Reference values of 5-Aminolevulinate dehydrase and Porphobilinogen deaminase in the Spanish population from Madrid
5-Aminolevulinate dehydrase (ALA-D) and porphobilinogen deaminase (PBG- D) are cytosolic enzymes involved in heme biosynthesis. ALA-D activity is altered both genetically and by the action of various environmental factors, including exposure to lead. The activity of PBG-D is reduced in acute intermi...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
Academic Press
1998
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 08314caa a22009137a 4500 | ||
|---|---|---|---|
| 001 | PAPER-19915 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205118.0 | ||
| 008 | 190411s1998 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0032031929 | |
| 024 | 7 | |2 cas |a porphobilinogen deaminase, 9036-47-9, 9074-91-3; porphobilinogen synthase, 9036-37-7 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a EESAD | ||
| 100 | 1 | |a Santos, J.L. | |
| 245 | 1 | 0 | |a Reference values of 5-Aminolevulinate dehydrase and Porphobilinogen deaminase in the Spanish population from Madrid |
| 260 | |b Academic Press |c 1998 | ||
| 270 | 1 | 0 | |m Santos, J.L.; Porphyria Unit, Hosp. Universitario 'Doce Octubre', Madrid, Spain |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Anderson, P.M., Desnick, R.J., Porphobilinogen deaminase: Methods and principles of the enzymatic assay (1982) Enzyme, 28, pp. 146-157 | ||
| 504 | |a Baghurst, P.A., McMichael, A.J., Wigg, N.R., Vimpani, G.V., Robertson, E.F., Roberts, R.J., Tong, S.L., Environmental exposure to lead and children's intelligence at the age of seven years (1992) N. Engl. J. Med., 327, pp. 1279-1284 | ||
| 504 | |a Berlin, A., Schaller, K.H., European standardized method for the determination of aminolevulinic acid dehydratase activity in blood (1974) J. Clin. Chem. Clin. Biochem., 12, pp. 389-390 | ||
| 504 | |a Bland, M., Clinical Measurement (1995) An Introduction of Medical Statistics, , Oxford: Oxford Univ. Press. p. 276-279 | ||
| 504 | |a Bottomley, S.S., Muller-Eberhard, U., Pathophysiology of heme synthesis (1988) Semin. Hematol., 25, pp. 282-302 | ||
| 504 | |a Elder, G.H., Hift, R.J., Meissner, P.N., The acute porphyrias (1997) Lancet, 349, pp. 1613-1617 | ||
| 504 | |a Fontanellas, A., Coronel, F., Santos, J.L., Herrero, J.A., Moran, M.J., Guerra, P., Tornero, F., Enríquez De Salamanca, R., Heme biosynthesis in uremic patients on CAPD or hemodialysis (1994) Kidney Int., 45, pp. 220-223 | ||
| 504 | |a Fujita, H., Oriil, Y., Sano, S., Evidence of increased synthesis of 5-aminolevulinic acid dehydratase in experimental lead poisioned rats (1981) Biochim. Biophys. Acta., 678, pp. 39-50 | ||
| 504 | |a Geisse, S., Brüller, J., Doss, M., Porphobilinogen synthase (δ-aminolevulinic acid dehydratase) activity in human erythrocyte: Reactivation by zinc and dithiothreitol depending on influence of storage (1983) Clin. Chim. Acta, 135, pp. 239-245 | ||
| 504 | |a Gulson, B.L., Mahaffey, K.R., Mizon, K.J., Korsch, M.J., Cameron, M.A., Vimpani, G., Contribution of tissue lead to blood lead in adult female subjects based on stable lead isotope methods (1995) J. Lab. Clin. Med., 125, pp. 703-712 | ||
| 504 | |a Kappas, A., Sassa, S., Galbraith, R.A., Nordmann, Y., The porphyrias (1989) The Metabolic Basis of Inherited Diseases, , New York: McGraw-Hill. p. 939-1007 | ||
| 504 | |a Kleinbaum, D.G., Kupper, L.L., Muller, K.E., Testing hypothesis in multiple regression (1988) Applied Regression Analysis and Other Multivariable Methods, , Boston: PWS-Kent. p. 124-143 | ||
| 504 | |a McColl, K.E.L., Moore, M.R., Thompson, G.G., Goldberg, A., Abnormal heam biosynthesis in chronic alcoholics (1981) Eur. J. Clin. Invest., 11, pp. 461-468 | ||
| 504 | |a Mitchell, R.A., Drake, J.E., Wittlin, L.A., Rejent, T.A., Erythrocyte porphobilinogen synthase (delta aminolevulinate dehydratase) activity: A reliable and quantitative indicator of lead exposure in humans (1977) Clin. Chem., 23, pp. 273-280 | ||
| 504 | |a Moore, M.R., Lead poisoning (1986) Semin. Dermatol., 5, pp. 169-177 | ||
| 504 | |a Moore, M.R., Disler, P.B., Chemistry and biochemistry of the porphyrins and porphyrias (1985) Clin. Dermatol., 3, pp. 7-23 | ||
| 504 | |a Passing, H., Bablock, W., A new biometrical procedure for testing the equality of measurements from two different analytical methods (1983) Clin. Chem. Clin. Biochem., 21, pp. 709-720 | ||
| 504 | |a Piepkorn, M.W., Hamernyik, P., Labbe, P.K., Modified erythrocyte uroporphyrinogen I synthase assay and its clinical interpretation (1978) Clin. Chem., 24, pp. 1751-1754 | ||
| 504 | |a Polo, C.F., Afonso, S.G., Navone, N.M., Rossetti, M.V., Batlle, A.M.C., Zinc aminolevulinic acid dehydratase reactivation index as a tool for diagnosis of lead exposure (1995) Ecotoxicol. Environ. Saf., 32, pp. 267-272 | ||
| 504 | |a Rodríguez, L.H., (1996) Un Paquete Estadístico Computacional Para Comparación de Métodos Diagnósticos en Química Clínica e Inmunolgía, , Universidad de Chile, Santiago de Chile | ||
| 504 | |a Sakai, T., Mortia, Y., Delta aminolevulinic acid in plasma or whole blood as a sensitive indicator of lead effects, and its relation to the other heme-related parameters (1996) Int. Arch. Occup. Environ. Health, 68, pp. 126-132 | ||
| 504 | |a Simmonds, P.L., Luckhurst, C.L., Woods, J.S., Quantitative evaluation of heme biosynthetic pathway parameters as biomarkers of low-level lead exposure in rats (1995) J. Toxicol. Environ. Health, 44, pp. 351-367 | ||
| 504 | |a (1995) Stata Statistical Software Release 4.0, , Stata Corp, College Station, TX | ||
| 504 | |a Turk, D.S., Schonfeld, D.J., Cullen, M., Rainey, P., Sensitivity of erythrocyte protoporphyrin as a screening test for lead poisoning (1992) N. Engl. J. Med., 326, pp. 137-138 | ||
| 520 | 3 | |a 5-Aminolevulinate dehydrase (ALA-D) and porphobilinogen deaminase (PBG- D) are cytosolic enzymes involved in heme biosynthesis. ALA-D activity is altered both genetically and by the action of various environmental factors, including exposure to lead. The activity of PBG-D is reduced in acute intermittent porphyria. The aim of this work is to establish the 95% reference range of the erythrocytic activity of ALA-D and PBG-D in a control population. ALA-D activity limits were 15.8 and 50.2 nmol of PBG/ml of red blood cells (RBCS) per minute. For the activity of ALA-D restored by addition of zinc and dithiothreitol ('restored ALA-D'), these limits were 44.1 and 86.5 units. It has been found that the 'restored ALA-D'/ALA-D ratio is very useful for the evaluation of lead toxicity, and its 95% reference range was between 1.22 and 3.06. It has been demonstrated that the best method for measuring erythrocytic PBG-D is using PBG, but not ALA, as substrate; its 95% reference range was between 20.9 and 63.2 nmol of uroporphyrin/ml of RBCs per hour. Knowledge of these reference range values in a control population constitutes the basis for an accurate diagnosis of heavy metal intoxication and acute intermittent porphyria. |l eng | |
| 593 | |a Porphyria Unit, Hosp. Universitario Doce de Octubre, Madrid, Spain | ||
| 593 | |a Ctro. de Invest. Sobre Porfirinas Y., Ciudad Universitaria, Pabellon II, 2do Piso, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a AMINOLEVULINATE DEHYDRASE |
| 690 | 1 | 0 | |a PORPHOBILINOGEN DEAMINASE |
| 690 | 1 | 0 | |a REFERENCE RANGE |
| 690 | 1 | 0 | |a PORPHOBILINOGEN DEAMINASE |
| 690 | 1 | 0 | |a PORPHOBILINOGEN SYNTHASE |
| 690 | 1 | 0 | |a ADOLESCENT |
| 690 | 1 | 0 | |a ADULT |
| 690 | 1 | 0 | |a AGED |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CHILD |
| 690 | 1 | 0 | |a CYTOSOL |
| 690 | 1 | 0 | |a ENZYME ACTIVITY |
| 690 | 1 | 0 | |a ENZYME ANALYSIS |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HEME SYNTHESIS |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a LEAD POISONING |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a NORMAL HUMAN |
| 690 | 1 | 0 | |a PORPHYRIA |
| 690 | 1 | 0 | |a REFERENCE VALUE |
| 690 | 1 | 0 | |a SPAIN |
| 700 | 1 | |a Fontanellas, A. | |
| 700 | 1 | |a Batlle, A.M.C. | |
| 700 | 1 | |a De Salamanca, R.E. | |
| 773 | 0 | |d Academic Press, 1998 |g v. 39 |h pp. 168-171 |k n. 3 |p Ecotoxicol. Environ. Saf. |x 01476513 |w (AR-BaUEN)CENRE-4483 |t Ecotoxicology and Environmental Safety | |
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