Estrogens normalize the hypothalamic-pituitary-adrenal axis response to stress and increase glucocorticoid receptor immunoreactivity in hippocampus of aging male rats
Aging is associated with a disturbance in the regulation of the hypothalamic-pituitary-adrenal axis (HPA) and reduced levels of glucocorticoid receptors (GR) in the hippocampus. To compensate for these effects, we have investigated whether estrogen therapy normalized the HPA response to stress and G...
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1999
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| LEADER | 16707caa a22015977a 4500 | ||
|---|---|---|---|
| 001 | PAPER-19574 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205056.0 | ||
| 008 | 190411s1999 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0033039242 | |
| 024 | 7 | |2 cas |a Corticosterone, 50-22-6; Estradiol, 50-28-2; Ether, Ethyl, 60-29-7; Receptors, Glucocorticoid | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a NUNDA | ||
| 100 | 1 | |a Ferrini, M. | |
| 245 | 1 | 0 | |a Estrogens normalize the hypothalamic-pituitary-adrenal axis response to stress and increase glucocorticoid receptor immunoreactivity in hippocampus of aging male rats |
| 260 | |c 1999 | ||
| 270 | 1 | 0 | |m De Nicola, A.F.; Lab. Neuroendocrine Biochemistry, Inst. Biologia Medicina Experimental, Obligado 2490, 1428 Buenos Aires, Argentina; email: denicola@proteus.dna.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a Aging is associated with a disturbance in the regulation of the hypothalamic-pituitary-adrenal axis (HPA) and reduced levels of glucocorticoid receptors (GR) in the hippocampus. To compensate for these effects, we have investigated whether estrogen therapy normalized the HPA response to stress and GR in hippocampus and paraventricular (PVN) nucleus. Young (3-4 months) and old (20 months) male Sprague-Dawley rats were bled by tail cut in the basal state and following ether stress. While basal and ether-stimulated levels of plasma corticosterone (CORT) were similar in the two groups, old animals presented a delayed termination of the response to ether stress. A dexamethasone inhibition test carried out in old animals, showed a failure to completely block plasma CORT after ether stimulation. Furthermore, in old rats GR-immunoreactive levels were reduced in CA1-CA2 hippocampal subfields and subiculum, while normal levels were obtained in CA3-CA4 and PVN. We observed that prolonged estrogen treatment (6 weeks) of old rats normalized the termination of the stress response, restored dexamethasone inhibition of plasma CORT, and increased GR immunoreactivity in CA1 and CA2 hippocampal subfields and subiculum. The results suggest that estrogen treatment enhanced the glucocorticoid feedback signal by increasing GR in hippocampus, and corrected the disturbances in HPA axis regulation. These animal experiments may be important to elucidate the effects of estrogenic on the hippocampal and HPA dysfunction associated with aging and Alzheimer's disease in humans. |l eng | |
| 593 | |a Lab. of Neuroendocrine Biochemistry, Inst. de Biol. y Med. Experimental, UBA-CONICET, Buenos Aires, Argentina | ||
| 593 | |a Department of Human Biochemistry, Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Chair of Cell Biology and Histology, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Inst. Univ. de Ciencias de la Salud, Fundación Barceló, Buenos Aires, Argentina | ||
| 593 | |a Lab. of Neuroendocrine Biochemistry, Inst. de Biol. y Med. Experimental, Obligado 2490, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a ADRENAL STEROID RECEPTORS |
| 690 | 1 | 0 | |a ADRENAL STEROIDS |
| 690 | 1 | 0 | |a AGING |
| 690 | 1 | 0 | |a CORTICOTROPIN |
| 690 | 1 | 0 | |a GONADAL STEROIDS |
| 690 | 1 | 0 | |a HIPPOCAMPUS |
| 690 | 1 | 0 | |a STRESS |
| 690 | 1 | 0 | |a CORTICOSTERONE |
| 690 | 1 | 0 | |a ESTROGEN |
| 690 | 1 | 0 | |a GLUCOCORTICOID RECEPTOR |
| 690 | 1 | 0 | |a AGING |
| 690 | 1 | 0 | |a ALZHEIMER DISEASE |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a CORTICOSTERONE BLOOD LEVEL |
| 690 | 1 | 0 | |a ESTROGEN THERAPY |
| 690 | 1 | 0 | |a FEEDBACK SYSTEM |
| 690 | 1 | 0 | |a HIPPOCAMPUS |
| 690 | 1 | 0 | |a HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM |
| 690 | 1 | 0 | |a IMMUNOREACTIVITY |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a STRESS |
| 690 | 1 | 0 | |a SUBICULUM |
| 690 | 1 | 0 | |a ADRENAL GLANDS |
| 690 | 1 | 0 | |a AGING |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a CORTICOSTERONE |
| 690 | 1 | 0 | |a ESTRADIOL |
| 690 | 1 | 0 | |a ETHER, ETHYL |
| 690 | 1 | 0 | |a HIPPOCAMPUS |
| 690 | 1 | 0 | |a HYPOTHALAMUS |
| 690 | 1 | 0 | |a KINETICS |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a ORGAN SIZE |
| 690 | 1 | 0 | |a PITUITARY GLAND |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RATS, SPRAGUE-DAWLEY |
| 690 | 1 | 0 | |a RECEPTORS, GLUCOCORTICOID |
| 690 | 1 | 0 | |a STRESS |
| 700 | 1 | |a Piroli, G. | |
| 700 | 1 | |a Frontera, M. | |
| 700 | 1 | |a Falbo, A. | |
| 700 | 1 | |a Lima, A. | |
| 700 | 1 | |a De Nicola, A.F. | |
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