Effect of fatty acids on arenavirus replication: Inhibition of virus production by lauric acid
To study the functional involvement of cellular membrane properties on arenavirus infection, saturated fatty acids of variable chain length (C10-C18) were evaluated for their inhibitory activity against the multiplication of Junin virus (JUNV). The most active inhibitor was lauric acid (C12), which...
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2001
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 10350caa a22010817a 4500 | ||
|---|---|---|---|
| 001 | PAPER-2023 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203121.0 | ||
| 008 | 190411s2001 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0035003166 | |
| 024 | 7 | |2 cas |a Fatty Acids; lauric acid, 143-07-7; Lauric Acids; Membrane Glycoproteins; Triglycerides; Viral Proteins | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a ARVID | ||
| 100 | 1 | |a Bartolotta, S. | |
| 245 | 1 | 0 | |a Effect of fatty acids on arenavirus replication: Inhibition of virus production by lauric acid |
| 260 | |c 2001 | ||
| 270 | 1 | 0 | |m Damonte, E.B.; Departamento de Quimica Biologica, Fac. de Cien. Exactas y Naturales, UBA, Ciudad Universitaria, Pabellón 2, Piso 4, 1428 Buenos Aires, Argentina; email: edamonte@qb.fcen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a To study the functional involvement of cellular membrane properties on arenavirus infection, saturated fatty acids of variable chain length (C10-C18) were evaluated for their inhibitory activity against the multiplication of Junin virus (JUNV). The most active inhibitor was lauric acid (C12), which reduced virus yields of several attenuated and pathogenic strains of JUNV in a dose dependent manner, without affecting cell viability. Fatty acids with shorter or longer chain length had a reduced or negligible anti-JUNV activity. Lauric acid did not inactivate virion infectivity neither interacted with the cell to induce a state refractory to virus infection. From mechanistic studies, it can be concluded that lauric acid inhibited a late maturation stage in the replicative cycle of JUNV. Viral protein synthesis was not affected by the compound, but the expression of glycoproteins in the plasma membrane was diminished. A direct correlation between the inhibition of JUNV production and the stimulation of triacylglycerol cell content was demonstrated, and both lauric-acid induced effects were dependent on the continued presence of the fatty acid. Thus, the decreased insertion of viral glycoproteins into the plasma membrane, apparently due to the increased incorporation of triacylglycerols, seems to cause an inhibition of JUNV maturation and release. |l eng | |
| 593 | |a Laboratorio de Virología, Fac. de Ciencias Exactas y Naturales, Ciudad Universitaria, Buenos Aires, Argentina | ||
| 593 | |a Depto. de Quím. Biol., Fac. de Ciencias Exactas y Naturales, Ciudad Universitaria, Pabellón 2, Piso 4, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a ARENAVIRUS |
| 690 | 1 | 0 | |a CELL MEMBRANE |
| 690 | 1 | 0 | |a CELL STIMULATION |
| 690 | 1 | 0 | |a JUNIN VIRUS |
| 690 | 1 | 0 | |a LAURIC ACID |
| 690 | 1 | 0 | |a SATURATED FATTY ACID |
| 690 | 1 | 0 | |a TRIACYLGLYCEROL |
| 690 | 1 | 0 | |a VIRION |
| 690 | 1 | 0 | |a VIRUS GLYCOPROTEIN |
| 690 | 1 | 0 | |a VIRUS INFECTION |
| 690 | 1 | 0 | |a VIRUS PROTEIN |
| 690 | 1 | 0 | |a VIRUS REPLICATION |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a CELL LINE |
| 690 | 1 | 0 | |a CERCOPITHECUS AETHIOPS |
| 690 | 1 | 0 | |a DOSE-RESPONSE RELATIONSHIP, DRUG |
| 690 | 1 | 0 | |a FATTY ACIDS |
| 690 | 1 | 0 | |a INHIBITORY CONCENTRATION 50 |
| 690 | 1 | 0 | |a JUNIN VIRUS |
| 690 | 1 | 0 | |a LAURIC ACIDS |
| 690 | 1 | 0 | |a MEMBRANE GLYCOPROTEINS |
| 690 | 1 | 0 | |a MICROBIAL SENSITIVITY TESTS |
| 690 | 1 | 0 | |a TRIGLYCERIDES |
| 690 | 1 | 0 | |a VERO CELLS |
| 690 | 1 | 0 | |a VIRAL PROTEINS |
| 690 | 1 | 0 | |a VIRION |
| 690 | 1 | 0 | |a VIRUS REPLICATION |
| 690 | 1 | 0 | |a ARENAVIRUS |
| 690 | 1 | 0 | |a JUNIN VIRUS |
| 700 | 1 | |a García, C.C. | |
| 700 | 1 | |a Candurra, N.A. | |
| 700 | 1 | |a Damonte, E.B. | |
| 773 | 0 | |d 2001 |g v. 146 |h pp. 777-790 |k n. 4 |p Arch. Virol. |x 03048608 |t Archives of Virology | |
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| 856 | 4 | 0 | |u https://doi.org/10.1007/s007050170146 |y DOI |
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