Involvement of insulin-like growth factors-I and-II and their receptors in medroxyprogesterone acetate-induced growth of mouse mammary adenocarcinomas
The role of the insulin-like growth factors (IGFs) system was investigated in hormone-dependent (HD) and -independent (HI) in vivo lines of the medroxyprogesterone acetate (MPA)-induced mammary tumor model in Balb/c mice. IGF-II protein and message showed a three- to four-fold increase in HD lines g...
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| Formato: | Capítulo de libro |
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1998
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| LEADER | 18719caa a22014897a 4500 | ||
|---|---|---|---|
| 001 | PAPER-19777 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205109.0 | ||
| 008 | 190411s1998 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0032213229 | |
| 024 | 7 | |2 cas |a Insulin-Like Growth Factor I, 67763-96-6; Insulin-Like Growth Factor II, 67763-97-7; Medroxyprogesterone 17-Acetate, 71-58-9; Oligonucleotides, Antisense; Receptor, IGF Type 1, EC 2.7.1.112; Receptor, IGF Type 2 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a JSBBE | ||
| 100 | 1 | |a Elizalde, P.V. | |
| 245 | 1 | 0 | |a Involvement of insulin-like growth factors-I and-II and their receptors in medroxyprogesterone acetate-induced growth of mouse mammary adenocarcinomas |
| 260 | |c 1998 | ||
| 270 | 1 | 0 | |m Elizalde, P.V.; Instituto de Biologia/Medicina Exp., Obligado 2490, Buenos Aires 1428, Argentina; email: elizalde@proteus.dna.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Beukers, M.W., Youngman, O., Zhang, H., Ling, N., Rosenfeld, R., (Leu 27) Insulin-like growth factor II is highly selective for the type-II IGF receptor in binding, cross-linking and thymidine incorporation experiments (1991) Endocrinology, 1128, pp. 1201-1203 | ||
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| 504 | |a Moats-Staats, B.M., Retsch-Bogart, G.Z., Price, W.A., Jarvis, H.W., D'Ercole, A.J., Stiles, A.D., Insulin-like growth factor-I (IGF-I) antisense oligodeoxynucleotide mediated inhibition of DNA synthesis by WI-38 cells: Evidence for autocrine actions of IGF-I (1993) Mol. Endocrinol., 7, pp. 171-180 | ||
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| 520 | 3 | |a The role of the insulin-like growth factors (IGFs) system was investigated in hormone-dependent (HD) and -independent (HI) in vivo lines of the medroxyprogesterone acetate (MPA)-induced mammary tumor model in Balb/c mice. IGF-II protein and message showed a three- to four-fold increase in HD lines growing in MPA-treated mice, as compared with HD tumors growing in untreated mice. Progression to a hormone-independent phenotype in all these lines was accompanied by a high constitutive expression of IGF-II. Similar IGF-I mRNA levels were detected in HD and HI lines. Both IGE-I and -II messages arose from the malignant epithelial cells, as shown by in situ hybridization studies. A significant decrease in Man-6P/type II IGF-R content was detected in HD tumors growing in MPA-treated mice as compared with HD lines growing in untreated mice. On the other hand, in HI tumors, notwithstanding high IGF-II synthesis, the levels of Man-6P/type II IGF-R remain high. Competitive inhibition and affinity labeling studies showed an almost exclusive binding of IGF-II to Man-6P/type II IGF-R on tumor membranes. The involvement of IGFs in the growth of epithelial primary cultures of the C4-HD line was evaluated. Exogenous IGF-I potentiated MPA stimulatory effect at concentrations of 50-100 ng/ml. Treatment of C4-HD cells with antisense oligodeoxynucleotides (ASODNs) to type I IGF-R and to IGF-II RNA resulted in a dose-dependent inhibition of MPA-mediated cell proliferation. The inhibition caused by IGF-II ASODNs could not be overcome by the addition of IGF-II up to 150 ng/ml. ASODNs to type I IGF-R at 40 μg/ml reduced by 75% the number of type I IGF-R; ASODNs to IGF-II at 1 μM decreased by 83% the levels of IGF-II protein. Our results provide support for the involvement of IGE-I and -II in MPA-induced mammary tumor growth by autocrine pathways. |l eng | |
| 536 | |a Detalles de la financiación: National Council for Scientific Research | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: 94/120 N CRP/ARG 93-01 | ||
| 536 | |a Detalles de la financiación: Acknowledgements--The authors thank Dr A. R. Kornblihtt for useful advice and Dr E. Bal de Kier Joff6 for critical discussion and review of the manuscript. This work was supported by grants from The United Nations Industrial Development Organization, UNIDO Contract 94/120 N CRP/ARG 93-01, from the National Scientific Council of Argentina, CONICET, and from Fundacion SALES. | ||
| 593 | |a Inst. de Biologia y Med. Exp. IBYME, Obligado 2490, Buenos Aires 1428, Argentina | ||
| 593 | |a Inst. de Invest. en Ingeniera G., Obligado 2490, Buenos Aires 1428, Argentina | ||
| 690 | 1 | 0 | |a SOMATOMEDIN B |
| 690 | 1 | 0 | |a SOMATOMEDIN B RECEPTOR |
| 690 | 1 | 0 | |a SOMATOMEDIN C |
| 690 | 1 | 0 | |a SOMATOMEDIN C RECEPTOR |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a BREAST ADENOCARCINOMA |
| 690 | 1 | 0 | |a BREAST EPITHELIUM |
| 690 | 1 | 0 | |a CANCER GROWTH |
| 690 | 1 | 0 | |a CELL PROLIFERATION |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a IN SITU HYBRIDIZATION |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PROTEIN EXPRESSION |
| 690 | 1 | 0 | |a ADENOCARCINOMA |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a BASE SEQUENCE |
| 690 | 1 | 0 | |a CELL DIVISION |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a IN SITU HYBRIDIZATION |
| 690 | 1 | 0 | |a INSULIN-LIKE GROWTH FACTOR I |
| 690 | 1 | 0 | |a INSULIN-LIKE GROWTH FACTOR II |
| 690 | 1 | 0 | |a MAMMARY NEOPLASMS, EXPERIMENTAL |
| 690 | 1 | 0 | |a MEDROXYPROGESTERONE 17-ACETATE |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a MICE, INBRED BALB C |
| 690 | 1 | 0 | |a OLIGONUCLEOTIDES, ANTISENSE |
| 690 | 1 | 0 | |a RECEPTOR, IGF TYPE 1 |
| 690 | 1 | 0 | |a RECEPTOR, IGF TYPE 2 |
| 690 | 1 | 0 | |a TUMOR CELLS, CULTURED |
| 690 | 1 | 0 | |a ANIMALIA |
| 700 | 1 | |a Lanari, C. | |
| 700 | 1 | |a Molinolo, A.A. | |
| 700 | 1 | |a Guerra, F.K. | |
| 700 | 1 | |a Balañá, M.E. | |
| 700 | 1 | |a Simian, M. | |
| 700 | 1 | |a Iribarren, A.M. | |
| 700 | 1 | |a Charreau, E.H. | |
| 773 | 0 | |d 1998 |g v. 67 |h pp. 305-317 |k n. 4 |p J. Steroid Biochem. Mol. Biol. |x 09600760 |w (AR-BaUEN)CENRE-5799 |t Journal of Steroid Biochemistry and Molecular Biology | |
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| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_09600760_v67_n4_p305_Elizalde |y Handle |
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