Functionally active cardiac antibodies in chronic Chagas' disease are specifically blocked by Trypanosoma cruzi antigens
Antibodies of chronic chagasic patients have been shown to interfere with electric and mechanical activities of cardiac embryonic myocytes in culture and with whole mammalian hearts. A mechanism proposed for this effect involves interaction of the antibodies with G-protein-linked membrane receptors,...
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| Otros Autores: | , , , , , , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1998
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| Acceso en línea: | Registro en Scopus Handle Registro en la Biblioteca Digital |
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| LEADER | 12647caa a22013097a 4500 | ||
|---|---|---|---|
| 001 | PAPER-19772 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205109.0 | ||
| 008 | 190411s1998 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0031762029 | |
| 024 | 7 | |2 cas |a Antigens, Protozoan; Autoantibodies; Receptors, Muscarinic; Ribosomal Proteins | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a FAJOE | ||
| 100 | 1 | |a Masuda, M.O. | |
| 245 | 1 | 0 | |a Functionally active cardiac antibodies in chronic Chagas' disease are specifically blocked by Trypanosoma cruzi antigens |
| 260 | |c 1998 | ||
| 270 | 1 | 0 | |m De Carvalho, A.C.C.; Inst. de Biofis. Carlos Chagas Filho, CCS, Ilha do Fundao 21949-900, Rio de Janeiro, RJ, Brazil; email: acarlos@ibccf.biof.ufrj.br |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Chagas, C., Nova trypanozomiase humana. Estudos sobre a morfologia e o ciclo evolutivo do Schizotrypanum cruzi n.gen., n.sp., agente etiológico de nova entidade morbida do homem (1909) Mem. Inst. Oswaldo Cruz, 1, pp. 59-65 | ||
| 504 | |a Andrade, Z.A., Mechanisms of myocardial damage on T. cruzi infection (1983) Ciba Foundation Symposium 99: Cytopathology of Parasitic Diseases, pp. 214-233. , Pitman Books, London, U.K | ||
| 504 | |a Koberle, F., Chagas' disease and Chagas syndromes: The pathology of American trypanosomiasis (1968) Adv. Parasitol., 6, pp. 63-116 | ||
| 504 | |a Dias, J.C.P., Acute Chagas' disease (1984) Mem. Inst. Oswaldo Cruz, 79 (SUPPL.), pp. 85-92 | ||
| 504 | |a Laranja, F.S., Dias, E., Nóbrega, G., Miranda, A., Chagas' disease: A clinical, epidemiologic, and pathologic study (1905) Circulation, 14, pp. 1035-1060 | ||
| 504 | |a Lopes, E.R., Chapadeiro, E., Almeida, H.O., Rocha, A., Contribuição ao estudo da anatomia patológica dos coraç̃es de chagásicos falecidos súbitamente (1975) Rev. Soc. Bras. Med. Trop., 6, pp. 269-282 | ||
| 504 | |a Brenner, Z., The pathogenesis of Chagas' disease: An overview of current theories (1994) Chagas' Disease and the Nervous System, pp. 30-46. , Pan American Health Organization (Scientific Publication # 547) | ||
| 504 | |a Borda, E.S., Pascual, J., Cossio, P., Vega, M., Arana, R., Sterin-Borda, L., A circulating IgG in Chagas' disease which binds to β-adrenoreceptors of myocardium and modulates their activity (1984) Clin. Exp. Immunol., 57, pp. 679-686 | ||
| 504 | |a Sterin-Borda, L., Gorelik, G., Borda, E.S., Chagasic IgG binding with cardiac muscarinic cholinergic receptors modifies cholinergic-mediated cellular transmembrane signals (1991) Clin. Immunol. Immunopathol., 61, pp. 387-397 | ||
| 504 | |a Rosenbaum, M.B., Chiale, P.A., Schejtman, D., Levin, M.J., Elizari, M.V., Antibodies to β-adrenergic receptors disclosing agonist-like properties in idiopathic dilated cardiomyopathy and Chagas' heart disease (1994) J. Cardiovasc. Electrophysiol., 5, pp. 367-375 | ||
| 504 | |a Ferrari, I., Levin, M.J., Wallukat, G., Elies, R., Lebesgue, D., Chiale, P., Elizari, M., Hoebeke, J., Molecular mimicry between the immunodominant ribosomal protein P0 of Trypanosoma cruzi and a functional epitope on the human β1-adrenergic receptor (1995) J. Exp. Med., 182, pp. 59-65 | ||
| 504 | |a Chiale, P.A., Rosenbaum, M.B., Elizari, M.V., Hjalmarson, A., Magnusson, Y., Wallukat, G., Hoebeke, J., High prevalence of antibodies against betal and beta2-adrenoreceptors in patients with primary electrical cardiac abnormalities (1995) J. Am. Coll. Cardiol., 26, pp. 864-869 | ||
| 504 | |a Mijares, A., Lebesgue, D., Argibay, J., Hoebecke, J., Anti-peptide antibodies sensitive to the active state of beta-adrenergic receptors (1996) FEBS Lett, 399, pp. 188-191 | ||
| 504 | |a Elies, R., Ferrari, I., Wallukat, G., Lebesgue, D., Chiale, P., Elizari, M., Rosenbaum, M., Levin, M.J., Structural and functional analysis of the B cell epitopes recognized by anti-receptor autoantibodies in patients with Chagas' disease (1996) J. Immunol., 157, pp. 4203-4211 | ||
| 504 | |a Lopez-Bergami, P., Heckert, P.C., Levitus, G., Elias, F., Quintana, F., Regenmortel, M., Laguens, Levin, M.J., Immunization with recombinant T. cruzi ribosomal P2β protein induces changes in electrocardiogram of immunized mice (1997) FEMS Immunol. Med. Microbiol., 18, pp. 75-85 | ||
| 504 | |a Goin, J.C., Leiros, C.P., Borda, E., Sterin-Borda, L., Interaction of human chagasic IgG with the second extracellular loop of the human muscarinic acetylcholine receptor: Functional and pathological implications (1997) FASEB J., 10, pp. 77-83 | ||
| 504 | |a Farias de Oliveira, S., Pedrosa, R.C., Nascimento, J.H.M., Campos de Carvalho, A.C., Masuda, M.O., Sera from chronic chagasic patients with complex cardiac arrhythmias depress electrogenesis and conduction in isolated rabbit hearts (1997) Circulation, 96, pp. 2031-2037 | ||
| 504 | |a Levin, M.J., Franco da Silveira, J., Frasch, A.C.C., Camargo, M.E., Lafon, S., Degrave, W.M., Rangel-Aldao, R., Recombinant Trypanosoma cruzi antigens and Chagas' disease diagnosis: Analysis of a workshop (1991) FEMS Microbiol. Immunol., 89, pp. 11-20 | ||
| 504 | |a Affranchino, J.L., Ibanez, C.F., Luquetti, A.O., Rassi, A., Reyes, M.B., Macina, R.A., Aslund, L., Frasch, A.C.C., Identification of a Trypanosoma cruzi antigen that is shed during the acute phase of Chagas' disease (1989) Mol. Biochem. Parasitol., 34, pp. 221-228 | ||
| 504 | |a Levin, M.J., Mesri, E., Benarous, R., Levitus, G., Schijman, A., Levy-Yeyati, P., Chiale, P., Segura, E.L., Identification of major Trypanosoma cruzi antigenic determinants in chronic Chagas' heart disease (1989) Am. J. Trop. Med. Hyg., 41, pp. 530-539 | ||
| 504 | |a Lafaille, J.J., Linss, J., Krieger, M.A., Souto-Padrón, T., De Souza, W., Goldenberg, S., Structure and expression of two Trypanosoma cruzd genes encoding antigenic proteins bearing repetitive epitopes (1989) Mol. Biochem. Parasitol., 35, pp. 127-136 | ||
| 504 | |a Cotrim, P.C., Paranhos, G.S., Mortara, R.A., Wanderley, J., Rassi, A., Camargo, M.E., Franco da Silveira, J., Expression in Escherichia coli of a dominant immunogen of Trypanosoma cruzi recognized by human sera (1990) J. Clin. Microbiol., 28, pp. 519-524 | ||
| 504 | |a Levin, M.J., Vazquez, M., Kaplan, D., Schijman, A., The Trypanosoma cruzi ribosomal P protein family: Classification and Antigenicity (1993) Parasitol. Today, 9, pp. 381-384 | ||
| 504 | |a Kaplan, D., Ferrari, I., Lopez-Bergami, P., Mahler, E., Levitus, G., Chiale, P., Hoebeke, J., Levin, M., Antibodies to ribosomal P proteins of Trypanosoma cruzi in Chagas' disease possess functional autoreactivity with heart tissue and differ from anti-P ribosomal autoantibodies in lupus (1997) Proc. Natl. Acad. Sci. USA, 94, pp. 10301-10306 | ||
| 504 | |a Hoebeke, J., Autoimunidad contra receptores cardiovasculares: Implicaciones estruturales y functionales (1995) Rev. Argent. Cardiol., 63, pp. 221-227 | ||
| 504 | |a Perez, M.A., Sarabanda, A.V.L., Padilha, W.L.N., Masuda, M.O., Effect of salicylate on normal and digoxinintoxicated isolated rabbit hearts (1984) Braz. J. Med. Biol. Res., 17, pp. 189-196 | ||
| 504 | |a Bradford, M.M., Rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding (1976) Anal. Biochem., 72, pp. 248-254 | ||
| 504 | |a Magnusson, Y., Marullo, S., Hover, S., Waagstein, F., Andersson, B., Vahine, A., Guillet, J.-G., Hoebeke, J., Mapping of a functional autoimmune epitope on the β1-adrenergic receptor in patients with idiopathic dilated cardiomyopathy (1990) J. Clin. Invest., 86, pp. 1658-1663 | ||
| 504 | |a Hoebeke, J., La seconde bonde extracellulaire des récepteurs couplés aux porteines G: Une cible préférentielle pour les anticorps fonctionels (1995) Médicin/Sci., 11, pp. 1661-1667 | ||
| 504 | |a Levin, M.J., Rossi, R., Levitus, G., Mesri, E., Bonnefoy, S., Kerner, N., Hontebeyrie-Joskowicz, M., The cloned C-terminal region of a Trypanososma cruzi P ribosomal protein harbors two antigenic determinants (1990) Immunol. Lett., 24, pp. 69-74 | ||
| 504 | |a Ferrari, I., Levin, M.J., Elizari, M.V., Rosenbaum, M.B., Chiale, P.A., Cholinergic autoantibodies in sinus- Node dysfunction (1997) Lancet, 350, pp. 262-263 | ||
| 504 | |a Matsui, S., Fu, M.L.X., Katsuda, S., Hayase, M., Yamaguchi, N., Teraoka, K., Kurihara, T., Hjalmarson, A., Peptides derived from cardiovascular G-protein-coupled receptors induce morphological cardiomyopathic changes in immunized rabbits (1997) J. Mol. Cell. Cardiol., 29, pp. 641-655 | ||
| 520 | 3 | |a Antibodies of chronic chagasic patients have been shown to interfere with electric and mechanical activities of cardiac embryonic myocytes in culture and with whole mammalian hearts. A mechanism proposed for this effect involves interaction of the antibodies with G-protein-linked membrane receptors, thus leading to activation of beta adrenergic and muscarinic receptors; more specifically, IgG of chagasic patients would interact with the negatively charged regions of the second extracellular loop of these receptors. We performed competition experiments to test this hypothesis. We evaluated the effect of sera/IgG from patients previously known to depress electrogenesis and/or atrioventricular conduction in isolated rabbit hearts after incubation with live and lysed parasites, the peptide corresponding to the second extracellular loop (O2) of the M2 receptor, and different peptides derived from two ribosomal proteins of T. cruzi: P0 and P2β. Our results indicate that 1) the antigenic factor inducing the functionally active IgGs in the chagasic patients is probably an intracellular T. cruzi antigen; 2) IgG/serum is interacting with the O2 region of the M2 receptor in the rabbit heart; and 3) the negative charges present in the ribosomal proteins of T. cruzi are important in mediating the interaction between the patients' serum/IgG and the receptor. |l eng | |
| 593 | |a Inst. de Biofis. Carlos Chagas Filho, CCS, UFRJ, Rio de Janeiro, RJ, Brazil | ||
| 593 | |a Hosp. Univ. Clementin Fraga Filho, CCS, UFRJ, Rio de Janeiro, RJ, Brazil | ||
| 593 | |a Inst. de Invest. en Ing. Genet. y B., 1428 Buenos Aires, Argentina | ||
| 593 | |a Lab. d'Enzymol. et de Chim. de P., Ctr. Natl. de la Rech. Scientifique, F-37032 Tours, France | ||
| 593 | |a Inst. de Biofis. Carlos Chagas Filho, CCS, bloco G, Ilha do Funclão, 21949-900 Rio de Janeiro, RJ, Brazil | ||
| 690 | 1 | 0 | |a HEART BLOCK |
| 690 | 1 | 0 | |a IMMUNOGLOBULIN |
| 690 | 1 | 0 | |a MUSCARINIC RECEPTOR |
| 690 | 1 | 0 | |a RIBOSOMAL P PROTEINS |
| 690 | 1 | 0 | |a GUANINE NUCLEOTIDE BINDING PROTEIN |
| 690 | 1 | 0 | |a RIBOSOME PROTEIN |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ANTIGEN SPECIFICITY |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a ATRIOVENTRICULAR CONDUCTION |
| 690 | 1 | 0 | |a CELL INTERACTION |
| 690 | 1 | 0 | |a CHAGAS DISEASE |
| 690 | 1 | 0 | |a CHRONIC DISEASE |
| 690 | 1 | 0 | |a GENE TARGETING |
| 690 | 1 | 0 | |a HEART BLOCK |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PATHOGENESIS |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROTEIN ISOLATION |
| 690 | 1 | 0 | |a RABBIT |
| 690 | 1 | 0 | |a TRYPANOSOMA CRUZI |
| 690 | 1 | 0 | |a AMINO ACID SEQUENCE |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a ANTIGENS, PROTOZOAN |
| 690 | 1 | 0 | |a AUTOANTIBODIES |
| 690 | 1 | 0 | |a CHAGAS DISEASE |
| 690 | 1 | 0 | |a CROSS REACTIONS |
| 690 | 1 | 0 | |a ELECTROCARDIOGRAPHY |
| 690 | 1 | 0 | |a HEART |
| 690 | 1 | 0 | |a MOLECULAR SEQUENCE DATA |
| 690 | 1 | 0 | |a MYOCARDIUM |
| 690 | 1 | 0 | |a RABBITS |
| 690 | 1 | 0 | |a RECEPTORS, MUSCARINIC |
| 690 | 1 | 0 | |a RIBOSOMAL PROTEINS |
| 690 | 1 | 0 | |a TRYPANOSOMA CRUZI |
| 690 | 1 | 0 | |a ANIMALIA |
| 690 | 1 | 0 | |a MAMMALIA |
| 690 | 1 | 0 | |a ORYCTOLAGUS CUNICULUS |
| 690 | 1 | 0 | |a TRYPANOSOMA |
| 690 | 1 | 0 | |a TRYPANOSOMA CRUZI |
| 700 | 1 | |a Levtn, M. | |
| 700 | 1 | |a De Oliveira, S.F. | |
| 700 | 1 | |a Dos Santos Costa, P.C. | |
| 700 | 1 | |a Bergami, P.L. | |
| 700 | 1 | |a Dos Santos Almeida, N.A. | |
| 700 | 1 | |a Pedrosa, R.C. | |
| 700 | 1 | |a Ferrari, I. | |
| 700 | 1 | |a Hoebeke, J. | |
| 700 | 1 | |a De Carvalho, A.C.C. | |
| 773 | 0 | |d 1998 |g v. 12 |h pp. 1551-1558 |k n. 14 |p FASEB J. |x 08926638 |w (AR-BaUEN)CENRE-996 |t FASEB Journal | |
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| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_08926638_v12_n14_p1551_Masuda |y Handle |
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