Trypanosoma cruzi: Aberrant expression of class II major histocompatibility complex molecules in skeletal and heart muscle cells of chronically infected mice
In isolated skeletal, heart, and smooth muscle cells from BALB/c and C3H/HeJ mice infected with different strains of Trypanosoma cruzi the presence of class II MHC molecules was investigated by immunocytochemical techniques. We employed single muscle fibers instead of conventional cryostat sections...
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| Formato: | Capítulo de libro |
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1991
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 08741caa a22010457a 4500 | ||
|---|---|---|---|
| 001 | PAPER-19366 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205043.0 | ||
| 008 | 190411s1991 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0026101983 | |
| 024 | 7 | |2 cas |a Histocompatibility Antigens Class II | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a EXPAA | ||
| 100 | 1 | |a Meckert, P.C. | |
| 245 | 1 | 0 | |a Trypanosoma cruzi: Aberrant expression of class II major histocompatibility complex molecules in skeletal and heart muscle cells of chronically infected mice |
| 260 | |c 1991 | ||
| 270 | 1 | 0 | |m Laguens, R.P.; Cátedra de Patología II, Facultad de Ciencias Médicas, Universidad de La Plata, Calle 60 y 120, 1900 La Plata, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Andrade, Chagas' disease: Pathology of the cardiac lesions (1976) American Trypanosomiasis Research Pan American Health Organization Scientific Publication 318, pp. 146-151 | ||
| 504 | |a Ben Younes-Chennoufi, Hontebeyrie-Joskowicz, Tricottet, Eisen, Reynes, Said, Persistence of Try-panosoma antigens in inflammatory lesions of chronically infected mice (1988) Transactions of the Royal Society of Tropical Medicine and Hygiene, 82, pp. 77-83 | ||
| 504 | |a Ben Younes-Chennoufi, Said, Eisen, Durand, Hontebeyrie-Joskowicz, Cellular immunity to Trypanosoma cruzi is mediated by helper T cells (CD4+) (1988) Transactions of the Royal Society of Tropical Medicine and Hygiene, 82, pp. 84-89 | ||
| 504 | |a Bottazzo, Dean, McNally, MacKay, Swift, Gamble, In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis (1985) New England Journal of Medicine, 313, pp. 353-360 | ||
| 504 | |a Bottazzo, Todd, Mirakian, Belfiore, Pujol Borrel, Organ specific autoimmunity: A 1986 overview (1986) Immunological Reviews, 94, pp. 137-169 | ||
| 504 | |a Cabeza Meckert, Laguens, Selectivity of alterations in skeletal fibers in chronic Chagas' disease in the mouse (1988) Experientia, 44, pp. 14-16 | ||
| 504 | |a Dean, Walker, Bone, Baird, Cooke, Prediabetes in the spontaneously diabetic BB/E rat: Lymphocyte subpopulations in the pancreatic infiltrate and expression of rat MHC class II molecules in endocrine cells (1985) Diabetologia, 28, pp. 464-466 | ||
| 504 | |a Guesdon, Tenynck, Avrameas, The use of avidin biotin interaction in immunoenzymatic technics (1979) Journal of Histochemistry and Cytochemistry, 27, pp. 11-31 | ||
| 504 | |a Hanafusa, Fugino-Kurihara, Myazaki, Yamada, Nakajima, Miyagawa, Tarui, Expression of class II major histocompatibility complex antigens on pancreatic B cells in NOD mouse (1987) Diabetologia, 30, pp. 104-108 | ||
| 504 | |a Hart, Waldschmidt, Hanley-Hyde, Moore, Kemp, Schelper, Brain microvascular smooth muscle express class II antigens (1987) The Journal of Immunology, 138, pp. 2960-2963 | ||
| 504 | |a Hontebeyrie-Joskowicz, Said, Milon, Marchal, Eisen, L3T4+ cells able to mediate parasite-specific delayed type hypersensibility play a role in the pathology of experimental Chagas disease (1987) European Journal of Immunology, 17, pp. 1033-1037 | ||
| 504 | |a Jonasson, Holm, Skalli, Gabbiani, Hansson, Expression of class II transplantation antigen on vascular smooth muscle cells in humans atherosclerosis (1985) Journal of Clinical Investigation, 76, pp. 125-131 | ||
| 504 | |a Laguens, Cabeza Meckert, Gelpi, Chronic Chagas disease in the mouse. I Electrocardiographic and morphological patterns of the cardiopathy (1981) Medicina (Buenos Aires), 41, pp. 35-39 | ||
| 504 | |a Laguens, Cabeza Meckert, Chambo, Gelpi, Chronic Chagas disease in the mouse. II Transfer of the heart disease by means of immunocompetent cells (1981) Medicina (Buenos Aires), 41, pp. 40-43 | ||
| 504 | |a Laguens, Cabeza Meckert, Chambo, Anti-heart antibody-dependent cytotoxicity in the sera of mice chronically infected with Trypanosoma cruzi (1988) Infection and Immunity, 56, pp. 993-997 | ||
| 504 | |a Mosquera, Interferon-γ induces class II antigen expression on cultured rat mesangial smooth muscle cells (1989) Clinical Immunology and Immunopathology, 53, pp. 341-345 | ||
| 504 | |a Petry, Eisen, Chagas disease: A model for the study of autoimmune disease (1989) Parasitology Today, 5, pp. 111-116 | ||
| 504 | |a Pierres, Kourilsky, Rebonah, Dosseto, Gibbol, Distinct epitopes on Iak gene products identified by monoclonal antibodies (1980) European Journal of Immunology, 10, pp. 950-957 | ||
| 504 | |a Said, Joskowicz, Barreira, Eisen, Neuropathy associated with experimental Chagas disease (1985) Annals of Neurology, 18, pp. 676-683 | ||
| 504 | |a Wright, Hauptfeld, Lacy, Induction of Ia antigens expression on murine islet parenchymal cells does not dininish islet allograft survival (1989) American Journal of Pathology, 134, pp. 237-242 | ||
| 520 | 3 | |a In isolated skeletal, heart, and smooth muscle cells from BALB/c and C3H/HeJ mice infected with different strains of Trypanosoma cruzi the presence of class II MHC molecules was investigated by immunocytochemical techniques. We employed single muscle fibers instead of conventional cryostat sections to obtain a more accurate antigen localization. Approximately half of the skeletal muscle cells isolated from the reclus femoris expressed Ia antigens on their surface, irrespective of the mouse or parasite strain combination. Ia expression was apparent only at 30 days postinfection and thereafter. The heart muscle cells expressed class II molecules only at 1 and 3 months postinfection. In no case did the smooth muscle cells from infected mice express Ia antigens. Studies of the same molecules in the noninfected animals gave constantly negative results. We conclude that in the course of the chronic infection of mice with T. cruzi, ectopic expression of class II MHC molecules occurs at the surface of skeletal and heart muscle cells, providing a possible mechanism for explaining the anti-striped muscle autoreactivity present in Chagas' disease. © 1991. |l eng | |
| 536 | |a Detalles de la financiación: Institut National de la Santé et de la Recherche Médicale | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: ACKNOWLEDGMENTS This work was partially supportedb y a collaborative grant from INSERM (France)-CONICET (Argentine). | ||
| 593 | |a Cátedra de Patología II, Facultad de Ciencias Médicas, Universidad de La Plata, Calle 60 y 120, 1900 La Plata, Argentina | ||
| 593 | |a Unité d' Immunoparasitologie, Institut Pasteur, 25, Rue du Dr. Roux, 75724 Paris Cedex 15, France | ||
| 593 | |a Laboratorio de Biología Molecular de la Enfermedad de Chagas, I.N.G.E.B.I., Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a AUTOIMMUNITY |
| 690 | 1 | 0 | |a CHAGAS' DISEASE |
| 690 | 1 | 0 | |a HEART MUSCLE CELLS |
| 690 | 1 | 0 | |a IA ANTIGENS |
| 690 | 1 | 0 | |a SKELETAL MUSCLE CELLS |
| 690 | 1 | 0 | |a TRYPANOSOMA CRUZI |
| 690 | 1 | 0 | |a ANTIGEN |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANTIGEN EXPRESSION |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a MAJOR HISTOCOMPATIBILITY COMPLEX |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a TRYPANOSOMA CRUZI |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a CELLS, CULTURED |
| 690 | 1 | 0 | |a CHAGAS DISEASE |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HEART |
| 690 | 1 | 0 | |a HISTOCOMPATIBILITY ANTIGENS CLASS II |
| 690 | 1 | 0 | |a IMMUNOHISTOCHEMISTRY |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a MICE, INBRED BALB C |
| 690 | 1 | 0 | |a MICE, INBRED C3H |
| 690 | 1 | 0 | |a MUSCLE, SMOOTH |
| 690 | 1 | 0 | |a MUSCLES |
| 690 | 1 | 0 | |a SUPPORT, NON-U.S. GOV'T |
| 690 | 1 | 0 | |a TRYPANOSOMA CRUZI |
| 690 | 1 | 0 | |a ANIMALIA |
| 690 | 1 | 0 | |a TRYPANOSOMA |
| 690 | 1 | 0 | |a TRYPANOSOMA CRUZI |
| 700 | 1 | |a Hontebeyrie-Joskowicz, M. | |
| 700 | 1 | |a Chambo, J. | |
| 700 | 1 | |a Levin, M. | |
| 700 | 1 | |a Laguens, R.P. | |
| 773 | 0 | |d 1991 |g v. 72 |h pp. 8-14 |k n. 1 |p Exp. Parasitol. |x 00144894 |w (AR-BaUEN)CENRE-4717 |t Experimental Parasitology | |
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| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00144894_v72_n1_p8_Meckert |y Handle |
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