Effects of LHRH and ANG II on prolactin stimulation are mediated by hypophysial AT1 receptor subtype
We have used the nonpeptide angiotensin II (ANG II) receptor antagonists losartan (receptor subtype AT1) and PD-123319 (AT2) to determine the participation of ANG II receptor subtypes in luteinizing hormone-releasing hormone (LHRH)-induced prolactin release in a perifusion study using intact pituita...
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| Otros Autores: | , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1994
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| Materias: | |
| Acceso en línea: | Registro en Scopus Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 05020caa a22008897a 4500 | ||
|---|---|---|---|
| 001 | PAPER-19130 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205029.0 | ||
| 008 | 190411s1994 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0028260124 | |
| 024 | 7 | |2 cas |a 1 (4 dimethylamino 3 methylbenzyl) 5 diphenylacetyl 4,5,6,7 tetrahydro 1h imidazo[4,5 c]pyridine 6 carboxylic acid, 130663-39-7; angiotensin, 11128-99-7, 1407-47-2; follitropin, 9002-68-0; gonadorelin, 33515-09-2, 9034-40-6; losartan potassium, 124750-99-8; losartan, 114798-26-4; luteinizing hormone, 39341-83-8, 9002-67-9; prolactin, 12585-34-1, 50647-00-2, 9002-62-4; Angiotensin II, 11128-99-7; Biphenyl Compounds; Gonadorelin, 33515-09-2; Imidazoles; Losartan, 114798-26-4; PD 123319, 130663-39-7; Prolactin, 9002-62-4; Pyridines; Receptors, Angiotensin; Tetrazoles | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a AJPMD | ||
| 100 | 1 | |a Becu-Villalobos, D. | |
| 245 | 1 | 0 | |a Effects of LHRH and ANG II on prolactin stimulation are mediated by hypophysial AT1 receptor subtype |
| 260 | |c 1994 | ||
| 270 | 1 | 0 | |m Libertun, C.; Laboratorio de Neuroendocrinologia, IBME, CONICET, V. Obligado 2490, 1428 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 520 | 3 | |a We have used the nonpeptide angiotensin II (ANG II) receptor antagonists losartan (receptor subtype AT1) and PD-123319 (AT2) to determine the participation of ANG II receptor subtypes in luteinizing hormone-releasing hormone (LHRH)-induced prolactin release in a perifusion study using intact pituitaries in vitro. LHRH (1.85 x 10-7 M) released prolactin consistently, whereas losartan (10-5 M) abolished prolactin response without modifying basal prolactin or luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release. PD-123319 (10-5 M) had no effect on basal or LHRH-induced prolactin, LH, or FSH release. We also determined that the effect of ANG II on prolactin release was mediated by the same receptor subtype. In adenohypophysial cells dispersed in vitro ANG II (10-8 M) released prolactin. Losartan (10-7 and 10-6 M), but not PD-123319, inhibited this effect. We conclude that in intact hypophyses of 15-day-old female rats the effect of LHRH on prolactin release is readily demonstrated. LHRH-induced prolactin release appears to be mediated by ANG II acting in a paracrine manner on AT1 receptors located on lactotrophs. |l eng | |
| 593 | |a Laboratorio de Neuroendocrinologia, IBME, CONICET, V. Obligado 2490, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a ANGIOTENSIN II RECEPTOR SUBTYPES |
| 690 | 1 | 0 | |a LOSARTAN |
| 690 | 1 | 0 | |a LUTEINIZING HORMONE-RELEASING HORMONE |
| 690 | 1 | 0 | |a PARACRINE |
| 690 | 1 | 0 | |a PD-123319 |
| 690 | 1 | 0 | |a PITUITARY |
| 690 | 1 | 0 | |a 1 (4 DIMETHYLAMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID |
| 690 | 1 | 0 | |a ANGIOTENSIN |
| 690 | 1 | 0 | |a ANGIOTENSIN RECEPTOR |
| 690 | 1 | 0 | |a FOLLITROPIN |
| 690 | 1 | 0 | |a GONADORELIN |
| 690 | 1 | 0 | |a LOSARTAN |
| 690 | 1 | 0 | |a LOSARTAN POTASSIUM |
| 690 | 1 | 0 | |a LUTEINIZING HORMONE |
| 690 | 1 | 0 | |a PROLACTIN |
| 690 | 1 | 0 | |a RECEPTOR SUBTYPE |
| 690 | 1 | 0 | |a ADENOHYPOPHYSIS |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a FOLLITROPIN RELEASE |
| 690 | 1 | 0 | |a LUTEINIZING HORMONE RELEASE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROLACTIN RELEASE |
| 690 | 1 | 0 | |a PROLACTIN SECRETING CELL |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a ANGIOTENSIN II |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a BIPHENYL COMPOUNDS |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a GONADORELIN |
| 690 | 1 | 0 | |a IMIDAZOLES |
| 690 | 1 | 0 | |a IN VITRO |
| 690 | 1 | 0 | |a LOSARTAN |
| 690 | 1 | 0 | |a PERFUSION |
| 690 | 1 | 0 | |a PITUITARY GLAND |
| 690 | 1 | 0 | |a PROLACTIN |
| 690 | 1 | 0 | |a PYRIDINES |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RATS, SPRAGUE-DAWLEY |
| 690 | 1 | 0 | |a RECEPTORS, ANGIOTENSIN |
| 690 | 1 | 0 | |a SUPPORT, NON-U.S. GOV'T |
| 690 | 1 | 0 | |a TETRAZOLES |
| 653 | 0 | 0 | |a dup 753, du pont merck, United States; pd 123319, parke davis, United States |
| 700 | 1 | |a Lacau-Mengido, I.M. | |
| 700 | 1 | |a Thyssen, S.M. | |
| 700 | 1 | |a Diaz-Torga, G.S. | |
| 700 | 1 | |a Libertun, C. | |
| 773 | 0 | |d 1994 |g v. 266 |h pp. E274-E278 |k n. 2 29-2 |p AM. J. PHYSIOL. ENDOCRINOL. METAB. |x 00029513 |w (AR-BaUEN)CENRE-1678 |t American Journal of Physiology - Endocrinology and Metabolism | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028260124&partnerID=40&md5=9e6bd6bd2c89929a3c96979a14ff9076 |y Registro en Scopus |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00029513_v266_n229-2_pE274_BecuVillalobos |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00029513_v266_n229-2_pE274_BecuVillalobos |y Registro en la Biblioteca Digital |
| 961 | |a paper_00029513_v266_n229-2_pE274_BecuVillalobos |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||