Activation of GABA B receptors in the anterior pituitary inhibits prolactin and luteinizing hormone secretion
Previous work from our laboratory showed that baclofen could lower serum prolactin (PRL) levels acting at the central nervous system. The present experiments were designed to evaluate whether the γ-aminobutyric acid B agonist was also effective in inhibiting hormone release at the pituitary level. I...
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| Otros Autores: | , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1992
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| Materias: | |
| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 03853caa a22006497a 4500 | ||
|---|---|---|---|
| 001 | PAPER-19289 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205038.0 | ||
| 008 | 190411s1992 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0027100472 | |
| 024 | 7 | |2 cas |a 3 aminopropanephosphonic acid, 13138-33-5; baclofen, 1134-47-0; luteinizing hormone, 39341-83-8, 9002-67-9; phaclofen, 108351-35-5; prolactin, 12585-34-1, 50647-00-2, 9002-62-4; protirelin, 24305-27-9 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a NUNDA | ||
| 100 | 1 | |a Lux-Lantos, V. | |
| 245 | 1 | 0 | |a Activation of GABA B receptors in the anterior pituitary inhibits prolactin and luteinizing hormone secretion |
| 260 | |c 1992 | ||
| 270 | 1 | 0 | |m Libertum, C.; Laboratorio de Neuroendocrinologia, Inst de Biologia y Medicina Exptl, V. de Obligado 2490, 1428 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 520 | 3 | |a Previous work from our laboratory showed that baclofen could lower serum prolactin (PRL) levels acting at the central nervous system. The present experiments were designed to evaluate whether the γ-aminobutyric acid B agonist was also effective in inhibiting hormone release at the pituitary level. In monolayer cultures of adenohypophyseal dispersed cells, baclofen inhibited basal PRL secetion after 1 or 2 h of incubation. This inhibition was significantly abolished by three antagonists: phaclofen, 3-aminopropyl-phosphonic acid and 4-aminobutylphosphonic acid. Furthermore, baclofen inhibited the thyrotropin-releasing hormone-induced PRL release in a concentration-dependent manner. With regard to gonadotropin secretion, baclofen was unable to modify basal luteinizing hormone (LH) secretion, but significantly inhibited the LH-releasing hormone-induced LH release. These results show that baclofen, in addition to its central neuroendocrine effects, inhibits pituitary hormone secretion, under basal and/or stimulated conditions, by direct action at the pituitary level. |l eng | |
| 593 | |a Laboratorio de Neuroendocrinologia, Inst de Biologia y Medicina Exptl, V. de Obligado 2490, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a ADENOHYPOPHYSEAL CELL CULTURES |
| 690 | 1 | 0 | |a BACLOFEN |
| 690 | 1 | 0 | |a LUTEINIZING HORMONE |
| 690 | 1 | 0 | |a PROLACTIN |
| 690 | 1 | 0 | |a 3 AMINOPROPANEPHOSPHONIC ACID |
| 690 | 1 | 0 | |a 4 AMINOBUTANEPHOSPHONIC ACID |
| 690 | 1 | 0 | |a 4 AMINOBUTYRIC ACID B RECEPTOR |
| 690 | 1 | 0 | |a BACLOFEN |
| 690 | 1 | 0 | |a LUTEINIZING HORMONE |
| 690 | 1 | 0 | |a PHACLOFEN |
| 690 | 1 | 0 | |a PROLACTIN |
| 690 | 1 | 0 | |a PROTIRELIN |
| 690 | 1 | 0 | |a ADENOHYPOPHYSIS |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a GONADOTROPIN RELEASE |
| 690 | 1 | 0 | |a HYPOPHYSIS CELL |
| 690 | 1 | 0 | |a LUTEINIZING HORMONE RELEASE |
| 690 | 1 | 0 | |a MONOLAYER CULTURE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROLACTIN RELEASE |
| 690 | 1 | 0 | |a RAT |
| 653 | 0 | 0 | |a lioresal, Ciba Geigy, Argentina |
| 700 | 1 | |a Rey, E. | |
| 700 | 1 | |a Libertum, C. | |
| 773 | 0 | |d 1992 |g v. 56 |h pp. 687-693 |k n. 5 |p NEUROENDOCRINOLOGY |x 00283835 |w (AR-BaUEN)CENRE-6253 |t Neuroendocrinology | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027100472&doi=10.1159%2f000126294&partnerID=40&md5=17dc7917d71d4695c9733b43893433b8 |y Registro en Scopus |
| 856 | 4 | 0 | |u https://doi.org/10.1159/000126294 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00283835_v56_n5_p687_LuxLantos |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00283835_v56_n5_p687_LuxLantos |y Registro en la Biblioteca Digital |
| 961 | |a paper_00283835_v56_n5_p687_LuxLantos |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 80242 | ||