Estradiol increases glucocorticoid binding and glucocorticoid induction of ornithine decarboxylase in the rat spinal cord
Previous results demonstrated that estradiol (E2) treatment of ovariectomized-adrenalectomized (OVX-ADX) rats increased glucocorticoid (GC) binding in brain regions. The experimental protocol was extended to the spinal cord, a GC target tissue in which ornithine decarboxylase (ODC) is markedly induc...
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| Formato: | Capítulo de libro |
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1993
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 07082caa a22011177a 4500 | ||
|---|---|---|---|
| 001 | PAPER-19205 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205033.0 | ||
| 008 | 190411s1993 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0027397541 | |
| 024 | 7 | |2 cas |a Estradiol, 50-28-2; Glucocorticoids; Ornithine Decarboxylase, EC 4.1.1.17; Receptors, Glucocorticoid | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a LIFSA | ||
| 100 | 1 | |a Ferrini, M. | |
| 245 | 1 | 0 | |a Estradiol increases glucocorticoid binding and glucocorticoid induction of ornithine decarboxylase in the rat spinal cord |
| 260 | |c 1993 | ||
| 270 | 1 | 0 | |m Ferrini, M.; Laboratorio de Bioquímica Neuroendócrina, Instituto de Biología y Medicina Experimental, Obligado 2490, 1428 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Mcewen, Brinton, Chao, Coirini, Gannon, Gould, Callaghan, Wooley, (1990) Neuroendocrine Perspectives, pp. 93-130. , E.E. Muller, R.M. Macleod, Springer-Verlag, Berlin | ||
| 504 | |a Turner, Weaver, (1985) Brain Res., 343, pp. 16-23 | ||
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| 504 | |a Pfeiffer, Bardin, (1988) Mol. Cell. Endocrinol., 55, pp. 115-120 | ||
| 504 | |a Ferrini, Magariños, De Nicola, J. Steroid Biochem. (1989) J. Steroid Biochem., 50, pp. 673-678 | ||
| 504 | |a Ferrini, De Nicola, (1991) Life Sci., 48, pp. 2593-2601 | ||
| 504 | |a Reul, De Kloet, (1985) Endocrinology, 117, pp. 2502-2511 | ||
| 504 | |a Burgess, Handa, (1990) Soc. Neurosci. Abstr., 16, p. 1070 | ||
| 504 | |a Turner, (1992) Brain Res., 581, pp. 229-236 | ||
| 504 | |a De Nicola, Moses, Gonzalez, Orti, (1989) Cell Mol. Neurobiol., 9, pp. 179-192 | ||
| 504 | |a Orti, Moses, Grillo, De Nicola, (1987) J. Neurochem., 48, pp. 425-431 | ||
| 504 | |a Gonzalez, Moses, De Nicola, (1990) J. Neurochem., 54, pp. 834-840 | ||
| 504 | |a Maclusky, Roy, Shanabrough, Eisenfeld, (1986) J. Neurosci. Methods, 16, pp. 131-140 | ||
| 504 | |a Moses, Orti, De Nicola, (1987) Brain Res., 408, pp. 118-124 | ||
| 504 | |a Palkovits, Brownstein, (1988) Maps and Guide to microdissection of the Rat Brain, , Elsevier, N.Y | ||
| 504 | |a Magariños, Ferrini, De Nicola, (1989) Neuroendocrinology, 50, pp. 673-678 | ||
| 504 | |a Lowry, Rosebrough, Farr, Randall, (1951) J. Biol. Chem., 193, pp. 265-275 | ||
| 504 | |a Weisenberg, De Nicola, Arakelian, Libertun, (1979) Endocrinology, 105, pp. 1552-1557 | ||
| 504 | |a Russell, Snyder, (1968) Proc. Natl. Acad. Sci. U.S.A., 60, pp. 1420-1427. , Second Edition | ||
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| 504 | |a Braughler, Hall, (1981) Brain Res., 219, pp. 464-469 | ||
| 504 | |a Cintra, Fuxe, Agnati, Persson, Harfstrand, Zoli, Eneroth, Zini, (1987) Neurosci. Lett., 76, pp. 269-274 | ||
| 504 | |a Gould, Wooley, Ewen, (1990) Neurosci., 37, pp. 367-375 | ||
| 504 | |a A.F.DE NICOLA, in: Neural Regeneration (F. S. SEIL, ed.) Raven Press, New York (in press); Kanje, Fransson, Edstrom, Lowkvist, (1986) Brain Res, 381, pp. 24-28 | ||
| 504 | |a Soifer, Moretto, Spencer, Sabri, Axotomy-induced ornithine decarboxylase activity in the mouse dorsal root ganglion is inhibited by the vinca alkaloids (1988) Neurochemical Research, 13, pp. 1169-1173 | ||
| 520 | 3 | |a Previous results demonstrated that estradiol (E2) treatment of ovariectomized-adrenalectomized (OVX-ADX) rats increased glucocorticoid (GC) binding in brain regions. The experimental protocol was extended to the spinal cord, a GC target tissue in which ornithine decarboxylase (ODC) is markedly induced by GC treatment. First, we measured GC binding to type I and type II receptors in ventral horn, dorsal horn and lateral funiculus of OVX-ADX rats treated during 4 days with E2 or vehicle. In E2-treated rats, type II receptors increased solely in dorsal horn, whereas type I sites remained unchanged. Second, in a group of OVX-ADX rats receiving dexamethasone (DEX), pretreatment with E2 superinduced ODC in ventral horn and lateral funiculus, but not in dorsal horn. Third, we found that the dorsal horn was relatively enriched in E2 receptors compared to other areas. Therefore, E2 stimulation of GC binding to type II sites may be mediated through E2 receptors localized in the dorsal horn. We suggest that combined treatment with E2 and DEX employs a transsynaptic mechanism for ODC induction at the ventral horn and lateral funiculus, with hormonal interaction taking place at the dorsal horn level. © 1993. |l eng | |
| 536 | |a Detalles de la financiación: This work was supported by a grant from N.I.H. (NS 20866-06AI) and by the National Research Council of Argentina (PID 3-010200/88). | ||
| 593 | |a Laboratorio de Bioquímica Neuroendócrina, Instituto de Biología y Medicina Experimental, Obligado 2490, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a DEXAMETHASONE |
| 690 | 1 | 0 | |a ESTRADIOL |
| 690 | 1 | 0 | |a ESTRADIOL RECEPTOR |
| 690 | 1 | 0 | |a GLUCOCORTICOID RECEPTOR |
| 690 | 1 | 0 | |a ORNITHINE DECARBOXYLASE |
| 690 | 1 | 0 | |a RADIOLIGAND |
| 690 | 1 | 0 | |a ADRENALECTOMY |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a BINDING SITE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a ENZYME INDUCTION |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a OVARIECTOMY |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a SPINAL CORD |
| 690 | 1 | 0 | |a SPINAL CORD DORSAL HORN |
| 690 | 1 | 0 | |a SPINAL CORD VENTRAL HORN |
| 690 | 1 | 0 | |a SUBCUTANEOUS DRUG ADMINISTRATION |
| 690 | 1 | 0 | |a ADRENALECTOMY |
| 690 | 1 | 0 | |a ANALYSIS OF VARIANCE |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a ENZYME INDUCTION |
| 690 | 1 | 0 | |a ESTRADIOL |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a GLUCOCORTICOIDS |
| 690 | 1 | 0 | |a ORNITHINE DECARBOXYLASE |
| 690 | 1 | 0 | |a OVARIECTOMY |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RATS, SPRAGUE-DAWLEY |
| 690 | 1 | 0 | |a RECEPTORS, GLUCOCORTICOID |
| 690 | 1 | 0 | |a SPINAL CORD |
| 690 | 1 | 0 | |a SUPPORT, NON-U.S. GOV'T |
| 690 | 1 | 0 | |a SUPPORT, U.S. GOV'T, P.H.S. |
| 690 | 1 | 0 | |a ANIMALIA |
| 700 | 1 | |a González, S. | |
| 700 | 1 | |a De Nicola, A.F. | |
| 773 | 0 | |d 1993 |g v. 52 |h pp. 677-685 |k n. 7 |p Life Sci. |x 00243205 |w (AR-BaUEN)CENRE-749 |t Life Sciences | |
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| 856 | 4 | 0 | |u https://doi.org/10.1016/0024-3205(93)90460-K |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00243205_v52_n7_p677_Ferrini |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00243205_v52_n7_p677_Ferrini |y Registro en la Biblioteca Digital |
| 961 | |a paper_00243205_v52_n7_p677_Ferrini |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 80158 | ||