Histamine modulates the expression of c-fos through cyclic AMP production via the H2 receptor in the human promonocytic cell line U937
We examined the effects of histamine and its agonists on the expression of the c-fos and c-myc proto-oncogenes at the transcriptional and translational levels in the human promonocytic U937 cell line. Histamine transiently increased cAMP and c-fos expression through H2 receptors. Dibutyryl cAMP also...
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| Formato: | Capítulo de libro |
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American Society for Pharmacology and Experimental Therapy
1997
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| LEADER | 13468caa a22012137a 4500 | ||
|---|---|---|---|
| 001 | PAPER-20146 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205132.0 | ||
| 008 | 190411s1997 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0030914524 | |
| 024 | 7 | |2 cas |a 1 (5 isoquinolinesulfonyl) 2 methylpiperazine, 84477-87-2; bucladesine, 16980-89-5, 362-74-3; cyclic AMP, 60-92-4; dimaprit, 65119-89-3; histamine, 51-45-6, 56-92-8, 93443-21-1; prostaglandin E2, 363-24-6 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a MOPMA | ||
| 100 | 1 | |a Shayo, C. | |
| 245 | 1 | 0 | |a Histamine modulates the expression of c-fos through cyclic AMP production via the H2 receptor in the human promonocytic cell line U937 |
| 260 | |b American Society for Pharmacology and Experimental Therapy |c 1997 | ||
| 270 | 1 | 0 | |m Baldi, A.; Biology/Experimental Medicine Inst., Obligado 2490 (1428), Buenos Aires, Argentina; email: abaldi@proteus.dna.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a We examined the effects of histamine and its agonists on the expression of the c-fos and c-myc proto-oncogenes at the transcriptional and translational levels in the human promonocytic U937 cell line. Histamine transiently increased cAMP and c-fos expression through H2 receptors. Dibutyryl cAMP also increased c-fos mRNA and protein, and levels remained elevated even after 12 hr of treatment. Dose-dependence studies using histamine and dimaprit showed that the EC50 values for cAMP production and c-fos increase were similar, suggesting that cAMP might be involved in c-fos induction via H2 receptors. Furthermore, studies carried out using H7, a protein kinase A/protein kinase C inhibitor, blocked c-fos induction, whereas no effect was observed with bisindolylmaleimide, a specific protein kinase C inhibitor. No modification of c-myc expression could be detected on treatment with histamine or its analogues. Nevertheless, dibutyryl cAMP induced a down- regulation of the levels of this proto-oncogene. In addition, dibutyryl cAMP inhibited cell growth in a dose-dependent manner, whereas histamine failed to affect proliferation and differentiation of U937 cells. Cells pretreated with dimaprit showed a decrease in the cAMP response to subsequent addition of H2 agonists, whereas the cAMP response to prostaglandin E2 remained unaltered. This homologous mechanism of H2 receptor desensitization was time dependent. These results indicate that histamine activates several mechanisms involved in the induction of differentiation, such as cAMP and c-fos production, but fails to promote differentiation of U937 cells, apparently due to the rapid desensitization of H2 receptors. |l eng | |
| 593 | |a Inst. of Biol. and Exp. Medicine, Natl. Research Council of Argentina, Obligado 2490, (1428) Buenos Aires, Argentina | ||
| 593 | |a School of Sciences, University of Buenos Aires, Argentina | ||
| 593 | |a School of Pharmacy and Biochemistry, University of Buenos Aires, Junin 956, (1133) Buenos Aires, Argentina | ||
| 593 | |a Inst. of Biol. and Exp. Medicine, Obligado 2490, (1428), Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a 1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE |
| 690 | 1 | 0 | |a BISINDOLYLMALEIMIDE |
| 690 | 1 | 0 | |a BUCLADESINE |
| 690 | 1 | 0 | |a CYCLIC AMP |
| 690 | 1 | 0 | |a CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR |
| 690 | 1 | 0 | |a DIMAPRIT |
| 690 | 1 | 0 | |a HISTAMINE |
| 690 | 1 | 0 | |a HISTAMINE H2 RECEPTOR |
| 690 | 1 | 0 | |a HISTAMINE H2 RECEPTOR ANTAGONIST |
| 690 | 1 | 0 | |a MESSENGER RNA |
| 690 | 1 | 0 | |a PROSTAGLANDIN E2 |
| 690 | 1 | 0 | |a PROTEIN C FOS |
| 690 | 1 | 0 | |a PROTEIN KINASE C INHIBITOR |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CELL DIFFERENTIATION |
| 690 | 1 | 0 | |a CELL GROWTH |
| 690 | 1 | 0 | |a CHEMOTAXIS |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a HISTAMINE RELEASE |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a HUMAN CELL |
| 690 | 1 | 0 | |a MONOCYTE |
| 690 | 1 | 0 | |a ONCOGENE C FOS |
| 690 | 1 | 0 | |a ONCOGENE C MYC |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a STEM CELL |
| 653 | 0 | 0 | |a h 7, Sigma, United States |
| 700 | 1 | |a Davio, C. | |
| 700 | 1 | |a Brodsky, A. | |
| 700 | 1 | |a Mladovan, A.G. | |
| 700 | 1 | |a Legnazzi, B.L. | |
| 700 | 1 | |a Rivera, E. | |
| 700 | 1 | |a Baldi, A. | |
| 773 | 0 | |d American Society for Pharmacology and Experimental Therapy, 1997 |g v. 51 |h pp. 983-990 |k n. 6 |p MOL. PHARMACOL. |x 0026895X |t Molecular Pharmacology | |
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