Glucocorticoid regulation of motoneuronal parameters in rats with spinal cord injury
1. Glucocorticoids exert beneficial effects after acute CNS injury in humans and experimental animals. To elucidate potential mechanisms of glucocorticoid action in the lesioned spinal cord, we have studied if treatment with dexamethasone (DEX) modulated the neurotrophin binding receptor p75 (p75(NT...
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1999
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| LEADER | 17852caa a22016097a 4500 | ||
|---|---|---|---|
| 001 | PAPER-19541 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205053.0 | ||
| 008 | 190411s1999 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0033041953 | |
| 024 | 7 | |2 cas |a Choline O-Acetyltransferase, EC 2.3.1.6; Dexamethasone, 50-02-2; Glucocorticoids; Receptor, Nerve Growth Factor; Receptors, Nerve Growth Factor | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a CMNED | ||
| 100 | 1 | |a Gonzalez, S.L. | |
| 245 | 1 | 0 | |a Glucocorticoid regulation of motoneuronal parameters in rats with spinal cord injury |
| 260 | |c 1999 | ||
| 270 | 1 | 0 | |m De Nicola, A.F.; Lab. of Neuroendocrine Biochemistry, Inst. de Biol./Medicina Experimental, Obligado 2490, 1428 Buenos Aires, Argentina; email: denicola@proteus.dna.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a 1. Glucocorticoids exert beneficial effects after acute CNS injury in humans and experimental animals. To elucidate potential mechanisms of glucocorticoid action in the lesioned spinal cord, we have studied if treatment with dexamethasone (DEX) modulated the neurotrophin binding receptor p75 (p75(NTR)) and choline acetyltransferase (ChAT), a marker of neuronal functional viability. 2. Rats with a sham operation or with spinal cord transection at the thoracic level received vehicle or DEX several times postlesion and were sacrificed 48 hr after surgery. The lumbar region caudal to the lesion was processed for p75(NTR) and ChAT immunoreactivity (IR) using quantitative densitometric analysis. 3. We observed that p75(NTR)-IR was absent from ventral horn motoneurons of sham-operated rats, in contrast to strong staining of neuronal perikaryon in TRX rats. Administration of DEX to TRX rats had no effect on the number of neuronal cell bodies expressing p75(NTR)-IR but significantly increased the number and length of immunostained neuronal processes. 4. Furthermore, spinal cord transection reduced ChAT immunostaining of motoneurons by 50%, whereas DEX treatment reverted this pattern to cells with a strong immunoreaction intensity in perikaryon and cell processes. 5. It is hypothesized that increased expression of p75(NTR) in cell processes and of ChAT in motoneurons may be part of a mechanism by which glucocorticoids afford neuroprotection, in addition to their known antiinflammatory effects. |l eng | |
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires, MI3 | ||
| 536 | |a Detalles de la financiación: National Institutes of Health, NS 20866-08 | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas, PIP 4103 | ||
| 536 | |a Detalles de la financiación: Fondo para la Investigación Científica y Tecnológica, PICT 00438 | ||
| 536 | |a Detalles de la financiación: This work was supported by grants from the National Institutes of Health (NS 20866-08), the University of Buenos Aires (MI3), CONICET (PIP 4103), Fundación Barceló, and FONCYT (PICT 00438). | ||
| 593 | |a Lab. of Neuroendocrine Biochemistry, Inst. de Biol. y Med. Experimental, UBA-CONICET, Buenos Aires, Argentina | ||
| 593 | |a Inst. Univ. de Ciencias de la Salud, Fundación Barceló, Buenos Aires, Argentina | ||
| 593 | |a Lab. of Neuroendocrine Biochemistry, Inst. de Biol. y Med. Experimental, Obligado 2490, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a CHOLINE ACETYLTRANSFERASE |
| 690 | 1 | 0 | |a GLUCOCORTICOIDS |
| 690 | 1 | 0 | |a MOTONEURONS |
| 690 | 1 | 0 | |a NEUROPROTECTION |
| 690 | 1 | 0 | |a P75 NEUROTROPHIN RECEPTOR |
| 690 | 1 | 0 | |a SPINAL CORD TRANSECTION |
| 690 | 1 | 0 | |a DEXAMETHASONE |
| 690 | 1 | 0 | |a GLUCOCORTICOID |
| 690 | 1 | 0 | |a NEUROTROPIN |
| 690 | 1 | 0 | |a PROTEIN P75 |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ANTIINFLAMMATORY ACTIVITY |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DENSITOMETRY |
| 690 | 1 | 0 | |a DRUG MECHANISM |
| 690 | 1 | 0 | |a IMMUNOREACTIVITY |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a NEUROPROTECTION |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a QUANTITATIVE ASSAY |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a SPINAL CORD INJURY |
| 690 | 1 | 0 | |a SPINAL CORD MOTONEURON |
| 690 | 1 | 0 | |a STEROID METABOLISM |
| 690 | 1 | 0 | |a SUBCUTANEOUS DRUG ADMINISTRATION |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a CHOLINE O-ACETYLTRANSFERASE |
| 690 | 1 | 0 | |a DEXAMETHASONE |
| 690 | 1 | 0 | |a GLUCOCORTICOIDS |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MOTOR NEURONS |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RATS, SPRAGUE-DAWLEY |
| 690 | 1 | 0 | |a RECEPTOR, NERVE GROWTH FACTOR |
| 690 | 1 | 0 | |a RECEPTORS, NERVE GROWTH FACTOR |
| 690 | 1 | 0 | |a SPINAL CORD INJURIES |
| 690 | 1 | 0 | |a ANIMALIA |
| 700 | 1 | |a Saravia, F. | |
| 700 | 1 | |a Gonzalez Deniselle, M.C. | |
| 700 | 1 | |a Lima, A.E. | |
| 700 | 1 | |a De Nicola, A.F. | |
| 773 | 0 | |d 1999 |g v. 19 |h pp. 597-611 |k n. 5 |p Cell. Mol. Neurobiol. |x 02724340 |t Cellular and Molecular Neurobiology | |
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| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_02724340_v19_n5_p597_Gonzalez |y Handle |
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