Effect of a gonadotropin-releasing hormone agonist on luteinizing hormone receptors and steroidogenesis in ovarian cells

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Objective: To examine the effect of a gonadotropin-releasing hormone agonist (GnRH-a), leuprolide acetate (LA), on human chorionic gonadotropin/luteinizing hormone (LH) receptors content and progesterone (P) and estradiol (E2) production in cultured granulosa or luteal cells. Design: Prospective. Se...

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Detalles Bibliográficos
Autor principal: Guerrero, H.E
Otros Autores: Stein, P., Asch, R.H, De Fried, E.P, Tesone, M.
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 1993
Materias:
lupron, Abbott, Argentina; metrodine, Serono, Argentina; profasi, Serono
Acceso en línea:Registro en Scopus
Handle
Registro en la Biblioteca Digital
Aporte de:Registro referencial: Solicitar el recurso aquí
Biblioteca Central Dr. Luis F. Leloir (FCEN) de Universidad de Buenos Aires
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024 7 |2 scopus  |a 2-s2.0-0027510552 
024 7 |2 cas  |a aromatase, 9039-48-9; chorionic gonadotropin, 9002-61-3; estradiol, 50-28-2; gonadorelin, 33515-09-2, 9034-40-6; human menopausal gonadotropin, 61489-71-2; leuprorelin, 53714-56-0, 74381-53-6; luteinizing hormone, 39341-83-8, 9002-67-9; progesterone, 57-83-0; urofollitropin, 97048-13-0 
040 |a Scopus  |b spa  |c AR-BaUEN  |d AR-BaUEN 
030 |a FESTA 
100 1 |a Guerrero, H.E. 
245 1 0 |a Effect of a gonadotropin-releasing hormone agonist on luteinizing hormone receptors and steroidogenesis in ovarian cells 
260 |c 1993 
270 1 0 |m Tesone, M.; Instituto de Biol./Med. Experimental, Obligado 2490, 1428 Buenos Aires, Argentina 
506 |2 openaire  |e Política editorial 
520 3 |a Objective: To examine the effect of a gonadotropin-releasing hormone agonist (GnRH-a), leuprolide acetate (LA), on human chorionic gonadotropin/luteinizing hormone (LH) receptors content and progesterone (P) and estradiol (E2) production in cultured granulosa or luteal cells. Design: Prospective. Setting: Private Fertility Clinic and National Research Institute. Patients: Twenty patients undergoing in vitro fertilization or gamete intrafallopian transfer programs. Results: Human chorionic gonadotropin/LH receptors in human granulosa cells increased after 48 hours of culture, and LA inhibited such effect. Leuprolide acetate, 1 ng/mL, in the cultures produced an increase in P production. On the contrary, LA inhibited E2 production. Additionally, the in vivo effect of LA (2 μg/rat per 7 days) was studied in corpus luteum of superovulated rats. Luteal cells from LA- treated rats in culture produced lower P than the controls but showed an increase in aromatase activity. Luteal LH receptors declined after 48 hours of culture with LA. Conclusion: The high doses of gonadotropin necessary to induce ovarian hyperstimulation when GnRH-a is administered could be related with an inhibitory effect of these agonists on LH receptors and aromatase activity.  |l eng 
536 |a Detalles de la financiación: National Research Council 
536 |a Detalles de la financiación: Third World Academy of Sciences, RG BC 890-114 
536 |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas, 0488/88 
536 |a Detalles de la financiación: Fundación Antorchas 
536 |a Detalles de la financiación: Received April 15, 1992; revised and accepted November 13, 1992. * Supported by grants from Consejo Nacional de Investigaciones Cientificas y Tecnicas, 0488/88, National Research Council, Buenos Aires, Argentina, Third World Academy of Sciences, RG BC 890-114, Trieste, Italy, and Antorchas Foundation, Buenos Aires, Argentina. t Instituto de Biologia y Medicina Experimental. :j: Centro de Salud Reproductiva (CER). § Reprints request: Marta Tesone, Ph.D., Instituto de Biologia y Medicina Experimental, Obligado 2490 (1428), Buenos Aires, Argentina. 
593 |a Instituto de Biol./Med. Experimental, Obligado 2490, 1428 Buenos Aires, Argentina 
690 1 0 |a GNRH-A 
690 1 0 |a GRANULOSA CELLS 
690 1 0 |a LH RECEPTORS 
690 1 0 |a LUTEAL CELLS 
690 1 0 |a STEROIDOGENESIS 
690 1 0 |a AROMATASE 
690 1 0 |a CHORIONIC GONADOTROPIN 
690 1 0 |a ESTRADIOL 
690 1 0 |a GONADORELIN 
690 1 0 |a GONADORELIN AGONIST 
690 1 0 |a HUMAN MENOPAUSAL GONADOTROPIN 
690 1 0 |a LEUPRORELIN 
690 1 0 |a LUTEINIZING HORMONE 
690 1 0 |a LUTEINIZING HORMONE RECEPTOR 
690 1 0 |a PROGESTERONE 
690 1 0 |a UROFOLLITROPIN 
690 1 0 |a ANIMAL CELL 
690 1 0 |a ARTICLE 
690 1 0 |a BINDING SITE 
690 1 0 |a CELL CULTURE 
690 1 0 |a CLINICAL ARTICLE 
690 1 0 |a CONTROLLED STUDY 
690 1 0 |a CORPUS LUTEUM 
690 1 0 |a ECHOGRAPHY 
690 1 0 |a ENZYME ACTIVITY 
690 1 0 |a FEMALE 
690 1 0 |a GRANULOSA CELL 
690 1 0 |a HUMAN 
690 1 0 |a HUMAN CELL 
690 1 0 |a LUTEAL CELL 
690 1 0 |a NONHUMAN 
690 1 0 |a PRIORITY JOURNAL 
690 1 0 |a RADIOIMMUNOASSAY 
690 1 0 |a RAT 
690 1 0 |a STEROIDOGENESIS 
653 0 0 |a lupron, Abbott, Argentina; metrodine, Serono, Argentina; profasi, Serono 
700 1 |a Stein, P. 
700 1 |a Asch, R.H. 
700 1 |a De Fried, E.P. 
700 1 |a Tesone, M. 
773 0 |d 1993  |g v. 59  |h pp. 803-809  |k n. 4  |p FERTIL. STERIL.  |x 00150282  |w (AR-BaUEN)CENRE-4731  |t Fertility and Sterility 
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856 4 0 |u https://hdl.handle.net/20.500.12110/paper_00150282_v59_n4_p803_Guerrero  |y Handle 
856 4 0 |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00150282_v59_n4_p803_Guerrero  |y Registro en la Biblioteca Digital 
961 |a paper_00150282_v59_n4_p803_Guerrero  |b paper  |c PE 
962 |a info:eu-repo/semantics/article  |a info:ar-repo/semantics/artículo  |b info:eu-repo/semantics/publishedVersion 

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