Assessment of colour vision in epileptic patients exposed to single-drug therapy
Diplopia, blurred vision and colour disturbances are well-known side effects associated with anti-epileptic drugs (AEDs). Farnsworth-Munsell 100-hue colour test (F-100) is an accepted and sensitive tool to detect changes in colour perception. To determine the impact of AEDs upon colour vision, we ev...
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1999
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 06765caa a22009857a 4500 | ||
|---|---|---|---|
| 001 | PAPER-19555 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205054.0 | ||
| 008 | 190411s1999 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0345211602 | |
| 024 | 7 | |2 cas |a Anticonvulsants; Carbamazepine, 298-46-4; Phenytoin, 57-41-0; Valproic Acid, 99-66-1 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a EUNEA | ||
| 100 | 1 | |a López, L. | |
| 245 | 1 | 0 | |a Assessment of colour vision in epileptic patients exposed to single-drug therapy |
| 260 | |c 1999 | ||
| 270 | 1 | 0 | |m Lopez, L.; Seccion Neura-oftalmologia, Inst. Invest. Neurol. Raul Carrea, FLENI, Montaneses 2325, 1428 Buenos Aires, Argentina; email: llopez@roche.com.ar |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Dichter, M., Brodie, M., New antiepileptic drugs (1996) N Engl J Med, 334, pp. 1583-1590 | ||
| 504 | |a Mattson, R., Cramer, J., Collins, J., Comparison of carbamazepine, phenobarbital, phenytoin and primidone in partial and secondarily generalized tonic-clonic seizures (1985) N Engl J Med, 313, pp. 145-151 | ||
| 504 | |a Macdonald, R.L., Kelly, K.M., Mechanism of action of currently prescribed and newly developed antiepileptic drugs (1994) Epilepsia, 35 (SUPPL. 4), pp. S41-S50 | ||
| 504 | |a Schmidt, D., (1982) Adverse Effects of Antiepileptic Drugs, pp. 125-127. , New York, Raven Press | ||
| 504 | |a Verriest, G., Van Laethem, J., Uvijls, A., A new assessment of the normal ranges of the Farnsworth-Munsell 100-hue test scores (1982) Am J Ophthalmol, 93, pp. 635-642 | ||
| 504 | |a Smith, V.C., Pokorny, J., Pass, A., Color-axis determination on the Farnsworth-Munsell 100-hue test (1985) Am J Ophthalmol, 100, pp. 176-182 | ||
| 504 | |a Büttner, Th., Patzld, T., Kuhn, W., Muller, Th., Przuntek, H., Impairment of colour discrimination in Parkinson's disease (1994) Neuroophthalmology, 4, pp. 91-95 | ||
| 504 | |a Haug, B.A., Kolle, R.U., Trenkwalder, C., Oertel, W.H., Paulus, W., Predominant affection of the blue-cone pathway in Parkinson's disease (1995) Brain, 118, pp. 771-778 | ||
| 504 | |a Hart W.M., Jr., Acquired dyschromatopsia (1987) Surv Ophthalmol, 32, pp. 10-31 | ||
| 504 | |a Paulus, W., Schwarz, G., Steinhoff, B., The effect of anti-epileptic drugs on visual perception in patients with epilepsy (1996) Brain, 119, pp. 539-549 | ||
| 504 | |a Bayer, A.U., Thiel, J., Zrenner, E., Dichgans, J., Kuehn, M., Paulus, W., Ried, S., Schmidt, D., Color vision test for early detection of antiepileptic drug toxicity (1997) Neurology, 48, pp. 1394-1397 | ||
| 504 | |a Hood, D.C., Benimoff, N.L., Greenstein, V.C., The response range of the blue-cone pathways: A source of vulnerability disease (1984) Invest Ophthalmol Vis Sci, pp. 864-867 | ||
| 504 | |a Falk, G., Retinal physiology (1991) Principles and Practice of Electrophysiology of Vision, pp. 69-84. , Heckenlively JR, Arden GB (eds): St Louis, Mosby | ||
| 504 | |a Wäsle, H., Boycott, B.B., Functional architecture of the mammalian retina (1991) Physiol Rev, 71, pp. 447-480 | ||
| 504 | |a Kolb, H., The neural organization in human retina (1991) Principles and Practice of Clinical Electrophysiology of Vision, pp. 25-52. , Heckenlively JR, Arden GB (eds): St Louis, Mosby | ||
| 520 | 3 | |a Diplopia, blurred vision and colour disturbances are well-known side effects associated with anti-epileptic drugs (AEDs). Farnsworth-Munsell 100-hue colour test (F-100) is an accepted and sensitive tool to detect changes in colour perception. To determine the impact of AEDs upon colour vision, we evaluated 37 consecutive patients with complex partial seizures exposed to monotherapy with phenytoin (PHT, carbamazepine (CBZ) or valproic acid (VPA). All had normal IQ and no congenital disturbances in colour vision or ocular diseases. Twenty normal controls were used for statistical analysis. Thirteen patients were exposed to PHT, 12 to CBZ and 12 to VPA. Visual colour perception was impaired in 30/37 (82%) of the study group. The most significant abnormality was detected in the blue-yellow axis in 10/13 patients exposed to PHT (p < 0.02) and in 8/12 treated with CBZ (p < 0.009). In 8/12 patients taking VPA, no significant abnormality was observed (p < 0.06). None of the studied patients complained of colour vision disturbances. Our findings strongly support the negative effect of AEDs upon colour vision discrimination, most likely due to changes at the retinal processing level. F-100 proved to be very useful to assess early toxicity due to AEDs. |l eng | |
| 593 | |a Neurology Department, Raul Carrea Inst. for Neurol. Res., Buenos Aires, Argentina | ||
| 593 | |a Neurology Service, British Hospital, Buenos Aires, Argentina | ||
| 593 | |a Secc. Neuro-oftalmología, Inst. Invest. Neurologicas Raul C., Montañeses 2325, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a COLOUR DISCRIMINATION |
| 690 | 1 | 0 | |a EPILEPTIC PATIENTS |
| 690 | 1 | 0 | |a FARNSWORTH-MUNSELL 100-HUE TEST |
| 690 | 1 | 0 | |a ANTICONVULSIVE AGENT |
| 690 | 1 | 0 | |a CARBAMAZEPINE |
| 690 | 1 | 0 | |a PHENYTOIN |
| 690 | 1 | 0 | |a VALPROIC ACID |
| 690 | 1 | 0 | |a ADOLESCENT |
| 690 | 1 | 0 | |a ADULT |
| 690 | 1 | 0 | |a AGED |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CLINICAL ARTICLE |
| 690 | 1 | 0 | |a COLOR VISION DEFECT |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a EPILEPSY |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a FILTER |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a VISION TEST |
| 690 | 1 | 0 | |a ADOLESCENT |
| 690 | 1 | 0 | |a ADULT |
| 690 | 1 | 0 | |a AGED |
| 690 | 1 | 0 | |a ANTICONVULSANTS |
| 690 | 1 | 0 | |a CARBAMAZEPINE |
| 690 | 1 | 0 | |a COLOR PERCEPTION |
| 690 | 1 | 0 | |a COLOR VISION DEFECTS |
| 690 | 1 | 0 | |a DIPLOPIA |
| 690 | 1 | 0 | |a EPILEPSY, COMPLEX PARTIAL |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MIDDLE AGED |
| 690 | 1 | 0 | |a PHENYTOIN |
| 690 | 1 | 0 | |a SEVERITY OF ILLNESS INDEX |
| 690 | 1 | 0 | |a SINGLE-BLIND METHOD |
| 690 | 1 | 0 | |a VALPROIC ACID |
| 700 | 1 | |a Thomson, A. | |
| 700 | 1 | |a Rabinowicz, A.L. | |
| 773 | 0 | |d 1999 |g v. 41 |h pp. 201-205 |k n. 4 |p Eur. Neurol. |x 00143022 |w (AR-BaUEN)CENRE-4689 |t European Neurology | |
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| 856 | 4 | 0 | |u https://doi.org/10.1159/000008051 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00143022_v41_n4_p201_Lopez |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00143022_v41_n4_p201_Lopez |y Registro en la Biblioteca Digital |
| 961 | |a paper_00143022_v41_n4_p201_Lopez |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 80508 | ||