Reduction of G protein-coupled receptor kinase 2 expression in U-937 cells attenuates H2 histamine receptor desensitization and induces cell maturation
Histamine and H2 agonists transiently induce an important cAMP response in promonocytic U-937 cells but fail to induce monocytic differentiation because of a rapid receptor desensitization mediated by G protein-coupled receptor kinases (GRKs). The aims of the present study were to investigate the pa...
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| Formato: | Capítulo de libro |
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2002
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| LEADER | 12455caa a22012017a 4500 | ||
|---|---|---|---|
| 001 | PAPER-20250 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205138.0 | ||
| 008 | 190411s2002 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0036892374 | |
| 024 | 7 | |2 cas |a beta-Adrenergic Receptor Kinase, EC 2.7.1.-; Cyclic AMP, 60-92-4; Cyclic AMP-Dependent Protein Kinases, EC 2.7.1.37; DNA, Antisense; Histamine Agonists; Receptors, Histamine H2 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a MOPMA | ||
| 100 | 1 | |a Fernández, N. | |
| 245 | 1 | 0 | |a Reduction of G protein-coupled receptor kinase 2 expression in U-937 cells attenuates H2 histamine receptor desensitization and induces cell maturation |
| 260 | |c 2002 | ||
| 270 | 1 | 0 | |m Shayo, C.; Inst. of Biol./Exp. Medicine, Obligado 2490, (1428) Buenos Aires, Argentina; email: cshayo@dna.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Brodsky, A., Davio, C., Shayo, C., Lemos Legnazzi, B., Barbosa, M., Lardo, M., Morelli, A., Rivera, E., Forskolin-induced U-937 cell line differentiation: A result of a sustained cAMP elevation (1998) Eur J Pharmacol, 350, pp. 121-127 | ||
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| 504 | |a Lemos Legnazzi, B., Shayo, C., Monczor, F., Martin, M.E., Fernandez, N., Brodsky, A., Baldi, A., Davio, C., Rapid desensitization and slow recovery of the cAMP response mediated by histamine H2 receptors in the U937 cell line (2000) Biochem Pharmacol, 60, pp. 159-166 | ||
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| 504 | |a Sallesse, M., Salvatore, L., D'Urbano, E., Sala, G., Storto, M., Launey, T., Nicoletti, F., De Blasi, A., The G-protein-coupled receptor kinase GRK4 mediates homologous desensitization of metabotropic glutamate receptor 1 (2000) FASEB J, 14, pp. 2569-2580 | ||
| 504 | |a Shayo, C., Davio, C., Brodsky, A., Mladovan, A., Lemos Legnazzi, B., Rivera, E., Baldi, A., Histamine modulates the expression of c-fos through cyclic AMP production via the H2 receptor in the human promonocytic cell line U-937 (1997) Mol Pharmacol, 51, pp. 983-990 | ||
| 504 | |a Shayo, C., Fernandez, N., Lemos Legnazzi, B., Monczor, F., Mladovan, A., Baldi, A., Davio, C., Histamine H2 receptor desensitization. Involvement of a select array of G protein-coupled receptor kinases (GRKs) (2001) Mol Pharmacol, 60, pp. 1049-1056 | ||
| 504 | |a Tasaka, K., Doi, M., Nakaya, N., Mio, M., Reinforcement effect of histamine on the differentiation of murine myeloblast and promyelocytes: Externalization of granulocyte colony-stimulating factor receptors induced by histamine (1994) Mol Pharmacol, 45, pp. 837-845 | ||
| 504 | |a Teramoto, H., Crespo, P., Coso, O.A., Igishi, T., Xu, N., Gutkind, J.S., The small GTP-binding protein rho activates c-Jun N-terminal kinases/stress-activated protein kinases in human kidney 293T cells. Evidence for a Pak-independent signaling pathway (1996) J Biol Chem, 271, pp. 25731-25734 | ||
| 504 | |a Troispoux, C., Guillou, F., Elalouf, J.M., Firsov, D., Iacovelli, L., De Blassi, A., Combarnous, Y., Reiter, E., Involvement of G protein-coupled receptor kinases and arrestins in desensitization to follicle-stimulating hormone action (1999) Mol Endocrinol, 13, pp. 1599-1614 | ||
| 504 | |a Willets, J.M., Parent, J., Benovic, J.L., Kelly, E., Selective reduction in A2 adenosine receptor desensitization following antisense-induced suppression of G protein-coupled receptor kinase 2 expression (1999) J Neurochem, 73, pp. 1781-1789 | ||
| 504 | |a Zhu, Y., Michalovich, D., Wu, H.-L., Tan, K.B., Dytko, G.M., Mannan, I.J., Boyce, R., Li, X., Cloning, expression and pharmacological characterization of a novel human histamine receptor (2001) Mol Pharmacol, 59, pp. 434-441 | ||
| 520 | 3 | |a Histamine and H2 agonists transiently induce an important cAMP response in promonocytic U-937 cells but fail to induce monocytic differentiation because of a rapid receptor desensitization mediated by G protein-coupled receptor kinases (GRKs). The aims of the present study were to investigate the participation of GRK2 in the desensitization mechanism of the H2 receptor in U-937 cells by reducing GRK2 levels through antisense technology and to evaluate the differentiating capacity of cells expressing lower GRK2 level, stimulated by H2 agonists. By stable U-937 cell transfection with a GRK2-antisense cDNA, we obtained D5 and A2 cell clones exhibiting a reduction in GRK2 expression and an H3 clone with no significant difference in GRK2 expression from control cells. The cAMP response induced by the H2 agonist in D5 and A2 but not in H3 cells was higher than in U-937 and persisted for a longer period of time, although the number of H2 receptors in D5 and A2 cells was lower than in U-937. Furthermore, D5 and A2 cells treated with H2 agonist showed patterns of c-Fos and CD88 expression consistent with monocytic differentiated cells. Overall, these results indicate a direct correlation between the expression of GRK2 and the desensitization of natively expressed H2 receptors in U-937 cells, suggesting that GRK2 plays a major role in the regulation of these receptors' response. In turn, desensitization process is a key component of H2 receptor signaling, determining the differentiation capability of promonocytic cells. |l eng | |
| 593 | |a Natl. Research Council of Argentina, Buenos Aires, Argentina | ||
| 593 | |a Inst. of Biol./Exp. Medicine, Obligado 2490, (1428) Buenos Aires, Argentina | ||
| 593 | |a Radioisotopes Laboratory, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Department of Physiology, School of Sciences, University of Buenos Aires, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a COMPLEMENT COMPONENT C5A RECEPTOR |
| 690 | 1 | 0 | |a COMPLEMENTARY DNA |
| 690 | 1 | 0 | |a CYCLIC AMP |
| 690 | 1 | 0 | |a G PROTEIN COUPLED RECEPTOR KINASE 2 |
| 690 | 1 | 0 | |a HISTAMINE H2 RECEPTOR |
| 690 | 1 | 0 | |a HISTAMINE H2 RECEPTOR AGONIST |
| 690 | 1 | 0 | |a PROTEIN C FOS |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CELL CLONING |
| 690 | 1 | 0 | |a CELL DIFFERENTIATION |
| 690 | 1 | 0 | |a CELL MATURATION |
| 690 | 1 | 0 | |a CELL STRAIN U937 |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a GENE EXPRESSION |
| 690 | 1 | 0 | |a GENE TECHNOLOGY |
| 690 | 1 | 0 | |a GENETIC TRANSFECTION |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a HUMAN CELL |
| 690 | 1 | 0 | |a MONOCYTE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a RECEPTOR DOWN REGULATION |
| 690 | 1 | 0 | |a SIGNAL TRANSDUCTION |
| 690 | 1 | 0 | |a BETA-ADRENERGIC RECEPTOR KINASE |
| 690 | 1 | 0 | |a CELL AGING |
| 690 | 1 | 0 | |a CYCLIC AMP |
| 690 | 1 | 0 | |a CYCLIC AMP-DEPENDENT PROTEIN KINASES |
| 690 | 1 | 0 | |a DNA, ANTISENSE |
| 690 | 1 | 0 | |a HISTAMINE AGONISTS |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a MONOCYTES |
| 690 | 1 | 0 | |a RECEPTORS, HISTAMINE H2 |
| 690 | 1 | 0 | |a U937 CELLS |
| 700 | 1 | |a Monczor, F. | |
| 700 | 1 | |a Lemos, B. | |
| 700 | 1 | |a Notcovich, C. | |
| 700 | 1 | |a Baldi, A. | |
| 700 | 1 | |a Davio, C. | |
| 700 | 1 | |a Shayo, C. | |
| 773 | 0 | |d 2002 |g v. 62 |h pp. 1506-1514 |k n. 6 |p Mol. Pharmacol. |x 0026895X |t Molecular Pharmacology | |
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| 856 | 4 | 0 | |u https://doi.org/10.1124/mol.62.6.1506 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_0026895X_v62_n6_p1506_Fernandez |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0026895X_v62_n6_p1506_Fernandez |y Registro en la Biblioteca Digital |
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