93, pp. 859-862 | ||
| 504 | |a Dmowski, W.P., Gebel, H., Braun, D.P., Decreased apoptosis and sensitivity to macrophage mediated cytolysis of endometrial cells in endometriosis (1998) Hum Reprod Update, 4, pp. 696-701 | ||
| 504 | |a Wigfield, M., Macpherson, A., Healy, D., Rogers, P., Cell proliferation is increased in the endometrium of women with endometriosis (1995) Fertil Steril, 64, pp. 340-346 | ||
| 504 | |a Scotti, S., Regidor, P.A., Schindler, A.E., Winterhager, E., Reduced proliferation and cell adhesion in endometriosis (2000) Mol Hum Reprod, 6, pp. 610-617 | ||
| 504 | |a Pierro, E., Minici, F., Alesiani, O., Miceli, F., Proto, C., Screpanti, I., Stromal-epithelial interactions modulate estrogen responsiveness in normal human endometrium (2001) Biol Reprod, 64, pp. 831-838 | ||
| 504 | |a Rider, V., Kimler, B.F., Justice, W.M., Progesterone-growth factor interactions in uterine stromal cells (1998) Biol Reprod, 59, pp. 464-469 | ||
| 504 | |a Spellacy, W.N., Kalra, P.S., Buhi, W.C., Birk, S.A., Pituitary and ovarian responsiveness to a graded gonadotropin releasing factor stimulation test in women using a low dose or a regular type of oral contraceptive (1980) Am J Obstet Gynecol, 137, pp. 109-115 | ||
| 504 | |a Bergqvist, I.A., Hormonal regulation of endometriosis and the rational and effects of GnRH-a treatment: A review (1995) Hum Reprod, 10, pp. 446-452 | ||
| 504 | |a Muzii, L., Marana, R., Carvana, P., Catalano, G., Margutti, F., Panici, P., Postoperative administration of monophasic combined oral contraceptives after laparoscopic treatment of ovarian endometriomas: A prospective, randomized trial (2000) Am J Obstet Gynecol, 183, pp. 588-592 | ||
| 504 | |a Mahnke, J., Dawood, Y., Huang, J., Vascular endothelial growth factor and interleukin-6 in peritoneal fluid of women with endometriosis (2000) Fertil Steril, 73, pp. 166-170 | ||
| 504 | |a Moyer, D.L., Felix, J.C., The effects of progesterone and progestins on endometrial proliferation (1998) Contraception, 57, pp. 399-403 | ||
| 504 | |a Critchley, H.O.D., Tong, S., Cameron, S.T., Drudy, T.A., Kelly, R.W., Baird, D.T., Regulation of bcl-2 gene family members in human endometrium by antiprogestin administration in vivo (1999) J Reprod Fertil, 115, pp. 389-395 | ||
| 504 | |a Fedele, L., Bianchi, S., Zanconato, G., Portuese, A., Raffaelli, R., Use of a levonorgestrel - Releasing intrauterine device in the treatment of rectovaginal endometriosis (2001) Fertil Steril, 75, pp. 485-488 | ||
| 504 | |a Moghissi, K.S., Treatment of endometriosis with estrogen - Progestogen combination and progestogen alone (1988) Clin Obstet Gynecol, 31, pp. 823-828 | ||
| 520 | 3 | |a Objective: To evaluate the effects of administering combination oral contraceptives (COCs) to patients with endometriosis on the regulation of cell growth in the eutopic endometrium. Design: Prospective study. Setting: Research institute and clinical fertility center. Patient(s): Thirteen women with untreated endometriosis and 13 controls. Intervention(s): Biopsy specimens of the eutopic endometrium were obtained from all subjects. Apoptosis, cell proliferation, and Bcl-2 and Bax expression were examined at the epithelial and stromal levels in the eutopic endometrium from patients with endometriosis before and after 30 days of daily exposure to COCs and from controls. Main Outcome Measure(s): Apoptotic cells were detected by using the dUTP nick-end labeling assay; Ki-67, Bcl-2, and Bax expressions were assessed by using immunohistochemical techniques. Result(s): After exposure to COCs, apoptosis was significantly increased in the eutopic endometrium compared with before COC administration, both at epithelial and stromal levels. Cell proliferation was significantly lowered by COCs. Conclusion(s): COCs showed a positive effect on patients with endometriosis by down-regulating cell proliferation and enhancing apoptosis in the eutopic endometrium. © 2002 by American Society for Reproductive Medicine. |l eng | |
| 593 | |a Instituto de Biología y Medicina Experimental (IBYME), Buenos Aires, Argentina | ||
| 593 | |a Instituto de Ginecología y Fertilidad (IFER), Buenos Aires, Argentina | ||
| 593 | |a Instituto de Bioloǵa y Medicina Experimental, Vuelta de Obligado 2490, Buenos Aires (1428), Argentina | ||
| 690 | 1 | 0 | |a APOPTOSIS |
| 690 | 1 | 0 | |a CELL PROLIFERATION |
| 690 | 1 | 0 | |a ENDOMETRIOSIS |
| 690 | 1 | 0 | |a EUTOPIC ENDOMETRIUM |
| 690 | 1 | 0 | |a ORAL CONTRACEPTIVES |
| 690 | 1 | 0 | |a DEOXYURIDINETRIPHOSPHATE |
| 690 | 1 | 0 | |a KI 67 ANTIGEN |
| 690 | 1 | 0 | |a ORAL CONTRACEPTIVE AGENT |
| 690 | 1 | 0 | |a PHOSPHATE |
| 690 | 1 | 0 | |a PROTEIN BAX |
| 690 | 1 | 0 | |a PROTEIN BCL 2 |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
| 690 | 1 | 0 | |a APOPTOSIS |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CELL ASSAY |
| 690 | 1 | 0 | |a CELL GROWTH |
| 690 | 1 | 0 | |a CELL PROLIFERATION |
| 690 | 1 | 0 | |a CLINICAL ARTICLE |
| 690 | 1 | 0 | |a CLINICAL TRIAL |
| 690 | 1 | 0 | |a CONTROLLED CLINICAL TRIAL |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DOWN REGULATION |
| 690 | 1 | 0 | |a DRUG EFFECT |
| 690 | 1 | 0 | |a DRUG EXPOSURE |
| 690 | 1 | 0 | |a ENDOMETRIOSIS |
| 690 | 1 | 0 | |a ENDOMETRIUM BIOPSY |
| 690 | 1 | 0 | |a EPITHELIUM |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a GROWTH REGULATION |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a IMMUNOHISTOCHEMISTRY |
| 690 | 1 | 0 | |a NICK END LABELING |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROSPECTIVE STUDY |
| 690 | 1 | 0 | |a PROTEIN ANALYSIS |
| 690 | 1 | 0 | |a PROTEIN EXPRESSION |
| 690 | 1 | 0 | |a STROMA |
| 690 | 1 | 0 | |a APOPTOSIS |
| 690 | 1 | 0 | |a BCL-2-ASSOCIATED X PROTEIN |
| 690 | 1 | 0 | |a CELL DIVISION |
| 690 | 1 | 0 | |a CONTRACEPTIVES, ORAL |
| 690 | 1 | 0 | |a ENDOMETRIOSIS |
| 690 | 1 | 0 | |a ENDOMETRIUM |
| 690 | 1 | 0 | |a EPITHELIAL CELLS |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a KI-67 ANTIGEN |
| 690 | 1 | 0 | |a PROTO-ONCOGENE PROTEINS |
| 690 | 1 | 0 | |a PROTO-ONCOGENE PROTEINS C-BCL-2 |
| 690 | 1 | 0 | |a REFERENCE VALUES |
| 690 | 1 | 0 | |a STROMAL CELLS |
| 700 | 1 | |a Augé, L. | |
| 700 | 1 | |a Baraao, R.I. | |
| 700 | 1 | |a Lombardi, E. | |
| 700 | 1 | |a Tesone, M. | |
| 700 | 1 | |a Sueldo, C. | |
| 773 | 0 | |d 2002 |g v. 77 |h pp. 1141-1147 |k n. 6 |p Fertil. Steril. |x 00150282 |w (AR-BaUEN)CENRE-4731 |t Fertility and Sterility | |
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| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00150282_v77_n6_p1141_Meresman |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00150282_v77_n6_p1141_Meresman |y Registro en la Biblioteca Digital |
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| 999 | |c 81302 | ||