Survey of genetic counselors and clinical geneticists regarding recurrence risks for families with nonsyndromic cleft lip with or without cleft palate

Nonsyndromic cleft lip with or without cleft palate (CL/P) is a common congenital malformation affecting about 1/1,000 caucasian infants. Although the familial clustering of CLfP has been studied thoroughly, estimation of recurrence risk for genetic counseling purposes can be difficult. A survey was...

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Autor principal: Wyszynski, D.F
Otros Autores: Zeiger, J., Tilli, M.T, Bailey-Wilson, J.E, Beaty, T.H
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 1998
Acceso en línea:Registro en Scopus
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Registro en la Biblioteca Digital
Aporte de:Registro referencial: Solicitar el recurso aquí
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100 1 |a Wyszynski, D.F. 
245 1 0 |a Survey of genetic counselors and clinical geneticists regarding recurrence risks for families with nonsyndromic cleft lip with or without cleft palate 
260 |c 1998 
270 1 0 |m Wyszynski, D.F.; University of Buenos Aires, Conde 1972, 1428 Buenos Aires, Argentina; email: dfw@house.com.ar 
506 |2 openaire  |e Política editorial 
504 |a Amaratunga, A.D.S., Chandrasekera, A., Incidence of cleft lip and palate in Sri Lanka (1989) J Oral Maxillofac Surg, 47, pp. 559-561 
504 |a Bear, J.C., A genetic study of facial clefting in northern England (1976) Clinical Genet, 9, pp. 277-284 
504 |a Bixler, D., Fogh-Andersen, P., Conneally, P.M., Incidence of cleft lip and palate in the offspring of cleft parents (1971) Clin Genet, 2, pp. 155-159 
504 |a Carter, C.O., Genetics of common disorders (1969) Br Med Bull, 25, pp. 52-57 
504 |a Carter, C.O., Fraser Roberts, J.A., Evans, K.A., Buck, A.R., Genetic clinic. A follow up (1971) Lancet, 1, pp. 281-285 
504 |a Carter, C.O., Evans, K., Coffey, R., Fraser Roberts, J.A., Buck, A., Fraser Roberts, M., A three generation family study of cleft lip with or without cleft palate (1982) J Med Genet, 19, pp. 246-261 
504 |a Cereijo, A.I., Martínez-Frías, M.L., Prevalence of other birth defects among relatives of oral cleft probands (1992) J Med Genet, 29, p. 516 
504 |a Curtis, E.J., Clarke Fraser, F., Warburton, D., Congenital cleft lip and palate. Risk figures for counseling (1961) Am J Dis Child, 102, pp. 105-109 
504 |a Czeizel, A., Tusnady, G., A family study on cleft lip with or without cleft palate and posterior cleft palate in Hungary (1972) Hum Hered, 22, pp. 405-416 
504 |a Dionisopoulos, T., Williams, H.B., Congenital anomalies of the mouth, palate, and pharynx (1997) Congenital Anomalies of the Ear, Nose, and Throat, p. 244. , Tewfik TL, der Kaloustian VM (eds): New York: Oxford University Press 
504 |a Edwards, J.H., Risks of malformed relatives (1976) Lancet, 1, p. 1348 
504 |a Elston, R.C., Johnson, W.D., (1987) Essentials of Biostatistics, , Philadelphia: F.A. Davis Company 
504 |a Evers-Kiebooms, G., Van Den Berghe, H., Impact of genetic counselling: A review of published follow-up studies (1979) Clin Genet, 15, pp. 465-1174 
504 |a Fogh-Andersen, P., (1942) Inheritance of Harelip and Cleft Palate, , Copenhagen: Arnold Busck 
504 |a Fraser Roberts, J., Inherited diseases (1962) Methodology in Human Genetics, pp. 129-143. , Burdette WJ (ed): San Francisco: Holden-Day 
504 |a Fujino, H., Tashiro, H., Sanui, Y., Tanaka, K., Empirical genetic risk among offspring of cleft lip and cleft palate patients (1967) Jpn J Hum Genet, 12, pp. 62-68 
504 |a Koguchi, H., Recurrence rate in offspring and siblings of patients with cleft lip and/or cleft palate (1975) Jpn J Hum Genet, 20, pp. 207-221 
504 |a Leonard, C.O., Chase, G.A., Childs, B., Genetic counselling: A consumer's view (1972) N Engl J Med, 287, pp. 433-439 
504 |a Lie, R.T., Wilcox, A.J., Skjaerven, R., A population-based study of the risk of recurrence of birth defects (1994) N Engl J Med, 331, pp. 1-4 
504 |a Melnick, M., Bixler, D., Fogh-Andersen, P., Conneally, P.M., Cleft lip ± cleft palate: An overview of the literature and an analysis of Danish cases born between 1941 and 1968 (1980) Am J Med Genet, 6, pp. 83-97 
504 |a Milan, M., Astolfi, G., Volpato, S., Garani, G.P., Clementi, M., Tenconi, R., Boni, S., Calzolari, E., 766 cases of oral cleft in Italy (1994) Eur J Epidemiol, 10, pp. 317-324 
504 |a Mitchell, L.E., Christensen, K., Analysis of the recurrence patterns for nonsyndromic cleft lip with or without cleft palate in the families of 3,073 Danish probands (1996) Am J Med Genet, 61, pp. 371-376 
504 |a Mitchell, L.E., Christensen, K., Evaluation of family history data for Danish twins with nonsyndromic cleft lip with or without cleft palate (1997) Am J Med Genet, 72, pp. 120-121 
504 |a Murray, J.C., Daack-Hirsch, S., Buetow, K.H., Munger, R., Espina, L., Paglinawan, N., Villanueva, E., Magee, W., Clinical and epidemiological studies of cleft lip and palate in the Philippines (1997) Cleft Palate Craniofac J, 34, pp. 7-10 
504 |a Nemana, L.J., Marazita, M.L., Melnick, M., Genetic analysis of cleft lip with or without cleft palate in Madras, India (1992) Am J Med Genet, 42, pp. 5-9 
504 |a Smith, C., Computer programme to estimate recurrence risks for multifactorial familial disease (1972) BMJ, 1, pp. 495-497 
504 |a (1997) Stata Statistical Software: Release 5.0, , College Station, TX: Stata Corporation 
504 |a Tolarová, M., A study of the incidence, sex-ratio, laterality and clinical severity in 3,660 probands with facial clefts in Czechoslovakia (1987) Acta Chir Plast, 29, pp. 77-87 
504 |a Woolf, C.M., Congenital cleft lip. A genetic study of 496 propositi (1971) J Med Genet, 8, pp. 65-83 
504 |a Woolf, C.M., Woolf, R.M., Broadbent, T.R., Cleft lip and heredity (1964) Plast Reconstr Surg, 34, pp. 11-14 
504 |a Wyszynski, D.F., Beaty, T.H., Maestri, N.E., Genetics of nonsyndromic oral clefts revisited (1996) Cleft Palate Craniofac J, 33, pp. 406-417 
504 |a Wyszynski, D.F., Lewanda, A.F., Beaty, T.H., Phenotypic discordance in a family with monozygotic twins and non-syndromic cleft lip and palate (1996) Am J Med Genet, 66, pp. 468-470 
520 3 |a Nonsyndromic cleft lip with or without cleft palate (CL/P) is a common congenital malformation affecting about 1/1,000 caucasian infants. Although the familial clustering of CLfP has been studied thoroughly, estimation of recurrence risk for genetic counseling purposes can be difficult. A survey was mailed to 912 board-certified genetic counselors, 542 non-board-certified genetic counselors, and 776 board-certified clinical geneticists to investigate the recurrence risks they would assign to three example families with CL/P. Responses were received from 155 (17%) board-certified genetic counselors, 36 (6.6%) non-board-certified genetic counselors, and 100 (18.5%) board-certified clinical geneticists. No major differences were found in their responses, suggesting that for these three families, geneticists would provide similar estimates of risk, regardless of their amount of experience with oral clefts patients, where they are currently employed, or their board certification status.  |l eng 
593 |a Department of Public Health, School of Medicine, University of Buenos Aires, Argentina 
593 |a Department of Epidemiology, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD, United States 
593 |a Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD, United States 
593 |a Western Maryland College, Westminster, MD, United States 
593 |a University of Buenos Aires, Conde 1972, 1 B, (1428) Buenos Aires, Argentina 
690 1 0 |a BIRTH DEFECTS 
690 1 0 |a CLEFT LIP 
690 1 0 |a CLEFT PALATE 
690 1 0 |a CONGENITAL MALFORMATIONS 
690 1 0 |a EPIDEMIOLOGY 
690 1 0 |a GENETIC COUNSELING 
690 1 0 |a ORAL CLEFTS 
690 1 0 |a ARTICLE 
690 1 0 |a CLEFT LIP 
690 1 0 |a CLEFT PALATE 
690 1 0 |a DIAGNOSTIC ACCURACY 
690 1 0 |a GENETIC COUNSELING 
690 1 0 |a GENETIC RISK 
690 1 0 |a MEDICAL SPECIALIST 
690 1 0 |a PRIORITY JOURNAL 
690 1 0 |a RECURRENT DISEASE 
690 1 0 |a RISK ASSESSMENT 
690 1 0 |a CLEFT LIP 
690 1 0 |a CLEFT PALATE 
690 1 0 |a DATA COLLECTION 
690 1 0 |a DISEASES IN TWINS 
690 1 0 |a GENETIC COUNSELING 
690 1 0 |a GENETIC PREDISPOSITION TO DISEASE 
690 1 0 |a GENETICS, MEDICAL 
690 1 0 |a HUMANS 
690 1 0 |a RISK FACTORS 
690 1 0 |a TRIPLETS 
700 1 |a Zeiger, J. 
700 1 |a Tilli, M.T. 
700 1 |a Bailey-Wilson, J.E. 
700 1 |a Beaty, T.H. 
773 0 |d 1998  |g v. 79  |h pp. 184-190  |k n. 3  |p Am. J. Med. Genet.  |x 01487299  |t American Journal of Medical Genetics 
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