Comparison of subcutaneous apomorphine versus dispersible madopar latency and effect duration in parkinson's disease patients: A double-blind single-dose study

Twelve parkinsonian patients with severely fluctuating symptoms were given a single dose of apomorphine or Dispersible Madopar on 2 consecutive days, to confirm the latter drug's usefulness in 'off' period rescue. According to our results, apomorphine proved faster in reverting '...

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Autor principal: Merello, M.
Otros Autores: Pikielny, R., Cammarota, A., Leiguarda, R.
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: Lippincott Williams and Wilkins 1997
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Acceso en línea:Registro en Scopus
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024 7 |2 cas  |a apomorphine, 314-19-2, 58-00-4; benserazide plus levodopa, 37270-69-2; levodopa, 59-92-7 
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100 1 |a Merello, M. 
245 1 0 |a Comparison of subcutaneous apomorphine versus dispersible madopar latency and effect duration in parkinson's disease patients: A double-blind single-dose study 
260 |b Lippincott Williams and Wilkins  |c 1997 
270 1 0 |m Merello, M.; Movement Disorders Section, Raul Carrea Neurological Res. Inst., Montaneses 2325, (1428) Buenos Aires, Argentina 
506 |2 openaire  |e Política editorial 
504 |a Marsden, C.D., Parkes, J.D., "On-off" effects in patients with Parkinson's disease on chronic levodopa therapy (1976) Lancet, 1, pp. 292-296 
504 |a Steiger, M.J., Stocchi, F., Bramante, L., Ruggieri, S., Quinn, N.P., The clinical efficacy of single morning dose of levodopa methyl ester: Dispersible Madopar and Sinernet plus in Parkinson's disease (1992) Clin Neuropharmacol, 15, pp. 501-504 
504 |a Steiger, M.J., Stocchi, F., Carta, A., Ruggieri, S., Agnoli, A., Quinn, N.P., Marsden, C.D., The clinical efficacy of oral levodopa methyl ester solution in reversing afternoon "off" periods in Parkinson's disease (1991) Clin Neuropharmacol, 14, pp. 241-244 
504 |a Stibe, C.M.H., Kempster, P.A., Lees, A.J., Stern, G.M., Subcutaneous apomorphine in parkinsonian on-off oscillations (1988) Lancet, 1, pp. 403-406 
504 |a Cooper, D.R., Marrel, C., Testa, B., L-dopa methyl-ester: A candidate for chronic systemic delivery of L-dopa in Parkinson's disease (1984) Clin Neuropharmacol, 7, pp. 89-98 
504 |a Stibe, C.M.H., Lees, A.J., Stern, G.M., Subcutaneous infusion of apomorphine and lisuride in the treatment of parkinsonian on-off fluctuation (1987) Lancet, 1, p. 871 
504 |a Le Witt, P.A., Ward, C.D., Larsen, T.A., Comparison of pergolide and bromocriptine therapy in parkinsonism (1983) Neurology, 33, pp. 1009-1014 
504 |a Hardie, R.J., Lee, A.J., Stern, G.M., On-off fluctuations in Parkinson's disease: A clinical and neuropharmacology studs (1984) Brain, 107, pp. 487-506 
520 3 |a Twelve parkinsonian patients with severely fluctuating symptoms were given a single dose of apomorphine or Dispersible Madopar on 2 consecutive days, to confirm the latter drug's usefulness in 'off' period rescue. According to our results, apomorphine proved faster in reverting 'off' periods and should still be regarded as the drug of choice for this treatment modality.  |l eng 
593 |a Movement Disorders Section, Neurology Department, Raul Carrea Inst. for Neurol. Res., Buenos Aires, Argentina 
593 |a Movement Disorders Section, Raul Carrea Inst. for Neurol. Res., Montañeses 2325, 1428 Buenos Aires, Argentina 
690 1 0 |a 'ON-OFF' PERIODS 
690 1 0 |a APOMORPHINE 
690 1 0 |a DISPERSIBLE MADOPAR 
690 1 0 |a MOTOR FLUCTUATION 
690 1 0 |a PARKINSON'S DISEASE 
690 1 0 |a APOMORPHINE 
690 1 0 |a BENSERAZIDE PLUS LEVODOPA 
690 1 0 |a BRITAJECT 
690 1 0 |a LEVODOPA 
690 1 0 |a UNCLASSIFIED DRUG 
690 1 0 |a ADULT 
690 1 0 |a ARTICLE 
690 1 0 |a CLINICAL ARTICLE 
690 1 0 |a CLINICAL TRIAL 
690 1 0 |a CONTROLLED CLINICAL TRIAL 
690 1 0 |a CONTROLLED STUDY 
690 1 0 |a DOUBLE BLIND PROCEDURE 
690 1 0 |a FEMALE 
690 1 0 |a HUMAN 
690 1 0 |a MALE 
690 1 0 |a MOTOR DYSFUNCTION 
690 1 0 |a ON OFF PHENOMENON 
690 1 0 |a PARKINSON DISEASE 
690 1 0 |a PRIORITY JOURNAL 
690 1 0 |a SUBCUTANEOUS DRUG ADMINISTRATION 
653 0 0 |a britaject; madopar 
700 1 |a Pikielny, R. 
700 1 |a Cammarota, A. 
700 1 |a Leiguarda, R. 
773 0 |d Lippincott Williams and Wilkins, 1997  |g v. 20  |h pp. 165-167  |k n. 2  |p CLIN. NEUROPHARMACOL.  |x 03625664  |t Clinical Neuropharmacology 
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