α-Difluoromethylornithine modifies gonadotropin-releasing hormone release and follicle-stimulating hormone secretion in the immature female rat
Polyamines play an essential role in tissue growth and differentiation, in body weight increment, in brain organization, and in the molecular mechanisms of hormonal action, intracellular signaling, and cell-to-cell communication. In a previous study, inhibition of their synthesis by α- difluoromethy...
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1997
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| LEADER | 14237caa a22012617a 4500 | ||
|---|---|---|---|
| 001 | PAPER-20065 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205127.0 | ||
| 008 | 190411s1997 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0031011546 | |
| 024 | 7 | |2 cas |a eflornithine, 67037-37-0, 70052-12-9; follitropin, 9002-68-0; gonadorelin, 33515-09-2, 9034-40-6; luteinizing hormone, 39341-83-8, 9002-67-9; prolactin, 12585-34-1, 50647-00-2, 9002-62-4; Eflornithine, 70052-12-9; Follicle Stimulating Hormone, 9002-68-0; Gonadotropin-Releasing Hormone, 33515-09-2; Luteinizing Hormone, 9002-67-9; Potassium, 7440-09-7; Prolactin, 9002-62-4; Receptors, LHRH | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a PSEBA | ||
| 100 | 1 | |a Thyssen, S.M. | |
| 245 | 1 | 0 | |a α-Difluoromethylornithine modifies gonadotropin-releasing hormone release and follicle-stimulating hormone secretion in the immature female rat |
| 260 | |c 1997 | ||
| 270 | 1 | 0 | |m Libertun, C.; Laboratorio de Neuroendocrinologia, Insto. Biologia Med. Experimental, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Sltokin, T.A., Bartolome, J., Role of ornithine decarboxylase and the polyamines in nervous system development: A review (1986) Brain Res Bull, 17, pp. 307-320 | ||
| 504 | |a Gilad, G.M., Dornay, M., Gilad, V.H., Polyamines induce precocious development in rats. Possible interaction with growth factors (1989) Int J Dev Neurosci, 7, pp. 641-653 | ||
| 504 | |a Khan, N.A., Quemener, V., Moulinoux, J.-P., Polyamine membrane transport regulation (1991) Cell Biol Int Reports, 15, pp. 9-24 | ||
| 504 | |a Scalabrino, G., Lorenzini, E.C., Ferioli, M.E., Polyamines and mammalian hormones. Part I: Biosynthesis, interconversion and hormone effects (1991) Mol Cell Endocrinol, 77, pp. 1-35 | ||
| 504 | |a Scalabrino, G., Lorenzini, E.C., Polyamines and mammalian hormones. Part II: Paracrine signals and intracellular regulators (1991) Mol Cell Endocrinol, 77, pp. 37-56 | ||
| 504 | |a Slotkin, T.A., Seidler, F.J., Trepanier, P.A., Whitmore, W.L., Lerea, L., Barnes, G.A., Weigel, S.J., Bartolome, J., Ornithine decarboxylase and polyamines in tissues of the neonatal rat: Effects of α-difluoromethylornithine, a specific, irreversible inhibitor of ornithine decarboxylase (1982) J Pharmacol Exp Ther, 222, pp. 741-745 | ||
| 504 | |a Najm, I., Vanderklish, P., Lynch, G., Baudry, M., Effect of treatment with difluoromethylornithine on polyamine and spectrin breakdown levels in neonatal rat brain (1991) Dev Brain Res, 63, pp. 287-289 | ||
| 504 | |a Bartolome, J.V., Schweitzer, L., Slotkin, T.A., Nadler, J.V., Impaired development of cerebellar cortex in rats treated postnatally with α-difluoromethylornithine (1985) Neuroscience, 15, pp. 203-213 | ||
| 504 | |a Slotkin, T.A., Grignolo, A., Whitmore, W.L., Lerea, L., Trepanier, P.A., Barnes, G.A., Weigel, S.J., Bartolome, J., Impaired development of central and peripheral catecholamine neurotransmitter systems in preweanling rats treated with α-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase (1982) J Pharmacol Exp Ther, 222, pp. 746-751 | ||
| 504 | |a White, W.F., Cohen, A.I., Rippel, R.H., Story, J.C., Schally, A.V., Some hypothalamic polyamines that deplete pituitary follicle stimulating hormone (1968) Endocrinology, 82, pp. 742-752 | ||
| 504 | |a Persson, L., Nilsson, M., Rosengren, E., Ornithine decarboxylase activity and polyamines in the anterior pituitary gland during the rat oestrous cycle (1985) J Endocrinol, 107, pp. 83-87 | ||
| 504 | |a Aslam, M., Nicholson, S., Gillham, B., Jones, M., Permissive role for ornithine decarboxylase and putrescine in the luteinizing hormone surge (1987) Neuroendocrinology, 45, pp. 473-478 | ||
| 504 | |a Nicholson, S.A., Wynne-Jones, G.A., Differential effect of difluoromethylornithine on the increases in plasma concentrations of reproductive hormones on the afternoon of pro-oestrus in the rat (1989) J Endocrinol, 121, pp. 495-499 | ||
| 504 | |a Thyssen, S.M., Libertun, C., α-Difluoromethylornithine modifies FSH secretion and puberty onset in the female rat (1996) Proc Soc Exp Biol Med, 211, pp. 76-80 | ||
| 504 | |a Becu De Villalobos, D., Lux, V.A.R., Lacau De Mengido, I.M., Libertun, C., Sexual differences in the serotoninergic control of prolactin and luteinizing hormone secretion in the rat (1984) Endocrinology, 115, pp. 84-89 | ||
| 504 | |a Lacau-Mengido, I.M., Becu-Villalobos, D., Thyssen, S.M., Rey, E.B., LuxLantos, V.A.R., Libertun, C., Antidopaminergic-induced hypothalamic LHRH release and pituitary gonadotrophin secretion in 12 day-old female and male rats (1993) J Neuroendocrinol, 5, pp. 705-709 | ||
| 504 | |a Clayton, R.N., Catt, K.J., Gonadotropin-releasing hormone receptors: Characterization, physiological regulation, and relationship to reproductive function (1981) Endocr Rev, 2, pp. 185-209 | ||
| 504 | |a Pieper, D.R., Richards, J.S., Marshall, J.C., Ovarian gonadotropin-releasing hormone (GnRH) receptors: Characterization, distribution, and induction by GnRH (1981) Endocrinology, 108, pp. 1148-1155 | ||
| 504 | |a Marchetti, B., Labrie, F., Prolactin inhibits pituitary luteinizing hormone-releasing hormone receptors in the rat (1982) Endocrinology, 111, pp. 1209-1216 | ||
| 504 | |a Ellinwood, W.E., Ronnekleiv, O.K., Kelly, M.J., Resko, J.A., A new antiserum with conformational specificity for LHRH: Usefulness for radio-immunoassay and Immunocytochemistry (1985) Peptides, 6, pp. 45-52 | ||
| 504 | |a Becu-Villalobos, D., Lacau-Mengido, I.M., Thyssen, S.M., Diaz-Torga, G.S., Libertun, C., Effects of LHRH and Ang II on prolactin stimulation are mediated by hypophysial ATl receptor subtype (1994) Am J Physiol Endocrinol Metab, 266, pp. E274-E278 | ||
| 504 | |a Becu-Villalobos, D., Lacau-Mengido, I.M., Libertun, C., Ontogenic studies of the neural control of the adenohypophyseal hormones in the rat: Gonadotropins (1990) Cell Mol Neurobiol, 10, pp. 473-484 | ||
| 504 | |a Becu-Villalobos, D., Lacau-Mengido, I.M., Diaz-Torga, G., Libertun, C., Ontogenic studies of the neural control of adenohypophyseal hormones in the rat: Prolactin (1992) Cell Mol Neurobiol, 12, pp. 1-19 | ||
| 504 | |a Lacau De Mengido, I.M., Becu-Villalobos, D., Diaz, G., Libertun, C., Chronic activation of dopamine receptors in the female infantile rat: Effect on hypophyseal hormones and on the onset of puberty (1989) Endocrinology, 124, pp. 746-753 | ||
| 504 | |a Hage, A.J., Groen-Klevant, A.C., Welschen, R., Follicle growth in the immature rat ovary (1978) Acta Endocrinol, 88, pp. 375-382 | ||
| 504 | |a Schwartz, N.B., The role of FSH and LH and of their antibodies on follicle growth and on ovulation (1974) Biol Reprod, 10, pp. 236-272 | ||
| 504 | |a Ojeda, S.R., Urbanski, H.F., Puberty in the rat (1994) The Physiology of Reproduction, pp. 363-410. , Knobil E, Neill J, Eds. New York: Raven Press | ||
| 504 | |a Becu-Villalobos, D., Lacau De Mengido, I.M., Libertun, C., Developmental changes in FSH secretion induced by 5-hydroxytryptophan, naloxone and haloperidol in male and female rats (1989) Dev Brain Res, 47, pp. 181-186 | ||
| 504 | |a Becu-Villalobos, D., Lacau-Mengido, I.M., Libertun, C., Sexual differentiation of the brain is involved in 5-hydroxytryptophan- and naloxone-induced FSH release in the infantile rat (1990) Neuroendocrinol Lett, 12, pp. 435-442 | ||
| 504 | |a Dohler, K.D., Wuttke, W., Serum, L.H., FSH, prolactin and progesterone from birth to puberty in female and male rats (1974) Endocrinology, 94, pp. 1003-1008 | ||
| 504 | |a Van Den Dungen, H.M., Van Dieten, J.A.M.J., Tilders, F.J.H., Van Rees, G.P., Schoemaker, J., Administration of a GnRH-antagonist to immature rats affects subsequent female and male pubertal development differently (1989) Acta Endocrinol, 120, pp. 778-784 | ||
| 504 | |a Wray, S., Gainer, H., Effect of neonatal gonadectomy on postnatal development in rat LHRH cell subtypes in male and female rats (1987) Neuroendocrinology, 45, pp. 413-419 | ||
| 504 | |a Lamberts, S.W.J., MacLeod, R.M., Regulation of prolactin secretion at the level of the lactotroph (1990) Physiol Rev, 70, pp. 279-318 | ||
| 504 | |a Kamberi, L.A., McCann, S.M., Effect of biogenic amines, FSH-releasing factor (FRF) and other substances on the release of FSH by pituitaries incubated "in vitro." (1969) Endocrinology, 85, pp. 815-824 | ||
| 504 | |a Ramaley, J.A., Pituitary gonadotropin-releasing hormone responsiveness in the prepubertal period: Effect of delayed puberty onset (1982) Neuroendocrinology, 34, pp. 387-394 | ||
| 504 | |a Dalkin, A.C., Bourne, G.A., Pieper, D.R., Regiani, S., Marshall, J.C., Pituitary and gonadal gonadotropin-releasing hormone receptors during sexual maturation in the rat (1981) Endocrinology, 108, pp. 1658-1664 | ||
| 520 | 3 | |a Polyamines play an essential role in tissue growth and differentiation, in body weight increment, in brain organization, and in the molecular mechanisms of hormonal action, intracellular signaling, and cell-to-cell communication. In a previous study, inhibition of their synthesis by α- difluoromethylornithine (DFMO), a specific and irreversible inhibitor of ornithine decarboxylase, during development in female rats, was followed by prolonged high follicle-stimulating hormone (FSH) serum level and a delayed puberty onset. Those changes were relatively independent of body mass and did not impair posterior fertility. The present work studies the mechanisms and site of action of polyamine participation in FSH secretion during development. DFMO was injected in female rats between Days 1 and 9 on alternate days. At 10 days of age, hypothalami from control and DFMO rats were perifused in vitro, and basal and potassium-induced gonadotropin- releasing hormone (GnRH) release were measured. The response to membrane depolarization was altered in DFMO hypothalami. Increased GnRH release in response to a low K + concentration was evidenced. Adenohypophyses of the same treated prepubertal rats were perifused in vitro and the response to GnRH pulses was checked. In DFMO-treated rats, higher FSH release was observed, with no changes in LH or PRL secretion. Finally, pituitary GnRH receptor number in adenohypophyseal membranes from treated and control groups was quantified. A significant reduction in specific binding was evident in hypophyses from DFMO-treated rats when compared with binding in the control group. In summary, DFMO treatment in a critical developmental period in the female rat impacts the immature GnRH neuronal network and immature gonadotropes. A delay in maturation is evidenced by a higher sensitivity to secretagogs in both pituitary glands and hypothalamic explants. These events could explain the prolonged high FSH serum levels and delayed puberty onset seen in this experimental model. |l eng | |
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires | ||
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires | ||
| 536 | |a Detalles de la financiación: Fundación Antorchas | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: Thyssen Sandra M. 1 Becú-Villalobos Damasia Lacau-Mengido Isabel M. 2 Libertun Carlos 2 3 Laboratory of Neuroendocrinology, Institute of Biology and Experimental Medicine-CONICET, 1428 Buenos Aires, Argentina 1 Research Fellow, UBA. 2 Research investigator, CONICET. 3 To whom reprint requests should be addressed at Laboratorio de Neuroendocrinologia, Instituto de Biologia y Medicina Experimental, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina. This work was supported by the University of Buenos Aires (UBA), Consejo Nacional de Investigaciones Cientificas y Técnicas (CONICET), and Fundación Antorchas, Argentina. 6 1997 215 2 192 197 | ||
| 593 | |a UBA, Argentina | ||
| 593 | |a CONICET, Argentina | ||
| 593 | |a Laboratorio de Neuroendocrinologia, Instituto de Biologia y Medicina Experimental, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina | ||
| 593 | |a Laboratory of Neuroendocrinology, Institute of Biology and Experimental Medicine-CONICET, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a EFLORNITHINE |
| 690 | 1 | 0 | |a FOLLITROPIN |
| 690 | 1 | 0 | |a GONADORELIN |
| 690 | 1 | 0 | |a LUTEINIZING HORMONE |
| 690 | 1 | 0 | |a POLYAMINE |
| 690 | 1 | 0 | |a PROLACTIN |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DELAYED PUBERTY |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a FOLLITROPIN BLOOD LEVEL |
| 690 | 1 | 0 | |a GONADORELIN RELEASE |
| 690 | 1 | 0 | |a IMMATURITY |
| 690 | 1 | 0 | |a LUTEINIZING HORMONE RELEASE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PROLACTIN RELEASE |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a EFLORNITHINE |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a FOLLICLE STIMULATING HORMONE |
| 690 | 1 | 0 | |a GONADOTROPIN-RELEASING HORMONE |
| 690 | 1 | 0 | |a LUTEINIZING HORMONE |
| 690 | 1 | 0 | |a PITUITARY GLAND, ANTERIOR |
| 690 | 1 | 0 | |a POTASSIUM |
| 690 | 1 | 0 | |a PROLACTIN |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RATS, SPRAGUE-DAWLEY |
| 690 | 1 | 0 | |a RECEPTORS, LHRH |
| 690 | 1 | 0 | |a SECRETORY RATE |
| 690 | 1 | 0 | |a ANIMALIA |
| 700 | 1 | |a Becú-Villalobos, D. | |
| 700 | 1 | |a Lacau-Mengido, I.M. | |
| 700 | 1 | |a Libertun, C. | |
| 773 | 0 | |d 1997 |g v. 215 |h pp. 192-197 |k n. 2 |p PROC. SOC. EXP. BIOL. MED. |x 00379727 |w (AR-BaUEN)CENRE-2685 |t Proceedings of the Society for Experimental Biology and Medicine | |
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| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00379727_v215_n2_p192_Thyssen |y Handle |
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| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||