Recent developments in the control of Trypanosoma cruzi, the causative agent for Chagas' disease
Chagas' disease is a terrible illness that affects million of people in Central and South America. The causative agent for this disease is the hemoflagellate protozoan Trypanosoma (Schizotrypanum) cruzi which is transmitted to the human body by Reduviid insects, such as Triatoma infectans, popu...
Guardado en:
| Autor principal: | |
|---|---|
| Otros Autores: | |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1995
|
| Materias: | |
| Acceso en línea: | Registro en Scopus Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 04669caa a22006977a 4500 | ||
|---|---|---|---|
| 001 | PAPER-19006 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230607131910.0 | ||
| 008 | 190411s1995 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0028827091 | |
| 024 | 7 | |2 cas |a 2 (2,4 difluorophenyl) 1 [3 [2 [4 (2,2,3,3 tetrafluoropropoxy)phenyl]vinyl] 1,2,4 triazol 1 yl] 3 (1,2,4 triazol 1 yl) 2 propanol, 103961-78-0, 141113-28-2; ajoene, 92285-01-3; benznidazole, 22994-85-0; chlorpromazine, 50-53-3, 69-09-0; cisplatin, 15663-27-1, 26035-31-4, 96081-74-2; clotrimazole, 23593-75-1; crystal violet, 467-63-0, 548-62-9; fenoxycarb, 72490-01-8; fluconazole, 86386-73-4; ionomycin, 56092-81-0; ketoconazole, 65277-42-1; mevinolin, 75330-75-5; nifurtimox, 23256-30-6; purpurin, 81-54-9; sinefungin, 58944-73-3; snake venom, 55230-69-8; terbinafine, 91161-71-6; trypanothione, 96304-42-6 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a CMCHE | ||
| 100 | 1 | |a Rodriguez, J.B. | |
| 245 | 1 | 0 | |a Recent developments in the control of Trypanosoma cruzi, the causative agent for Chagas' disease |
| 260 | |c 1995 | ||
| 270 | 1 | 0 | |m Rodriguez, J.B.; Depto. de Quimica Organica, Fac. de Ciencias Exactas/Naturales, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 520 | 3 | |a Chagas' disease is a terrible illness that affects million of people in Central and South America. The causative agent for this disease is the hemoflagellate protozoan Trypanosoma (Schizotrypanum) cruzi which is transmitted to the human body by Reduviid insects, such as Triatoma infectans, popularly known as 'vinchuca', and Rhodnius prolixus. This parasite is also transmitted by transfusion of infected blood. Despite of the progresses made in chemotherapy, new compounds are needed because the trypanocidal drugs presently in use cause considerable side effects on patients and present lack of efficacy and specificity against all stages of the disease. There is no effective treatment available for Chagas' disease in spite of the important advances made in the study of the biochemistry of the microorganism responsible for the mentioned disease. The urgency for more selective and less toxic drugs has led to evaluate chemical therapy based on the knowledge of T. cruzi biochemistry and the mode of action of these compounds. In addition, due to the risk that T. cruzi may be transmitted in blood bank for transfusions, it is very important to have new compounds to kill this parasite in blood to be transfused. At present the drug in use for this purpose suffers from serious limitations concerning its safety. In the present work, the recent advances made in order to control the replication of this parasite are presented. |l eng | |
| 593 | |a Depto. de Quimica Organica, Fac. de Ciencias Exactas/Naturales, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a 2 (2,4 DIFLUOROPHENYL) 1 [3 [2 [4 (2,2,3,3 TETRAFLUOROPROPOXY)PHENYL]VINYL] 1,2,4 TRIAZOL 1 YL] 3 (1,2,4 TRIAZOL 1 YL) 2 PROPANOL |
| 690 | 1 | 0 | |a AJOENE |
| 690 | 1 | 0 | |a ALKALOID |
| 690 | 1 | 0 | |a ANTIFUNGAL AGENT |
| 690 | 1 | 0 | |a ANTINEOPLASTIC AGENT |
| 690 | 1 | 0 | |a ANTITRYPANOSOMAL AGENT |
| 690 | 1 | 0 | |a BENZNIDAZOLE |
| 690 | 1 | 0 | |a CHLORPROMAZINE |
| 690 | 1 | 0 | |a CISPLATIN |
| 690 | 1 | 0 | |a CLOTRIMAZOLE |
| 690 | 1 | 0 | |a CRYSTAL VIOLET |
| 690 | 1 | 0 | |a ENZYME INHIBITOR |
| 690 | 1 | 0 | |a FENOXYCARB |
| 690 | 1 | 0 | |a FLUCONAZOLE |
| 690 | 1 | 0 | |a IONOMYCIN |
| 690 | 1 | 0 | |a JUVENILE HORMONE DERIVATIVE |
| 690 | 1 | 0 | |a KETOCONAZOLE |
| 690 | 1 | 0 | |a METAL COMPLEX |
| 690 | 1 | 0 | |a MEVINOLIN |
| 690 | 1 | 0 | |a NIFURTIMOX |
| 690 | 1 | 0 | |a NUCLEOSIDE DERIVATIVE |
| 690 | 1 | 0 | |a PURPURIN |
| 690 | 1 | 0 | |a SINEFUNGIN |
| 690 | 1 | 0 | |a SNAKE VENOM |
| 690 | 1 | 0 | |a TERBINAFINE |
| 690 | 1 | 0 | |a TRYPANOTHIONE |
| 690 | 1 | 0 | |a AGED |
| 690 | 1 | 0 | |a CHAGAS DISEASE |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a REVIEW |
| 690 | 1 | 0 | |a TRYPANOSOMA CRUZI |
| 653 | 0 | 0 | |a ici 195739 |
| 700 | 1 | |a Gros, E.G. | |
| 773 | 0 | |d 1995 |g v. 2 |h pp. 723-742 |k n. 3 |p CURR. MED. CHEM. |x 09298673 |t Current Medicinal Chemistry | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028827091&partnerID=40&md5=b5cff04d18edd31eb6b342cc890479fd |y Registro en Scopus |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_09298673_v2_n3_p723_Rodriguez |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09298673_v2_n3_p723_Rodriguez |y Registro en la Biblioteca Digital |
| 961 | |a paper_09298673_v2_n3_p723_Rodriguez |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 79959 | ||