Effect of stage of development and sex on gonadotropin-releasing hormone secretion in in vitro hypothalamic perifusion
Marked sexual and ontogenic differences have been described in gonadotropin regulation in the rat. These could arise from events occurring both at the hypothalamic or hypophyseal levels. The present experiments were designed to evaluate the capacity of the hypothalamus in releasing GnRH in vitro, ba...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1998
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| Acceso en línea: | Registro en Scopus Handle Registro en la Biblioteca Digital |
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| LEADER | 10947caa a22011057a 4500 | ||
|---|---|---|---|
| 001 | PAPER-19840 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205113.0 | ||
| 008 | 190411s1998 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0031916881 | |
| 024 | 7 | |2 cas |a Follicle Stimulating Hormone, 9002-68-0; Gonadotropin-Releasing Hormone, 33515-09-2; Luteinizing Hormone, 9002-67-9; Potassium, 7440-09-7; Testosterone, 58-22-0 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a PSEBA | ||
| 100 | 1 | |a Lacau-Mengido, I.M. | |
| 245 | 1 | 0 | |a Effect of stage of development and sex on gonadotropin-releasing hormone secretion in in vitro hypothalamic perifusion |
| 260 | |c 1998 | ||
| 270 | 1 | 0 | |m Libertun, C.; Inst. de Biol./Medicina Experimental, Vuelta de Obigado 2490, (1428) Buenos Aires, Argentina; email: libertun@proteus.dna.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Becu-Villalobos, D., Lacau-Mengido, I.M., Libertun, C., Ontogenic studies of the neural control of the adenohypophyseal hormones in the rat: Gonadotropins (1990) Cell Mol Neurobiol, 10, pp. 473-484 | ||
| 504 | |a Ojeda, S.R., Urbanski, H.F., Puberty in the rat (1994) The Physiology of Reproduction, pp. 363-409. , Knobil E, Neill J, Eds. New York: Raven Press, Ltd | ||
| 504 | |a Becu-Villalobos, D., Lacau De Mengido, I.M., Libertun, C., Developmental changes in FSH secretion induced by 5-hydroxytryptophan, naloxone, and haloperidol in male and female rats (1989) Dev Brain Res, 47, pp. 181-186 | ||
| 504 | |a Ojeda, S.R., Jameson, H.E., McCann, S.M., Developmental changes in pituitary responsiveness to luteinizing-hormone releasing hormone (LHRH) in the female rat: Ovarian adrenal influences during the infantile period (1977) Endocrinology, 100, pp. 440-451 | ||
| 504 | |a Diaz-Torga, G., Becu-Villalobos, D., Lacau De Mengido, I.M., Libertun, C., Sexual and ontogenic differences in K+ induced gonadotropins and prolactin release in vitro (1992) Dev Brain Res, 70, pp. 103-108 | ||
| 504 | |a Debeljuk, L., Arimura, A., Schally, A.V., Studies on the pituitary responsiveness to luteinizing hormone-releasing hormone (LHRH) in intact male rats at different ages (1972) Endocrinology, 90, pp. 585-589 | ||
| 504 | |a Aubert, M.L., Begeot, M., Winiger, B.P., Morel, G., Sizonenko, P.C., Dubois, P.M., Ontogeny of hypothalamic luteinizing hormone-releasing hormone (GnRH) and pituitary GnRH receptors in fetal and neonatal rats (1985) Endocrinology, 116, pp. 1565-1576 | ||
| 504 | |a Hompes, P.G.A., Vermes, I., Tilders, F.J.H., Schoemaker, J., In vitro release of LHRH from the hypothalamus of female rats during prepubertal development (1982) Neuroendocrinology, 35, pp. 8-12 | ||
| 504 | |a Jakubowski, M., Blum, M., Roberts, J.L., Postnatal development of gonadotropin-releasing hormone and cylophilin gene expression in the female and male rat brain (1991) Endocrinology, 128, pp. 2702-2708 | ||
| 504 | |a Dutlow, C.M., Rachman, J., Jacobs, T.W., Millar, R.P., Prepubertal increases in gonadotropin-releasing hormone mRNA, gonadotropin-releasing hormone precursor, and subsequent maturation of precursor processing in male rats (1992) J Clin Invest, 90, pp. 2496-2501 | ||
| 504 | |a Harter, D.E., Ramirez, V.D., Responsiveness of immature versus adult male rat hypothalami to dibutyryl cyclic AMP and Forskolin-induced LHRH release in vitro (1985) Neuroendocrinology, 40, pp. 476-482 | ||
| 504 | |a Naish, S.J., Brawer, J., Robaire, B., Ruf, K.B., Changes in the dynamics of luteinizing hormone-releasing hormone-stimulated secretion of luteinizing hormone during sexual maturation of female rats (1986) Biol Reprod, 34, pp. 549-557 | ||
| 504 | |a Dorner, G., Sexual differentiation of the brain (1981) Vit Horm, 38, pp. 325-381 | ||
| 504 | |a Becu-Villalobos, D., Libertun, C., Ontogenesis of 3(H) serotonin binding sites in the hypothalamus of the female rate: Relation to serotonin-induced LH release in moxestrol pretreated rats (1986) Dev Brain Res, 25, pp. 111-116 | ||
| 504 | |a Lacau-Mengido, I.M., Becu-Villalobos, D., Thyssen, S.M., Rey, E.B., Var, L.-L., Libertun, C., Antidopaminergic-induced hypothalamic LHRH release and pituitary gonadotrophin secretion in 12-day-old female and male rats (1993) J Neuroendocrinol, 5, pp. 705-709 | ||
| 504 | |a Chiappa, S.A., Fink, G., Releasing factor and hormonal changes in the hypothalamic-pituitary-gonadotrophin and -adrenocorticotrophin systems before and after birth and puberty in male, female, and adrogenized female rats (1977) J Endocrinol, 72, pp. 211-224 | ||
| 504 | |a Bourguignon, J.-P., Franchimont, P., Puberty related increase in episodic LHRH release from rat hypothalamus in vitro (1984) Endocrinology, 114, pp. 1941-1943 | ||
| 504 | |a Clough, R.W., Hoffman, G.E., Sladek, C.D., Peripubertal development of noradrenergic stimulation of luteinizing hormone-releasing hormone neurosecretion in vitro (1988) Brain Res, 446, pp. 121-132 | ||
| 504 | |a Ojeda, S.R., Negro-Vilar, A., Release of prostaglandin E2 from the hypothalamus depends on extracellular Ca2+ availability: Relation to LHRH release (1984) Neuroendocrinology, 39, pp. 442-447 | ||
| 504 | |a Lacau De Mengido, I.M., Becu-Villalobos, D., Libertun, C., Sexual differences in the dopaminergic control of LH secretion in the developing rat (1987) Dev Brain Res, 35, pp. 91-95 | ||
| 504 | |a Becu-Villalobos, D., Lacau-Mengido, I.M., Libertun, C., Sexual differentiation of the brain is involved in 5-hydroxytryptophan- and naloxone-induced FSH release in the infantile rat (1990) Neuroendocrinol Lett, 12, pp. 435-442 | ||
| 504 | |a Becu-Villalobos, D., Libertun, C., Development of GnRH neuron regulation in the female rat (1995) Cell Mol Neurobiol, 15, pp. 165-176 | ||
| 504 | |a Blank, M.S., Panerai, A.E., Friesen, H.G., Opioid peptides modulate luteinizing hormone secretion during sexual maturation (1979) Science, 203, pp. 1129-1131 | ||
| 504 | |a Wu, T.J., Morris, D.L., McArthur, N.H., Harms, P.G., A priming effect of naloxone on in vitro LHRH release from the hypothalamus of midluteal ewes (1991) Biol Reprod, 44, pp. 546-549 | ||
| 504 | |a Kalra, S.P., Kalra, P.S., Do testosterone and estradiol-17B enforce inhibition or stimulation of luteinizing hormone-releasing hormone secretion? (1989) Biol Reprod, 41, pp. 559-570 | ||
| 504 | |a Knight, P.G., Variations in hypothalamic luteinizing hormone-releasing hormone content and release in vitro and plasma concentrations of luteinizing hormone and testosterone in developing cockerels (1983) J Endocrinol, 99, pp. 311-319 | ||
| 504 | |a Piva, F., Limonta, P., Maggi, R., Dondi, D., Messi, E., Zanisis, M., Martini, L., Effect of aging on opioid and LHRH receptors in the brain, pituitary, and testis of the male rat (1994) Neurobiol Aging, 15, pp. 553-557 | ||
| 520 | 3 | |a Marked sexual and ontogenic differences have been described in gonadotropin regulation in the rat. These could arise from events occurring both at the hypothalamic or hypophyseal levels. The present experiments were designed to evaluate the capacity of the hypothalamus in releasing GnRH in vitro, basally and in response to depolarization with KCl, during ontogeny in the rat. To that end we chose two well-defined developmental ages that differ markedly in sexual and ontogenic characteristics of gonadotropin regulation, 15 and 30 days. We compared GnRH release from hypothalami of females, neonatal androgenized females and males. Mediobasal hypothalami were perifused in vitro, and GnRH measured in the effluent. Basal secretion of the decapeptide increased with age in the three groups with no sexual differences encountered. When studying GnRH release induced by membrane depolarization, no differences within sex or age were encountered. On the other hand FSH serum levels decreased with age in females and increased in males, and in neonatal androgenized females followed a similar pattern to that of females. LH levels were higher in infantile females than in age-matched males or androgenized females. Such patterns of gonadotropin release were therefore not correlated to either basal or K+-induced GnRH release from the hypothalamus. We conclude that sexual and ontogenic differences in gonadotropin secretion in the developing rat era not dependent on the intrinsic capability of the hypothalamus to release GnRH in response to membrane depolarization. The hormonal differences observed during development and between sexes are probably related to differences in the sensitivity of the GnRH neuron to specific secretagogue and neurotransmitter regulation, and/or to differences in hypophyseal GnRH receptors and gonadotrope sensitivity. |l eng | |
| 593 | |a Laboratorio de Neuroendocrinología, Instituto de Biología y Medicina Experimental, CONICET, Vuelta de Obigado 2490, (1428) Buenos Aires, Argentina | ||
| 593 | |a Instituto de Biología y Medicina Experimental, Vuelta de Obigado 2490, (1428) Buenos Aires, Argentina | ||
| 593 | |a CONICET | ||
| 593 | |a UBA | ||
| 690 | 1 | 0 | |a GONADORELIN |
| 690 | 1 | 0 | |a SEX HORMONE |
| 690 | 1 | 0 | |a ANDROGEN THERAPY |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a EMBRYO DEVELOPMENT |
| 690 | 1 | 0 | |a GONADOTROPIN RELEASE |
| 690 | 1 | 0 | |a HORMONAL REGULATION |
| 690 | 1 | 0 | |a HORMONE RELEASE |
| 690 | 1 | 0 | |a HYPOTHALAMUS |
| 690 | 1 | 0 | |a HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM |
| 690 | 1 | 0 | |a IN VITRO STUDY |
| 690 | 1 | 0 | |a MEMBRANE DEPOLARIZATION |
| 690 | 1 | 0 | |a NEUROTRANSMITTER RELEASE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a ONTOGENY |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a AGING |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a ANIMALS, NEWBORN |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a FOLLICLE STIMULATING HORMONE |
| 690 | 1 | 0 | |a GONADOTROPIN-RELEASING HORMONE |
| 690 | 1 | 0 | |a HYPOTHALAMUS |
| 690 | 1 | 0 | |a LUTEINIZING HORMONE |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a POTASSIUM |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RATS, SPRAGUE-DAWLEY |
| 690 | 1 | 0 | |a SEX CHARACTERISTICS |
| 690 | 1 | 0 | |a TESTOSTERONE |
| 690 | 1 | 0 | |a ANIMALIA |
| 700 | 1 | |a Iglesias, A.G. | |
| 700 | 1 | |a Díaz-Torga, G. | |
| 700 | 1 | |a Thyssen-Cano, S. | |
| 700 | 1 | |a Libertun, C. | |
| 700 | 1 | |a Becú-Villalobos, D. | |
| 773 | 0 | |d 1998 |g v. 217 |h pp. 445-449 |k n. 4 |p Proc. Soc. Exp. Biol. Med. |x 00379727 |w (AR-BaUEN)CENRE-2685 |t Proceedings of the Society for Experimental Biology and Medicine | |
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| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00379727_v217_n4_p445_LacauMengido |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00379727_v217_n4_p445_LacauMengido |y Registro en la Biblioteca Digital |
| 961 | |a paper_00379727_v217_n4_p445_LacauMengido |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||