In vivo prevention and reversal by the antimitotic colchicine and other related compounds of some porphyrinogenic drug action on heme pathway

1. The effect of colchicine, vincristin and griseofulvin (GRIS) on the porphyrinogenic action of 2-allyl-2-isopropylacetamide (AIA) and veronal was studied in vivo and using the in vitro experimental model of tissue explant cultures. 2. Complete prevention by colchicine was found in liver and heart...

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Autor principal: Afonso, S.G
Otros Autores: Polo, C.F, Navone, N.M, Vazquez, E.S, Buzaleh, A.M, Schoua, E., Alcira Maria, d.C.B
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 1990
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Acceso en línea:Registro en Scopus
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Registro en la Biblioteca Digital
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LEADER 08590caa a22011177a 4500
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003 AR-BaUEN
005 20230518205045.0
008 190411s1990 xx ||||fo|||| 00| 0 eng|d
024 7 |2 scopus  |a 2-s2.0-0025354496 
024 7 |2 cas  |a 5-Aminolevulinate Synthetase, EC 2.3.1.37; Allylisopropylacetamide, 299-78-5; Colchicine, 64-86-8; Griseofulvin, 126-07-8; Heme, 14875-96-8; Lactate Dehydrogenase, EC 1.1.1.27; Porphyrins; Vincristine, 57-22-7 
040 |a Scopus  |b spa  |c AR-BaUEN  |d AR-BaUEN 
030 |a GEPHD 
100 1 |a Afonso, S.G. 
245 1 3 |a In vivo prevention and reversal by the antimitotic colchicine and other related compounds of some porphyrinogenic drug action on heme pathway 
260 |c 1990 
270 1 0 |m Alcira Maria, d.C.B.; Centro de Investigaciones sobre Porfirinas y Porfirias, CIPYP (CONICET, FCE y N, UBA) Ciudad Universitaria, Pabellón 11, 1428 Buenos Aires, Argentina 
506 |2 openaire  |e Política editorial 
504 |a Behuke, Forer, Vinblastine as a cause of direct transformation of some microtubules into helical structures (1972) Experimental Cell Research, 73, pp. 506-508 
504 |a Briggs, Condie, Sedman, Tephly, δ-Aminolevulinic acid synthetase activity (1976) J. Biol. Chem., 251, pp. 4996-4999 
504 |a Buzaleh, Afonso, Polo, Navone, Bianchi, Schoua, Batlle, Vázquez, Induction of porphyrin biosynthesis in the non-animal experimental model of tissue explant cultures (1988) Prevention and reversal by the antimitotic colchicine, 16, pp. 137-144. , Alternatives Lab. Anim 
504 |a De Matteis, Disturbances of liver porphyrin metabolism caused by drugs (1967) Pharmac. Rev., 19, pp. 523-557 
504 |a De Matteis, Rapid loss of cytochrome P-450 and haem caused in the liver microsomes by the porphyrinogenic agent 2-allyl-2-isopropylacetamide (1970) FEBS Lett., 6 (4), pp. 343-345 
504 |a De Matteis, Loss of haem in rat liver caused by the porphyrinogenic agent 2-allyl-2-isopropylacetamice (1971) Biochem. J., 124, pp. 767-777 
504 |a De Matteis, Gibbs, Stimulation of liver 5-aminolevulinate synthetase by drugs and its relevance to drug-induced accumulation of cytochrome P-450 (1972) Biochem. J., 126, pp. 1149-1154 
504 |a Disler, Moore, Drug therapy in the acute porphyrias (1985) Clinics in Dermatology, Vol. 3(2), pp. 112-124. , Lippincott, Philadelphia 
504 |a Dixon, Lactic dehydrogenase from yeast (1955) Methods in Enzymology, 1, pp. 444-449. , S. Colowick, N. Kaplan, Academic Press, New York 
504 |a Fell, Robison, The growth development and phosphatase activity of embryonic avian femora and limb-buds cultivated in vitro (1929) Biochem J, 23, pp. 767-784 
504 |a Granick, The induction in vitro of the synthesis of δ-aminolevulinic acid synthetase in chemical porphyria (1966) A response to certain drugs, sex hormones and foreign chemicals, 241, pp. 1359-1375. , J. Biol. Chem 
504 |a Hayashi, Yoda, Kikuchi, Mechanism of allylisopropylacetamide induced increase of δ-aminolevulinate synthetase in liver mitochondria (1969) Arch. Biochem. Biophys., 131, pp. 83-91 
504 |a Hayashi, Kurashima, Kikuchi, Mechanism of allylisopropyl acetamide-induced increase of δ-aminolevulinate synthetase in liver mitochondria V. Mechanism of regulation by hemin of the level of δ-amino levulinate synthetase in rat liver mitochondria (1972) Arch. Biochem. Biophys., 148, pp. 10-21 
504 |a Pesanti, Axline, Colchicine effects on lysosomal enzyme induction and intracellular degradation in the cultivated macrophage (1975) J. Exp. Med., 141, pp. 1030-1046 
504 |a Polo, Navone, Afonso, Buzaleh, Schoua, Vázquez, Batlle, Allyl-isopropylacetamide and glycerine reproduce clinical and biochemical manifestations of acute intermittent porphyria in mice (1987) Med. Sci. Res., 15, pp. 1335-1336 
504 |a Polo, Frisardi, Resnik, Schoua, Batlle, Factors influencing free porphyrins fluorescence spectra (1988) Clin. Chem., 34, pp. 757-760 
504 |a Vázquez, Navone, Polo, Afonso, Buzaleh, Batlle, Biosíntesis de porfirinas en cultivos de explantes tisulares (1987) Condiciones óptimas, 68, pp. 121-129. , Rev. Arg. Derm 
504 |a Wehland, Herzog, Weber, Interaction of griseofulvin with microtubules, microtubule protein and tubulin (1977) J. Molec. Biol., 111, pp. 329-342 
504 |a Wilson, Bryan, Biochemical and pharmacological properties of microtubules (1974) Adv. Cell. Molec. Biol., 3, pp. 21-72 
504 |a Wilson, Bamburg, Mizel, Grisham, Creswell, Interaction of drugs with microtubule protein (1974) Fedn Proc., 33, pp. 158-166 
504 |a Wysenbeck, Schoenfeld, Epstein, Greenblat, Atsmon, Inhibition of experimental porphyria with colchicine (1985) Int. J. Biochem., 17, pp. 937-940 
504 |a Yamauchi, Hayashi, Kikuchi, Translocation of δ-aminolevulinate synthase from the cytosol to the mitochondria and its regulation by hemin in the rat liver (1980) J. Biol. Chem., 255, pp. 1746-1751 
520 3 |a 1. The effect of colchicine, vincristin and griseofulvin (GRIS) on the porphyrinogenic action of 2-allyl-2-isopropylacetamide (AIA) and veronal was studied in vivo and using the in vitro experimental model of tissue explant cultures. 2. Complete prevention by colchicine was found in liver and heart explant from animals treated with AIA and veronal. 3. Vincristin, GRIS and colchicine reversed AIA induction in liver explants, however reversal was partial or nil in skin and heart explants depending on the antimitotic and the tissue. 4. The usefulness of the combination of the in vivo experimental model and the in vitro explant tissue culture model, for this kind of studies is emphasized. © 1990.  |l eng 
536 |a Detalles de la financiación: Universidad de Buenos Aires 
536 |a Detalles de la financiación: Secretaria de Ciencia y Tecnica, Universidad de Buenos Aires 
536 |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas 
536 |a Detalles de la financiación: Acknowledgemems--A. M. del C. Batlle holds the post of Scientific Researcher in the CONICET; C. Polo, N. M. Navone, S. Afonso, A. M. Buzaleh and E. V~zquez are Research Fellows at the CONICET. This work was supported by grants from the CONICET, the SECYT, UBA, Salud Pfiblica, Banco de la Naci6n Argentina. 
593 |a Centro de Investigaciones sobre Porfirinas y Porfirias, CIPYP (CONICET, FCE y N, UBA) Ciudad Universitaria, Pabellón 11, 1428 Buenos Aires, Argentina 
690 1 0 |a ALLYLISOPROPYLACETAMIDE 
690 1 0 |a BARBITAL 
690 1 0 |a COLCHICINE 
690 1 0 |a GRISEOFULVIN 
690 1 0 |a LACTATE DEHYDROGENASE 
690 1 0 |a PORPHYRIN 
690 1 0 |a VINCRISTINE 
690 1 0 |a ANIMAL CELL 
690 1 0 |a ANIMAL EXPERIMENT 
690 1 0 |a ARTICLE 
690 1 0 |a HEART 
690 1 0 |a HEME SYNTHESIS 
690 1 0 |a INTRAPERITONEAL DRUG ADMINISTRATION 
690 1 0 |a LIVER 
690 1 0 |a MALE 
690 1 0 |a MOUSE 
690 1 0 |a NONHUMAN 
690 1 0 |a PORPHYRIA 
690 1 0 |a PRIORITY JOURNAL 
690 1 0 |a SKIN 
690 1 0 |a TISSUE CULTURE 
690 1 0 |a 5-AMINOLEVULINATE SYNTHETASE 
690 1 0 |a ALLYLISOPROPYLACETAMIDE 
690 1 0 |a ANIMAL 
690 1 0 |a COLCHICINE 
690 1 0 |a ENZYME INDUCTION 
690 1 0 |a GRISEOFULVIN 
690 1 0 |a HEME 
690 1 0 |a IN VITRO 
690 1 0 |a LACTATE DEHYDROGENASE 
690 1 0 |a MALE 
690 1 0 |a MICE 
690 1 0 |a PORPHYRINS 
690 1 0 |a SUPPORT, NON-U.S. GOV'T 
690 1 0 |a VINCRISTINE 
653 0 0 |a veronal 
700 1 |a Polo, C.F. 
700 1 |a Navone, N.M. 
700 1 |a Vazquez, E.S. 
700 1 |a Buzaleh, A.M. 
700 1 |a Schoua, E. 
700 1 |a Alcira Maria, d.C.B. 
773 0 |d 1990  |g v. 21  |h pp. 423-426  |k n. 4  |p Gen. Pharmacol. Vasc. Syst.  |x 03063623  |w (AR-BaUEN)CENRE-4808  |t General Pharmacology 
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856 4 0 |u https://doi.org/10.1016/0306-3623(90)90692-F  |y DOI 
856 4 0 |u https://hdl.handle.net/20.500.12110/paper_03063623_v21_n4_p423_Afonso  |y Handle 
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