Mechanisms of action of endothelin-i in rat adrenal
Displacement curves of 125I-Endothelin-1 (ET-1) binding to rat adrenal cells with unlabeled ET-1, and the ET-1 receptor-related peptides sarafotoxin and BQ-123, show that rat adrenal cortex possess, as its bovine counterpart, two different receptors to ET-1 named ET-A and ET-B. Binding of ET-1 to it...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
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Elsevier Inc.
1998
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 10061caa a22012857a 4500 | ||
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| 001 | PAPER-19789 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205110.0 | ||
| 008 | 190411s1998 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0032483232 | |
| 024 | 7 | |2 cas |a 1 (5 isoquinolinesulfonyl) 2 methylpiperazine, 84477-87-2; aldosterone, 52-39-1, 6251-69-0; calcium 45, 13966-05-7; corticotropin, 11136-52-0, 9002-60-2, 9061-27-2; cyclo(dextro tryptophyl dextro aspartylprolyl dextro valylleucyl), 136553-81-6; iodine 125, 14158-31-7, 22822-81-7; ouabain, 11018-89-6, 630-60-4; sarafotoxin S6b, 116303-65-2 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a LIFSA | ||
| 100 | 1 | |a Pecci, A. | |
| 245 | 1 | 0 | |a Mechanisms of action of endothelin-i in rat adrenal |
| 260 | |b Elsevier Inc. |c 1998 | ||
| 270 | 1 | 0 | |m Cozza, E.N.; Departamento de Quimica Biologica, Fac. de Ciencias Exactas y Naturales, Cdad. Universitaria, Pab. II, Piso 4, 1428 Buenos Aires, Argentina; email: ecozza@qb.fcen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a Displacement curves of 125I-Endothelin-1 (ET-1) binding to rat adrenal cells with unlabeled ET-1, and the ET-1 receptor-related peptides sarafotoxin and BQ-123, show that rat adrenal cortex possess, as its bovine counterpart, two different receptors to ET-1 named ET-A and ET-B. Binding of ET-1 to its rat adrenal receptors stimulates i) aldosterone production, in vivo and in vitro ii) calcium influx, which is mediated through voltage dependent- and receptor operated- calcium channels, iii) cholesterol uptake, iv) stimulation of Na+/K+-ATPase and iv) diacylglycerol production. While the last effect is mediated through ET-A receptors the others involve binding of ET-1 to ET-B receptors. Finally, ouabain potentiates the ET-1-mediated stimulation of aldosterone production, suggesting that the effect of the peptidic hormone on Na+/K+-ATPase could act as a negative feedback mechanism. |l eng | |
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires | ||
| 536 | |a Detalles de la financiación: This work was supported by grants from Fundacion Antorchas, Consejo National de InvestigacionesC ienthicas y Tecnicas and Universidad de Buenos Aires. The authors thank Dr. Enrique IsoIa, Ciba-Geigy, Argentina for providii aminoglutethimidea nd Mrs. M. E. Otero de Bedners for her technicala ssistance. | ||
| 593 | |a Depto. de Quimica Biológica, Fac. de Cie. Exactas y Naturales, Univ. de Buenos Aires and P., 1428 Buenos Aires, Argentina | ||
| 593 | |a Depto. de Quimica Biológica, Fac. de Cie. Exactas y Naturales, Cdad. Universitaria, Pab. II, Piso 4, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a ADRENAL CELLS |
| 690 | 1 | 0 | |a ALDOSTERONE |
| 690 | 1 | 0 | |a ENDOTHELIN-1 |
| 690 | 1 | 0 | |a 1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE |
| 690 | 1 | 0 | |a ALDOSTERONE |
| 690 | 1 | 0 | |a CALCIUM 45 |
| 690 | 1 | 0 | |a CALCIUM CHANNEL |
| 690 | 1 | 0 | |a CORTICOTROPIN |
| 690 | 1 | 0 | |a CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL) |
| 690 | 1 | 0 | |a ENDOTHELIN 1 |
| 690 | 1 | 0 | |a ENDOTHELIN A RECEPTOR |
| 690 | 1 | 0 | |a ENDOTHELIN B RECEPTOR |
| 690 | 1 | 0 | |a IODINE 125 |
| 690 | 1 | 0 | |a OUABAIN |
| 690 | 1 | 0 | |a SARAFOTOXIN S6B |
| 690 | 1 | 0 | |a ADRENAL CORTEX |
| 690 | 1 | 0 | |a ADRENAL GLAND |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a NEGATIVE FEEDBACK |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a RENIN ANGIOTENSIN ALDOSTERONE SYSTEM |
| 690 | 1 | 0 | |a ZONA GLOMERULOSA |
| 653 | 0 | 0 | |a bq 123 |
| 700 | 1 | |a Romero, D.G. | |
| 700 | 1 | |a Lantos, C.P. | |
| 700 | 1 | |a Cozza, E.N. | |
| 773 | 0 | |d Elsevier Inc., 1998 |g v. 63 |h pp. 1315-1328 |k n. 15 |p Life Sci. |x 00243205 |w (AR-BaUEN)CENRE-749 |t Life Sciences | |
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