Complete structure of the glycan of lipopeptidophosphoglycan from Trypanosoma cruzi epimastigotes

The lipopeptidophosphoglycan is the major cell surface glycoconjugate of the epimastigote forms of the parasitic protozoan Trypanosoma cruzi. A detailed partial structure for this molecule has been reported (Previato, J. O., Gorin, P. A. J., Mazurek, M., Xavier, M. T., Fournet, B., Wieruszesk, J. M....

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Detalles Bibliográficos
Autor principal: De Lederkremer, R.M
Otros Autores: Lima, C., Ramirez, M.I, Ferguson, M.A.J, Homans, S.W, Thomas-Oates, J.
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 1991
Acceso en línea:Registro en Scopus
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Registro en la Biblioteca Digital
Aporte de:Registro referencial: Solicitar el recurso aquí
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024 7 |2 scopus  |a 2-s2.0-0026334201 
024 7 |2 cas  |a lipopeptidophosphoglycan; Oligosaccharides; Peptidoglycan; Phospholipids 
040 |a Scopus  |b spa  |c AR-BaUEN  |d AR-BaUEN 
030 |a JBCHA 
100 1 |a De Lederkremer, R.M. 
245 1 0 |a Complete structure of the glycan of lipopeptidophosphoglycan from Trypanosoma cruzi epimastigotes 
260 |c 1991 
270 1 0 |m Departamento de Quimica Organica, Fac. de Ciencas Exactas y Naturales, Universidad de Buenos AiresArgentina 
506 |2 openaire  |e Política editorial 
520 3 |a The lipopeptidophosphoglycan is the major cell surface glycoconjugate of the epimastigote forms of the parasitic protozoan Trypanosoma cruzi. A detailed partial structure for this molecule has been reported (Previato, J. O., Gorin, P. A. J., Mazurek, M., Xavier, M. T., Fournet, B., Wieruszesk, J. M., and Mendonca-Previato, L. (1990) J. Biol. Chem. 265, 2518-2526). In this study, we complete the primary structure assignments and describe the microheterogeneity found in the lipopeptidophosphoglycan glycan, using a combination of 1H and 31P NMR, fast atom bombardment mass spectrometry, methylation linkage analysis, and exoglycosidase sequencing. The lipopeptidophosphoglycan is a glycosylated inositol-phosphoceramide with striking homology to glycosylphosphatidylinositol membrane anchors found attached to a wide variety of plasma membrane proteins throughout the eukaryotes.  |l eng 
593 |a Departamento de Quimica Organica, Fac. de Ciencas Exactas y Naturales, Universidad de Buenos Aires, Argentina 
593 |a Department of Biochemistry, University of Dundee, Dundee DD1 4HN, United Kingdom 
593 |a Bijvoet Ctr. for Biomol. Research, Faculty of Chemistry, University of Utrecht, P. O. Box 80083, 3508 TB Utrecht, Netherlands 
593 |a Beit Memorial Research 
690 1 0 |a GLYCAN 
690 1 0 |a GLYCAN PHOSPHATE LIPOPROTEIN 
690 1 0 |a UNCLASSIFIED DRUG 
690 1 0 |a ARTICLE 
690 1 0 |a CHEMICAL STRUCTURE 
690 1 0 |a EPIMASTIGOTE 
690 1 0 |a NONHUMAN 
690 1 0 |a PRIORITY JOURNAL 
690 1 0 |a TRYPANOSOMA CRUZI 
690 1 0 |a ACYLATION 
690 1 0 |a ANIMAL 
690 1 0 |a CARBOHYDRATE SEQUENCE 
690 1 0 |a CHROMATOGRAPHY, HIGH PRESSURE LIQUID 
690 1 0 |a MAGNETIC RESONANCE SPECTROSCOPY 
690 1 0 |a MOLECULAR SEQUENCE DATA 
690 1 0 |a OLIGOSACCHARIDES 
690 1 0 |a PEPTIDOGLYCAN 
690 1 0 |a PHOSPHOLIPIDS 
690 1 0 |a SPECTROMETRY, MASS, FAST ATOM BOMBARDMENT 
690 1 0 |a SUPPORT, NON-U.S. GOV'T 
690 1 0 |a TRYPANOSOMA CRUZI 
700 1 |a Lima, C. 
700 1 |a Ramirez, M.I. 
700 1 |a Ferguson, M.A.J. 
700 1 |a Homans, S.W. 
700 1 |a Thomas-Oates, J. 
773 0 |d 1991  |g v. 266  |h pp. 23670-23672  |k n. 35  |p J. Biol. Chem.  |x 00219258  |w (AR-BaUEN)CENRE-175  |t Journal of Biological Chemistry 
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856 4 0 |u https://hdl.handle.net/20.500.12110/paper_00219258_v266_n35_p23670_DeLederkremer  |y Handle 
856 4 0 |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00219258_v266_n35_p23670_DeLederkremer  |y Registro en la Biblioteca Digital 
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963 |a NORI 
999 |c 80249